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Insulin receptor binding and degradation in IM-9 cultured human lymphocytes - importance of extracellular degradation.

Abstract：

:Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% trichloroacetic acid and have little or no biological activity. Inhibition of binding with Concanavalin A or antireceptor antibody does not affect the rate of insulin degradation.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Misbin RI,Mehl TD

doi

10.1007/BF03348223

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

77-81

issue

1

eissn

0391-4097

issn

1720-8386

journal_volume

3

pub_type

杂志文章

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