当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Significance of HLA Antibody Detected by PRA-Bead Method in Kidney Transplant Outcomes.

Significance of HLA Antibody Detected by PRA-Bead Method in Kidney Transplant Outcomes.

Abstract：

BACKGROUND:The impact of specific HLA antibodies on the allograft function in the Luminex era is not clearly known. This study aimed to investigate kidney transplantation outcomes in patients with different anti-HLA antibody status as detected by Luminex PRA. METHODS:This retrospective study included 106 deceased-donor kidney transplantation (DDKT) patients divided into 3 groups by PRA status as detected by PRA-bead: (1) PRA = 0; (2) positive PRA but with negative antibody against donor's HLA antigens; and (3) positive PRA with positive anti-HLA antibody specificity against donor's HLA antigens. RESULTS:There were 65, 23, and 18 patients in groups 1, 2, and 3, respectively. Early allograft rejections were highest in group 3 (22.2%) (P = .02). In multivariate analysis, delayed graft function was the only factor that was associated with allograft rejection (hazard ratio, 8.9; 95% confidence interval, 1.9-39.8; P = .004). Estimated glomerular filtration rates at 1 year of the 3 groups were 54.6, 55.8, and 60.0 mL/min (P = .71). One-year allograft failure and death were not different among the 3 groups. Expanded-criteria deceased donors were associated with both allograft failure (P = .003) and patient death (P = .02). CONCLUSIONS:Anti-HLA antibody as detected by Luminex PRA was associated with early allograft rejection but not graft or patient survival. The effect of newer treatment modalities can improve the outcomes of PRA-positive patients to be similar to nonsensitized patients at 1 year.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Wiwattanathum P,Ingsathit A,Thammanichanond D,Mongkolsuk T,Sumethkul V

doi

10.1016/j.transproceed.2016.02.029

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

761-5

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(16)00269-4

journal_volume

48

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • A prospective comparison of bladder versus enteric drainage in vascularized pancreas transplantation.

    abstract：:Although the number of pancreas transplants has increased significantly in previous years, debate continues concerning the optimum technique for exocrine pancreas drainage. Enteric drainage (ED) has recently been increasingly popular due to the long-term complications with bladder drainage (BD). We prospectively assig...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.05.027

    authors： Adamec M,Janousek L,Lipár K,Hampl F,Saudek F,Koznarová R,Boucek P,Havrdová T

    更新日期：2004-05-01 00:00:00

  • Hepatitis C virus recurrence after liver transplantation: influence of immunosuppressive regimens on viral load and liver histology.

    abstract：:Cyclosporine has recently been reported to produce in vitro suppression of hepatitis C virus replication driven by blockade of cyclophilins, an effect not shown for tacrolimus. However, the clinical consequence of this in vitro finding have not been well studied in vivo. We compared viral load and fibrosis in transpla...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.055

    authors： Oton E,Barcena R,Castillo M,Barreales M,Blesa C,Moreno-Planas JM,Barrios C,Garrido A,Cuervas V

    更新日期：2006-10-01 00:00:00

  • Mechanical assist devices as bridging systems to transplantation: A current review, possible risks, and perspectives.

    abstract：:Mechanical circulatory support is of increasing interest because of its considerable demographic importance concerning myocardial failure and because of stagnant transplantation volumes. This study offers an overview of the present state of the art. Institutions with a mechanical circulatory assist program usually dis...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2004.10.082

    authors： Litmathe J,Boeken U,Feindt P,Marktanner R,Gams E

    更新日期：2004-12-01 00:00:00

  • Intrathecal implants of microencapsulated xenogenic chromaffin cells provide a long-term source of analgesic substances.

    abstract：:Adrenal medullary chromaffin cells secrete several neuroactive substances including catecholamines and opioid peptides that produce analgesic effects in the central nervous system. This study was designed to investigate whether intrathecal microencapsulated chromaffin cells could release analgesic materials producing ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.098

    authors： Jeon Y,Kwak K,Kim S,Kim Y,Lim J,Baek W

    更新日期：2006-11-01 00:00:00

  • Alleviating ischemia-reperfusion injury in aged rat liver by induction of heme oxygenase-1.

