Effects of hypothyroidism and endocrine disruptor-dependent non-thyroidal illness syndrome on the GnRH-gonadotroph axis of the adult male rat.

Abstract:

:Effects of primary hypothyroidism (HYPO) on the male gonadal axis are controversial, with only scanty data on the gonadotroph cell response and no information on GnRH tuberoinfundibular neurons, even in animal models. HYPO has been reported to variably induce hypogonadotropic hypogonadism, a hypergonadotropic state, or to have no effects on basal levels of pituitary gonadotropins, both in adult male rats and humans. Similarly, the exogenous administration of GnRH to HYPO rats and humans may increase or decrease gonadotropin secretion. Since inhibitory effects of HYPO on the GnRH-gonadotropin axis are reversed by replacement with L-T4, it has been suggested that thyroid hormone (TH) may regulate tuberoinfundibular GnRH and pituitary gonadotropin biosynthesis and/or secretion. To shed light on this hypothesis, we conducted immunocytochemical studies on the distribution and immunostaining characteristics of hypophysiotropic GnRH neurons, LH, PRL and vasoactive intestinal polypeptide (VIP) immunoreactive (IR) cells in the pituitary of adult, male rats. We show that HYPO reduces IR-GnRH in a restricted population of tuberoinfundibular perikarya and their proximal axons compared to euthyroid controls, but increases IR-VIP both in pituitary cells in direct association with LH-gonadotrophs and within IR-LH cells, itself. We propose that VIP may serve as a juxtacrine/paracrine/autocrine regulator of LH secretion and that, when GnRH biosynthesis is reduced by HYPO, gonadotropin secretion may be rescued by local activating effects of VIP. Polychlorinated biphenyls (PCB), industry toxicants found in food and water, also have inhibitory effects on the gonadal axis, decreasing fertility and suppressing basal and GnRHinduced LH release in male rats. Since PCB may also exert endocrine disruptor-dependent (EDD) effects on the thyroid axis producing a non-thyroidal illness syndrome (NTIS) (coined EDD-NTIS), we developed a rat model of EDD-NTIS to determine whether central hypothyroidism may contribute to the pathophysiology of PCB-induced hypogonadism. On the basis of preliminary animal data, we speculate that one of the mechanisms for Partial Androgen Deficiency of the Aging Male may involve central hypothyroidism and EDD-NTIS, resulting in inhibition of the GnRH-gonadotroph axis.

journal_name

J Endocrinol Invest

authors

Toni R,Della Casa C,Castorina S,Cocchi D,Celotti F

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

20-7

issue

11 Suppl Proceedings

eissn

0391-4097

issn

1720-8386

journal_volume

28

pub_type

杂志文章,评审
  • Reproducibility and validity of the Italian version of the International Physical Activity Questionnaire in obese and diabetic patients.

    abstract:PURPOSE:Aims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population. METHODS:Ninety patients...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0746-3

    authors: Minetto MA,Motta G,Gorji NE,Lucini D,Biolo G,Pigozzi F,Portincasa P,Maffiuletti NA

    更新日期:2018-03-01 00:00:00

  • Growth hormone insensitivity: diagnostic and therapeutic approaches.

    abstract:INTRODUCTION:Growth hormone resistance defines several genetic (primary) and acquired (secondary) pathologies that result in completely or partially interrupted activity of growth hormone. An archetypal disease of this group is the Laron-type dwarfism caused by mutations in growth hormone receptors. The diagnosis is ba...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-015-0327-2

    authors: Kurtoğlu S,Hatipoglu N

    更新日期:2016-01-01 00:00:00

  • Abnormal development of the sella turcica and lack of pituitary visualization in a patient with partial hypopituitarism.

    abstract::We report the case of a 17-year-old girl presenting short stature (height 149 cm, below the 3rd percentile), obesity (weight 83.5 kg, body mass index 37 kg/m2) and secondary amenorrhea, in whom endocrinological evaluation disclosed an absolute lack of GH responsiveness to both suprapituitary challenges and repetitive ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347844

    authors: Scacchi M,Alé G,Silvestri P,Cavagnini F

    更新日期:1995-05-01 00:00:00

  • Historical milestones in endocrinology.

    abstract::The 1865 volume of the "II Morgagni", one of the most important Italian medical journals of the 19th century, presented two important articles, milestones for further scientific studies in the field of sexual differentiation. One was the original description of the "ramified cells" of testicular tubules by E. Sertoli,...

