Pulsatile flow and simple flow control method during weaning period in centrifugal pump: toward more expanded usage in open heart surgery.


:To expand the usage of the centrifugal pump (CP) in open heart surgery, we performed two studies. In the first, we evaluated pulsatile flow in the CP. In vitro pump performance of the Terumo Capiox pump (TCP) and the Sarns Delphin pump (SDP) and increase of free hemoglobin (mg/dl) after driving 6 h were investigated using bovine blood. A roller pump (RP) was used as a comparison. Equally effective pulsatile flow was obtained in both CPs. Hemolysis was less severe in TCP (120 mg/dl) than SDP (210 mg/dl) and RP (320 mg/dl). In the second study, we evaluated a simple flow control method. Flow rate was easily controlled with step-wise clamping of 3-pronged tubing (Triple-flow) without changing rotational speed, regardless of afterload. Fluctuation of flow was much less with this method than with the rotational speed change method. The use of pulsatile flow of TCP, with its minimum increase of hemolysis and the easier flow control method during the weaning process, may expand the usage of CP in open heart surgery.


Artif Organs


Artificial organs


Nishida H,Koyanagi H,Endo M,Suzuki S,Oshiyama H,Nojiri C,Fukasawa H,Akutsu T




Has Abstract


1994-09-01 00:00:00












  • Estimation of theophylline clearance during continuous arteriovenous hemofiltration.

    abstract::Pharmacologic agents and other non-protein-bound compounds smaller than 5,000 daltons have the potential to be removed by continuous arteriovenous hemofiltration (CAVH). A proposed method for estimating drug clearance by CAVH (ClCAVH) equates ultrafiltrate clearance to the product of the sieving coefficient and the av...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Horton MW,Godley PJ,Moore ES,Fineg J,Gillespie WR

    更新日期:1990-12-01 00:00:00

  • Predictive Factors Upon Discontinuation of Renal Replacement Therapy for Long-Term Chronic Dialysis and Death in Acute Kidney Injury Patients.

    abstract::The specific timing for discontinuing renal replacement therapy (RRT) in acute kidney injury (AKI) patients is debatable. The predictive abilities of variables at the time of discontinuation of RRT for the long-term prognoses of patients have not been explored. This study aimed to explore the prognostic factors upon d...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Yang T,Sun S,Lin L,Han M,Liu Q,Zeng X,Zhao Y,Li Y,Su B,Huang S,Yang L

    更新日期:2017-12-01 00:00:00

  • Promigratory activity of oxytocin on umbilical cord blood-derived mesenchymal stem cells.

    abstract::Recent studies show that oxytocin has various effects on cellular behaviors. Oxytocin is reported to stimulate cardiomyogenesis of embryonic stem cells and endothelial cell proliferation. Mesenchymal stem cells (MSCs) are widely used for cardiac repair, and we elucidated the effect of oxytocin on umbilical cord derive...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kim YS,Kwon JS,Hong MH,Kim J,Song CH,Jeong MH,Cho JG,Park JC,Kang JC,Ahn Y

    更新日期:2010-06-01 00:00:00

  • Evaluation of membrane oxygenators and reservoirs in terms of capturing gaseous microemboli and pressure drops.

    abstract::An increasing amount of evidence points to cerebral embolization during cardiopulmonary bypass (CPB) as the principal etiologic factor of neurologic complications. In this study, the capability of capturing and classification of gaseous emboli and pressure drop of three different membrane oxygenators (Sorin Apex, Teru...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Guan Y,Palanzo D,Kunselman A,Undar A

    更新日期:2009-11-01 00:00:00

  • Pseudoendothelium formation in expanded polytetrafluoroethylene grafts implanted in the inferior vena cava of normal and defibrinogenated dogs.

    abstract::The outgrowth of endothelial cells in an expanded polytetrafluoroethylene graft implanted in the canine inferior vena cava was studied by scanning electron microscopy. The adjacent endothelial cells of the vena cava started to invade the anastomotic area three days after the implantation and reached approximately the ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ishimaru S,Berglin E,Hansson HA,Teger-Nilsson AC,William-Olsson G