    abstract：BACKGROUND:Heme oxygenase-1 (HO-1), a cytoprotective protein, may be important in ameliorating hepatic ischemia-reperfusion (I/R) injury, a critical factor in the dysfunction of the aged liver after transplantation. METHODS:We used hemin to overexpress HO-1 and analyze its effects in a model of I/R in aged livers used...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.10.066

    authors： Wang XH,Wang K,Zhang F,Li XC,Qian XF,Cheng F,Li GQ,Fan Y

    更新日期：2004-12-01 00:00:00

  • Pulse Oximeter Usefulness for Blood Pressure Monitoring in Patients Implanted With Latest-Generation Continuous-Flow Device HeartMate 3.

    abstract：INTRODUCTION:The measurement of blood pressure (BP) and the management of hypertension in patients with continuous-flow ventricular assist devices (CF-VADs) can present unique challenges. Patients with CF-VADs often do not have a palpable pulse, and therefore traditional blood pressure measurement by auscultation or au...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.transproceed.2018.04.086

    authors： Montalto A,Palermo A,Gherli R,Cammardella A,Contento C,Piazza V,Musumeci F

    更新日期：2019-01-01 00:00:00

  • Effectiveness of a new drug, bredinin, on canine kidney allotransplant survival.

    abstract：:BR has remarkable effectiveness on canine kidney allograft survival. Its effectiveness in suppression of the immune responses is dependent on the dosage. Atrophy of the spleen and the mesenteric lymph nodes is prominent in treated dogs. Septic complications are slight, with no reduction in the number of peripheral whi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Uchida H,Yokota K,Akiyama N,Masaki Y,Aso K,Okubo M,Okudaira M,Kato M,Kashiwagi N

    更新日期：1979-03-01 00:00:00

  • Impact of donor cause of death on transplant outcomes: UNOS registry analysis.

    abstract：:Donor cause of death (DCOD) has been described to influence allograft survival. Whether this effect is independent of other donor characteristics and whether it is similar across different solid organ allografts is not known. The aim of our study was to determine the impact of DCOD on organ utilization and on transpla...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.06.192

    authors： Singhal AK,Sheng X,Drakos SG,Stehlik J

    更新日期：2009-11-01 00:00:00

  • Development of Squamous Cell Carcinoma After Pulmonary Aspergillosis in the Native Lung of a Lung Transplant Recipient: A Case Report.

    abstract：:Lung transplant recipients have a significant incidence of posttransplant lung nodules. Such nodules can occur from various etiologies, both in the lung allograft or in the native lung. They most commonly originate from infections, such as Pseudomonas or Aspergillus species, or from posttransplant lymphoproliferative ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.07.034

    authors： Madan N,Abdelrazek H,Patil PD,Ross MD,Roy SB,Thawani N,Hahn MF,Bremner RM,Panchabhai TS

    更新日期：2018-12-01 00:00:00

  • Everolimus-based immunosuppression therapy for BK virus nephropathy.

    abstract：BACKGROUND:Mammalian target of rapamycin inhibitors (mTOR-i) have been proposed as possible immunosuppressants of choice in BK virus nephropathy (BKN) because of their antiviral capacity. On this basis, in 2007, our Service proposed a conversion to everolimus (EVE)-based therapy from calcineurin inhibitors with an anti...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.11.008

    authors： Polanco N,González Monte E,Folgueira MD,Morales E,Gutiérrez Martínez E,Bengoa I,Hernández A,Morales JM,Praga M,Andrés A

    更新日期：2015-01-01 00:00:00

  • Molecular and phenotypic characteristics of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in transplantation wards.

