Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA.

Abstract:

:Peripheral mononuclear cells (MNC) of patients with autoimmune thyroid disease have been shown to proliferate when cultured with human thyroglobulin (hTg). In addition, such a phenomenon is apparent in a certain number of healthy individuals. In this study we have attempted to correlate hTg-induced MNC proliferation, occurrence of anti-hTg autoantibodies and HLA phenotype (including Class II DR and DQ loci) in a population of HLA-typed normal blood donors. Fourteen out of 56 subjects showed a significant MNC proliferation to hTg. Three of them had anti-hTg autoantibodies in the serum, while none of the hTg-unresponsive subjects showed such antibodies. No correlation with HLA phenotype (including Class II DR5 specificity, referred as associated with Hashimoto's thyroiditis, and DQ alleles) was observed.

journal_name

J Endocrinol Invest

authors

Bagnasco M,Orlandini A,Melioli G,Venuti D,Canonica GW,Ferrara GB

doi

10.1007/BF03347192

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

203-6

issue

2

eissn

0391-4097

issn

1720-8386

journal_volume

10

pub_type

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