    更新日期:1981-11-01 00:00:00

  • Cadaver fitting study of the DexAide right ventricular assist device.

    abstract::The DexAide right ventricular assist device (RVAD) has been developed to provide an implantable RVAD option to surgeons. The aim of this study was to determine the optimal cannula design and optimal implantation location of the DexAide RVAD in preparation for its clinical use. Separately, a HeartMate XVE left ventricu...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ootaki Y,Ootaki C,Kamohara K,Akiyama M,Cingoz F,Kopcak MW Jr,Dessoffy R,Liu J,Massiello A,Horvath D,Chen JF,Zhou Q,Benefit S,Golding LA,Fukamachi K

    更新日期:2007-08-01 00:00:00

  • Replacing cardiopulmonary bypass with extracorporeal membrane oxygenation in lung transplantation operations.

    abstract::Cardiopulmonary bypass (CPB) is required in some lung transplantation (LTx) operations. However, it increases risks of bleeding and early graft dysfunction. We report our experiences of replacing CPB with heparin-bound extracorporeal membrane oxygenation (ECMO) in LTx operations. If extracorporeal circulation was anti...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ko WJ,Chen YS,Lee YC

    更新日期:2001-08-01 00:00:00

  • Research of flow dynamics and occlusion condition in roller pump systems used for ventricular assist.

    abstract::Roller pumps have been widely used in the ventricular assist field for many years, while the significant hemolysis caused by its mechanical stress is still a fundamental problem. Although the usual under-occlusion setting was considered as an effective method to reduce the hemolysis rate, its nonocclusive condition of...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Zhou Y,Sun B,Chen M,Cui C

    更新日期:2020-07-31 00:00:00

  • Delivery of the bioactive gas hydrogen sulfide during cold preservation of rat liver: effects on hepatic function in an ex vivo model.

    abstract::The insults sustained by transplanted livers (hepatectomy, hypothermic preservation, and normothermic reperfusion) could compromise hepatic function. Hydrogen sulfide (H₂S) is a physiologic gaseous signaling molecule, like nitric oxide (NO) and carbon monoxide (CO). We examined the effect of diallyl disulfide as a H₂S...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Balaban CL,Rodriguez JV,Guibert EE

    更新日期:2011-05-01 00:00:00

  • Unsteady fluid dynamics of several mechanical prosthetic heart valves using a two component laser Doppler anemometer system.

    abstract::Five typical mechanical heart valves (Starr-Edwards, Björk-Shiley convexo-concave (c-c), Björk-Shiley monostrut, Bicer-Val, and St. Jude Medical) were tested in the mitral position under the pulsatile flow condition. The test program included measurements of velocity and turbulent stresses at 5 downstream locations. T...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Akutsu T,Modi VJ

    更新日期:1997-10-01 00:00:00

  • Diabetes-induced alterations in latissimus dorsi muscle properties impair effectiveness of dynamic cardiomyoplasty in rats.

    abstract::Short-term diabetes was induced in male Wistar rats with streptozotocin injection. The effects of diabetes on latissimus dorsi (LD) muscle contractile and biochemical properties and acute cardiomyoplasty (CDM) were assessed and compared with data from 16 control rats. Isometric force, contractile properties, and fatig...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: De Angelis K,Senna S,Irigoyen MC,Cestari IA

    更新日期:2004-04-01 00:00:00

  • Heparin coating of small-caliber decellularized xenografts reduces macrophage infiltration and intimal hyperplasia.

    abstract::Small-caliber decellularized xenografts with surface heparin coating are known to reduce in vivo thrombogenicity. This study was performed to examine whether heparin coating on the small-caliber decellularized xenografts would reduce macrophage infiltration and intimal hyperplasia. In a rabbit model of bilateral carot...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Cai WW,Gu YJ,Wang XN,Chen CZ

    更新日期:2009-06-01 00:00:00

  • A compact mock circulation loop for the in vitro testing of cardiovascular devices.

    abstract::In vitro cardiovascular device performance evaluation in a mock circulation loop (MCL) is a necessary step prior to in vivo testing. A MCL that accurately represents the physiology of the cardiovascular system accelerates the assessment of the device's ability to treat pathological conditions. To serve this purpose, a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Timms DL,Gregory SD,Greatrex NA,Pearcy MJ,Fraser JF,Steinseifer U

