Ultrastructural study of hyaluronic acid before and after the use of a pulsed electromagnetic field, electrorydesis, in the treatment of wrinkles.


BACKGROUND:Treatment of wrinkles has become an increasing problem for dermatologists. Hyaluronic acid is a component of the family of glycosaminoglycans (GAGS, substances known for their property of retaining water), that significantly decreases with aging and in wrinkles. A new technique that uses a specific pulsed electromagnetic field, electrorydesis, has been introduced in the treatment of wrinkles associated with aging. The treatment is based on the reported in vitro effects of specific electromagnetic fields on fibroblast cultures (e.g., an increase in DNA synthesis and in the production of collagen and presumably also of GAGS). METHODS:The in vivo effects of the electromagnetic field on aged skin (3 subjects aged 50, 56 and 60 years), with particular focus on the ultrastructural modifications and GAGS amount before and after the treatment, were evaluated by electron microscope. RESULTS:The ultrastructural study (tissue stained with alcian blue) showed after treatment a significant increase (p < 0.005) of the electron-dense granules (corresponding to hyaluronic acid), located in collagen elastic fibers, and in the soluble matrix. This presumably leads to subsequent edema that was clinically evident after the treatment. CONCLUSIONS:These data suggest that the increased levels of GAGS and the subsequent edema of the dermis could explain at least in part the clinical changes observed after electrorydesis treatment (e.g., swelling and "disappearance" of the wrinkle).


Int J Dermatol


Ghersetich I,Teofoli P,Benci M,Lotti T




Has Abstract


1994-09-01 00:00:00












  • Phenytoin induces in vitro melanocyte proliferation.

    abstract:BACKGROUND:Phenytoin (5,5 diphenylhydantoin), a widely-used anticonvulsant, has been employed both topically and systemically in the treatment of some dermatological disorders. Immunological and non-immunological defects suggests that phenytoin could be therapeutically effective for vitiligo repigmentation. AIM OF STU...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Porojan D,Bâldea I,Achim M,Cosgarea R

    更新日期:2012-11-01 00:00:00

  • IgG from atopic dermatitis patients induces IL-17 and IL-10 production in infant intrathymic TCD4 and TCD8 cells.

    abstract:INTRODUCTION:Our group recently demonstrated that IgG modulates αβT cell cytokine production during the maturation process in the human thymus. The effects of this modulation are IgG repertoire dependent and can exert a systemic and long-term impact. OBJECTIVE:To investigate whether IgG from atopic dermatitis (AD) pat...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sgnotto FDR,de Oliveira MG,Lira AAL,Inoue AHS,Titz TO,Orfali RL,Bento-de-Souza L,Sato MN,Aoki V,Duarte AJS,Victor JR

    更新日期:2018-04-01 00:00:00

  • Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway.

    abstract:BACKGROUND:Keloids are benign dermal tumors characterized by fibroblastic proliferation and excessive accumulation of collagen. Oxymatrine (OMT) is an alkaloid extracted from the Chinese herb Sophora japonica with capacities of anti-fibrosis. OBJECTIVE:To evaluate the effects of OMT on collagen production and to explo...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Fan DL,Zhao WJ,Wang YX,Han SY,Guo S

    更新日期:2012-04-01 00:00:00

  • Prurigo pigmentosa: not an uncommon disease in the Turkish population.

    abstract:BACKGROUND:Prurigo pigmentosa (PP) is a rare inflammatory dermatosis of unknown etiology. It is characterized by erythematous papules of the trunk that resolve leaving a reticulate hyperpigmentation. The original report from Japan in 1971 was followed by new cases, mostly of Japanese origin. METHODS:We scrutinized PP ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Baykal C,Buyukbabani N,Akinturk S,Saglik E

    更新日期:2006-10-01 00:00:00

  • Topical mechlorethamine for psoriasis. An attempt to avoid the development of sensitization by the use of a topical tolerogenic schedule.

    abstract::The topical application of mechlorethamine is associated with a high incidence of irritant contact dermatitis. An attempt was made to avoid this complication by the use of a topical tolerogenic schedule. Seven of ten patients developed contact dermatitis to the medication after they had completed the schedule, The use...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Price NM

    更新日期:1979-06-01 00:00:00

  • Effects of vitamin C vs. multivitamin on melanogenesis: comparative study in vitro and in vivo.

    abstract:BACKGROUND:Vitamin C has been used for the treatment of hyperpigmented diseases. However, there is no study available on hypopigmenting effect of multivitamin. OBJECTIVES:To investigate the inhibitory effects of multivitamin and vitamin C on melanogenesis. METHODS:We assessed the effect of multivitamin and vitamin C ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,随机对照试验


    authors: Choi YK,Rho YK,Yoo KH,Lim YY,Li K,Kim BJ,Seo SJ,Kim MN,Hong CK,Kim DS

    更新日期:2010-02-01 00:00:00

  • Nd:YAG laser for "fractional" treatment of angiofibromas.