    abstract：OBJECTIVES:Hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) frequently causes therapeutic problems and provides information about the epidemiological condition of the ward. MATERIALS AND METHODS:HA-MRSA isolated from patients on transplantation wards in 1991, 1994, 1996, and from 2005 to 2007 we...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.08.026

    authors： Mlynarczyk A,Szymanek-Majchrzak K,Grzybowska W,Durlik M,Deborska-Materkowska D,Paczek L,Chmura A,Swoboda-Kopec E,Tyski S,Mlynarczyk G

    更新日期：2014-10-01 00:00:00

  • Rapamycin induces autophagy in islets: relevance in islet transplantation.

    abstract：:Islet transplantation can provide insulin independence in patients with type 1 diabetes mellitus. However, islet allograft recipients exhibit a gradual decline in insulin independence, and only 10% do not require insulin at 5 years. This decline may reflect drug toxicity to islet beta cells. Rapamycin, a central immun...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.10.032

    authors： Tanemura M,Saga A,Kawamoto K,Machida T,Deguchi T,Nishida T,Sawa Y,Doki Y,Mori M,Ito T

    更新日期：2009-01-01 00:00:00

  • The impact of experience of a transplantation center on the outcomes of orthotopic liver transplantation.

    abstract：:The so-called learning factor has been disregarded for many years in analyzing the causes of surgical complications and post-operative mortality; it is also the case for OLT. In our center until April 2003, 209 OLT were performed in 196 patients. We evaluated the impact of experience of the transplantation team on the...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00834-0

    authors： Krawczyk M,Grzelak I,Zieniewicz K,Nyckowski P,Pawlak J,Michałowicz B,Patkowski W,Alsharabi A,Wróblewski T,Paluszkiewicz R,Małkowski P,Hevelke P,Pszenny C,Remiszewski P,Skwarek A,Smoter P,Grodzicki M,Kornasiewicz O,Kor

    更新日期：2003-09-01 00:00:00

  • Effect of low-level laser irradiation on in vitro function of pancreatic islets.

    abstract：INTRODUCTION:Although islet isolation and transplantation techniques have improved extensively in recent years, the loss of healthy functional islets is one of the major obstacles in this enterprise. A biostimulatory effect of low-level laser irradiation has been proven on proliferation of some kinds of cells. The aim ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.09.065

    authors： Irani S,Mohseni Salehi Monfared SS,Akbari-Kamrani M,Ostad SN,Abdollahi M,Larijani B

    更新日期：2009-12-01 00:00:00

  • Frequency of Human Papilloma Virus Occurrence Among Pathological Changes of the Oral Cavity in Kidney Allotransplant Recipients Undergoing Long-Term Pharmacological Immunosuppressive Therapy.

    abstract：:Recipients of allotransplants are more susceptible to viral infections, among which the human papilloma virus infection is an independent factor inducing precancerous lesions and cancers of both the anogenital and the cervicocephalic region. MATERIALS AND METHODS:The study included a group of 69 allogenic kidney tran...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.05.008

    authors： Szubińska-Lelonkiewicz D,Osiak M,Wychowański P,Siewert-Gutowska M,Fiedor P

    更新日期：2018-01-01 00:00:00

  • Donor-reactive cytokine production after HLA-identical living related kidney transplantation: a protein-array analysis.

    abstract：:In the present pilot study, we investigated which proteins are produced after donor stimulation of peripheral blood mononuclear cells from recipients of HLA-identical living related kidney transplant. We used a protein-array analysis to determine cytokines, chemokines, and growth factors in supernatant from donor-stim...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.183

    authors： Gerrits JH,van de Wetering J,Weimar W,van Besouw NM

    更新日期：2006-11-01 00:00:00

  • Diagnostic value of antibodies against Pseudomonas aeruginosa in bronchoalveolar lavage fluid after lung transplantation.

    abstract：BACKGROUND:Pseudomonal airway colonization is a risk factor for chronic allograft dysfunction after lung transplantation (LTx). Pseudomonas aeruginosa exoproteases are involved in initiating colonization, and immune complexes directed against these proteases may activate innate immune responses. OBJECTIVE:To investiga...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.07.017

    authors： Vos R,Vanaudenaerde BM,Verleden SE,De Vleeschauwer SI,Willems-Widyastuti A,Van Raemdonck DE,Dupont LJ,Verleden GM