    更新日期:2011-04-01 00:00:00

  • Morphological characteristics and proliferation of keratocytes cultured under simulated microgravity.

    abstract::This study probed the changes of keratocytes cultured under simulated microgravity. Keratocytes were isolated from rabbit corneas using collagenase digestion method. Cells were seeded in a 55-mL capacity high-aspect-ratio vessel (HARV) of rotary cell culture system (RCCS) at a density of 1 x 10(4) cells/mL. Dehydrated...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Chen J,Chen R,Gao S

    更新日期:2007-09-01 00:00:00

  • Effect of cyclosporine therapy with low doses of corticosteroids on idiopathic nephrotic syndrome.

    abstract::Cyclosporine (CyA) has an immunosuppressive effect that might suggest a therapeutic role in idiopathic glomerular conditions. We focused on the optimization of CyA treatment control in patients with idiopathic nephrotic syndrome by using trough-level CyA measurements (C0) and the 2-h postdose levels (C2). Twenty-two p...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Griveas I,Visvardis G,Papadopoulou D,Nakopolou L,Karanikas E,Gogos K,Stavianoudakis G

    更新日期:2010-03-01 00:00:00

  • Heparin-coated cardiopulmonary bypass circuits in coronary bypass surgery.

    abstract::Cardiopulmonary bypass (CPB) is a nonphysiologic environment for an organism. The damage of blood components may also lead to organ dysfunction, some-times recognized as postperfusion syndrome. One possible way to diminish the risk of these complications would be to reduce the thorombogenicity and to improve the bioco...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章


    authors: Horimoto H,Kondo K,Asada K,Sasaki S

    更新日期:1996-08-01 00:00:00

  • Significance of percutaneous cardiopulmonary bypass support for volume reduction surgery with severe hypercapnia.

    abstract::In patients with reduced respiratory function, lung resection is associated with high risk because separate ventilation is generally needed for safe management. For patients with end-stage emphysema, intraoperative respiratory management is important and particularly difficult because neither incomplete oxygenation no...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tsunezuka Y,Sato H,Tsubota M,Seki M

    更新日期:2000-01-01 00:00:00

  • Oral treatment for jaundice using immobilized bilirubin oxidase.

    abstract::Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Soltys PJ,Mullon C,Langer R

    更新日期:1992-08-01 00:00:00

  • Liposome encapsulated hemoglobin as a resuscitation fluid for hemorrhagic shock.

    abstract::The effectiveness of the blood substitute neo red cells (NRC) on hemorrhagic shock was evaluated in dogs. Shock was induced by bloodletting, and NRC was infused immediately until the dogs recovered from shock; the process was repeated 3 times (mild shock), or NRC was infused after shock was maintained for 30 min, and ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Usuba A,Osuka F,Kimura T,Sato R,Fujita Y,Yamashita M,Hoshino C

    更新日期:1998-02-01 00:00:00

  • Effect of heparin, platelets, activated platelets, platelet fragments, and hematocrit on activated clotting time.

    abstract::Activated clotting time (ACT) is the most commonly used laboratory test to control the heparin effect during extracorporeal techniques. The study was undertaken in order to test in vitro the influence of heparin, platelet count, hematocrit, platelet fragmentation, and platelet activation on ACT. Blood was drawn from v...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Girardi L,Sudi K,Muntean W

    更新日期:2000-07-01 00:00:00

  • Treatment of severe hyperlipidemia: six years' experience with low-density lipoprotein apheresis.

    abstract::In total, 30 patients suffering from familial hypercholesterolemia, resistant to diet and lipid-lowering drugs, were treated for up to 6 years (3.6 + or - 1.6; range, 0.2-6.8 years) with low-density lipoprotein (LDL) apheresis. Three different systems were used; the dextran sulfate adsorption system (Kaneka) for 27 of...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章


    authors: Bambauer R,Schiel R,Latza R,Klinkmann J

    更新日期:1996-04-01 00:00:00

  • Dialyzer reuse: interaction between dialyzer membrane, disinfectant (formalin), and blood during dialyzer reprocessing.

