Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia.

abstract：BACKGROUND:Caffeine is widely used to manage apnea of prematurity, and reduces the incidence of bronchopulmonary dysplasia (BPD). Deregulated transforming growth factor (TGF)-β signaling underlies arrested postnatal lung maturation in BPD. It is unclear whether caffeine impacts TGF-β signaling or postnatal lung develop...

journal_title：Pediatric research

authors： Rath P,Nardiello C,Surate Solaligue DE,Agius R,Mižíková I,Hühn S,Mayer K,Vadász I,Herold S,Runkel F,Seeger W,Morty RE

更新日期：2017-05-01 00:00:00

abstract：:Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although systemic and cerebrovascular physiologic factors play an important role in the initial phases of hypoxic-ischemic injuries, the intrinsic vulnerability of specific cell types and systems in the developing brain may be more important...

journal_title：Pediatric research

authors： Johnston MV,Trescher WH,Ishida A,Nakajima W

更新日期：2001-06-01 00:00:00

abstract：:Innate immunity and urinary tract response play a central role in the development of urinary tract infection (UTI). Heat shock protein (HSP) 72 and Toll-like receptor (TLR) 4 are among the key elements of innate defence mechanisms. This study assesses the role of HSPA1B A(1267)G and TLR4 A(896)G polymorphisms using al...

journal_title：Pediatric research

authors： Karoly E,Fekete A,Banki NF,Szebeni B,Vannay A,Szabo AJ,Tulassay T,Reusz GS

更新日期：2007-03-01 00:00:00

abstract：:BackgroundPost-hemorrhagic ventricular dilatation (PHVD) is predictive of mortality and morbidity among very-low-birth-weight preterm infants. Impaired cerebral blood flow (CBF) due to elevated intracranial pressure (ICP) is believed to be a contributing factor.MethodsA hyperspectral near-infrared spectroscopy (NIRS) ...

journal_title：Pediatric research

authors： McLachlan PJ,Kishimoto J,Diop M,Milej D,Lee DSC,de Ribaupierre S,St Lawrence K

更新日期：2017-10-01 00:00:00

abstract：:Lung development requires extracellular matrix remodeling. This involves matrix metalloproteinases (MMPs) and their endogenous inhibitors [tissue inhibitors of metalloproteinases (TIMPs)]. Because these have been generally studied only in whole lung, we focused specifically on mesenchymal and epithelial cells freshly ...

journal_title：Pediatric research

authors： Boucherat O,Bourbon JR,Barlier-Mur AM,Chailley-Heu B,D'Ortho MP,Delacourt C

更新日期：2007-07-01 00:00:00

abstract：:The uterus is unique among smooth muscular organs in that, during pregnancy, it undergoes profound, largely reversible, changes orchestrated by the ovarian hormones. These changes facilitate uterine adaptation to the stretch induced by the growing fetus such that a state of myometrial contractile quiescence can be mai...

journal_title：Pediatric research

authors： Riemer RK,Heymann MA

更新日期：1998-11-01 00:00:00

abstract：:Very young children with organic brain damage, intractable seizures, and developmental retardation are at particular risk of developing fatal hepatic dysfunction coincident with valproate therapy, especially if the children are also receiving other anticonvulsant drugs. The mechanism of valproate-associated hepatic fa...

journal_title：Pediatric research

authors： Thurston JH,Hauhart RE

更新日期：1992-04-01 00:00:00

abstract：:The present study was performed to investigate simultaneously total lung water, T(1) and T(2) relaxation times, and hyaluronan (HA) in preterm and term rabbits. Attempts were also made to establish the relationship of HA to total lung water and to T(2)-derived motionally distinct water fractions. Experiments were perf...

journal_title：Pediatric research

authors： Sedin G,Bogner P,Berényi E,Repa I,Nyúl Z,Sulyok E

更新日期：2000-10-01 00:00:00

abstract：:Small for gestational age (SGA) children have a higher prevalence of cardiovascular risk factors at a young age. It is not known whether this increased risk is caused by their size at birth, a familial predisposition for cardiovascular disease or smallness at birth or a combination of these factors. The cardiovascular...

