Parallel induction of nitric oxide and glucose-6-phosphate dehydrogenase in activated bone marrow derived macrophages.

abstract：:In the early postnatal period, cerebellar granule cells exhibit an activity-dependent downregulation of a set of immaturation genes involved in cell growth and migration and are shifted to establishment of a mature network formation. Through the use of a granule cell culture and both pharmacological and RNA interferen...

journal_title：Biochemical and biophysical research communications

authors： Okazawa M,Abe H,Nakanishi S

更新日期：2016-05-13 00:00:00

abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

journal_title：Biochemical and biophysical research communications

authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

更新日期：1992-04-30 00:00:00

abstract：:Infection of influenza virus could induce acute lung inflammatory injury (ALII) that was at least partially caused by excessive innate immune responses. To study whether down-regulating Toll-like receptor (TLR)-mediated innate immune response could lessen influenza virus-induced ALII, a microsatellite DNA mimicking ol...

journal_title：Biochemical and biophysical research communications

authors： Fang M,Wan M,Guo S,Sun R,Yang M,Zhao T,Yan Y,Zhang Y,Huang W,Wu X,Yu Y,Wang L,Hua S

更新日期：2011-11-18 00:00:00

abstract：:Recently, two reports [R. E. Davis et al. (1997) Proc. Natl. Acad. Sci. USA 94, 4564-4569 and E. Fahy et al. (1997) Nucleic Acids Res. 25, 3102-3109] described a series of heteroplasmic mitochondrial DNA (mtDNA) mutations in the genes encoding two cytochrome c oxidase subunits (CO1 and CO2) which segregated in higher ...

journal_title：Biochemical and biophysical research communications

authors： Davis JN 2nd,Parker WD Jr

更新日期：1998-03-27 00:00:00

abstract：:Ovarian clear cell carcinoma (OCCC) is an aggressive subtype of epithelial ovarian cancer, which generally exhibits chemoresistance. Effective therapy for OCCC is currently unavailable, requiring the development of new therapeutic strategies. ABT-263 (navitoclax), an inhibitor of the anti-apoptotic BCL-2/BCL-XL, has a...

journal_title：Biochemical and biophysical research communications

authors： Inoue-Yamauchi A,Oda H

更新日期：2020-06-04 00:00:00

abstract：:The current state of the AD research field is highly dynamic is some respects, while seemingly stagnant in others. Regarding the former, our current lack of understanding of initiating disease mechanisms, the absence of effective treatment options, and the looming escalation of AD patients is energizing new research d...

journal_title：Biochemical and biophysical research communications

authors： Briggs CA,Chakroborty S,Stutzmann GE

更新日期：2017-02-19 00:00:00

abstract：:Interleukin 12 has demonstrated a wide spectrum of bioactivity on T and NK cells both in vitro and in vivo. Therapeutic potential of these activities has been suggested by studies in murine tumor, viral and microbial models of disease. We have investigated the in vivo effect of rhlL-12 in cynomolgus monkeys treated wi...

journal_title：Biochemical and biophysical research communications

authors： Bree AG,Schlerman FJ,Kaviani MD,Hastings RC,Hitz SL,Goldman SJ

更新日期：1994-11-15 00:00:00

abstract：:Avian leukosis virus (ALV) is one of the main causative agent of tumor development, which brings enormous economic losses to the poultry industry worldwide. ALV can be transmitted horizontally and vertically, and the latter often give rise to more adverse pathogenicity. However, the propagation and evolution of ALV un...

journal_title：Biochemical and biophysical research communications

authors： Gao X,Li Q,Fang L,Song H,Cui Z,Meng F,Zhang Z

更新日期：2020-01-22 00:00:00

abstract：:Serum prealbumin isolated from a Japanese patient with familial amyloidotic polyneuropathy (FAP) has been found to consist of a mixture of normal prealbumin and a prealbumin variant which contains a methionine for valine substitution at position 30. The prealbumin variant in the serum is identical to the prealbumin va...

journal_title：Biochemical and biophysical research communications

authors： Nakazato M,Kangawa K,Minamino N,Tawara S,Matsuo H,Araki S

更新日期：1984-07-31 00:00:00

abstract：:Abnormal plasma ascorbic acid (AA) and dehydroascorbic acid (DHAA) levels observed in diabetes may be correlated to a deficiency in the recycling of AA. Ascorbic acid and DHAA levels are altered in diabetic liver in the present study. In addition, a coupling of the hexose monophosphate (HMP) shunt by way of NADPH to g...

