Differential induction of antiviral effects against West Nile virus in primary mouse macrophages derived from flavivirus-susceptible and congenic resistant mice by alpha/beta interferon and poly(I-C).

abstract：:The 3C region of human rhinovirus 14 was expressed in Escherichia coli. The microbially synthesized protease was functional, since the expressed precursor underwent autoproteolytic processing to generate mature molecules of the expected molecular weight and antigenicity. Mutation of the putative active-site Cys-146 re...

journal_title：Journal of virology

authors： Cordingley MG,Register RB,Callahan PL,Garsky VM,Colonno RJ

更新日期：1989-12-01 00:00:00

abstract：:Rodent fibroblasts infected with the ts371 Kirsten murine sarcoma virus (KiMuSV) are temperature sensitive for the maintenance of transformation because of the production of an abnormal p21 protein. We cloned the ts371 KiMuSV provirus from the genome of a conditionally transformed nonproducer cell line, ts371 KiMuSV N...

journal_title：Journal of virology

authors： Stein RB,Tai JY,Scolnick EM

更新日期：1986-11-01 00:00:00

abstract：:The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are incompletely understood because early infection in humans is rarely identified, particularly in those individuals who subsequently demonstrate spontaneous virus eradication. We have established a large national network of patients wi...

journal_title：Journal of virology

authors： Smyk-Pearson S,Tester IA,Klarquist J,Palmer BE,Pawlotsky JM,Golden-Mason L,Rosen HR

更新日期：2008-02-01 00:00:00

abstract：:Changes in the envelope glycoprotein ectodomains of a nonpathogenic simian-human immunodeficiency virus (SHIV-89.6) that was serially passaged in vivo have been shown to be responsible for the increased pathogenicity of the resulting virus, SHIV-KB9 (G. B. Karlsson, et al., J. Exp. Med. 188:1159-1171, 1998). The 12 am...

journal_title：Journal of virology

authors： Etemad-Moghadam B,Sun Y,Nicholson EK,Fernandes M,Liou K,Gomila R,Lee J,Sodroski J

更新日期：2000-05-01 00:00:00

abstract：:The E1 helicase of papillomaviruses is required for replication of the viral double-stranded DNA genome, in conjunction with cellular factors. DNA replication is initiated at the viral origin by the assembly of E1 monomers into oligomeric complexes that have unwinding activity. In vivo, this process is catalyzed by th...

journal_title：Journal of virology

authors： Titolo S,Brault K,Majewski J,White PW,Archambault J

更新日期：2003-05-01 00:00:00

abstract：:Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS), in combination with proteolytic protection assays, has been used to identify the functional epitope on human immunodeficiency virus envelope glycoprotein gp41 for the broadly neutralizing anti-gp41 human monoclonal antibody 2F5. In this protecti...

journal_title：Journal of virology

authors： Parker CE,Deterding LJ,Hager-Braun C,Binley JM,Schülke N,Katinger H,Moore JP,Tomer KB

更新日期：2001-11-01 00:00:00

abstract：:HIV-1 circulates within an infected host as a genetically heterogeneous viral population. Viral intrahost diversity is shaped by substitutional evolution and recombination. Although many studies have speculated that recombination could have a significant impact on viral phenotype, this has never been definitively demo...

journal_title：Journal of virology

authors： Brown RJ,Peters PJ,Caron C,Gonzalez-Perez MP,Stones L,Ankghuambom C,Pondei K,McClure CP,Alemnji G,Taylor S,Sharp PM,Clapham PR,Ball JK

更新日期：2011-06-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of reactivation from laten...

journal_title：Journal of virology

authors： Harrison KS,Zhu L,Thunuguntla P,Jones C

更新日期：2019-06-14 00:00:00

abstract：:Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in vivo and for productive infection of nonpermissive cells, such as peripheral blood mononuclear cells (PBMC). Vif counte...

journal_title：Journal of virology

authors： Ribeiro AC,Maia e Silva A,Santa-Marta M,Pombo A,Moniz-Pereira J,Goncalves J,Barahona I

更新日期：2005-01-01 00:00:00

abstract：:Splicing of human immunodeficiency virus type 1 (HIV-1) exon 6D is regulated by the presence of a complex splicing regulatory element (SRE) sequence that interacts with the splicing factors hnRNP H and SC35. In this work, we show that, in the context of the wild-type viral sequence, hnRNP H acts as a repressor of exon...

