Abstract:
:Twelve previously undescribed polyketide derivatives, heterocornols A-L, and seven known analogues were isolated from a culture of the fungus Pestalotiopsis heterocornis associated with sponge. Their structures were elucidated by a comprehensive spectroscopic data analysis and CD Cotton effects. These compounds were evaluated for cytotoxic and antibacterial activities in vitro. Among them, heterocornols A-C, F-H, methyl-(2-formyl-3-hydroxyphenyl)propanoate, agropyrenol, and vaccinol G exhibited cytotoxicities against four human cancer cell lines with IC50 values 15-100 μM, and they also showed antibacterial activities against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis with MIC values ranging from 25 to 100 μg/mL. Moreover, compounds heterocornol C, heterocornol G, agropyrenol, and vaccinol G showed weak antifungal activities against Candida parapsilosis and Cryptococcus neoformans with MIC values 100 μg/mL.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Lei H,Lin X,Han L,Ma J,Dong K,Wang X,Zhong J,Mu Y,Liu Y,Huang Xdoi
10.1016/j.phytochem.2017.06.009subject
Has Abstractpub_date
2017-10-01 00:00:00pages
51-59eissn
0031-9422issn
1873-3700pii
S0031-9422(17)30229-7journal_volume
142pub_type
杂志文章相关文献
PHYTOCHEMISTRY文献大全abstract::Three phenolic glycosides were isolated together with two known flavonol glycosides from the H2O-soluble fraction of rhizomes of Kaempferia parviflora. Their structures were determined to be rel-(5aS,10bS)-5a,10b-dihydro-1,3,5a,9-tetrahydroxy-8-methoxy-6H-benz[b]indeno[1,2-d]furan-6-one 5a-O-[alpha-L-rhamnopyranosyl-(...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2008.09.001
更新日期:2008-11-01 00:00:00
abstract::From the dried roots of Cephaelis acuminata, five tetrahydroisoquinoline-monoterpene glycosides, 2-O-beta-D-glucopyranosyldemethylalangiside, demethylisoalangiside, 6"-O-beta-D-glucopyranosylipecoside, 6"-O-alpha-D-glucopyranosylipecoside and (4R)-4-hydroxyipecoside, were isolated. The structures of these glycosides w...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(01)00418-6
更新日期:2002-01-01 00:00:00
abstract::Cassane diterpenoids: pulcherrin A, pulcherrin B, pulcherrin C, neocaesalpin P, neocaesalpin Q and neocaesalpin R, together with eight known compounds: isovouacapenol C, 6beta-cinnamoyl-7beta-hydroxy-vouacapen-5alpha-ol, pulcherrimin E, pulcherrimin C, alpha-cadinol, 7-hydroxycadalene, teucladiol and bonducellin were ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2008.12.006
更新日期:2009-01-01 00:00:00
abstract::The degradation of the beta-conglycinin protein reserves in soybean seeds during germination and early growth begins with the proteolysis of its alpha and alpha' subunits by an enzyme called Protease C1. In the pathway, a number of proteolytic intermediates are produced and subsequently degraded. Determination of the ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/0031-9422(95)00896-9
更新日期:1996-05-01 00:00:00
abstract::A new flavonol tetraglycoside, together with two known flavonol glycosides, kaempferol 7-rhamnoside and kaempferol 3-rhamnosyl(1-->6) galactoside-7-rhamnoside, were isolated from fresh plant material of Cephalocereus senilis. The structure of the new compound was established as kaempferol 3-O-beta-D-glucopyranosyl(1--...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(00)97043-2
更新日期:1994-05-01 00:00:00
abstract::Two new acetogenins, gardnerilins A and B, have been isolated from the roots of Goniothalamus gardneri. Both are C35 acetogenins containing non-tetrahydrofuran rings. Their structures have been established on the basis of spectral evidence. ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(97)00959-x
更新日期:1998-11-01 00:00:00
abstract::Four coumaronochromones, formosanatins A-D (-4), and a flavanone, euchrenone a(16), along with four known compounds, euchretins E and G, euchrestaflavanone A, and daidzein, were isolated from the roots of Euchresta formosana. The structures of - were established by spectroscopic analyses. ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(02)00017-1
更新日期:2002-08-01 00:00:00
abstract::Two isoflavanones (5,7-dihydroxy-2',3',4'-trimethoxy-isoflavanone and 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxy-isoflavanone), four isoflavanone O-glycosides (5,7-dihydroxy-2',3',4'-trimethoxy-isoflavanone 7-O-beta-glucopyranoside, 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxy-isoflavanone 7-O-beta-glucopyranoside...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2007.02.015