    journal_title:Journal of endocrinological investigation

    pub_type: 历史文章,杂志文章

    doi:10.1007/BF03345329

    authors: Virdis R

    更新日期:2005-11-01 00:00:00

  • The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP).

    abstract::Puberty is a major developmental stage. Damaging mutations, considered as "mistakes of nature", have contributed to the unraveling of the networks implicated in the normal initiation of puberty. Genes involved in the abnormal hypothalamic-pituitary-gonadal (HPG) axis development, in the normosmic idiopathic hypogonado...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-017-0627-9

    authors: Leka-Emiri S,Chrousos GP,Kanaka-Gantenbein C

    更新日期:2017-08-01 00:00:00

  • Human placenta and fetal membranes express nerve growth factor mRNA and protein.

    abstract::The present study investigated whether trophoblast, decidua and fetal membranes express nerve growth factor (NGF) mRNA and peptide. Tissue specimens were collected in the first and third trimester of pregnancy from women undergoing voluntary pregnancy interruption (no.= 6; from 8 to 12 gestational weeks) and from wome...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03344105

    authors: Toti P,Ciarmela P,Florio P,Volpi N,Occhini R,Petraglia F

    更新日期:2006-04-01 00:00:00

  • Serum leptin levels in males with delayed puberty during short-term pulsatile GnRH administration.

    abstract::Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345471

    authors: Giusti M,Guido R,Valenti S,Giordano G

    更新日期:1999-01-01 00:00:00

  • Isolated growth hormone deficiency after severe head trauma.

    abstract::In a 12-yr-old boy growth arrest occurred after severe head trauma. Evaluation of pituitary endocrine function revealed isolated growth hormone (GH) deficiency. Lack of GH response to GH-releasing factor indicated that the responsible lesion was most likely to be localized in the pituitary gland. GH substitution resul...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349069

    authors: Eichler I,Frisch H,Eichler HG,Soukop W

    更新日期:1988-06-01 00:00:00

  • Improving the prediction of malignancy in cytologically suspicious thyroid nodules.

    abstract:BACKGROUND:Fine needle cytology aspirates (FNA) classified as THY4 are a heterogeneous group suspicious for malignancy [papillary thyroid cancer (PTC)], which is confirmed in 50-80% of cases after surgery. AIM:To better stratify THY4 FNA specimens for the relative risk of malignancy. METHODS:We retrospectively analyz...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8958

    authors: Arena S,Latina A,Marturano I,Muscia V,La Rosa GL,Stornello M,Squatrito S,Italia S,Vigneri R

    更新日期:2013-11-01 00:00:00

  • Synthesis of esters of androgens with unsaturated fatty acids for androgen requiring therapy.

    abstract::Androgens' metabolism and activity are gaining a more and more important role in human physiology particularly referring to aging and to neurodegenerative diseases. Androgen treatment is often required for long-lasting disorders. In order to improve their duration and effects, androgens can be administered as esters o...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8655

    authors: Aiello F,Garofalo A,Aloisi AM,Lamponi S,Magnani A,Petroni A

    更新日期:2013-06-01 00:00:00

  • Heterogeneous phenotype in children affected by non-autoimmune hypothyroidism: an update.

    abstract:BACKGROUND:In the last decades, a higher incidence of congenital hypothyroidism (CH) has been recorded in Italy (1:1940) and worldwide, mainly due to the shift to lower screening TSH cutoffs. Although CH can also be caused by dysgenetic defects, most CH cases have recently been found to be more frequently associated wi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-015-0288-5

    authors: Vigone MC,Di Frenna M,Weber G

    更新日期:2015-08-01 00:00:00

  • Prolactin secretion in pubertal and adult male subjects.

    abstract::Prolactin, LH and FSH circadian secretion were studied in a group of 20 boys in various pubertal stages and in 13 normal male adults. Prolactin 24-hour integrated concentration was similar in all groups except in stage 2 boys, in which it was significantly higher with respect to stage 3-4 boys. This pattern was observ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348421

    authors: Minuto F,Barreca A,Ferrini S,Del Monte P,Bernasconi D,Giordano G

    更新日期:1984-06-01 00:00:00

  • Multiple intracranial recurrent tumors with hyperprolactinemia combined with a parasellar malignant fibrous histiocytoma long after transfrontal surgery and irradiation to a pituitary adenoma.