    abstract::The growing practice of dialyzer reuse in recent years is mainly based on medical and economic considerations. However, adverse reactions such as immunohemolytic anemia due to anti-Nform antibody associated with dialyzer reuse have been reported. In this study, scanning electron microscopy and cytologic staining were ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ng YY,Yang AH,Wong KC,Lan HY,Hung TL,Kerr PG,Huang TP

    更新日期:1996-01-01 00:00:00

  • Multifunctional implantable nerve stimulator for cardiac assistance by skeletal muscle.

    abstract::Different methods are used, clinically and experimentally, to assist severely impaired heart function by means of skeletal muscle. The efficiency of these methods is restricted by skeletal muscle losing strength after transpositioning and during conditioning and not being sufficiently resistant to fatigue. This is mai...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Lanmüller H,Sauermann S,Unger E,Schnetz G,Mayr W,Bijak M,Girsch W

    更新日期:1999-04-01 00:00:00

  • Lixelle adsorbent to remove inflammatory cytokines.

    abstract::A beta2-microglobulin (beta2M) selective adsorbent (Lixelle) for direct hemoperfusion has been used for the treatment of hemodialysis patients with the long-term complication of dialysis related amyloidosis (DRA), but there is no significant correlation between the serum level of beta2M and the occurrence of DRA. Infl...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tsuchida K,Takemoto Y,Nakamura T,Fu O,Okada C,Yamagami S,Kishimoto T

    更新日期:1998-12-01 00:00:00

  • General planning of an artificial organ center.

    abstract::There is an increasing need for research and development centers to deal with design and evaluation of organ replacement systems, the improvement of older devices, and the study of biocompatibility problems. Special attention, in this article, is focused on the determinant role of the background of the investigators i...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Vanholder R,Ringoir S

    更新日期:1989-12-01 00:00:00

  • Preservation of human saphenous vein against reactive oxygen species-induced oxidative stress by green tea polyphenol pretreatment.

    abstract::The injurious effects of reactive oxygen species on venous tissues and the potential protective role played by green tea polyphenol (GTPP) on human saphenous veins were investigated. Oxidative stress was induced exogenously in the vein segments, either by adding 0.8 or 1.6 M of H2O2, or by using 80 or 160 U/L of xanth...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Han DW,Suh H,Park YH,Cho BK,Hyon SH,Park JC

    更新日期:2003-12-01 00:00:00

  • The ethics of technology introduction.

    abstract::The rapid acceleration of technology development is outpacing our ability to assess it objectively and competently. Our challenge is to develop new assessment methods that take into account the fast moving nature of technology development while still protecting the patients' and the public interest. ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Abele JE

    更新日期:1998-01-01 00:00:00

  • Application of a pressure-relieving air compliance chamber in a single-pulsatile extracorporeal life support system: an experimental study.

    abstract::Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving c...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kim TS,Sun K,Lee KB,Lee HW,Baek KJ,Park SY,Son HS,Kim KT,Kim HM

    更新日期:2004-12-01 00:00:00

  • Is the dog a useful model for accelerated calcification study of cardiovascular bioprostheses?

    abstract::Chitosan posttreatment has been shown to be effective in prevention of calcification of the glutaraldehyde treated bovine pericardium when implanted subdermally in rats for 12 weeks. The efficacy of chitosan posttreatment in complete calcium mitigation of the glutaraldehyde treated porcine aortic valves implanted in t...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Chanda J,Kuribayashi R,Abe T,Sekine S,Shibata Y,Yamagishi I

    更新日期:1997-05-01 00:00:00

  • The accurate control of ultrafiltration.

    abstract::An apparatus has been contructed to regulate ultrafiltration accurately during dialysis. The principle of the apparatus is that, per unit of time, exactly the same amount of dialysate is introduced into the dialyzer as is discharged from it. The apparatus consists of two isovolumetric pumps connected in line. The four...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Flendrig JG,Carpay WM,Dekkers WT

    更新日期:1978-05-01 00:00:00