Spontaneous waves in the dentate gyrus of slices from the ventral hippocampus.

Abstract:

:Spontaneous negative-going potentials occurring at an average frequency of 0.7 Hz were recorded from the dentate gyrus of slices prepared from the temporal hippocampus of young adult rats. These events (here termed "dentate waves") in several respects resembled the dentate spikes described for freely moving rats during immobile behaviors and slow-wave sleep. Action potentials were observed on the descending portion of the in vitro waves and, as expected from this, whole cell recordings established that the waves were composed of depolarizing currents. Dentate waves appeared to be locally generated within the granule cell layer and were greatly reduced by antagonists of AMPA-type glutamate receptors or by lesions to the entorhinal cortex. Simultaneous recordings indicated that the waves were often synchronized in the inner and outer blades of the dentate gyrus. Knife cuts through the perforant path and the commissural/associational system did not eliminate synchronization, leaving electrotonic propagation via gap junctions as its probable cause. In accord with this, cuts that separated the two blades of the dentate eliminated synchronization between them, and a compound that inhibits gap junctions reduced wave activity. Dentate waves were regularly accompanied by sharp waves in field CA3 and were reduced in size by the acetylcholinesterase inhibitor, physostigmine. It is hypothesized that dentate waves occur when spontaneous glutamate release from dentate afferents produces action potentials in neighboring granule cells that then summate electrotonically into a population event; once initiated, the waves propagate, again electrotonically, and thereby engage a significant portion of the granule cell population.

journal_name

J Neurophysiol

authors

Colgin LL,Kubota D,Brucher FA,Jia Y,Branyan E,Gall CM,Lynch G

doi

10.1152/jn.00478.2004

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

3385-98

issue

6

eissn

0022-3077

issn

1522-1598

pii

00478.2004

journal_volume

92

pub_type

杂志文章
  • Physiology of neuronal subtypes in the respiratory-vocal integration nucleus retroamigualis of the male zebra finch.

    abstract::Learned vocalizations, such as bird song, require intricate coordination of vocal and respiratory muscles. Although the neural basis for this coordination remains poorly understood, it likely includes direct synaptic interactions between respiratory premotor neurons and vocal motor neurons. In birds, as in mammals, th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00257.2005

    authors: Kubke MF,Yazaki-Sugiyama Y,Mooney R,Wild JM

    更新日期:2005-10-01 00:00:00

  • Identification of the physical stimulus and the neural basis of fabric-evoked prickle.

    abstract::1. The neurophysiological basis for the sensation of prickle evoked by contact of some fabrics with the skin is reported. 2. Single-unit sensory nerve recordings from the rabbit saphenous nerve were used to identify the receptors responsible for fabric-evoked prickle. These recordings showed that all low-threshold mec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.59.4.1083

    authors: Garnsworthy RK,Gully RL,Kenins P,Mayfield RJ,Westerman RA

    更新日期:1988-04-01 00:00:00

  • Genetic modifications of seizure susceptibility and expression by altered excitability in Drosophila Na(+) and K(+) channel mutants.

    abstract::A seizure-paralysis repertoire characteristic of Drosophila "bang-sensitive" mutants can be evoked electroconvulsively in tethered flies, in which behavioral episodes are associated with synchronized spike discharges in different body parts. Flight muscle DLMs (dorsal longitudinal muscles) display a stereotypic sequen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00499.2006

    authors: Lee J,Wu CF

    更新日期:2006-11-01 00:00:00

  • Corticoreticular pathways in the cat. II. Discharge activity of neurons in area 4 during voluntary gait modifications.

    abstract::We propose that the descending command from area 4 that is responsible, in part, for the change in limb trajectory required to step over an obstacle in one's path also plays a role in triggering the anticipatory postural modifications that accompany this movement. To test this hypothesis, we recorded the discharge cha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.1.406

    authors: Kably B,Drew T

    更新日期:1998-07-01 00:00:00

  • Increased spinal reflex excitability is associated with enhanced central activation during voluntary lengthening contractions in human spinal cord injury.

