Phytotoxins from the fungus Malbranchea aurantiaca.

Abstract:

:Bioassay-directed fractionation of an ethyl acetate extract from cultures of the fungus Malbranchea aurantiaca led to the isolation of two phytotoxic compounds, namely, 1-hydroxy-2-oxoeremophil-1(10),7(11),8(9)-trien-12(8)-olide (1) and penicillic acid (2). The structure of 1 was established by spectroscopic and X-ray crystallographic analyses. Metabolites 1 and 2 caused significant inhibition of radicle growth of Amaranthus hypochondriacus with IC(50) values 6.57 and 3.86 microM, respectively. In addition, 1 inhibited activation of the calmodulin-dependent enzyme cAMP phosphodiesterase (IC(50)=10.2 microM).

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Martínez-Luis S,González MC,Ulloa M,Mata R

doi

10.1016/j.phytochem.2005.03.005

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

1012-6

issue

9

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(05)00108-1

journal_volume

66

pub_type

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