Macroprolactinoma associated with Cushing's disease, successfully treated with cabergoline.

abstract：PURPOSE:Intravenous glucocorticoids (ivGCs) given as 12-weekly infusions are the first-line treatment for moderate-to-severe and active Graves' orbitopathy (GO), but they are not always effective. In this study, we evaluated whether response at 6 weeks correlated with outcomes at 12 (end of intervention) and 24 (follow...

journal_title：Journal of endocrinological investigation

authors： Bartalena L,Veronesi G,Krassas GE,Wiersinga WM,Marcocci C,Marinò M,Salvi M,Daumerie C,Bournaud C,Stahl M,Sassi L,Azzolini C,Boboridis KG,Mourits MP,Soeters MR,Baldeschi L,Nardi M,Currò N,Boschi A,Bernard M,von Arx

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Mutations of the thyrotropin receptor (TSHR) and/or Gαs gene have been found in a number of, but not all, autonomously functioning thyroid nodules (AFTNs). Recently, in a 15-year-old girl with a hyperfunctioning papillary thyroid carcinoma, we found two somatic and germline single nucleotide polymorphisms (S...

journal_title：Journal of endocrinological investigation

authors： Vicchio TM,Giovinazzo S,Certo R,Cucinotta M,Micali C,Baldari S,Benvenga S,Trimarchi F,Campennì A,Ruggeri RM

更新日期：2014-07-01 00:00:00

abstract：:We investigated the influence of calcium ions on the secretion of anterior pituitary hormones basally and in response to exogenous hypothalamic releasing factors in 6 men with pituitary tumors. To this end, concentrations of LH, FSH, TSH, growth hormone and prolactin were measured in blood collected at 10-min interval...

journal_title：Journal of endocrinological investigation

authors： Davis M,Nassberg B,Borges JL,Iranmanesh A,Lizzaralde G,Santen RJ,Drake C,Rogol AD,Kaiser DL,Thorner MO

更新日期：1987-10-01 00:00:00

abstract：:We describe a patient with Cushing's syndrome and metastatic small cell lung cancer. The plasma ACTH concentrations were markedly elevated (91.6 pmol/L), and the AM cortisol did not suppress by > 50% overnight after administration of 8 mg dexamethasone, both consistent with the ectopic ACTH syndrome. Immunohistochemic...

journal_title：Journal of endocrinological investigation

authors： Auchus RJ,Mastorakos G,Friedman TC,Chrousos GP

更新日期：1994-06-01 00:00:00

abstract：:The aim of this study was to determine the protein pattern of human thyroid fine needle aspiration fluid (FNA) using a proteomic approach. FNA proteins were separated using 2-dimensional gel electrophoresis (2DE), digested and then analyzed by peptide mass fingerprinting. For the first time, we provided an image of th...

journal_title：Journal of endocrinological investigation

authors： Giusti L,Iacconi P,Ciregia F,Giannaccini G,Basolo F,Donatini G,Miccoli P,Lucacchini A

更新日期：2007-11-01 00:00:00

abstract：:Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Guido R,Valenti S,Giordano G

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:We previously identified a four-generation family with medullary thyroid cancer (MTC) and a germline p.Y791F RET mutation whose cancer lacked a strong genotype-phenotype correlation. The entire gene coding region of the RET gene should be sequenced when genotype-phenotype discrepancies are observed in patien...

journal_title：Journal of endocrinological investigation

authors： Valente FO,Dias da Silva MR,Camacho CP,Kunii IS,Bastos AU,da Fonseca CC,Simião HP,Tamanaha R,Maciel RM,Cerutti JM

更新日期：2013-12-01 00:00:00

abstract：:Leptin, insulin, ghrelin, and IGF-I are circulating peptide hormones concerned with energy homeostasis and the regulation of GH axis. They are present in human milk, and are thought to promote neonatal development. The aim of the present study was to detect these substances in goat milk and determine whether their lev...

journal_title：Journal of endocrinological investigation

authors： Rosi F,Aufy AA,Magistrelli D

更新日期：2009-06-01 00:00:00

abstract：:Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic reso...

journal_title：Journal of endocrinological investigation

authors： Syro LV,Horvath E,Kovacs K

更新日期：2000-01-01 00:00:00

abstract：:The effect of an oral dose of 200 or 400 mg sodium valproate (DPA) on ACTH and cortisol secretion was assessed in 11 patients with Cushing's disease (3 bilaterally adrenalectomized), 3 patients with Nelson's syndrome and 6 patients with Addison's disease. In none of the patients examined DPA induced changes in ACTH (a...

