Growth hormone insensitivity: diagnostic and therapeutic approaches.

abstract：:Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...

journal_title：Journal of endocrinological investigation

authors： Pinilla L,Tena-Sempere M,Aguilar E

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Elevated γ-glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT) could predict the risk of Type 2 diabetes (T2D), but the reason for their elevation was unclear. GGT and ALT mediated the metabolism of many amino acids (AA). Up to now, it was not investigated whether abnormal AA concentration was a...

journal_title：Journal of endocrinological investigation

authors： Chen T,Zhang X,Long Y,Yu H,Ran X,Gao Y,Lu H,Xie X,Chen X,Ren Y,Shi J,Tian H

更新日期：2012-09-01 00:00:00

abstract：:The regulation of GH secretion involves the harmonious integration of factors acting at the hypothalamic and pituitary levels summating to produce the peripheral patterns of intermittent GH secretion observed in man and experimental animals under physiologic and experimental conditions. SRIH and GHRH act primarily at ...

journal_title：Journal of endocrinological investigation

authors： Root AW

更新日期：1989-01-01 00:00:00

abstract：:Antithyroid hormone autoantibodies (THBA), described in both humans and animals, result in variable interference when thyroid hormone plasma levels are measured by immunoassays. We previously described a quick chromatographic method to detect circulating THBA in humans. In the present experience, we applied the method...

journal_title：Journal of endocrinological investigation

authors： Savastano S,Tommaselli AP,Valentino R,Dorato M,Scarpitta MT,Persechino A,Ciaramella P,Lombardi G

更新日期：1996-12-01 00:00:00

abstract：:An immunohistochemical study with two rabbit polyclonal antibodies I-AR76 and CA-08-351 against Endothelin-1 (ET-1) was performed in 133 human thyroid specimens: 5 normal thyroids, 30 multinodular goiters (15 toxic and 15 nontoxic), 20 Graves' diseases, 5 Hashimoto's thyroiditis, 26 adenomas (6 Hürthle cell, 16 toxic ...

journal_title：Journal of endocrinological investigation

authors： Lenziardi M,Viacava P,Fiorini I,Castagna M,Nardini V,Pollina L,De Negri F,Goletti O,Di Coscio G,Bevilacqua G

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Neonatal hypothyroidism has serious effects on growth, development, and metabolism. AIM:This study aims to investigate the effects of the neonatal hypothyroidism on carbohydrate metabolism, islet insulin secretion and morphology of the pancreatic islets in adult male offspring. MATERIALS/SUBJECTS AND METHO...

journal_title：Journal of endocrinological investigation

authors： Farahani H,Ghasemi A,Roghani M,Zahediasl S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:While it is now accepted that genes and their products affect food intake, the concept that locomotor behavior or the propensity for physical activity is controlled by neuro hum oral regulators is frequently underappreciated. In mammals, complex interactions have developed to allow the cross-talk between fue...

journal_title：Journal of endocrinological investigation

authors： Ceccarini G,Maffei M,Vitti P,Santini F

更新日期：2015-02-01 00:00:00

abstract：:Somatomedin was measured by rat bioassay in samples obtained from renal artery and vein, in order to study the role of this organ in the production of somatomedin activity. The results showed a significant difference, with an increase of the activity in the venous samples. According to the data reported in the literat...

journal_title：Journal of endocrinological investigation

authors： Minuto F,Barreca A,Grimaldi P,Cocco R,Garibotto G,Ferrini S,Giordano G

更新日期：1979-07-01 00:00:00

abstract：:This study, carried out on 9 nonfunctioning pituitary adenomas, was undertaken in order to evaluate the ability of these tumors to synthesize and release gonadotropins and/or free alpha-subunit (alpha-SU) of glycoproteins. The morphological study included electron microscopy and immunofluorescence analysis while hormo...

journal_title：Journal of endocrinological investigation

authors： Saccomanno K,Gil del Alamo P,Bassetti M,Reza-Elahi F,Spada A

更新日期：1993-02-01 00:00:00

abstract：:The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance...

journal_title：Journal of endocrinological investigation

authors： Piaggi P,Vinales KL,Basolo A,Santini F,Krakoff J

更新日期：2018-01-01 00:00:00

abstract：:We summarized the clinical course of 10 patients with silent thyroiditis and evaluated the clinical usefulness of ultrasonography, in combination with clinical and laboratory findings, for the differentiation from Graves' disease. Serum T3 and T4 were increased in all cases, and the ratio of T3/T4 (ng/micrograms) was ...