    abstract:BACKGROUND:Tuberous sclerosis is an autosomal dominant disorder with hamartomas in multiple organ systems. Facial angiofibromas (AF) are a common cutaneous manifestation of tuberous sclerosis. They may lead to significant cosmetic and psychological problems. Many treatment modalities have been used with variable satisf...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ma G,Wu P,Lin X,Chen H,Li W,Hu X,Jin Y

    更新日期:2014-05-01 00:00:00

  • Pheohyphomycosis caused by Exophiala spinifera: a rare occurrence.

    abstract::A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Singal A,Pandhi D,Bhattacharya SN,Das S,Aggarwal S,Mishra K

    更新日期:2008-01-01 00:00:00

  • IgA dermatosis in an adult Chinese population. A 10-year study of linear IgA and dermatitis herpetiformis in Singapore.

    abstract::During a 10-year period (1976-1985), eight Chinese patients from a population of 2.5 million fulfilled the criteria for dermatitis herpetiformis and linear IgA bullous dermatosis (LABD). These rare diseases among Asians presented during the third decade of life with homogenous linear IgA deposits along the dermoepider...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ratnam KV

    更新日期:1988-01-01 00:00:00

  • Nail pigmentation due to hydroxycarbamide.

    abstract::A 47-year-old male developed both longitudinal melanonychia and periungual hyperpigmentation 6 months after initiation of hydroxycarbamide (synonym: hydroxyurea) therapy for chronic myeloproliferative disease. Based on the clinical symptoms observed in this patient, the broad differential diagnostic spectrum of hyperp...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ceulen RP,Frank J,Poblete-Gutiérrez P

    更新日期:2007-11-01 00:00:00

  • Main pigmentary features and melanocortin 1 receptor (MC1R) gene polymorphisms in the population of the Canary Islands.

    abstract:BACKGROUND:Sun exposure, light skin pigmentation, and melanocortin 1 receptor (MC1R) gene variants are independent risk factors for skin cancer. The Canary Islands have a sunny and temperate climate, but data regarding the phenotypic and genotypic risk factors among the population are lacking. METHODS:The main phenoty...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: de-Misa RF,Pérez-Méndez LI,Hernández-Jiménez JG,Rodríguez Mdel C,Vilar MC,Suárez J,Claveríe-Martín F

    更新日期:2008-08-01 00:00:00

  • Lymphoid proliferation and lymphoma associated with human retroviruses (HTLV and HIV).

    abstract::There are rapidly increasing opportunities for dermatologists to see patients suffering from retrovirus infections. The HTLV-I was the first class of human oncogenic retrovirus that was found in cultured cells of a patient with skin manifestations similar or identical to those of CTCL (MF). It was soon recognized as t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Jimbow K,Jewell LD

    更新日期:1991-09-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus in community-acquired pyoderma.

    abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. It can also cause community-acquired infections. Indian reports about MRSA in community-acquired infections are rare. AIM:To evaluate the rate of MRSA in community-acquired pyoderma and the nasal colonisation with S. aur...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Nagaraju U,Bhat G,Kuruvila M,Pai GS,Jayalakshmi,Babu RP

    更新日期:2004-06-01 00:00:00

  • The combined use of topical benzoyl peroxide and tretinoin in the treatment of acne vulgaris.

    abstract::A clinical trial using tretinoin lotion 0.05%, benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Handojo I

    更新日期:1979-07-01 00:00:00

  • Epidemiological and clinical patterns of genital lesions.

    abstract::A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive ba...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sehgal VN,Rege VL,Sehgal N,Kharangate VN,Mascarenhas MF

    更新日期:1976-10-01 00:00:00

  • Tachyphylaxis to topical steroid measured by histamine-induced wheal suppression.

    abstract::Ten healthy volunteers were studied to find out whether tachyphylaxis occurs on repeated application of topical steroids. The Singh and Singh modification of the Reddy and Singh (1976) technique was used. Fluocinolone acetonide cream (0.1%) under occlusion was applied daily for 14 days on the flexor aspect of the fore...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Singh G,Singh PK

    更新日期:1986-06-01 00:00:00

  • Long-term results of the use of oxybutynin for the treatment of plantar hyperhidrosis.

    abstract:BACKGROUND:Plantar hyperhidrosis is a common illness with significant impact on quality of life. Oxybutynin presents good short-term results, but longer follow-up results are lacking. We evaluated oxybutynin effectiveness in patients who were not surgically treated and who had at least six months of follow-up. METHODS...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Wolosker N,Teivelis MP,Krutman M,de Paula RP,Kauffman P,de Campos JR,Puech-Leão P

    更新日期:2015-01-01 00:00:00

  • Autologous epidermal grafting with PUVA-irradiated donor skin for the treatment of vitiligo.

    abstract:BACKGROUND:Epidermal autografting has been used to treat vitiligo. The pigmentation achieved at the recipient site can be variegated and incomplete compared with that of the surrounding normal skin, and sometimes remains that way for a fairly long time. OBJECTIVE:We investigated whether the clinical results from epide...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lee AY,Jang JH