journal_title：Biochemical and biophysical research communications

authors： Bode AM,Yavarow CR,Fry DA,Vargas T

更新日期：1993-03-31 00:00:00

abstract：:Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 ...

journal_title：Biochemical and biophysical research communications

authors： Planchart A

更新日期：2013-11-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) represents a unique subgroup of breast cancers (BCa) with potential to be highly proliferative and invasive. Patient with TNBC are prone to developing resistance to chemotherapy. Therefore, TNBC usually has a poor clinical outcome. The key factors driving these malignant features r...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Yang T,Yuan Y,Sun X

更新日期：2020-02-26 00:00:00

abstract：:Integrins are a family of cell surface adhesion molecules which mediate cell adhesion and initiate signaling pathways that regulate cell spreading, migration, differentiation, and proliferation. TGF-beta is a multifunctional factor that induces a wide variety of cellular processes. In this study, we show that, TGF-bet...

journal_title：Biochemical and biophysical research communications

authors： Cai T,Lei QY,Wang LY,Zha XL

更新日期：2000-08-02 00:00:00

abstract：:Picrotoxin is a CYP2B inducer in mammals (1). However, in primary cultures of rainbow trout hepatocytes we showed CYP1A1 gene expression to be strongly induced as characterized by 7-ethoxyresorufin-O-deethylase activity, immunoblots of CYP1A1 protein, and Northern blots of CYP1A1 mRNA. Induction of CYP1A1 in these cel...

journal_title：Biochemical and biophysical research communications

authors： Sadar MD,Ash R,Andersson TB

更新日期：1995-09-25 00:00:00

abstract：:Isolated P. chabaudi parasites were permeabilized with digitonin and the function of intracellular Ca2+ stores was studied using the Ca2+ indicators arsenazo III or Fluo 3-acid in the medium. Addition of the second messenger InsP3 (5 microM) to permeabilized parasites leads to Ca2+ release into the medium, with the me...

journal_title：Biochemical and biophysical research communications

authors： Passos AP,Garcia CR

更新日期：1998-04-07 00:00:00

abstract：:The extracellular matrix regulates many fundamental cellular processes such as proliferation, migration, and differentiation. Among the ECM components, type I collagen induces endothelial tube formation in vitro. By analysing genes participating in this event, the bone morphogenetic protein receptor-II (BMPR-II) was d...

journal_title：Biochemical and biophysical research communications

authors： Regazzoni C,Winterhalter KH,Rohrer L

更新日期：2001-05-04 00:00:00

abstract：:Here we investigate the effects of the dihydropyridine-type antagonists of calcium channels nitrendipine, nimodipine, nisoldipine and the calcium channel agonist BAY K 8644 on the induction of nitric oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide; LPS) in J774.2 macrophages cultured in vitro. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Szabó C,Thiemermann C,Vane JR

更新日期：1993-10-29 00:00:00

abstract：:Evaluation of analogs of the blocked insect myotropic neuropeptide leucopyrokinin (LPK) has demonstrated its relative insensitivity to amino acid substitution in the N-terminal in contrast to the C-terminal region. Truncated analogs of LPK without the first, second, and third N-terminal amino acids retain a significan...

journal_title：Biochemical and biophysical research communications

authors： Nachman RJ,Holman GM,Cook BJ

更新日期：1986-06-30 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The autophagy pathway has previously been suggested as an important protective factor in liver injury. The purpose of this study is to demonstrate the protective, autophagy-modulating effect of tri-iodothyronine (T3) on liver ischemia reperfusion injury. METHODS:Liver ischemia reperfusion was...

journal_title：Biochemical and biophysical research communications

authors： Yang J,Wang Y,Sui M,Liu F,Fu Z,Wang QX

更新日期：2015-11-27 00:00:00

abstract：:Monosomy 7 and interstitial deletions in the long arm of chromosome 7 (-7/7q-) is a common nonrandom chromosomal abnormality found frequently in myeloid disorders including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML). Using a short probe-based microarray co...

journal_title：Biochemical and biophysical research communications

authors： Asou H,Matsui H,Ozaki Y,Nagamachi A,Nakamura M,Aki D,Inaba T

更新日期：2009-05-29 00:00:00

abstract：:Activation of the extracellular calcium-sensing receptor (CaR) stimulates mitogen-activated protein kinases to upregulate the synthesis and secretion of parathyroid hormone related peptide (PTHrP) from cells expressing the CaR heterologously or endogenously. The current experiments demonstrate that this occurs because...