journal_title：Journal of endocrinological investigation

authors： Loli P,Berselli ME,Frascatani F,Muratori F,Tagliaferri M

更新日期：1984-04-01 00:00:00

abstract：UNLABELLED:ABSTRACT. Several data show that meal intake and nutritional status regulate circulating ghrelin concentrations in humans. Ghrelin mainly circulates in two different forms: octanoyl and des-octanoyl ghrelin. Most circulating ghrelin is des-octanoyl ghrelin which is considered inactive because it lacks endocr...

journal_title：Journal of endocrinological investigation

authors： Lucidi P,Murdolo G,Di Loreto C,Parlanti N,De Cicco A,Ranchelli A,Fatone C,Taglioni C,Fanelli C,Santeusanio F,De Feo P

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Myogenesis is susceptible to the availability of nutrients and humoral factors and suboptimal fetal environments affect the number of myofibers and muscle mass. AIM:We examined the mechanisms regulating cell cycle progression and arrest in skeletal myoblasts. MATERIALS AND METHODS:Mouse C2C12 myoblasts wer...

journal_title：Journal of endocrinological investigation

authors： Grabiec K,Gajewska M,Milewska M,Błaszczyk M,Grzelkowska-Kowalczyk K

更新日期：2014-03-01 00:00:00

abstract：:Seventy years after the first successful radioiodine treatment of metastatic differentiated thyroid cancer (DTC), radioiodine (131I) therapy for this type of tumor is still without alternative. During the last decade, some key issues such as individual dosimetry, and preparation of 131I therapy by recombinant human TS...

journal_title：Journal of endocrinological investigation

authors： Luster M,Hänscheid H,Freudenberg LS,Verburg FA

更新日期：2012-01-01 00:00:00

abstract：UNLABELLED:The aim of this study was to assess the behaviour of insulin sensitivity and insulin resistance (IR) indexes in a group of obese adolescents with Type 2 diabetes mellitus (T2DM) in comparison to obese adolescents without diabetes and normal controls, moreover to compare these parameters with the cardiac auto...

journal_title：Journal of endocrinological investigation

authors： Cerutti F,Rabbia F,Rabbone I,Bobbio A,Ignaccolo MG,Greco G,Bertello MC,Mulatero P,Veglio F,Pacini G

更新日期：2010-09-01 00:00:00

abstract：:American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical decision making for ...

journal_title：Journal of endocrinological investigation

authors： Gharib H,Papini E,Paschke R,Duick DS,Valcavi R,Hegedüs L,Vitti P,AACE\/AME\/ETA Task Force on Thyroid Nodules.

更新日期：2010-01-01 00:00:00

abstract：:We have developed a sandwich-type enzyme immunoassay for human chorionic gonadotropin (hCG), in which antibody Fab'-beta-D-galactosidase complex and an antibody-immobilized silicone rubber solid phase were used. Despite the fact this assay system crossreacted about 40% with human luteinizing hormone (LH) that contains...

journal_title：Journal of endocrinological investigation

authors： Sekiya T,Furuhashi Y,Goto S,Kaseki S,Tomoda Y,Kato K

更新日期：1981-07-01 00:00:00

abstract：:Eleven patients with Paget's disease of bone, treated intermittently for 2-4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline ( uHOP ) during pCT administration] were treated with 0.5-0.25 mg/day of human calcitonin (hC...

journal_title：Journal of endocrinological investigation

authors： Lo Cascio V,Adami S,Galvanini G,Lazzaretto R,Ferrari M,Tartarotti D,Scuro LA

更新日期：1984-04-01 00:00:00

abstract：:Patients with simple exogenous obesity are characterized by increased B-endorphin (B-EP) plasma levels, despite normal ACTH and B-Lipotropin (B-LPH). To evaluate the origin of such an hyperendorphinemia, 42 obese patients were submitted to a short overnight dexamethasone suppression test (DST: 1 mg at 23:00 h). Blood ...

journal_title：Journal of endocrinological investigation

authors： Facchinetti F,Giovannini C,Petraglia F,Barletta C,Comitini G,Genazzani AR

更新日期：1988-02-01 00:00:00

abstract：INTRODUCTION:Vitamin D (VD) insufficiency has been repeatedly observed in the medical conditions associated with inflammation, such as cardiovascular disease, diabetes and depression. However, contrasting to the observational evidence, randomized trials of VD supplementation failed to demonstrate such link. Given the r...