    abstract::This study of chronic incomplete spinal cord injury (SCI) subjects investigated patterns of central motor drive (i.e., central activation) of the plantar flexors using interpolated twitches, and modulation of soleus H-reflexes during lengthening, isometric, and shortening muscle actions. In a recent study of the knee ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01074.2014

    authors: Kim HE,Corcos DM,Hornby TG

    更新日期:2015-07-01 00:00:00

  • Selection and coordination of human locomotor forms following cerebellar damage.

    abstract::We have previously shown that control subjects use two distinct temporal strategies when stepping on an inclined surface during walking: one for level and 10 degrees surfaces and another for 20 and 30 degrees surfaces. These two temporal strategies were characterized by systematic shifts in the timing of muscle activi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.2.759

    authors: Earhart GM,Bastian AJ

    更新日期:2001-02-01 00:00:00

  • Functional brain stem circuits for control of nose motion.

    abstract::Rodents shift their nose from side to side when they actively explore and lateralize odors in the space. This motor action is driven by a pair of muscles, the deflector nasi. We studied the premotor control of this motion. We used replication-competent rabies virus to transsynaptically label inputs to the deflector na...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00608.2018

    authors: Kurnikova A,Deschênes M,Kleinfeld D

    更新日期:2019-01-01 00:00:00

  • Interlimb coordination in human crawling reveals similarities in development and neural control with quadrupeds.

    abstract::The study of quadrupeds has furnished most of our understanding of mammalian locomotion. To allow a more direct comparison of coordination between the four limbs in humans and quadrupeds, we studied crawling in the human, a behavior that is part of normal human development and mechanically more similar to quadrupedal ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91125.2008

    authors: Patrick SK,Noah JA,Yang JF

    更新日期:2009-02-01 00:00:00

  • Entrainment of visual steady-state responses is modulated by global spatial statistics.

    abstract::The rhythmic delivery of visual stimuli evokes large-scale neuronal entrainment in the form of steady-state oscillatory field potentials. The spatiotemporal properties of stimulus drive appear to constrain the relative degrees of neuronal entrainment. Specific frequency ranges, for example, are uniquely suited for enh...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00129.2017

    authors: Nguyen T,Kuntzelman K,Miskovic V

    更新日期:2017-07-01 00:00:00

  • Slow oscillating population activity in developing cortical networks: models and experimental results.

    abstract::During early development neuronal networks express slow oscillating synchronized activity. The activity can be driven by several, not necessarily mutually exclusive, mechanisms. Each mechanism might have distinctive consequences for the phenomenology, formation, or sustainment of the early activity pattern. Here we st...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00889.2010

    authors: Baltz T,Herzog A,Voigt T

    更新日期:2011-09-01 00:00:00

  • Visual orientation and spatial frequency discrimination: a comparison of single neurons and behavior.

    abstract::Neurons in the visual cortex respond selectively to stimulus orientation and spatial frequency. Changes in response amplitudes of these neurons could be the neurophysiological basis of orientation and spatial frequency discrimination. We have estimated the minimum differences in stimulus orientation and spatial freque...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1987.57.3.755

    authors: Bradley A,Skottun BC,Ohzawa I,Sclar G,Freeman RD

    更新日期:1987-03-01 00:00:00

  • Differential activation and classification of cutaneous afferents in the rat.

    abstract::1. A total of 312 cutaneous afferent units identified in the rat foot as belonging to one of nine major types of sensory receptors were included in the present study. A natural stimulus set was defined to differentiate optimally among those receptor types according to the distinguishing response patterns that it produ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.6.2411

    authors: Leem JW,Willis WD,Weller SC,Chung JM

    更新日期:1993-12-01 00:00:00

  • Similarity in the response of smooth pursuit and manual tracking to a change in the direction of target motion.

    abstract::Subjects were asked to track, with their eyes or their hand, the movement of a target that maintained a constant speed and made a single, abrupt change in direction. The tracking speed and direction of motion after the step change in target direction were compared for the eyes and the hand. After removal of the saccad...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.2000.84.3.1149

    authors: Engel KC,Anderson JH,Soechting JF

    更新日期:2000-09-01 00:00:00

  • Interjoint coordination in the stick insect leg-control system: the role of positional signaling.

