Repeated transient hypergonadotropic amenorrhea during pharmacologic induction of multiple follicular development with exogenous gonadotropins.

abstract：BACKGROUND:The aim of the current study was to evaluate the association of osteoprotegerin and vascular endothelial growth factor (VEGF) with glycemic indices and diabetes status. METHODS:A total of 44 normoalbuminuric Type 1 diabetic patients and 44 healthy control subjects, matched for age, body mass index, sex rati...

journal_title：Journal of endocrinological investigation

authors： Esteghamati A,Arefzadeh A,Zandieh A,Salehi Sadaghiani M,Noshad S,Nakhjavani M

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Activation of the farnesoid X receptor (FXR), a member of the nuclear receptor steroid superfamily, leads to anti-inflammatory and anti-fibrotic effects in several tissues, including the lung. We have recently demonstrated a protective effect of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) i...

journal_title：Journal of endocrinological investigation

authors： Comeglio P,Filippi S,Sarchielli E,Morelli A,Cellai I,Corno C,Adorini L,Vannelli GB,Maggi M,Vignozzi L

更新日期：2019-08-01 00:00:00

abstract：:Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Guido R,Valenti S,Giordano G

更新日期：1999-01-01 00:00:00

abstract：:Effects of primary hypothyroidism (HYPO) on the male gonadal axis are controversial, with only scanty data on the gonadotroph cell response and no information on GnRH tuberoinfundibular neurons, even in animal models. HYPO has been reported to variably induce hypogonadotropic hypogonadism, a hypergonadotropic state, o...

journal_title：Journal of endocrinological investigation

authors： Toni R,Della Casa C,Castorina S,Cocchi D,Celotti F

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Growth hormone resistance defines several genetic (primary) and acquired (secondary) pathologies that result in completely or partially interrupted activity of growth hormone. An archetypal disease of this group is the Laron-type dwarfism caused by mutations in growth hormone receptors. The diagnosis is ba...

journal_title：Journal of endocrinological investigation

authors： Kurtoğlu S,Hatipoglu N

更新日期：2016-01-01 00:00:00

abstract：:The IGFs are ubiquitous and have pleoitropic effects. They are critical for normal growth and development, and for normal functioning of adult tissues. A liver-specific gene-deletion knockout of the IGF-I gene resulted in a mouse model with reduced circulating IGF-I levels, that led to insulin resistance due to the se...

journal_title：Journal of endocrinological investigation

authors： Yakar S,Pennisi P,Kim CH,Zhao H,Toyoshima Y,Gavrilova O,LeRoith D

更新日期：2005-01-01 00:00:00

abstract：:Pheochromocytoma (PHEO) occasionally associates with pathological lesions of the adrenal cortex. In most of them, ectopic adrenocorticotropic hormone (ACTH) produced by PHEO resulted in bilateral adrenocortical hyperplasia. The coexistence of PHEO and pre-clinical Cushing's syndrome (PCS) of the same adrenal gland has...

journal_title：Journal of endocrinological investigation

authors： Erem C,Hacihasanoglu A,Ersöz HO,Reis AK,Calik A,Ukinç K,Koçak M

更新日期：2005-06-01 00:00:00

abstract：:No head-to-head comparisons are available to analyze the efficacy of octreotide (LAR) and lanreotide (LAN) as first-line treatment of acromegaly.We compared the efficacy of these two drugs in 54 newly diagnosed patients (21 women, 33 men), 27 treated with LAR (10-30 mg every 28 days) and 27 with LAN (60-90 mg/28 days)...

journal_title：Journal of endocrinological investigation

authors： Auriemma RS,Pivonello R,Galdiero M,De Martino MC,De Leo M,Vitale G,Lombardi G,Colao A

更新日期：2008-11-01 00:00:00

abstract：:Cardiovascular problems have long been recognized as responsible for an increased morbidity and mortality in patients with acromegaly. The aim of the present study was to evaluate echocardiographically the prevalence of cardiomyopathy in a cohort of acromegalic patients and to analyze the results in relation to demogr...

journal_title：Journal of endocrinological investigation

authors： Terzolo M,Avonto L,Matrella C,Pozzi R,Luceri S,Borretta G,Pecchio F,Ugliengo G,Magro GP,Reimondo G

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Apart from waist circumference, other adiposity measures, such as subscapular skin fold (SST), arouse growing interest due to their relationship to metabolic complications and cardiovascular risk. The IGF-I system is deregulated in obese subjects in proportion to their degree of visceral adiposity. AIM:To e...