journal_title：Journal of virology

authors： Jablonski JA,Buratti E,Stuani C,Caputi M

更新日期：2008-08-01 00:00:00

abstract：:Influenza viral complementary RNA (cRNA), i.e., viral mRNA was radioactive when purified from the cytoplasmic fraction of cordycepin-treated canine kidney cells that were incubated with [methyl-3H]methionine during infection. Approximately 55 to 60% of the methyl-3H radioactivity was in internal N6-methyladenosine, a ...

journal_title：Journal of virology

authors： Krug RM,Morgan MA,Shatkin AJ

更新日期：1976-10-01 00:00:00

abstract：:Previously we have described a stepwise, energy-dependent pathway for human immunodeficiency virus type 1 (HIV-1) capsid assembly in a cell-free system. In this pathway, Gag polypeptides utilize the cellular factor HP68 and assemble into immature capsids by way of assembly intermediates that have defined biochemical c...

journal_title：Journal of virology

authors： Dooher JE,Lingappa JR

更新日期：2004-02-01 00:00:00

abstract：:In contrast to infrequent and low-titer cross-neutralization of human immunodeficiency virus type 1 (HIV-1) isolates by HIV-2- and simian immunodeficiency virus (SIV)-positive sera, extensive cross-neutralization of HIV-2NIH-Z, SIVMAC251, and SIVAGM208K occurs with high titer, suggesting conservation of epitopes and m...

journal_title：Journal of virology

authors： Robert-Guroff M,Aldrich K,Muldoon R,Stern TL,Bansal GP,Matthews TJ,Markham PD,Gallo RC,Franchini G

更新日期：1992-06-01 00:00:00

abstract：:Hepatitis delta virus (HDV) is a defective RNA virus which is dependent on hepatitis B virus for essential helper functions. Only a single highly basic phosphoprotein, HDV antigen (HDAg), is expressed by the HDV genome during infection in humans. Antibody directed to HDAg is important in the diagnosis of HDV infection...

journal_title：Journal of virology

authors： Wang JG,Jansen RW,Brown EA,Lemon SM

更新日期：1990-03-01 00:00:00

abstract：:A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. In this study, we assessed the immunogenicity of the CAP256 superinfecting viral envelope (CAP256 SU) protein delivered by modified vaccinia virus Ankara (MVA) and DNA vaccines in different prime-boost com...

journal_title：Journal of virology

authors： van Diepen MT,Chapman R,Douglass N,Galant S,Moore PL,Margolin E,Ximba P,Morris L,Rybicki EP,Williamson AL

更新日期：2019-04-03 00:00:00

abstract：:Direct evidence is presented for a host-specific role of the cucumovirus capsid protein in long-distance movement within infected plants. Cucumber (Cucumis sativus L.) is a systemic host for cucumber mosaic cucumovirus (CMV). Tomato aspermy cucumovirus, strain 1 (1-TAV), multiplied to the levels of CMV (i.e., replicat...

journal_title：Journal of virology

authors： Taliansky ME,García-Arenal F

更新日期：1995-02-01 00:00:00

abstract：:We have developed a system for producing murine leukemia virus (MLV) pseudotyped with human hepatitis B virus (HBV) large (L) and small (S) surface antigens (HBsAg) for targeting primary human hepatocytes. Using the MLV(HBV) pseudotype virus containing a beta-galactosidase reporter gene, we demonstrated that this pseu...

journal_title：Journal of virology

authors： Sung VM,Lai MM

更新日期：2002-01-01 00:00:00

abstract：:Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses ...

journal_title：Journal of virology

authors： Aandahl EM,Michaëlsson J,Moretto WJ,Hecht FM,Nixon DF

更新日期：2004-03-01 00:00:00

abstract：:The gastric mucosa is an important portal of entry for lymphocytic choriomeningitis virus (LCMV) infections. Within hours after intragastric (i.g.) inoculation, virus appears in the gastric epithelia, then in the mesenteric lymph nodes and spleen, and then in the liver and brain. By 72 h i.g.-inoculated virus is widel...

journal_title：Journal of virology

authors： Yin C,Djavani M,Schenkel AR,Schmidt DS,Pauza CD,Salvato MS

更新日期：1998-11-01 00:00:00

abstract：:To study the function of the varicella-zoster virus (VZV) gB cytoplasmic domain during viral infection, we produced a VZV recombinant virus that expresses a truncated form of gB lacking the C-terminal 36 amino acids of its cytoplasmic domain (VZV gB-36). VZV gB-36 replicates in noncomplementing cells and grows at a ra...

