Polyketide derivatives from a marine-sponge-associated fungus Pestalotiopsis heterocornis.

Abstract:

:Twelve previously undescribed polyketide derivatives, heterocornols A-L, and seven known analogues were isolated from a culture of the fungus Pestalotiopsis heterocornis associated with sponge. Their structures were elucidated by a comprehensive spectroscopic data analysis and CD Cotton effects. These compounds were evaluated for cytotoxic and antibacterial activities in vitro. Among them, heterocornols A-C, F-H, methyl-(2-formyl-3-hydroxyphenyl)propanoate, agropyrenol, and vaccinol G exhibited cytotoxicities against four human cancer cell lines with IC50 values 15-100 μM, and they also showed antibacterial activities against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis with MIC values ranging from 25 to 100 μg/mL. Moreover, compounds heterocornol C, heterocornol G, agropyrenol, and vaccinol G showed weak antifungal activities against Candida parapsilosis and Cryptococcus neoformans with MIC values 100 μg/mL.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Lei H,Lin X,Han L,Ma J,Dong K,Wang X,Zhong J,Mu Y,Liu Y,Huang X

doi

10.1016/j.phytochem.2017.06.009

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

51-59

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(17)30229-7

journal_volume

142

pub_type

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