journal_title：Journal of endocrinological investigation

authors： Savastano S,Barbato A,Di Somma C,Guida B,Pizza G,Barrea L,Avallone S,Schiano di Cola M,Strazzullo P,Colao A

更新日期：2012-11-01 00:00:00

abstract：:Multiple pituitary hormone hypersecretions have already been described, but the co-occurrence of PRL and ACTH excess is very rare. To our knowledge, medical treatment with cabergoline only, avoiding pituitary surgery and radiotherapy in this type of tumor has never been reported before. This case report deals with a 3...

journal_title：Journal of endocrinological investigation

authors： T'Sjoen G,Defeyter I,Van De Saffele J,Rubens R,Vandeweghe M

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...

journal_title：Journal of endocrinological investigation

authors： Zatelli MC,Lamartina L,Meringolo D,Arvat E,Damiani L,Grani G,Nervo A,Durante C,Giacomelli L

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Due to the lack of specific pediatric studies, no data are available about natural history of endogenous subclinical hyperthyroidism (SH) in childhood. AIMS:(a) To investigate for the first time the natural history of SH [suppressed thyrotropin (TSH) and normal free thyroxine free thyroxine (FT4) levels] wh...

journal_title：Journal of endocrinological investigation

authors： Aversa T,Valenzise M,Corrias A,Salerno M,Mussa A,Capalbo D,Salzano G,De Luca F,Wasniewska M

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Two yr after legislation of salt iodization of 40 parts per million (ppm) in 1994, goiter was still endemic and urinary iodine concentration (UIC) remained elevated in many provinces of Iran. Goiter prevalence and UIC were compared 2 and 7 yr after sustained consumption of uniformly iodized salt by Iranian ho...

journal_title：Journal of endocrinological investigation

authors： Azizi F,Mehran L,Sheikholeslam R,Ordookhani A,Naghavi M,Hedayati M,Padyab M,Mirmiran P

更新日期：2008-05-01 00:00:00

abstract：:Eight-year follow-up evaluation and analysis of factors related to postoperative thyroid dysfunction were made in 216 patients with Graves' disease treated by subtotal thyroidectomy. The postoperative status of thyroid function were as follows according to hypersensitive TSH level: 65 patients (30.1%) were euthyroid, ...

journal_title：Journal of endocrinological investigation

authors： Sugino K,Mimura T,Toshima K,Iwabuchi H,Kitamura Y,Kawano M,Ozaki O,Ito K

更新日期：1993-03-01 00:00:00

abstract：:Orbital fibroblasts exhibit a unique phenotype including exaggerated responses to proinflammatory cytokines. We hypothesize that the unusual susceptability of these fibroblasts to molecular cues underlies the involvement of the orbit in Graves' ophthalmopathy. A number of attributes of orbital fibroblasts are reviewed...

journal_title：Journal of endocrinological investigation

authors： Smith TJ

更新日期：2004-03-01 00:00:00

abstract：:Gonadotropins control male and female gonadal function by acting through specific receptors. The recent description of several mutations in LH and FSH receptors has significantly improved our understanding of the pathophysiology of several sexual disorder. Both gain- and loss-of-function germline mutations leading to ...

journal_title：Journal of endocrinological investigation

authors： Beck-Peccoz P,Romoli R,Persani L

更新日期：2000-10-01 00:00:00

abstract：:This is a brief case report on a four-month-old girl who was admitted for failure to thrive and moderate dehydration. On admission she was mildly dehydrated and undernourished but with otherwise normal physical findings. Laboratory investigation disclosed mild but constant hyponatremia and hyperkalemia, very high plas...

journal_title：Journal of endocrinological investigation

authors： Mardesić D,Sarnavka V,Dumić M,Stipić V

更新日期：1992-03-01 00:00:00

abstract：:Rats bearing mammosomatotropic tumors have raised insulin but lowered glucose concentrations. To determine if growth hormone (GH) secreted by these tumors causes insulin antagonism, pancreatic suppression tests utilizing infusions (per kg per min) of glucose (8 mg), insulin (200 ng) and somatostatin (1.4 micrograms) f...

journal_title：Journal of endocrinological investigation

authors： Davidson MB,Shen DC,Venkatesan N,Sladen G

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Acromegaly is known to be associated to vascular damage characterized by an increase of vascular wall thickness and an impairment of vascular function. AIM:The aim of this study was to evaluate the effect of medical treatment with the GH receptor antagonist pegvisomant on vascular structure and function in ...