    abstract::We herein describe a 40-year-old woman with hyperprolactinemia, an empty sella and two extrasellar intracranial recurrent tumors which were revealed 23 years after the first transfrontal craniotomy and 18 years after the second transfrontal surgery and irradiation to a provable prolactin-producing pituitary macroadeno...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03351046

    authors: Fujikawa M,Okamura K,Sato K,Shiratsuchi M,Yao T,Mizokami T,Fujishima M

    更新日期:2001-06-01 00:00:00

  • Decrease of thyroid antibodies during pregnancy.

    abstract::The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349385

    authors: D'Armiento M,Salabé H,Vetrano G,Scucchia M,Pachi A

    更新日期:1980-10-01 00:00:00

  • Decreased peak bone mass is associated with a 3-bp deletion/insertion of the CYP19 intron 4 polymorphism: preliminary data from the GOOS study.

    abstract::Finding that estrogen plays an important role in bone homeostasis in men prompted research on relationship of polymorphism at the CYP19 gene and the bone mass. Therefore, influence of 3-bp deletion/insertion polymorphism of CYP19 (TTTA)7 allele on the peak bone mass attainment in males was studied. Fifty-eight unrelat...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346329

    authors: Kastelan D,Grubic Z,Kraljevic I,Duric K,Kardum I,Dusek T,Stingl K,Giljevic Z,Kerhin-Brkljacic V,Suchanek E,Korsic M

    更新日期:2007-06-01 00:00:00

  • Hypoxia inducible factor-1α gene polymorphisms in Korean patients with pre-eclampsia.

    abstract:BACKGROUND:Placental hypoxia has been implicated in the pathogenesis of pre-eclampsia. Hypoxia inducible factor-1α (HIF-1α) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia. AIM:We determined whether maternal blood c.1722C>T (Pro582Ser) and c.1790G>A (Ala...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8009

    authors: Kim SY,Park SY,Lim JH,Lee BY,Yang JH,Ryu HM

    更新日期:2012-07-01 00:00:00

  • In vitro detection of glycoprotein production and secretion by human nonfunctioning pituitary adenomas.

    abstract::This study, carried out on 9 nonfunctioning pituitary adenomas, was undertaken in order to evaluate the ability of these tumors to synthesize and release gonadotropins and/or free alpha-subunit (alpha-SU) of glycoproteins. The morphological study included electron microscopy and immunofluorescence analysis while hormo...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347659

    authors: Saccomanno K,Gil del Alamo P,Bassetti M,Reza-Elahi F,Spada A

    更新日期:1993-02-01 00:00:00

  • The erythrocyte glutathione levels during oral glucose tolerance test.

    abstract::Erythrocytes glutathione (GSH) levels were measured in erythrocytes from 33 subjects, at baseline and after 2-hour glucose loading in order to investigate the effect of glucose ingestion on the erythrocyte GSH. According to the World Health Organisation criteria 18 subjects had normal glucose tolerance (NGT)(mean age ...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03348003

    authors: Konukoğlu D,Hatemi H,Ozer EM,Gönen S,Akçay T

    更新日期:1997-09-01 00:00:00

  • Does kidney transplantation normalise cortisol metabolism in apparent mineralocorticoid excess syndrome?

    abstract::The syndrome of apparent mineralocorticoid syndrome (AME) results from defective 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2). This enzyme is co-expressed with the mineralocorticoid receptor (MR) in the kidney and converts cortisol to its inactive metabolite cortisone. Its deficiency allows the unmetabolized co...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343755

    authors: Palermo M,Delitala G,Sorba G,Cossu M,Satta R,Tedde R,Pala A,Shackleton CH

    更新日期:2000-07-01 00:00:00

  • Identification of genes in thyrocytes regulated by unfolded protein response by using disulfide bond reducing agent of dithiothreitol.

    abstract::Disulfide bonds are formed between the sulfhydryl groups in two cysteine residues of a protein. The formation of these bonds is necessary for the proper folding of a protein into its active three-dimensional form. In this study, the genes associated with disulfide bond formation of proteins from the rat thyroid cell l...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345141

    authors: Park S,Hwang I,Shong M,Kwon OY

    更新日期:2003-02-01 00:00:00

  • Effects of a short-term calcium and vitamin D treatment on serum cytokines, bone markers, insulin and lipid concentrations in healthy post-menopausal women.

