Abstract：
:Orbital fibroblasts exhibit a unique phenotype including exaggerated responses to proinflammatory cytokines. We hypothesize that the unusual susceptability of these fibroblasts to molecular cues underlies the involvement of the orbit in Graves' ophthalmopathy. A number of attributes of orbital fibroblasts are reviewed in this article. In addition, we have found IgG circulating in patients with Graves' disease that binds and activates the insulin-like growth factor-1 receptor displayed on fibroblasts from many anatomic regions. Activation of this receptor leads to the expression of T-cell chemoattractants. Thus, fibroblast activation, and the resulting T-cell trafficking to connective tissue in Graves' disease may be systemic. The consequences of lymphocyte-derived cytokine action may differ vastly in the orbit and other tissues manifesting clinically obvious disease.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Smith TJdoi
10.1007/BF03345273keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
246-53issue
3eissn
0391-4097issn
1720-8386pii
5387journal_volume
27pub_type
杂志文章,评审abstract：BACKGROUND:Protein tyrosine phosphatase (PTP)- 1B, encoded by the PTPN1 gene, negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment. Several rare single nucleotide polymorphisms (SNP) have been linked to diseases accompanying insulin r...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346629
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To investigate the inflammatory markers in polycystic ovary syndrome (PCOS) and associations of these markers with obesity and in vitro fertilization (IVF) outcomes. METHODS:A total of 292 women underwent IVF procedure either with PCOS (n = 146) or without PCOS (n = 146, age, and body mass index (BMI) matche...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-016-0446-4
更新日期：2016-08-01 00:00:00
abstract：:The association of several risk factors, obesity, dyslipoproteinemia, hepatic steatosis, insulin resistance and hypertension with Type 2 (non-insulin-dependent) diabetes mellitus and myocardial infarction has long been known and has been termed the "metabolic syndrome". In 1988 Reaven introduced syndrome X as the link...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:The purpose of this study was to detect in vitro growth hormone (GH) and prolactin (PRL) secretion from adenomas clinically associated with GH or PRL hypersecretion. The reverse hemolytic plaque assay (RHPA) was applied in order to reveal possible differences among various morphologic adenoma types, and to examine the...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343628
更新日期：1999-10-01 00:00:00
abstract：:This report describes the results of the second part of the collaborative study organized by a working group sponsored by the Community Bureau of Reference of the European Community Commission. The whole study was designed to understand the causes of discrepancy among LH immunoassay methods. In the parent report we de...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03347727
更新日期：1994-06-01 00:00:00
abstract：:Fifty seven male patients either complaining of poor sexual development, gynecomastia or dwarfism and signs of sexual infantilism were studied. Plasma prolactin (PRL) and testosterone (T) were estimated in all patients while 33 of them were also subjected to full pituitary function tests. Twelve of the latter had an e...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346965
更新日期：1986-12-01 00:00:00
abstract：:Growth hormone (GH) response to provocative tests was compared in normal short children. Seven of 23 children failed to respond to insulin hypoglycemia. Using insulin hypoglycemia followed by L-dopa only 2 of 23 children did not respond and giving bromocriptine combined with insulin hypoglycemia only 1 of 8 children f...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03351005
更新日期：1984-08-01 00:00:00
abstract：PURPOSE:The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-016-0470-4
更新日期：2016-09-01 00:00:00
abstract：:Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disease which may comprise many endocrine and non-endocrine components. GH insufficiency has not been recognised as a classical manifestation of this syndrome. We describe the case of a girl with APECED, who presented with four end...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345481
更新日期：1999-01-01 00:00:00
abstract：:Osteoporosis is a multifactorial chronic disease that may become even more prevalent and more of a public health problem in the decades to come. Recent research has indicated that a number of macro- and micronutrients are involved in the development of bone health. In the past decade it became evident that vitamin K p...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Seasonal plasma testosterone and androstenedione levels were determined by radioimmunoassay in the Gentile di Puglia ram. Androstenedione remains steady throughout the years, while testosterone shows seasonal changes. Testosterone is at high levels in winter, spring and summer and drops to a low concentration in autum...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348490
更新日期：1985-06-01 00:00:00
abstract：PURPOSE:To investigate the effects of metabolic abnormalities, hyperandrogenemia and ovulation induction by clomiphene/acupuncture on liver function parameters among women with polycystic ovary syndrome (PCOS). METHODS:This is a secondary analysis of a randomized controlled trial. All 1000 subjects were diagnosed as P...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0953-6
更新日期：2019-05-01 00:00:00