    abstract::Interjoint coordination is essential for proper walking behavior in multi-jointed insect legs. We have shown previously that movement signals from the femur-tibia (FT) joint can shape motor activity of the adjacent coxa-trochanter (CT) joint in the stick insect, Carausius morosus. Here, we present data on the role of ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00637.2002

    authors: Bucher D,Akay T,DiCaprio RA,Buschges A

    更新日期:2003-03-01 00:00:00

  • Decomposition of surface EMG signals from cyclic dynamic contractions.

    abstract::Over the past 3 decades, various algorithms used to decompose the electromyographic (EMG) signal into its constituent motor unit action potentials (MUAPs) have been reported. All are limited to decomposing EMG signals from isometric contraction. In this report, we describe a successful approach to decomposing the surf...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00555.2014

    authors: De Luca CJ,Chang SS,Roy SH,Kline JC,Nawab SH

    更新日期:2015-03-15 00:00:00

  • Relationship of membrane properties, spike burst responses, laminar location, and functional class of dorsal horn neurons recorded in vitro.

    abstract::The input-output and discharge properties of neurons are shaped by both passive and active electrophysiological membrane properties. Whole cell patch-clamp recordings in lamina I-III neurons in an isolated preparation of the whole spinal cord of juvenile rats with attached dorsal roots and dorsal root ganglia were use...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00187.2016

    authors: Dougherty PM,Chen J

    更新日期:2016-09-01 00:00:00

  • [K+]o clearance in cortex: a new analytical model.

    abstract::1. It has been suggested that passive diffusion is the principal mechanism of the clearance of locally elevated extracellular potassium, K+o, in the cerebral cortex. This concept was based on the assumption that elevated K+ could be modeled as a point source. In the present study, the functional role of passive diffus...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1977.40.5.1015

    authors: Vern BA,Schuette WH,Thibault LE

    更新日期:1977-09-01 00:00:00

  • Dynamics of reflex cocontraction in hermit crab abdomen: experiments and a systems model.

    abstract::1. Both stretch and release of the ventral superficial muscles (VSM) in the abdomen of the hermit crab, Pagurus pollicarus, activate the VSM motoneurons in the intact animal and in the isolated abdomen. 2. This reflex was studied by recording intracellularly from muscle fibers innervated by single motoneurons during s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.6.1904

    authors: Chapple WD

    更新日期:1993-06-01 00:00:00

  • Slow oscillation state facilitates epileptiform events in the hippocampus.

    abstract::In mesial temporal lobe (MTL) epilepsy, which typically involves the hippocampus (HPC), epileptiform events are enhanced during slow wave sleep (SWS). It remains unclear how and why the electroencephalographic (EEG) states that constitute SWS might predispose the HPC to this type of pathological activity. Recently our...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90795.2008

    authors: Nazer F,Dickson CT

    更新日期:2009-09-01 00:00:00

  • Contribution of synchronized GABAergic neurons to dopaminergic neuron firing and bursting.

    abstract::In the ventral tegmental area (VTA), interactions between dopamine (DA) and γ-aminobutyric acid (GABA) neurons are critical for regulating DA neuron activity and thus DA efflux. To provide a mechanistic explanation of how GABA neurons influence DA neuron firing, we developed a circuit model of the VTA. The model is ba...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00232.2016

    authors: Morozova EO,Myroshnychenko M,Zakharov D,di Volo M,Gutkin B,Lapish CC,Kuznetsov A

    更新日期:2016-10-01 00:00:00

  • Adjustments of motor pattern for load compensation via modulated activations of muscle synergies during natural behaviors.

    abstract::It has been suggested that the motor system may circumvent the difficulty of controlling many degrees of freedom in the musculoskeletal apparatus by generating motor outputs through a combination of discrete muscle synergies. How a discretely organized motor system compensates for diverse perturbations has remained el...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01387.2007

    authors: Cheung VC,d'Avella A,Bizzi E

    更新日期:2009-03-01 00:00:00

  • Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex.

    abstract::Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are thought to play fundamental roles in sensory processing. Here, we have combined optogenetic stimulation, whole cell recordings, and computational modeling to define key functional microcircuits within layer 2/3 of mouse primary...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00917.2011

    authors: Avermann M,Tomm C,Mateo C,Gerstner W,Petersen CC

    更新日期:2012-06-01 00:00:00

  • Effects of bicuculline methiodide on fast (>200 Hz) electrical oscillations in rat somatosensory cortex.

