The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors.

abstract：:Implantable cardiac pacing and defibrillation devices are effective and commonly used therapies for patients with cardiac rhythm disorders. Because device implantation is not easily reversible, as well as the high healthcare costs inherent in device use, a clear understanding of the clinical benefits relative to costs...

journal_title：Annual review of medicine

authors： Groeneveld PW,Dixit S

更新日期：2017-01-14 00:00:00

abstract：:The development of an HIV vaccine is proving to be an unprecedented challenge. The difficulty in creating this vaccine arises from the enormous genetic variation of the virus and the unusual importance of cytotoxic T lymphocytes (CTL) in controlling its spread. Whereas traditional vaccine strategies are unlikely to co...

journal_title：Annual review of medicine

authors： Letvin NL

更新日期：2005-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset diseases, the genetic etiologies have been well identified. Three early onset forms of AD inherited as autosomal dominant traits account for less than 2% o...

journal_title：Annual review of medicine

authors： Roses AD

更新日期：1996-01-01 00:00:00

abstract：:The surgical management of arterial occlusive disease of the lower extremities is reviewed, with emphasis on extra-anatomic and reoperative methods. Consideration is given to alternative interventional radiologic techniques, both as definitive therapy as well as in conjunction with conventional surgical reconstruction...

journal_title：Annual review of medicine

authors： Whittemore AD,Couch NP,Mannick JA

更新日期：1985-01-01 00:00:00

abstract：:The Adult Respiratory Distress Syndrome is a complication of many illnesses such as sepsis, pneumonia and trauma afflicting over 150,000 patients per year. While progress in intensive care medicine has increased the survival rates in many of these underlying illnesses, major obstacles remain in the successful therapy ...

journal_title：Annual review of medicine

authors： Bernard GR,Brigham KL

更新日期：1985-01-01 00:00:00

abstract：:Epidermolysis bullosa is a group of genetically determined diseases characterized by abnormal fragility of the skin and mucosa. In this chapter, we review current thinking about classification, pathogenesis, and molecular genetics, and we discuss management guidelines. ...

journal_title：Annual review of medicine

authors： Lin AN,Carter DM

更新日期：1993-01-01 00:00:00

abstract：:Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly caused by genetic mutations, has become a global pandemic that severely diminishes the quality of life for millions. Despite the changing face of CKD, treatment options and resources remain woefully antiquated and have failed to arr...

journal_title：Annual review of medicine

authors： Reiser J,Sever S

更新日期：2013-01-01 00:00:00

abstract：:Following the "finished," euchromatic, haploid human reference genome sequence, the rapid development of novel, faster, and cheaper sequencing technologies is making possible the era of personalized human genomics. Personal diploid human genome sequences have been generated, and each has contributed to our better unde...

journal_title：Annual review of medicine

authors： Gonzaga-Jauregui C,Lupski JR,Gibbs RA

更新日期：2012-01-01 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a recently recognized autosomal-recessive trait characterized by recurrent bacterial infections, impaired pus formation and wound healing, and abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells. Features of this diseas...

journal_title：Annual review of medicine

authors： Anderson DC,Springer TA

更新日期：1987-01-01 00:00:00

abstract：:Societal expectations about drug safety and efficacy are rising while productivity in the pharmaceutical industry is falling. In 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, such as genomic...

journal_title：Annual review of medicine

authors： Woodcock J,Woosley R

更新日期：2008-01-01 00:00:00

abstract：:Acute pancreatitis is not the cause but may be a complication of chronic pancreatitis. Different forms of chronic pancreatitis are described. The most frequent type in all climates, chronic calcifying pancreatitis, has different causes but similar pathological changes. It is a lithiasis in which a new family of molecu...

journal_title：Annual review of medicine

authors： Sarles H,Bernard JP,Johnson C

更新日期：1989-01-01 00:00:00

abstract：:The incretin-based therapies, dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) analogs, are important new classes of therapy for type 2 diabetes mellitus (T2DM). These agents prolong the action of the incretin hormones, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), by inhibi...

journal_title：Annual review of medicine

authors： White WB,Baker WL

更新日期：2016-01-01 00:00:00

abstract：:CCR5 antagonists inhibit HIV-1 entry by blocking the interaction of HIV-1 with the CCR5 cellular receptor. In patients with established HIV-1 infection, some viral strains use an alternative coreceptor for HIV-1 entry, CXCR4; CCR5 antagonists are not effective in patients harboring these viral strains. Coreceptor trop...

journal_title：Annual review of medicine

authors： Wilkin TJ,Gulick RM

更新日期：2012-01-01 00:00:00

abstract：:The HIV Prevention Trials Network 052 study (HPTN 052) was a clinical trial designed to determine whether early treatment for HIV infection prevented transmission of the virus in couples where one partner was infected with HIV and the other was not, referred to as HIV serodiscordant or serodifferent couples. The study...

journal_title：Annual review of medicine

authors： Cohen MS,Gamble T,McCauley M

更新日期：2020-01-27 00:00:00

abstract：:The purpose of the psychiatric hospital changed dramatically during the twentieth century. Formerly the primary location for psychiatric treatment, the hospital now plays a more circumscribed role within a community-based system of care. Crisis stabilization, safety, and a focus on rapid discharge are the critical com...

