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Effect of chronic endogenous hypercalcemia on prolactin and thyrotropin responsiveness in man.

Abstract：

:To investigate whether chronic endogenous hypercalcemia influences TSH and/or PRL release from pituitary thyrotrophs and lactotrophs in man, 10 patients with endogenous hypercalcemia, due either to cancer or to primary hyperparathyroidism, were injected with 25 micrograms TRH iv. The TSH and PRL responses were compared with those obtained in an age-, sex-, and weight-matched group of patients comprised of 10 normocalcemic individuals with other diseases. The mean maximal TSH response in the hypercalcemic group (3.7 +/- 0.4 microU/ml) was 46% lower than in the normocalcemic group (6.8 +/- 1.2 microU/ml; p less than 0.02). Similarly, the mean maximal PRL response was 45% lower in the hypercalcemic (31 +/- 5 ng/ml) than in the normocalcemic patients (57 +/- 9 ng/ml; p less than 0.05). Feasible mechanisms behind this inhibitory influence of chronic endogenous hypercalcemia on TSH and PRL responsiveness are discussed.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Röjdmark S,Edström E,Nordlund M

doi

10.1007/BF03349498

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

635-9

issue

6

eissn

0391-4097

issn

1720-8386

journal_volume

7

pub_type

杂志文章

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