journal_title：Pediatric research

authors： De Kort SW,Van Dijk M,Willemsen RH,Ester WA,Viet L,De Rijke YB,Hokken-Koelega AC

更新日期：2008-07-01 00:00:00

abstract：:The objective was to determine in infants with perinatal depression whether the relative concentrations of N-acetylaspartate and lactate in the neonatal period are associated with (1) neurodevelopmental outcome at 30 mo of age or (2) deterioration in outcome from age 12 to 30 mo; and to determine whether socioeconomic...

journal_title：Pediatric research

authors： Miller SP,Newton N,Ferriero DM,Partridge JC,Glidden DV,Barnwell A,Chuang NA,Vigneron DB,Barkovich AJ

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Early recognition of patients at risk for sepsis is paramount to improve clinical outcomes. We hypothesized that subtle signatures of illness are present in physiological and biochemical time series of pediatric-intensive care unit (PICU) patients in the early stages of sepsis. METHODS:We developed multivar...

journal_title：Pediatric research

authors： Spaeder MC,Moorman JR,Tran CA,Keim-Malpass J,Zschaebitz JV,Lake DE,Clark MT

更新日期：2019-11-01 00:00:00

abstract：:The flavin-containing monooxygenases (FMOs) are important for the metabolism of numerous therapeutics and toxicants. Six mammalian FMO genes (FMO1-6) have been identified, each exhibiting developmental and tissue- and species-specific expression patterns. Previous studies demonstrated that human hepatic FMO1 is restri...

journal_title：Pediatric research

authors： Koukouritaki SB,Simpson P,Yeung CK,Rettie AE,Hines RN

更新日期：2002-02-01 00:00:00

abstract：:The mitochondrial trifunctional protein (TFP) is a multienzyme complex of the beta-oxidation cycle. Human TFP is an octamer composed of four alpha-subunits harboring long-chain enoyl-CoA hydratase and long-chain L-3-hydroxyacyl-CoA dehydrogenase and four beta-subunits encoding long-chain 3-ketoacyl-CoA thiolase. Mutat...

journal_title：Pediatric research

authors： Spiekerkoetter U,Khuchua Z,Yue Z,Bennett MJ,Strauss AW

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of imm...

journal_title：Pediatric research

authors： Wakiguchi H,Hasegawa S,Suzuki Y,Kudo K,Ichiyama T

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Data regarding neonatal arterial ischemic stroke (NAIS) topography are still sparse and inaccurate. Despite the importance of locating NAIS to predict the long-term outcome of neonates, a map of arterial territories is not yet available. Our aim was therefore to generate the first three-dimensional map of ...

journal_title：Pediatric research

authors： Núñez C,Arca G,Agut T,Stephan-Otto C,García-Alix A

更新日期：2020-06-01 00:00:00

abstract：:The use of tissue engineering to develop new urinary bladder could have direct impact on children suffering from congenital bladder dysfunction. Current bladder tissue engineering protocols rely on scaffolds to support the ingrowth of new cells and the subsequent development of new tissues. The interaction between cel...

journal_title：Pediatric research

authors： Roth CC

更新日期：2010-05-01 00:00:00

abstract：:Several epithelial ion transporters are developmentally regulated in the preweaning period, at the time when the circulating levels of glucocorticoid and mineralocorticoid hormones increase. The specific role of glucocorticoids and mineralocorticoids in the maturation of epithelial ion transport is still disputed. In ...

journal_title：Pediatric research

authors： Wang ZM,Yasui M,Celsi G

更新日期：1995-08-01 00:00:00

abstract：:Changes in high-density lipoprotein (HDL) subclass distribution were evaluated in a group of premature infants during the early postnatal period to ascertain whether enteral feeding brought about a rapid shift from neonatal to adult-like distributions. All infants were fed a combination of breast milk and formula. Cor...