    abstract::Fast oscillatory activity (more than approximately 200 Hz) has been attracting increasing attention regarding its possible role in both normal brain function and epileptogenesis. Yet, its underlying cellular mechanism remains poorly understood. Our prior investigation of the phenomenon in rat somatosensory cortex indi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.2.1016

    authors: Jones MS,Barth DS

    更新日期:2002-08-01 00:00:00

  • Differential changes in signal and background firing of accumbal neurons during cocaine self-administration.

    abstract::Learning theories of drug addiction propose that the disorder is, at least in part, attributable to drug effects on accumbal mechanisms that are normally involved in reward-related learning. The neurophysiological mechanisms that might transduce such a drug effect on accumbal mechanisms have yet to be identified. Prev...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00849.2002

    authors: Peoples LL,Cavanaugh D

    更新日期:2003-08-01 00:00:00

  • Current advances in invertebrate vision: insights from patch-clamp studies of photoreceptors in apposition eyes.

    abstract::Traditional electrophysiological research on invertebrate photoreceptors has been conducted in vivo, using intracellular recordings from intact compound eyes. The only exception used to be Drosophila melanogaster, which was exhaustively studied by both intracellular recording and patch-clamp methods. Recently, several...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00288.2016

    authors: Frolov RV

    更新日期:2016-08-01 00:00:00

  • Powerful, onset inhibition in the ventral nucleus of the lateral lemniscus.

    abstract::The function of the ventral nucleus of the lateral lemniscus (VNLL), a secondary processing site within the auditory brain stem, is unclear. It is known to be a major source of inhibition to the inferior colliculus (IC). It is also thought to play a role in coding the temporal aspects of sound, such as onsets and the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00167.2005

    authors: Nayagam DA,Clarey JC,Paolini AG

    更新日期:2005-08-01 00:00:00

  • Nonlinearity of spatial summation in simple cells of areas 17 and 18 of cat visual cortex.

    abstract::1. Nonlinearity of spatial summation in areas 17 and 18 of cat visual cortex was compared with the type of spatial nonlinearity that differentiates X and Y cells in the lateral geniculate nucleus (LGN) and retina. The comparisons were made to examine to what extent the information from X and Y cells may remain separat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.5.1667

    authors: Ferster D,Jagadeesh B

    更新日期:1991-11-01 00:00:00

  • Spontaneous electrical activity and interaction of large and small cells in cardiac ganglion of the crab, Portunus sanguinolentus.

    abstract::1. Semi-isolated preparations of the nine-celled cardiac ganglion of the crab, Portunus sanguinolentus, were studied electrophysiologically, using simultaneous recording from extracellular and two or three intracellular electrodes. Nine penetrations of small cells were achieved. 2. Three large (80 x 120 micron) cells ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1979.42.4.975

    authors: Tazaki K,Cooke IM

    更新日期:1979-07-01 00:00:00

  • Reflex responses in active muscles elicited by stimulation of low-threshold afferents from the human foot.

    abstract::1. Reflex responses were elicited in muscles that act at the ankle by electrical stimulation of low-threshold afferents from the foot in human subjects who were reclining supine. During steady voluntary contractions, stimulus trains (5 pulses at 300 Hz) were delivered at two intensities to the sural nerve (1.2-4.0 tim...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.67.5.1375

    authors: Aniss AM,Gandevia SC,Burke D

    更新日期:1992-05-01 00:00:00

  • Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.

    abstract::STX1 is a major neuronal syntaxin protein located at the plasma membrane of the neuronal tissues. Rodent STX1 has two highly similar paralogs, STX1A and STX1B, that are thought to be functionally redundant. Interestingly, some studies have shown that the distribution patterns of STX1A and STX1B at the central and peri...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00577.2015

    authors: Wu YJ,Tejero R,Arancillo M,Vardar G,Korotkova T,Kintscher M,Schmitz D,Ponomarenko A,Tabares L,Rosenmund C

    更新日期:2015-10-01 00:00:00