更新日期:2007-05-01 00:00:00
abstract::Ten stigmastane-type steroids bearing unusual Δ28-24-hydroxy side chains, dictyopterisins A-J, including three pairs of C-24 epimers, dictyopterisins B/C, F/G, and I/J, were isolated from the brown alga Dictyopteris undulata Holmes, together with two previously reported analogues, (24S)- and (24R)-saringosterol. Their...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2017.11.013
更新日期:2018-02-01 00:00:00
abstract::Willow is an important biomass crop for the bioenergy industry, and therefore optimal growth with minimal effects of biotic and abiotic stress is essential. The phenylpropanoid pathway is responsible for the biosynthesis of not only lignin but also of flavonoids, condensed tannins, benzenoids and phenolic glycosides w...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2015.06.005
更新日期:2015-09-01 00:00:00
abstract::Seven sesquiterpene lactones, 8-O-methacryloylelephanpane, 2,4-bis-O-methyl-8-O-methacryloylelephanpane, 4-O-ethyl-8-O-methacryloylelephanpane, 8-O-methacryloylisoelephanpane, 2-O-demethyltomenphantopin C, molephantin A, molephantin B, along with ten known ones, were isolated from Elephantopus mollis (Asteraceae). The...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2017.01.020
更新日期:2017-05-01 00:00:00
abstract::While a long shelf life for fruit products is highly desired, enzymatic browning is the main cause of quality loss in fruits and is therefore a main problem for the food industry. In this study polyphenol oxidase (PPO), the main enzyme responsible for browning was isolated from mamey fruit (Pouteria sapota) and charac...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2010.10.011
更新日期:2011-01-01 00:00:00
abstract::Two polyphenol oxidase isoforms with distinct expression patterns were identified in hybrid poplar (Populus trichocarpaxP. deltoides). PPO-1, corresponding to the previously cloned PtdPPO (Constabel et al., Plant Physiol. 124: 285-295) was primarily leaf tissue-specific and detected only after wounding. PPO-2 was expr...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(03)00159-6
更新日期:2003-09-01 00:00:00
abstract::The objective of proteomics is to get an overview of the proteins expressed at a given point in time in a given tissue and to identify the connection to the biochemical status of that tissue. Therefore sample throughput and analysis time are important issues in proteomics. The concept of proteomics is to encircle the ...
journal_title:Phytochemistry
pub_type: 杂志文章,评审
doi:10.1016/j.phytochem.2004.04.008
更新日期:2004-06-01 00:00:00
abstract::Five new oleanane-type saponins, polygalasaponins XLII-XLVI, along with two known saponins were isolated from the roots of Polygala glomerata Lour. The structures of polygalasaponins XLII-XLVI were elucidated as 3-O-beta-D-glucopyranosyl presenegenin 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl- (1-->2)-{...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(97)00439-1
更新日期:1998-02-01 00:00:00
abstract::Blueberry consumption is associated with health benefits contributing to a reduced risk for cardiovascular disease, diabetes and cancer. The aim of this study was to determine the anthocyanin profile of blueberry extracts and to evaluate their effects on B16-F10 metastatic melanoma murine cells. Seven blueberry cultiv...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2013.06.018
更新日期:2013-11-01 00:00:00
abstract::Giant fennel (Ferula communis L.) is well known in folk medicine for the treatment of various organ disorders. The biological importance of members of genus Ferula prompted us to investigate the leaves of the endangered Tunisian medicinal plant F. communis L. not previously investigated. An estimate of genetic diversi...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2016.01.012
更新日期:2016-04-01 00:00:00
abstract::Acylation is a prevalent chemical modification that to a significant extent accounts for the tremendous diversity of plant metabolites. To catalyze acyl transfer reactions, higher plants have evolved acyltransferases that accept beta-acetal esters, typically 1-O-glucose esters, as an alternative to the ubiquitously oc...
