Localized 7Li MR spectroscopy and spin relaxation in rat brain in vivo.

Abstract:

:Localized 7Li MR point-resolved spectroscopy (PRESS) was developed as a technique to measure lithium (Li) concentration in rat brain in vivo. Localized 7Li spectra could be obtained at 4.7 T in a 0.7-ml voxel in rat brain over the entire therapeutic range of serum Li for humans. Localized 7Li spin-lattice (T1) and spin-spin (T2) relaxation times were measured. Measured intensities were corrected for spin relaxation effects and 7Li MR visibility in vivo. The average T1 was 3.3 +/- 0.9 sec, and the average T2 was 82 +/- 20 ms. Neither T1 nor T2 correlated with brain concentration. No statistically significant change was found in either T1 or T2 from approximately 7-17 days of Li dosing.

journal_name

Magn Reson Med

authors

Komoroski RA,Pearce JM

doi

10.1002/mrm.20112

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

164-8

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

52

pub_type

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