    更新日期：2010-12-01 00:00:00

  • Ventricular assist device as a bridge to heart transplantation in adults.

    abstract：BACKGROUND:Because of the shortage of donor hearts, various ventricular asist devices (VAD) have been used in decompensated patients to prolong patient survival until a suitable heart becomes available. In this paper, we present our single-center report of adult patients in whom bridging was used with VAD. METHODS:We ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.01.147

    authors： Engin C,Ayik F,Oguz E,Eygi B,Yagdi T,Karakula S,Ozbaran M

    更新日期：2011-04-01 00:00:00

  • Anesthesia Management and Fluid Therapy in Right and Left Lobe Living Donor Hepatectomy.

    abstract：OBJECTIVE:Right lobe living donor hepatectomy poses a greater risk for the donor in relation to blood loss. The aims of this study were to compare anesthetic and intraoperative fluid management in right and left lateral segment living donor hepatectomy. PATIENTS AND METHODS:The anesthesia records of living donor hepat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.03.102

    authors： Wang CH,Chang KA,Chen CL,Cheng KW,Wu SC,Huang CJ,Shih TH,Yang SC,Juang SE,Huang CE,Jawan B,Lee YE

    更新日期：2018-11-01 00:00:00

  • Cloning and in vitro antiapoptotic effects of pig FLIPs.

    abstract：INTRODUCTION:Cellular FLICE-like protein (cFLIP) inhibits death receptor-mediated apoptosis signal transduction, such as that induced by Fas and TNFR. The present study examined the role of antiapoptotic molecules to protect pig cells from human natural killer (NK) cells in vitro, as a model of delayed-type xenograft r...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.08.024

    authors： Xu H,Firdawes S,Yamamoto A,Matsunami K,Ishimaru A,Kondo A,Fukuzawa M,Miyagawa S

    更新日期：2008-10-01 00:00:00

  • Intestinal transplantation: advances in immunosuppression and surgical techniques.

    abstract：:Campath-1H is being used as induction immunosuppression for intestinal/multivisceral transplantation. Patient and graft survival in this preliminary experience is similar to previous studies but there has been a significant decrease in the incidence and severity of acute rejections without increase of opportunistic in...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00734-6

    authors： Tzakis AG,Tryphonopoulos P,Kato T,Nishida S,Levi DM,Nery JR,Madariaga J,De Faria W,Mittal N,Thompson JF,Ruiz P

    更新日期：2003-08-01 00:00:00

  • Factors Affecting Recurrence and Survival After Liver Transplantation for Hepatocellular Carcinoma.

    abstract：INTRODUCTION:Liver transplantation (LT) remains the best treatment option for hepatocellular carcinoma (HCC). Patient selection is crucial and debated ever since the emerging of the Milan criteria in 1996. As live-donor LT is being more routinely performed worldwide, numerous new and/or expansions of the original crite...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.05.027

    authors： Yilmaz C,Karaca CA,Iakobadze Z,Farajov R,Kilic K,Doganay L,Kilic M

    更新日期：2018-12-01 00:00:00

  • Antigen sampling on the Peyer's patches in a murine small bowel transplantation model.

    abstract：AIM:This study investigated changes in the mucosal barrier of transplanted intestines with particular emphasis on antigen sampling by Peyer's patches (PPs). METHODS:Heterotopic small bowel transplantation (SBTx) was performed as described previously. C57BL/6 mice were used as donors and BALB/c (allogeneic) or C57BL/6 ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.08.057

    authors： Ping X,Li Y,Li J

    更新日期：2010-11-01 00:00:00

  • Hepatitis B virus, hepatitis C virus, and kidney transplant acute rejection and survival.