journal_title：Journal of endocrinological investigation

authors： Miyakawa M,Tsushima T,Onoda N,Etoh M,Isozaki O,Arai M,Shizume K,Demura H

更新日期：1992-04-01 00:00:00

abstract：:Recent evidence suggests that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. The pathomechanisms, however, are not completely understood yet. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we asse...

journal_title：Journal of endocrinological investigation

authors： Schneider HJ,Sämann PG,Schneider M,Croce CG,Corneli G,Sievers C,Ghigo E,Stalla GK,Aimaretti G

更新日期：2007-04-01 00:00:00

abstract：:The assessment of growth hormone (GH) secretory status is often difficult because of the intermittent nature of GH release and resulting wide swings in plasma GH levels. Urinary GH excretion holds promise as an index of integrated plasma GH free of this limitation, but technical problems have prevented its use until r...

journal_title：Journal of endocrinological investigation

authors： Winer LM,Shaw MA,Baumann G

更新日期：1989-07-01 00:00:00

abstract：:The activities of total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzymes were measured in cancerous and non-cancerous adjacent tissues from 15 patients with follicular thyroid cancer containing single nodule. SOD and GSH-Px activities were found lower but malondialdehyde levels hi...

journal_title：Journal of endocrinological investigation

authors： Durak I,Bayram F,Kavutcu M,Canbolat O,Oztürk HS

更新日期：1996-05-01 00:00:00

abstract：:During a multicentric pilot screening program for congenital hypothyroidism a comparison between the results obtained from Urbino, an area characterized by low iodine supply and endemic goiter, and Rome, a non-endemic area, has been made. The evaluation of neonatal urinary iodine excretion in the two areas showed sign...

journal_title：Journal of endocrinological investigation

authors： Carta Sorcini M,Diodato A,Fazzini C,Sabini G,Carta S,Grandolfo ME,Guidi M,Vasta M,Locatelli De Maestri J,Donati L

更新日期：1988-04-01 00:00:00

abstract：:The 1865 volume of the "II Morgagni", one of the most important Italian medical journals of the 19th century, presented two important articles, milestones for further scientific studies in the field of sexual differentiation. One was the original description of the "ramified cells" of testicular tubules by E. Sertoli,...

journal_title：Journal of endocrinological investigation

authors： Virdis R

更新日期：2005-11-01 00:00:00

abstract：:Pheochromocytoma (PHEO) occasionally associates with pathological lesions of the adrenal cortex. In most of them, ectopic adrenocorticotropic hormone (ACTH) produced by PHEO resulted in bilateral adrenocortical hyperplasia. The coexistence of PHEO and pre-clinical Cushing's syndrome (PCS) of the same adrenal gland has...

journal_title：Journal of endocrinological investigation

authors： Erem C,Hacihasanoglu A,Ersöz HO,Reis AK,Calik A,Ukinç K,Koçak M

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:To compare the histopathological features and the outcomes of the follicular variant and classical variant of papillary thyroid carcinoma. MATERIAL AND THE METHODS:Demographic data, histopathological features (tumor size, thyroid capsule invasion, extrathyroidal extension, vascular invasion and multicentricity...

journal_title：Journal of endocrinological investigation

authors： Tunca F,Sormaz IC,Iscan Y,Senyurek YG,Terzioglu T

更新日期：2015-12-01 00:00:00

abstract：:Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypoglobulinemia has been observed in this endocrine disorder. In 28 acromegalic patients and 56 control subjects sera have been analyzed for total pro...

journal_title：Journal of endocrinological investigation

authors： Federspil G,Vettor R,Bossi A,Sicolo N

更新日期：1979-04-01 00:00:00

abstract：:Cimetidine, an H2 receptor antagonist, is a potent stimulant of PRL secretion in normal women. In the present study, the PRL response to cimetidine was studied in 34 normal pregnant women and their fetuses during labor. Serum maternal PRL levels increased significantly after the acute iv injection of 400 mg cimetidine...

