Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.

Abstract:

:A xanthone derivative, named gaboxanthone (1), has been isolated from the seed shells of Symphonia globulifera, together with known compounds, symphonin (2), globuliferin (3), guttiferone A (4), sistosterol, oleanolic acid and methyl citrate. The structure of the compound was assigned as 5,10-dihydroxy-8,9-dimethoxy-2,2-dimethyl-12-(3-methylbut-2-enyl) pyrano [3,2-b]xanthen-6(2H)-one, by means of spectroscopic analysis. The anti-plasmodial and antioxidant activities of the phenolic compounds were evaluated, respectively, in culture against W2 strain of Plasmodium falciparum and using the free radical scavenging activity of the DPPH radical, respectively. Compounds 1-4 were found to be active against the Plasmodium parasites (IC(50) of 3.53, 1.29, 3.86 and 3.17 microM, respectively). Guttiferone A (4) showed a potent free radical scavenging activity compared to the well-known antioxidant caffeic acid.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Ngouela S,Lenta BN,Noungoue DT,Ngoupayo J,Boyom FF,Tsamo E,Gut J,Rosenthal PJ,Connolly JD

doi

10.1016/j.phytochem.2005.11.004

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

302-6

issue

3

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(05)00621-7

journal_volume

67

pub_type

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