journal_title:Phytochemistry
pub_type: 杂志文章,评审
doi:10.1016/j.phytochem.2009.07.023
更新日期:2009-10-01 00:00:00
abstract::Vernonia sensu lato is the largest and most complex genus of the tribe Vernonieae (Asteraceae). The tribe is chemically characterized by the presence of sesquiterpene lactones and flavonoids. Over the years, several taxonomic classifications have been proposed for Vernonia s.l. and for the tribe; however, there has be...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2018.03.007
更新日期:2018-06-01 00:00:00
abstract::Brugmansia arborea is a woody plant species that produces tropane alkaloids (TAs). The gene encoding tropine-forming reductase or tropinone reductase I (BaTRI) in this plant species was functionally characterised. The full-length cDNA of BaTRI encoded a 272-amino-acid polypeptide that was highly similar to tropinone r...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2016.03.008
更新日期:2016-07-01 00:00:00
abstract::The opium poppy Papaver somniferum L. produces the antimicrobial benzo[c]phenanthridine alkaloid sanguinarine and the narcotic analgesic morphinan alkaloid morphine. Transcripts of three genes of alkaloid biosynthesis in P. somniferum in developing seedlings, mature plants and plant cell suspension culture were monito...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(99)00600-7
更新日期:2000-03-01 00:00:00
abstract::The dichloromethane extract of the stem bark of Warburgia ugandensis afforded three new coloratane sesquiterpenes, namely: 6alpha,9alpha-dihydroxy-4(13),7-coloratadien-11,12-dial (1), 4(13),7-coloratadien-12,11-olide (2), and 7beta-hydroxy-4(13),8-coloratadien-11,12-olide (3), together with nine known sesquiterpenes, ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2005.07.018
更新日期:2005-10-01 00:00:00
abstract::The distribution and biosynthesis of iridoid glucosides in the Oleaceae is reviewed and five distinct biosynthetic pathways to iridoids have been identified in the family, deoxyloganic acid apparently being a common intermediate. Likewise, the distributions of caffeoyl phenylethanoid glycosides (CPGs), i.e. verbascosi...
journal_title:Phytochemistry
pub_type: 杂志文章,评审
doi:10.1016/s0031-9422(02)00102-4
更新日期:2002-06-01 00:00:00
abstract::Five flavonostilbenes (alopecurones H, I, J, K and L) and five known ones were isolated from roots of Sophora alopecuroides, in addition to ten other phenolic compounds. A non-enzymatic interconversion of the lavandulyl-substituted flavonostilbenes was observed among alopecurones A, H, I, and K through a Wessely-Moser...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2015.02.022
更新日期:2015-08-01 00:00:00
abstract::Bioassay guided fractionation of the lipophilic extract of the marine cyanobacterium Phormidium ectocarpi yielded a new natural product hierridin B and the previously described compound 2,4-dimethoxy-6-heptadecyl-phenol. Both structures were secured by extensive spectroscopic analysis (1D and 2D NMR, MS, GC-MS, IR). T...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(98)00440-3
更新日期:1998-12-01 00:00:00
abstract::The CH(2)Cl(2) extract of aerial parts of Eupatorium perfoliatum L. exhibits antiprotozoal activity under in vitro conditions, especially against Plasmodium falciparum (IC(50)=2.7μg/ml). The search for active compounds yielded seven sesquiterpene lactones: Four structurally similar guaianolides, one dimeric guaianolid...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2011.01.025
更新日期:2011-05-01 00:00:00
abstract::Although it is well known that solar ultraviolet B (UV-B) radiation enhances plant defenses, there is less knowledge about traits that define insect resistance in field-grown soybean. Here we study the effects of solar UV-B radiation on: a) the induction of phenolic compounds and trypsin proteinase inhibitors (TPI) in...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2017.05.006
更新日期:2017-09-01 00:00:00
abstract::Five p-terphenyl derivatives named thelephantins D-H (1-5) together with nine known compounds, thelephantins A-C (6-8), ganbajunin E (9), p-hydroxylbenzoic acid (10), ganbajunin C (11), thelephorin A (12), 2-O-methylatromentin (13) and atromentin (14), were isolated from the methanolic extract of fruit bodies of the T...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/s0031-9422(03)00220-6
更新日期:2003-08-01 00:00:00
abstract::Five pregnane glycosides were isolated from Caralluma tuberculata (1-5), in addition to a known one (russelioside E, 6). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB-MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activi...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2008.05.017
更新日期:2008-08-01 00:00:00
abstract::Thirty-three phenolic compounds were identified from the extract of fermented tea (Camellia sinensis L.), including three undescribed flavonoids, namely quamoreokchaside I-II and kamoreokchaside I, along with thirty known compounds. All isolates were tested to evaluate their inhibitory effects against amyloid-beta (Aβ...
journal_title:Phytochemistry
pub_type: 杂志文章
doi:10.1016/j.phytochem.2018.12.013
更新日期:2019-04-01 00:00:00