journal_title：Biochemical and biophysical research communications

authors： MacLeod RJ,Yano S,Chattopadhyay N,Brown EM

更新日期：2004-07-23 00:00:00

abstract：:Suppressor of cytokine signaling (SOCS) 1 was initially identified as an intracellular negative feedback regulator of the JAK-STAT signal pathway. Recently, it has been suggested that SOCS1 affects signals of growth factors and hormones. One of them, SOCS1, is also known to be involved in auto-regulation of IRS-1-medi...

journal_title：Biochemical and biophysical research communications

authors： Inaba M,Saito H,Fujimoto M,Sumitani S,Ohkawara T,Tanaka T,Kouhara H,Kasayama S,Kawase I,Kishimoto T,Naka T

更新日期：2005-03-25 00:00:00

abstract：:The amino acid sequence of a human placental bFGF was determined by a combination of protein and cDNA sequencing. The placental bFGF consists of 157 amino acid residues with a calculated molecular weight of 17,464 and is highly homologous to bovine pituitary bFGF. The human protein contains an amino terminal extension...

journal_title：Biochemical and biophysical research communications

authors： Sommer A,Brewer MT,Thompson RC,Moscatelli D,Presta M,Rifkin DB

更新日期：1987-04-29 00:00:00

abstract：:In mammalian epidermis, alpha6beta4 integrin is expressed exclusively on the basal layer localized to the hemidesmosomes, where it interacts extracellularly with the laminin-5 ligand. During differentiation, loss of alpha6beta4 is associated with keratinocyte detachment from the basement membrane and upward migration....

journal_title：Biochemical and biophysical research communications

authors： Alt A,Gartsbein M,Ohba M,Kuroki T,Tennenbaum T

更新日期：2004-01-30 00:00:00

abstract：:The isolation of human adrenal capillary endothelial (HACE) cells without resort to fluorescence activated cell sorting is described, together with their properties in culture. HACE cells were isolated by plating collagenase digests at high dilution in the presence of endothelial cell growth supplement, followed by cl...

journal_title：Biochemical and biophysical research communications

authors： Fawcett J,Harris AL,Bicknell R

更新日期：1991-01-31 00:00:00

abstract：:An important mechanism of regulation of the expression of the AT(1) receptors is the modulation of the mRNA stability. AUF1, a human RNA-binding protein, may play an important role. Since AUF1 seems to bind to AU-rich regions of the 3'-untranslated region of the mRNAs, we verified the nucleotide sequence of human AT(1...

journal_title：Biochemical and biophysical research communications

authors： Pende A,Giacchè M,Castigliola L,Contini L,Passerone G,Patrone M,Port JD,Lotti G

更新日期：1999-12-20 00:00:00

abstract：:Enzymatic lipid peroxidation in hepatocytes is believed to involve cytochrome P450. cAMP dependent phosphorylation of cytochrome P450 was found to increase the NADPH dependent production of malondialdehyde (lipid peroxidation) by about 30%. The cytochrome P450 inhibitor cyanide abolished this activity. The presence of...

journal_title：Biochemical and biophysical research communications

authors： Mkrtchian SL,Andersson KK

更新日期：1990-01-30 00:00:00

abstract：:An ubiquitous biochemical pathway known to synthesize nitric oxide (NO) from L-arginine has been identified in many cell types. Recent studies indicate that besides activating soluble guanylate cyclase NO is likely to have effects unrelated to the known signal transduction pathway. Activation of the soluble NO synthas...

journal_title：Biochemical and biophysical research communications

authors： Dimmeler S,Brüne B

更新日期：1991-08-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is one of the most common cancers worldwide and the third most common cause of cancer-related death. Imaging studies including ultrasound and computed tomography are recommended for early detection of HCC, but they are operator dependent, co...

journal_title：Biochemical and biophysical research communications

authors： Nomura F,Sogawa K,Noda K,Seimiya M,Matsushita K,Miura T,Tomonaga T,Yoshitomi H,Imazeki F,Takizawa H,Mogushi K,Miyazaki M,Yokosuka O

更新日期：2012-05-18 00:00:00

abstract：:Recombinant human OP-1 stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) significantly and in a dose-dependent manner in rat bone marrow cell culture. Newly formed MNCs either induced by hOP-1 alone or with 1,25(OH)2D3 were also positive for vitronectin recepto...

journal_title：Biochemical and biophysical research communications

authors： Hentunen TA,Lakkakorpi PT,Tuukkanen J,Lehenkari PP,Sampath TK,Väänänen HK

更新日期：1995-04-17 00:00:00