journal_title：Journal of endocrinological investigation

authors： Jiang P,Zhang L,Zhu W,Li H,Dang R,Tang M

更新日期：2014-11-01 00:00:00

abstract：:This report describes the results of the second part of the collaborative study organized by a working group sponsored by the Community Bureau of Reference of the European Community Commission. The whole study was designed to understand the causes of discrepancy among LH immunoassay methods. In the parent report we de...

journal_title：Journal of endocrinological investigation

authors： Costagliola S,Niccoli P,Florentino M,Carayon P

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND AND AIM:There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56- day) bed-rest in male adults. SUBJECTS AND METHODS:Twenty healthy male subjects underwent ...

journal_title：Journal of endocrinological investigation

authors： Belavý DL,Seibel MJ,Roth HJ,Armbrecht G,Rittweger J,Felsenberg D

更新日期：2012-01-01 00:00:00

abstract：:Many hirsute women may present a form of functional ovarian hyperandrogenism (FOH), since they show an exaggerated 17-hydroxyprogesterone (17-OHP) response to GnRH agonists administration. As the failure of dexamethasone to reduce testosterone levels may be indicative of an ovarian source of androgen secretion, we eva...

journal_title：Journal of endocrinological investigation

authors： Re T,Barbetta L,Dall'Asta C,Faglia G,Ambrosi B

更新日期：2002-01-01 00:00:00

abstract：:Endemic goiter in Morocco is localized in the Rif and Atlas mountains. In this study, performed in the Skoura-Toundoute areas (high Atlas), we demonstrate that iodine deficiency is the main factor involved in the development of endemic goiter. However it may not constitute the only etiological factor. The median urina...

journal_title：Journal of endocrinological investigation

authors： Aquaron R,Zarrouck K,el Jarari M,Ababou R,Talibi A,Ardissone JP

更新日期：1993-01-01 00:00:00

abstract：:A case of malignant islet-cell tumor with oncocytic features occurring in a 54-year-old woman with symptoms of organic hypoglycemia is reported. The tumor was composed of ribbons of cells arranged in an endocrine pattern. The cytoplasm of these cells was eosinophilic and finely granular. Ultrastructurally, the cells c...

journal_title：Journal of endocrinological investigation

authors： Sadoul JL,Saint-Paul MC,Hoffman P,Plazza M,Birtwisle Y,Freychet P,Loubiere R

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. METHODS:To establish the remission rates (normal IGF-1 for age/sex: IGF-1 ≤ 1.00 xULN) after w...

journal_title：Journal of endocrinological investigation

authors： Casagrande A,Bronstein MD,Jallad RS,Mota JI,Tabet A,Abucham J

更新日期：2017-05-01 00:00:00

abstract：AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...

journal_title：Journal of endocrinological investigation

authors： Gramaglia E,Ramella Gigliardi V,Olivetti I,Tomelini M,Belcastro S,Calvi E,Dotta A,Ghigo E,Benso A,Broglio F

更新日期：2014-02-01 00:00:00

abstract：:Pegvisomant, a GH receptor antagonist, is a new pharmaceutical approach to acromegaly. It enables IGF-I levels to return in the age- and sex-reference range in approximately 90% of patients. This new approach is particularly beneficial in those patients who do not experience control of hormone hypersecretion after sur...

journal_title：Journal of endocrinological investigation

authors： Colao A,Pivonello R,Cappabianca P,Auriemma RS,De Martino MC,Ciccarelli A,de Divitiis E,Lombardi G

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship betw...

journal_title：Journal of endocrinological investigation

authors： D'Elia L,Giaquinto A,Cappuccio FP,Iacone R,Russo O,Strazzullo P,Galletti F

更新日期：2020-05-01 00:00:00

abstract：:Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Traverso L,Cavagnaro P,Torre R,Durante R,Giordano G

更新日期：1989-09-01 00:00:00

abstract：:Endocrine changes have been reported in treated epileptic subjects, who often exhibit sexual dysfunctions, but the endocrine effects of single antiepileptic drugs have not been completely elucidated. In this study we have investigated the influence of phenobarbital (PB) on adenopituitary function and on peripheral sex...

journal_title：Journal of endocrinological investigation

authors： Murialdo G,Manni R,De Maria A,Bonura ML,Polleri A,Tartara A

更新日期：1987-02-01 00:00:00