journal_title：Journal of endocrinological investigation

authors： De Martino MC,Auriemma RS,Brevetti G,Vitale G,Schiano V,Galdiero M,Grasso L,Lombardi G,Colao A,Pivonello R

更新日期：2010-10-01 00:00:00

abstract：:We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean...

journal_title：Journal of endocrinological investigation

authors： Välimäki M,Liewendahl,Karonen SL,Helenius T,Suikkari AM

更新日期：1990-02-01 00:00:00

abstract：PURPOSE:In our previous study, we introduced a rat model of polycystic ovary syndrome (PCOS) induced by prenatal exposure to a single dose of testosterone on embryonic day 20. In the current study, we aimed to investigate whether prenatal exposure to a single dose of testosterone could also induce metabolic disturbance...

journal_title：Journal of endocrinological investigation

authors： Noroozzadeh M,Ramezani Tehrani F,Sedaghat K,Godini A,Azizi F

更新日期：2015-05-01 00:00:00

abstract：:A 50 year old man is described in whom primary hypothyroidism and isolated ACTH deficiency leading to adrenocortical insufficiency occurred simultaneously. Low thyroid hormone levels, elevated serum TSH values and high titers of antithyroid antibodies (ATA) were consistent with primary hypothyroidism. The diagnosis of...

journal_title：Journal of endocrinological investigation

authors： Roosens B,Maes E,Van Steirteghem A,Vanhaelst L

更新日期：1982-07-01 00:00:00

abstract：:To investigate whether chronic endogenous hypercalcemia influences TSH and/or PRL release from pituitary thyrotrophs and lactotrophs in man, 10 patients with endogenous hypercalcemia, due either to cancer or to primary hyperparathyroidism, were injected with 25 micrograms TRH iv. The TSH and PRL responses were compare...

journal_title：Journal of endocrinological investigation

authors： Röjdmark S,Edström E,Nordlund M

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a widespread environmental pollutant that causes alterations in human health acting as endocrine disruptor. Recent data suggest that cardiovascular system might be a contamination target tissue, since Cd is found in atheromatic plaques. Thus, the purpose of this study was to evaluate the cons...

journal_title：Journal of endocrinological investigation

authors： Fittipaldi S,Bimonte VM,Soricelli A,Aversa A,Lenzi A,Greco EA,Migliaccio S

更新日期：2019-06-01 00:00:00

abstract：:Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% tri...

journal_title：Journal of endocrinological investigation

authors： Misbin RI,Mehl TD

更新日期：1980-01-01 00:00:00

abstract：:D-aspartic acid (D-Asp), aromatase enzyme activity and the putative D-Asp involvement on aromatase induction have been studied in the testis of mature boars. The peroxidase-antiperoxidase and the indirect immunofluorescence methods, applied to cryostat and paraffin sections, were used to evaluate D-Asp and aromatase d...

journal_title：Journal of endocrinological investigation

authors： Lamanna C,Assisi L,Botte V,Di Fiore MM

更新日期：2006-02-01 00:00:00

abstract：:The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...

journal_title：Journal of endocrinological investigation

authors： Marcocci C,Gianchecchi D,Masini I,Golia F,Ceccarelli C,Bracci E,Fenzi GF,Pinchera A

更新日期：1990-06-01 00:00:00

abstract：:During diabetic ketoacidosis, in 17 adult patients, significant decreases in serum TBG and total T4 levels were observed, without significant alteration of the T4 to TBG binding property. In addition, serum free T4 (FT4) was moderately elevated and the TSH response to TRH was markedly blunted. No correlation, however,...

journal_title：Journal of endocrinological investigation

authors： Glinoer D,Naeije R,Golstein J,Fernandez-Deville M,Vanhaelst L

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Leptin and ghrelin appear to play a role in weight regain after a successful weight loss. The pre-treatment plasma levels of leptin/ghrelin ratio (L/G) could have power to predict this clinically relevant issue in the obesity treatment. OBJECTIVE:To evaluate the ability of the L/G as a non-invasive tool for...

journal_title：Journal of endocrinological investigation

authors： Crujeiras AB,Díaz-Lagares A,Abete I,Goyenechea E,Amil M,Martínez JA,Casanueva FF

更新日期：2014-02-01 00:00:00