abstract：:Raloxifene (RLX), a selective estrogen receptor modulator (SERM), is currently indicated for the prevention and treatment of post-menopausal osteoporosis. At present, RLX is evaluated in other areas of study that include the reduction of the risk of breast cancer and cardiovascular (CV) disease in post-menopausal wome...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The adiponectin gene has been identified as a susceptibility locus for metabolic syndrome, diabetes and cardiovascular disease. AIM:To examine the influence of two single nucleotide polymorphisms (SNPs) of this gene (+276G>T and +45T>G) on circulating adiponectin concentrations, and to evaluate their relati...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,随机对照试验
doi：10.3275/8972
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Cadmium (Cd) is a widespread environmental pollutant that causes alterations in human health acting as endocrine disruptor. Recent data suggest that cardiovascular system might be a contamination target tissue, since Cd is found in atheromatic plaques. Thus, the purpose of this study was to evaluate the cons...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0982-1
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Disorders of Sex Development (DSD) are a wide range of congenital conditions characterized by an incongruence of components involved in sexual differentiation, including gender psychosexual development. The management of such disorders is complex, and one of the most crucial decision is represented by gend...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-016-0482-0
更新日期：2016-11-01 00:00:00
abstract：:The 24-h profiles of plasma cortisol (F), 11-beta-hydroxyandrostenedione (11OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation o...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348129
更新日期：1987-06-01 00:00:00
abstract：OBJECTIVE:To our knowledge, no case of remission in autoimmune Addison's disease has previously been reported. We describe a patient with primary adrenal insufficiency caused by autoimmune adrenalitis in whom partial remission was observed after 7 yr. CASE:A 39-yr-old male was referred because of extreme fatigue, weig...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345623
更新日期：2008-07-01 00:00:00
abstract：:A study of the effects of salmon calcitonin (sCT) infusion on blood sugar and serum insulin levels under basal conditions and after intravenous glucose load in normal subjects is reported. Under basal conditions, a 30 min infusion of sCT at approximately a rate of 1 U/min produced a highly significant increase in the ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349315
更新日期：1979-04-01 00:00:00
abstract：:Monolayer cultures of medullary thyroid carcinoma (MTC) cells were prepared from 5 patients with familial and 4 with sporadic MTC. Basal calcitonin (CT) release decreased rapidly during 17 days in culture. Addition of extra calcium (2 mmol/l) or dibutyryl cyclic AMP (dBcAMP, 3 mmol/l) increased CT release in all inves...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347169
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Obesity represents a global public health problem due to its association with cardiovascular diseases and reduced lifespan. The most widely used classification of obesity is expressed as Body Mass Index (BMI); however, this formula is an imprecise adiposity measurement that ignores several important factors ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-013-0048-3
更新日期：2014-06-01 00:00:00
abstract：:Silver-Russell syndrome (SRS) is both clinically and genetically a heterogeneous congenital disorder. Patients are characterised by severe intrauterine and post-natal growth retardation, dysmorphic facial features and, asymmetry. Various chromosome abnormalities have been associated with the disease, involving most of...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348450
更新日期：1984-10-01 00:00:00
abstract：:LATS containing sera and a number of Graves' disease sera stimulated T4 release from mouse thyroids in vitro as determined by RIA, thus confirming the presence of a thyroid hormone releasing factor in sera of thyrotoxic patients. The pattern of stimulation was similar to that previously shown for TSH in terms of T4 re...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350973
更新日期：1978-10-01 00:00:00
abstract：:Nine chronic male alcoholics presenting with hypogonadism but without overt liver failure were examined under baseline conditions and after acute injection of gonadotropin releasing hormone (GnRH, 100 micrograms iv) and thyrotropin releasing hormone (TRH, 200 micrograms iv), performed at 60 min of a 3-h infusion of sa...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03348339
更新日期：1983-12-01 00:00:00
abstract：:Severe vitamin D deficiency has been found to be prevalent in institutionalized elderly persons in several countries. The aim of the present work was to assess the vitamin D status of institutionalized elderly and compare it to that of community-living independent elderly in southern Greece during summer. Serum 25-hyd...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349258
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship betw...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-019-01140-4
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0946-5
更新日期：2018-12-01 00:00:00
abstract：:Fifty-seven (35.6%) of 160 patients with papillary thyroid carcinoma had lymph node metastases at the primary treatment. Children and adolescents were most frequently affected (69.2%), followed by the age group of 21-40-year olds (38.8%). Those older than 40 had the lowest incidence of lymph node metastases (29.6%; p ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346863
更新日期：1991-07-01 00:00:00
abstract：:Seventy years after the first successful radioiodine treatment of metastatic differentiated thyroid cancer (DTC), radioiodine (131I) therapy for this type of tumor is still without alternative. During the last decade, some key issues such as individual dosimetry, and preparation of 131I therapy by recombinant human TS...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
