Abstract:
:The purpose of the present study was to examine whether single human carcinoma cells labeled with iron oxide nanoparticles could be detected by magnetic resonance (MR) imaging on a clinical 3-T scanner using a surface coil only. WiDr human colon carcinoma cells were loaded with two kinds of iron oxide nanoparticles differing by coating and size: aminosilan-coated (MagForce) and carboxy-dextran-coated particles (Resovist). The latter were preferred by the colon carcinoma cell line used here and taken up much faster (12 h) than the smaller carboxydextran-coated Resovist (48 h). Labeled single carcinoma cells, distributed in an agarose gel in a monodisperse layer as controlled by light microscopy, became detectable as punctuate signal extinctions when using a small circularly polarized surface coil in conjunction with a T(2)*-weighted GE sequence at 3 T. The threshold for the detectability of labeled colon carcinoma cells ranged at a load of 4-5 mug iron/10(6) cells. Obviating the need for special hardware additions, this study opens a new lane for single-cell tracking on clinical 3-T MR scanners amenable to patient studies.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Pinkernelle J,Teichgräber U,Neumann F,Lehmkuhl L,Ricke J,Scholz R,Jordan A,Bruhn Hdoi
10.1002/mrm.20455subject
Has Abstractpub_date
2005-05-01 00:00:00pages
1187-92issue
5eissn
0740-3194issn
1522-2594journal_volume
53pub_type
杂志文章abstract::A transrectal probe for 1H imaging and 31P MR spectroscopy of the prostate gland is described. The probe is covered with plastic and consists of an insectional portion containing an rf coil and a handle containing a tuning and matching circuit. Using this transrectal probe, 1H MR images and the first 31P MR spectra of...
journal_title:Magnetic resonance in medicine
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abstract:PURPOSE:Conventional fat/water separation techniques require that patients hold breath during abdominal acquisitions, which often fails and limits the achievable spatial resolution and anatomic coverage. This work presents a novel approach for free-breathing volumetric fat/water separation. METHODS:Multiecho data are ...
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abstract::Calibration of the spatial sensitivity functions of coil arrays is a crucial element in parallel magnetic resonance imaging (PMRI). The most common approach has been to measure coil sensitivities directly using one or more low-resolution images acquired before or after accelerated data acquisition. However, since it i...
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journal_title:Magnetic resonance in medicine
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更新日期:2012-11-01 00:00:00
abstract::Magnetic resonance (MR) can offer a unique window on the structure/function relationships in the brain, by utilizing the established link between tissue function, metabolism, and hemodynamics. This report focuses on recent applications of MR-based cerebral blood volume (CBV) imaging in humans. Our methodology uses hig...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910220227
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abstract::The complexity of biologic tissues, with multiple compartments each with its own diffusion and relaxation properties, requires complex formalisms to model water signal in most magnetic resonance imaging or magnetic resonance spectroscopy experiments. In this article, we describe a magnetic susceptibility-induced shift...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20565
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abstract::Diffusion tensor imaging (DTI) is a new imaging modality that can provide unique information on brain white matter anatomy. Measurements of water diffusion constant along multiple axes are fitted to a tensor model, from which the diffusion anisotropy and dominant fiber orientation can be estimated. Even though the ten...
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更新日期:2006-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2018-05-01 00:00:00
abstract:PURPOSE:To demonstrate the feasibility of imaging the first passage of a bolus of hyperpolarized (13)C urea through the rodent heart using flow-sensitizing gradients to reduce signal from the blood pool. METHODS:A flow-sensitizing bipolar gradient was optimized to reduce the bright signal within the cardiac chambers, ...
journal_title:Magnetic resonance in medicine
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更新日期:2016-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2015-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2019-08-01 00:00:00
abstract::Transparent pulses are defined by the property of having no net effect on stationary spins, while selectively nutating and dephasing flowing spins. They are derived from the inverse scattering transform, a nonlinear extension of the inverse Fourier transform. They can be used as presaturation pulses to suppress select...
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doi:10.1002/mrm.1910240212
更新日期:1992-04-01 00:00:00
abstract::An automatic fMRI protocol for the investigation of the human auditory cortex has been developed. For the activation of the auditory system, the scanner noise itself is the source of sound. Rapid switching of B0 gradients allows the generation of tones of defined frequencies and amplitude on a conventional scanner wit...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400621
更新日期:1998-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1169
更新日期:2001-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26704
更新日期:2018-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27964
更新日期:2020-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200103)45:3<431::aid-mrm1056>3.0
更新日期:2001-03-01 00:00:00
abstract::The reconstruction of non-Cartesian k-space trajectories often requires the estimation of nonuniform sampling density. Particularly for 3D, this calculation can be computationally expensive. The method proposed in this work combines an iterative algorithm previously proposed by Pipe and Menon (Magn Reson Med 1999;41:1...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.23041
更新日期:2012-03-01 00:00:00
abstract::Localized 7Li MR point-resolved spectroscopy (PRESS) was developed as a technique to measure lithium (Li) concentration in rat brain in vivo. Localized 7Li spectra could be obtained at 4.7 T in a 0.7-ml voxel in rat brain over the entire therapeutic range of serum Li for humans. Localized 7Li spin-lattice (T1) and spi...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20112
更新日期:2004-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910030306
更新日期:1986-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.26794
更新日期:2018-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2008-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350207
更新日期:1996-02-01 00:00:00
abstract::Cerebral blood volume changes with arterial carbon dioxide were monitored by proton T1-weighted MR images following administration of the intravascular contrast agent Gd-DTPA labeled with human serum albumin. Without MR contrast, no significant image intensity changes were observed with PaCO2. Following contrast, regi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910230104
更新日期:1992-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380209
更新日期:1997-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2014-01-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1990-08-01 00:00:00
abstract::The investigation of flow behavior in coronary arteries is of great importance for an understanding of heart failure and heart regulation mechanisms. The purpose of the present study was to demonstrate that flow velocity can be quantified in the coronary arteries of the isolated rat heart with high-resolution phase co...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10563
更新日期:2003-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24737
更新日期:2014-03-01 00:00:00
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更新日期:1994-07-01 00:00:00