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Endogenous testicular D-aspartic acid regulates gonadal aromatase activity in boar.

Abstract：

:D-aspartic acid (D-Asp), aromatase enzyme activity and the putative D-Asp involvement on aromatase induction have been studied in the testis of mature boars. The peroxidase-antiperoxidase and the indirect immunofluorescence methods, applied to cryostat and paraffin sections, were used to evaluate D-Asp and aromatase distributions. D-Asp level was dosed by an enzymatic method performed on boar testis extracts. Biochemical aromatase activity was determined by in vitro experiments carried out on testis extracts. D-Asp immunoreactivity was found in Leydig cells, and, to a lesser extent, in germ cells. Analogously, aromatase immunoreactivity was present in Leydig cells, but absent from seminiferous tubule elements. In vitro experiments showed that the addition of D-Asp to testicular tissue acetone powder induced a significant increase of aromatase activity, as assessed by testosterone conversion to 17beta-estradiol. Enzyme Km was not affected by D-Asp (about 25 nM in control and D-Asp added tests). These findings suggest that D-Asp could be involved in the local regulation of aromatase in boar Leydig cells and intervenes in this organ's production of estrogens.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Lamanna C,Assisi L,Botte V,Di Fiore MM

doi

10.1007/BF03344087

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

141-6

issue

2

eissn

0391-4097

issn

1720-8386

pii

1176

journal_volume

29

pub_type

杂志文章

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