journal_title：Journal of endocrinological investigation

authors： Messinis IE,Tsirkas N,Diamantis K,Vasakos S,Tsolas O,Lolis D

更新日期：1988-12-01 00:00:00

abstract：:A 71-yr-old man was admitted for further evaluation and trans-sphenoidal surgery of a pituitary tumor. He complained of impotence and decreased libido over a period of about 40 yr. Thirty-eight yr ago he was treated for bilateral gynecomastia with galactorrhea. Endocrinological investigation at presentation revealed o...

journal_title：Journal of endocrinological investigation

authors： Wiesli P,Brändle M,Brandner S,Kollias SS,Bernays RL

更新日期：2003-06-01 00:00:00

abstract：AIM:To evaluate if nutritional intakes and lipid profile fulfill international guidelines and recommendations before and after a structured dietician training to a Mediterranean- style diet in an Italian pediatric population with Type 1 diabetes. METHODS:A 6-month prospective cohort study. Baseline and after-intervent...

journal_title：Journal of endocrinological investigation

authors： Cadario F,Prodam F,Pasqualicchio S,Bellone S,Bonsignori I,Demarchi I,Monzani A,Bona G

更新日期：2012-02-01 00:00:00

abstract：:There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

journal_title：Journal of endocrinological investigation

authors： Warren MP,Goodman LR

更新日期：2003-09-01 00:00:00

abstract：:We evaluated the effect of six-month treatment with growth hormone (GH) or low-dose oxandrolone in a group of boys with constitutional growth delay (CGD). Sixteen boys were randomly assigned to two treatment groups. Group 1 received GH (0.6 U/kg/week sc 5-6 times/week) and Group 2 received oxandrolone (0.07 mg/kg po)....

journal_title：Journal of endocrinological investigation

authors： Loche S,Pintor C,Cambiaso P,Lampis A,Carta D,Corda R,Cappa M

更新日期：1991-10-01 00:00:00

abstract：:Seasonal plasma testosterone and androstenedione levels were determined by radioimmunoassay in the Gentile di Puglia ram. Androstenedione remains steady throughout the years, while testosterone shows seasonal changes. Testosterone is at high levels in winter, spring and summer and drops to a low concentration in autum...

journal_title：Journal of endocrinological investigation

authors： Dell'Aquila S,Crasto A,Alberico G,Varriale B,Pelosi A,Pierantoni R

更新日期：1985-06-01 00:00:00

abstract：:Evaluation of thyroid status by measurement of free thyroid hormone concentrations seems particularly helpful in conditions with altered serum binding proteins. In pregnancy, a condition of increased thyroxine binding globulin, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations have been reporte...

journal_title：Journal of endocrinological investigation

authors： Roti E,Gardini E,Minelli R,Bianconi L,Flisi M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Mutations of the thyrotropin receptor (TSHR) and/or Gαs gene have been found in a number of, but not all, autonomously functioning thyroid nodules (AFTNs). Recently, in a 15-year-old girl with a hyperfunctioning papillary thyroid carcinoma, we found two somatic and germline single nucleotide polymorphisms (S...

journal_title：Journal of endocrinological investigation

authors： Vicchio TM,Giovinazzo S,Certo R,Cucinotta M,Micali C,Baldari S,Benvenga S,Trimarchi F,Campennì A,Ruggeri RM

更新日期：2014-07-01 00:00:00

abstract：:Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor. We, therefore, re-evalu...

journal_title：Journal of endocrinological investigation

authors： Nagayama Y,Yamasaki H,Takeshita A,Kimura H,Ashizawa K,Yokoyama N,Yamashita S,Rapoport B,Nagataki S

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:The Middle East registers the highest rate of vitamin D deficiency worldwide. In Lebanon, previous studies looked at this deficiency in schoolchildren, university students, young adults and postmenopausal women. However, no previous study was performed in hospital workers. The objective of our study was to e...

journal_title：Journal of endocrinological investigation

authors： Gannagé-Yared MH,Helou E,Zaraket V,Abi Akl S,Antonios L,Moussalli ML,Wakim S

更新日期：2014-06-01 00:00:00

abstract：:The case of a 34-yr-old Caucasian male with Graves' disease presenting with a flaccid quadriplegia and severe hypokalemia is reported. The weakness was prevalent at the lower extremities and began during nocturnal sleep, after a strenuous physical exertion performed during the day. Correction of hypokalemia promptly r...

journal_title：Journal of endocrinological investigation

authors： Celani MF,Bonati ME,Cavalli M

更新日期：1995-03-01 00:00:00