Abstract:
:Peripheral mononuclear cells (MNC) of patients with autoimmune thyroid disease have been shown to proliferate when cultured with human thyroglobulin (hTg). In addition, such a phenomenon is apparent in a certain number of healthy individuals. In this study we have attempted to correlate hTg-induced MNC proliferation, occurrence of anti-hTg autoantibodies and HLA phenotype (including Class II DR and DQ loci) in a population of HLA-typed normal blood donors. Fourteen out of 56 subjects showed a significant MNC proliferation to hTg. Three of them had anti-hTg autoantibodies in the serum, while none of the hTg-unresponsive subjects showed such antibodies. No correlation with HLA phenotype (including Class II DR5 specificity, referred as associated with Hashimoto's thyroiditis, and DQ alleles) was observed.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Bagnasco M,Orlandini A,Melioli G,Venuti D,Canonica GW,Ferrara GBdoi
10.1007/BF03347192subject
Has Abstractpub_date
1987-04-01 00:00:00pages
203-6issue
2eissn
0391-4097issn
1720-8386journal_volume
10pub_type
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journal_title:Journal of endocrinological investigation
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pub_type: 杂志文章,已发布勘误
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更新日期:2020-09-01 00:00:00
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更新日期:1990-09-01 00:00:00
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更新日期:1980-07-01 00:00:00
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更新日期:1979-04-01 00:00:00
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更新日期:2004-04-01 00:00:00
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journal_title:Journal of endocrinological investigation
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更新日期:2003-01-01 00:00:00
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更新日期:2015-05-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
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更新日期:1997-09-01 00:00:00
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更新日期:1985-12-01 00:00:00
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更新日期:2005-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
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doi:10.1007/BF03346291
更新日期:2007-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1984-04-01 00:00:00
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更新日期:2009-09-01 00:00:00