journal_title：Journal of virology

authors： Heineman TC,Hall SL

更新日期：2002-01-01 00:00:00

abstract：:The subgroup A to E avian sarcoma and leukosis viruses (ASLVs) are highly related and are thought to have evolved from a common ancestor. These viruses use distinct cell surface proteins as receptors to gain entry into avian cells. Chickens have evolved resistance to infection by the ASLVs. We have identified the muta...

journal_title：Journal of virology

authors： Elleder D,Melder DC,Trejbalova K,Svoboda J,Federspiel MJ

更新日期：2004-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) gene expression is highly cell and tissue specific. Cell factor-mediated regulatory interactions are involved in regulating the restricted expression of the HCMV major immediate-early (IE) gene (J. F. Baskar, P. P. Smith, G. Nilaver, R. A. Jupp, S. Hoffmann, N. J. Peffer, D. J. Tenney, A. ...

journal_title：Journal of virology

authors： Wu J,O'Neill J,Barbosa MS

更新日期：1998-01-01 00:00:00

abstract：:PEPSCAN analysis has been used to characterize the immunogenic regions of the capsid protein (CP) in virions of plum pox potyvirus (PPV). In addition to the well-known highly immunogenic N- and C-terminal domains of CP, regions within the core domain of the protein have also shown high immunogenicity. Moreover, the N ...

journal_title：Journal of virology

authors： Fernández-Fernández MR,Martínez-Torrecuadrada JL,Roncal F,Domínguez E,García JA

更新日期：2002-12-01 00:00:00

abstract：:For paramyxoviruses, entry requires a receptor-binding protein (hemagglutinin-neuraminidase [HN], H, or G) and a fusion protein (F). Like other class I viral fusion proteins, F is expressed as a prefusion metastable protein that undergoes a refolding event to induce fusion. HN binding to its receptor triggers F refold...

journal_title：Journal of virology

authors： Connolly SA,Leser GP,Jardetzky TS,Lamb RA

更新日期：2009-11-01 00:00:00

abstract：:Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the release of nascent retroviral particles from infected cell surfaces. While human immunodeficiency virus type 1 (HIV-1) encodes the accessory gene vpu to overcome the action of tetherin, the lineage of primate lentiviruses that gave rise to H...

journal_title：Journal of virology

authors： Le Tortorec A,Neil SJ

更新日期：2009-11-01 00:00:00

abstract：:Although parvoviruses are found throughout the animal kingdom, only the human pathogenic B19 virus has so far been shown to possess a limited host range, with erythroid progenitor cells as the main target cells supporting B19 propagation. The underlying mechanism of such erythroid tropism is still unexplained. Synthes...

journal_title：Journal of virology

authors： Pallier C,Greco A,Le Junter J,Saib A,Vassias I,Morinet F

更新日期：1997-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) in vivo is known to establish persistent infection in resting, circulating memory B cells and to productively replicate in plasma cells. Until now, the molecular mechanism of how EBV switches from latency to lytic replication in vivo was not known. Here, we report that the plasma cell differen...

journal_title：Journal of virology

authors： Sun CC,Thorley-Lawson DA

更新日期：2007-12-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus (SARS-CoV) encodes numerous accessory proteins whose importance in the natural infection process is currently unclear. One of these accessory proteins is set apart by its function in the context of a related murine hepatitis virus (MHV) infection. SARS-CoV protein 6 in...

journal_title：Journal of virology

authors： Hussain S,Perlman S,Gallagher TM

更新日期：2008-07-01 00:00:00

abstract：:Inhibition of hepatitis B virus (HBV) replication and viral clearance from an infected host requires both the innate and adaptive immune responses. Expression of interferon (IFN)-inducible proteasome catalytic and regulatory subunits correlates with the IFN-alpha/beta- and IFN-gamma-mediated noncytopathic inhibition o...

journal_title：Journal of virology

authors： Robek MD,Garcia ML,Boyd BS,Chisari FV

更新日期：2007-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) productive replication in vitro is most often studied in fibroblasts. In vivo, fibroblasts amplify viral titers, but transmission and pathogenesis require the infection of other cell types, most notably epithelial cells. In vitro, the study of HCMV infection of epithelial cells has been al...

journal_title：Journal of virology

authors： Weng C,Lee D,Gelbmann CB,Van Sciver N,Nawandar DM,Kenney SC,Kalejta RF

更新日期：2018-07-31 00:00:00