    更新日期:1998-07-01 00:00:00

  • Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study.

    abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) is defined by the almost daily presence of urticaria for at least 6 weeks without an identifiable cause. Symptoms include short-lived wheals, itching, and erythema. CIU impedes significantly a patient's quality of life (QoL). Levocetirizine is an antihistamine from the late...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kapp A,Pichler WJ

    更新日期:2006-04-01 00:00:00

  • Risks for noncutaneous second primary malignancy in cutaneous malignant melanoma survivors: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) program.

    abstract:BACKGROUND:It is known that malignant melanoma (MM) survivors are at increased risk of future primary MM. However, the risk for noncutaneous second primary malignancies (SPMs) is not as well-understood. METHODS:An observational study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database w...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vakharia PP,Kelm RC,Orrell KA,Patel KR,Singam V,Ali Y,Rastogi S,Yousif R,Rangel SM,West DP,Nardone B

    更新日期:2020-04-01 00:00:00

  • Sexual precocity in hypomelanosis of Ito: mosaicism-associated case report and literature review.

    abstract:BACKGROUND:Hypomelanosis of Ito (HI), a neurocutaneous disorder characterized by hypopigmented skin lesions along Blaschko's line with multiple accompanying diseases, may occasionally present with sexual precocity. METHODS:We reviewed cases of HI with sexual precocity reported in the literature and focused on collecti...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Park JM,Kim HJ,Kim T,Chae HW,Kim DH,Lee MG

    更新日期:2011-02-01 00:00:00

  • Lipodermatosclerosis: a clinicopathologic correlation.

    abstract:BACKGROUND:Lipodermatosclerosis (LDS) is a chronic fibrosing panniculitis associated with venous insufficiency. Although LDS is often a clinical diagnosis, it can be confused with other panniculitides. Microscopic examination is therefore essential to support the diagnosis in this condition. Histopathologic changes, ho...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Choonhakarn C,Chaowattanapanit S,Julanon N

    更新日期:2016-03-01 00:00:00

  • Actinic granuloma successfully treated with acitretin.

    abstract::Actinic granuloma is a rare skin disorder that develops in an area of actinic elastosis. The pathogenesis of the disease is obscure but the most accepted hypothesis implicates the solar radiation as the triggering factor. Typically the disease presents in middle-aged individuals with significant past sun-exposure and ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Stefanaki C,Panagiotopoulos A,Kostakis P,Stefanaki K,Petridis A

    更新日期:2005-02-01 00:00:00

  • An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women.

    abstract:BACKGROUND:Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less succ...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Handog EB,Datuin MS,Singzon IA

    更新日期:2016-02-01 00:00:00

  • Serum angiopoietin-2 level as a novel biomarker in atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease. Angiopoietin is an intrinsic mediator induced by T helper 2 cytokines and has been reported it to play a critical role in the pathogenesis of AD. OBJECTIVES:To determine the relationship between circulating angiopoietin-2 (Ang-2) in AD...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Khattab FM,Said NM

    更新日期:2019-11-04 00:00:00

  • Epidemiology and prognosis of plantar melanoma in 62 Japanese patients over a 28-year period.

    abstract:BACKGROUND:The plantar surface is one of the commonest sites of malignant melanoma in the Japanese; however, the biological behavior is not sufficiently clarified, because of the paucity of long-term studies. We attempted an epidemiologic survey of the cases of plantar melanoma treated in our institute to study the sur...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kato T,Suetake T,Tabata N,Takahashi K,Tagami H

    更新日期:1999-07-01 00:00:00

  • Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample.

    abstract:BACKGROUND:This study reports the comorbidity of lifetime psychiatric disorders in children and adolescents with alopecia areata (AA) in a child and adolescent psychiatry clinical sample. METHODS:Fourteen patients with AA were interviewed using the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ghanizadeh A

    更新日期:2008-11-01 00:00:00

  • Dermatology, medical care, the government, and us.

    abstract::Several economic factors are forcing changes in the American health care system. Many of these future changes will be implemented by the government. If left unguided, the governmental agencies could regulate doctors' practices, duties, and fees and place them in a bureaucratic maze. The cost of these changes to societ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Burnett JW

    更新日期:1985-05-01 00:00:00

  • Lack of association between angiotensin I-converting enzyme insertion/deletion polymorphism and psoriasis or psoriatic arthritis in Spain.

    abstract::Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conduct...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Coto-Segura P,Alvarez V,Soto-Sánchez J,Morales B,Coto E,Santos-Juanes J

    更新日期:2009-12-01 00:00:00

  • Mycosis fungoides with oral involvement.

    abstract::Oral mucous membrane involvement occurs uncommonly in mycosis fungoides and reports of it are scarce. We present two patients with severe involvement of the oral mucous membranes. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vicente A,Martí RM,Martín E,Estrach T,Herrero C,Mascaró JM

    更新日期:1991-12-01 00:00:00