journal_title：Annual review of medicine

authors： Sharfstein SS

更新日期：2009-01-01 00:00:00

abstract：:Preeclampsia, a major cause of fetal and maternal morbidity and mortality, may be difficult to distinguish clinically from other hypertensive disorders of pregnancy. Signs helpful in its diagnosis include presentation during late gestation in a nullipara with edema and proteinuria, and one or more of the following: he...

journal_title：Annual review of medicine

authors： Lindheimer MD,Katz AI

更新日期：1989-01-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a syndrome observed after allogeneic marrow transplantation and presumably mediated by donor T lymphocytes reactive against the tissues of the recipient. Clinically relevant acute GVHD develops in 35-50% of patients given HLA-identical marrow grafts within the first 100 days of tran...

journal_title：Annual review of medicine

authors： Deeg HJ,Storb R

更新日期：1984-01-01 00:00:00

abstract：:New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenoty...

journal_title：Annual review of medicine

authors： Smith RG,Appel SH

更新日期：1995-01-01 00:00:00

abstract：:The familial nature of multiple endocrine neoplasia syndromes (FMEN) has been recognized for some time but little is known about their cause. Recent application of new molecular techniques has mapped FMEN syndromes to specific chromosomes and provided evidence for the mechanism through which neoplasia occurs. In this ...

journal_title：Annual review of medicine

authors： Nanes MS,Catherwood BD

更新日期：1992-01-01 00:00:00

abstract：:States of hypersecretion of PTH may occur primarily, or in response to other physiologic abnormalities. Primary hyperparathyroidism must be considered in the differential diagnosis of hypercalcemia, nephrolithiasis, metabolic bone disease, and pancreatitis and peptic-ulcer disease. The clinical manifestations of this ...

journal_title：Annual review of medicine

authors： Bone HG 3rd,Snyder WH 3rd,Pak CY

更新日期：1977-01-01 00:00:00

abstract：:Syncope is a common clinical problem comprising the sudden loss of both consciousness and postural tone, with a subsequent spontaneous and relatively prompt recovery. Often it is difficult to differentiate a true syncopal spell from other conditions, such as seizure disorders, or from some simple accidents. Even more ...

journal_title：Annual review of medicine

authors： Benditt DG,Remole S,Milstein S,Bailin S

更新日期：1992-01-01 00:00:00

abstract：:Life expectancy has increased dramatically in the United States and in much of the world in recent years and decades. The factors underlying this increase are incompletely understood and are undoubtedly complex. A question that drives current research is whether life expectancy can be further extended using current kn...

journal_title：Annual review of medicine

authors： Sierra F,Hadley E,Suzman R,Hodes R

更新日期：2009-01-01 00:00:00

abstract：:In the practice of internal medicine, the value of genetic testing in common (mono)genetic diseases such as familial hemochromatosis, hypercholesterolemia, Mediterranean fever, and thrombophilia is limited. The genotype insufficiently predicts the phenotype because of the powerful effects of other modifying genes, env...

journal_title：Annual review of medicine

authors： Lamberts SW,Uitterlinden AG

更新日期：2009-01-01 00:00:00

abstract：:Our understanding and treatment of chronic myelogenous leukemia (CML) has progressed since 1960 in parallel with work on cancer in general. CML provided the first evidence of a specific genetic change associated with a human cancer (the Philadelphia chromosome) and the clonal nature of these disorders. With improved c...

journal_title：Annual review of medicine

authors： Nowell PC

更新日期：2002-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now sh...

journal_title：Annual review of medicine

authors： Garzon R,Calin GA,Croce CM

更新日期：2009-01-01 00:00:00

abstract：:Remarkable progress made in the past few years has brought pancreatic islet transplantation to the threshold of human clinical trials. Islet transplants have reversed diabetes in experimental animals and prevented or reversed early diabetic complications in the recipients. Methods have been developed that prevent reje...

journal_title：Annual review of medicine

authors： Lacy PE,Scharp DW

更新日期：1986-01-01 00:00:00

abstract：:Caffeine is the most widely consumed stimulant drug in the world. This chapter reviews the human pharmacology of caffeine; the evidence for its role in causing human disease, including addiction; and its potential usefulness as a therapeutic agent. ...

journal_title：Annual review of medicine

authors： Benowitz NL

更新日期：1990-01-01 00:00:00

abstract：:Stress and starvation, especially when complicated by sepsis, will give rise to a rapid erosion of the cellular mass, which significantly affects morbidity and mortality. The best clinical evaluation of the nutritional state is obtained from the medical history and the physical examination. In the patient who cannot e...

journal_title：Annual review of medicine

authors： Shizgal HM

更新日期：1991-01-01 00:00:00

abstract：:Obesity is perhaps the most significant public health problem facing the United States today. Obese patients are at increased risk for numerous medical problems, which can adversely affect surgical outcome. However, these risks have not uniformly translated into increased or prohibitive operative morbidity and mortali...

journal_title：Annual review of medicine

authors： Flancbaum L,Choban PS

更新日期：1998-01-01 00:00:00

abstract：:Risk assessments are integral for the prevention and management of cardiometabolic disease (CMD). However, individuals may develop CMD without traditional risk factors, necessitating the development of novel biomarkers to aid risk prediction. The emergence of omic technologies, including genomics, proteomics, and meta...

journal_title：Annual review of medicine

authors： Tahir UA,Gerszten RE

更新日期：2020-01-27 00:00:00