    abstract：:The effect of hepatitis Bs-antigen (AgHBs) and anti-hepatitis C virus (HCV) positivity on renal transplant outcomes is still controversial. Some studies describe higher rates of acute rejection and allograft loss, and greater mortality in transplant recipients with hepatitis. We retrospectively evaluated data from 228...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.04.004

    authors： Grenha V,Parada B,Ferreira C,Figueiredo A,Macário F,Alves R,Coelho H,Sepúlveda L,Freire MJ,Retroz E,Mota A

    更新日期：2015-05-01 00:00:00

  • The role of dendritic cells in the gastrointestinal field effect.

    abstract：INTRODUCTION:Intestinal manipulation leads to local bowel wall inflammation that subsequently spreads over the entire gastrointestinal tract. Previously, this gastrointestinal field effect had been demonstrated by us in a rodent model. We herein postulated an immunologic mechanism mediated by activated leukocytes. The ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.087

    authors： Koscielny A,Boerner T,Wehner S,Kurts C,Kalff JC

    更新日期：2006-07-01 00:00:00

  • Mycophenolate mofetil monotherapy in patients who underwent liver transplantation for hepatitis C cirrhosis.

    abstract：INTRODUCTION:Mycophenolate mofetil (MMF) monotherapy has recently been proposed for liver transplant recipients with adverse events (nephrotoxicity, hypertension) related to calcineurin inhibitors. We analyzed the influence of MMF on the clinical course of recurrent hepatitis C. METHODS:Among 1038 patients who underwe...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.09.040

    authors： Manrique A,Jiménez C,Ortega P,Abradelo M,Gimeno A,Calvo J,Cambra F,-Sterup RL,Morales JM,Moreno E

    更新日期：2008-11-01 00:00:00

  • Very Long-term Survival of the Transplanted Kidney-Characteristics of Recipients.

    abstract：BACKGROUND:After kidney transplantation (KTx), donor- and recipient-dependent factors, as well as the immunosuppression protocol, may have an impact long-term graft function. The aim of this retrospective study was to identify and describe recipients from a single center who had their transplanted kidney survive for mo...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.02.114

    authors： Karcz M,Kusztal M,Boratyńska M,Klinger M

    更新日期：2018-01-01 00:00:00

  • Donor intracranial bleeding is associated with advanced transplant coronary vasculopathy: evidence from intravascular ultrasound.

    abstract：OBJECTIVES:We evaluated the impact of spontaneous intracranial bleeding (ICB) in the donor on transplant coronary vasculopathy using serial intravascular ultrasound examinations. MATERIALS AND METHODS:Between January 1995 and December 2000, 72 recipients underwent cardiac transplantation from donors who had experience...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.11.069

    authors： Yamani MH,Erinc K,Starling RC,Young JB,Ratliff NB,Cook DJ,Crowe T,Hobbs R,Rincon G,Bott-Silverman C,Bennett R,Smedira N,Tuzcu EM

    更新日期：2004-11-01 00:00:00

  • Hepatic steatosis in liver transplant donors: rare phenomenon or common feature of donor population?

    abstract：AIM:The aim of this research was a histopathological assessment of cadaveric donor liver steatosis including: the degree (percent of involved hepatocytes) and type size of vacuoles showing fatty change by various histologic techniques. MATERIALS AND METHODS:The study included 70 donor livers. Hematoxylin-eosin and Sud...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.11.088

    authors： Hałoń A,Patrzałek D,Rabczyński J

    更新日期：2006-01-01 00:00:00

  • Pneumococcal 13-Valent Conjugate Vaccine (Prevnar 13)-Associated Immune Thrombocytopenic Purpura in a Renal Transplant Recipient: A Case Report.

    abstract：BACKGROUND:Pneumococcal 13-valent conjugate vaccine (PCV13) is used for immunization to prevent invasive disease caused by Streptococcus pneumoniae. Rare cases of idiopathic thrombocytopenic purpura (ITP) after vaccination with PCV13 have been reported. METHODS:A case of ITP associated with PCV13 administration in a r...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.12.004

    authors： Gupta S,Brennan DC

    更新日期：2016-01-01 00:00:00