    abstract::In vitro studies have shown that 1,25 dihydroxyvitamin D3 [1,25(OH)2D3] decreases cytokine production by monocytes and lymphocytes. In addition, intravenous or oral pulse calcitriol treatment suppresses interleukin 6 (IL6) and interleukin1beta (IL1beta) in hemodialysis patients. We studied the effect of a daily 12-wee...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03347358

    authors: Gannagé-Yared MH,Azoury M,Mansour I,Baddoura R,Halaby G,Naaman R

    更新日期:2003-08-01 00:00:00

  • Hypothyroidism in the "Arnolfini Portrait" (1434) by Jan Van Eyck (1390-1441).

    abstract:BACKGROUND:The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE:The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these req...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0751-6

    authors: Ashrafian H

    更新日期:2018-01-01 00:00:00

  • Thyrotropin receptor-adenylate cyclase system in plasma membranes from normal and diseased human thyroid glands.

    abstract::Thyrotropin binding characteristics and adenylate cyclase (AC) activity of thyroid plasma membranes were studied in 52 tissues from normal and diseased human thyroids. Data from normal glands, Graves' goiters, non toxic multinodular goiters and nodular and perinodular tissue of toxic nodular goiters show the same basa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350977

    authors: Carayon P,Guibout M,Lissitzky S

    更新日期:1978-10-01 00:00:00

  • Epigenetics: spotlight on type 2 diabetes and obesity.

    abstract::Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research area...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-016-0473-1

    authors: Desiderio A,Spinelli R,Ciccarelli M,Nigro C,Miele C,Beguinot F,Raciti GA

    更新日期:2016-10-01 00:00:00

  • Plasma levels of luteinizing hormone, estradiol and androstenedione in sows with inadequate plasma progesterone.

    abstract::The authors report the profiles of luteinizing hormone (LH), estradiol (E2), progesterone (P) and androstenedione (A) in some female pigs with altered plasma hormonal levels. Twenty cycles are described and 19 out of them are characterized by low plasma P in luteal phase of different etiology, at least as measured by ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350557

    authors: Pierantoni R,Genazzani AR,Perotti L,Enne G,Inaudi P,d'Istria M,Musarò MA,Citarella F,Fasano S,Delrio G

    更新日期:1983-02-01 00:00:00

  • Lesion of the amygdala on the right and left side suppresses testosterone secretion but only left-sided intervention decreases serum luteinizing hormone level.

    abstract::The effect of right- and left-sided intra-amygdaloid injection of kainic acid on the hypothalamo-hypophyseal-testicular axis was studied in rats. Both right- and left-sided injection of the neurotoxin into the amygdala resulted in a significant decrease in basal testosterone secretion in vitro of both testes and in se...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345198

    authors: Banczerowski P,Csaba Z,Csernus V,Gerendai I

    更新日期:2003-05-01 00:00:00

  • The relationship between body composition and muscle power output in men and women with obesity.

    abstract::In order to investigate the effect of gender, age and level of obesity on body composition and anaerobic power output, and to test the hypothesis that variation in body composition affects muscle power output in obesity, a cohort of 377 subjects (112 males and 265 females, aged 18-75 yr) with different levels of obesi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346280

    authors: Lafortuna CL,Agosti F,Marinone PG,Marazzi N,Sartorio A

    更新日期:2004-10-01 00:00:00

  • Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats.

    abstract:BACKGROUND:Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitami...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0875-3

    authors: Saki F,Kasaee SR,Sadeghian F,Koohpeyma F,Omrani GHR

    更新日期:2019-01-01 00:00:00

  • Luteinizing hormone pulsatile secretion and pituitary response to gonadotropin releasing hormone and to thyrotropin releasing hormone in male epileptic subjects on chronic phenobarbital treatment.

    abstract::Endocrine changes have been reported in treated epileptic subjects, who often exhibit sexual dysfunctions, but the endocrine effects of single antiepileptic drugs have not been completely elucidated. In this study we have investigated the influence of phenobarbital (PB) on adenopituitary function and on peripheral sex...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347145

    authors: Murialdo G,Manni R,De Maria A,Bonura ML,Polleri A,Tartara A

    更新日期:1987-02-01 00:00:00

  • Immunohistochemical detection of estrogen and progesterone receptors in the normal urinary bladder and in pseudomembranous trigonitis.

    abstract::According to recent studies showing the presence of estrogens receptors (ERs) in the human female lower urinary tract, we performed ER and progesterone receptor (PR) assays in fresh frozen and paraffin embedded biopsies taken from the urinary bladder. Fourteen females undergoing endoscopy during staging for gynecologi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347639

    authors: Pacchioni D,Revelli A,Casetta G,Cassoni P,Piana P,Tizzani A,Bussolati G,Massobrio M

    更新日期:1992-11-01 00:00:00