journal_title：Pediatric research

authors： Genzel-Boroviczény O,D'Harlingue AE,Kao LC,Scott C,Forte TM

更新日期：1988-06-01 00:00:00

abstract：:Progress has been made in the reduction of morbidity and mortality from neonatal sepsis. However, diagnosis continues to rely primarily on conventional microbiologic techniques, which can be inaccurate. The objective of this review is to provide the clinician with an overview of the current information available on di...

journal_title：Pediatric research

authors： Iroh Tam PY,Bendel CM

更新日期：2017-10-01 00:00:00

abstract：:Since the description of bronchopulmonary dysplasia (BPD) in premature infants, the supplemental oxygen administered has been suspect in the etiology of BPD. This has prompted studies on the effect of hyperoxia on lung growth in neonatal animals. So far, these have not led to a treatment which either prevents or mitig...

journal_title：Pediatric research

authors： Wilborn AM,Evers LB,Canada AT

更新日期：1996-08-01 00:00:00

abstract：:Three members of a Virginia family with a bleeding disorder were found to have a serum defect in thromboplastin generation similar to the previously reported "Car. factor" deficiency. Sera from three members of the original Car. family did not correct the defect of affected members of the Virginia family. Partial thro...

journal_title：Pediatric research

authors： Komp DM

更新日期：1975-04-01 00:00:00

abstract：:The nutritional status, prenatally and early postnatally, plays a critical role in postnatal growth and development. Early malnutrition may change the original programming of organs, especially those in developmental phases, which can result in long-term changes in metabolism. The association between a low birth weigh...

journal_title：Pediatric research

authors： Engelbregt MJ,Houdijk ME,Popp-Snijders C,Delemarre-van de Waal HA

更新日期：2000-12-01 00:00:00

abstract：:Jejunal biopsies obtained from 45 children referred for a variety of clinical conditions were examined histologically and by standard immunofluorescence methods. The number of plasma cells was recorded per "mucosal tissue unit". The results showed that most of the immunoglobulin A (IgA) counts in infants under 3 yr wi...

journal_title：Pediatric research

authors： Maffei HV,Kingston D,Hill ID,Shiner M

更新日期：1979-06-01 00:00:00

abstract：:The effect of ingestion of uncooked cornstarch (2 g/kg body weight) in water, uncooked starch (1 g/kg) added to a meal, and glucose (2 g/kg) in water, was studied in eight patients with type IA glycogen storage disease (GSD) and one patient with type IB GSD. Blood glucose concentrations were determined at 30-min inter...

journal_title：Pediatric research

authors： Smit GP,Berger R,Potasnick R,Moses SW,Fernandes J

更新日期：1984-09-01 00:00:00

abstract：:It has been shown that glucocorticoids accelerate lung development by limiting alveolar formation resulting from a premature maturation of the alveolar septa. Based on these data, the aim of the present work was to analyze the influence of dexamethasone on cell cycle control mechanisms during postnatal lung developmen...

journal_title：Pediatric research

authors： Corroyer S,Schittny JC,Djonov V,Burri PH,Clement A

更新日期：2002-02-01 00:00:00

abstract：:A substantial proportion of the "apparently normal" preterm infants exhibit minor and moderate dysfunctions in neuromotor outcome as they grow older. Birth characteristics, minor abnormalities on the neonatal ultrasound scan of the brain, and motor milestones have only limited value in the early detection of these chi...

journal_title：Pediatric research

authors： Fallang B,Øien I,Hellem E,Saugstad OD,Hadders-Algra M

更新日期：2005-08-01 00:00:00

abstract：:The present study examined the extent to which abundance of the prolactin receptor (PRLR) and a range of primary mitochondrial proteins are influenced by either maternal nutrition and/or fetal number in adipose tissue. Pregnant sheep were control fed [consuming 100% of total metabolizable energy (ME) requirements (tak...

journal_title：Pediatric research

authors： Budge H,Dandrea J,Mostyn A,Evens Y,Watkins R,Sullivan C,Ingleton P,Stephenson T,Symonds ME

更新日期：2003-02-01 00:00:00

abstract：:Programmed proliferative degeneration of the human fetal ductus arteriosus (DA) preceding definite postnatal closure has a large developmental variability and is controlled by several signaling pathways. Among these vascular endothelial growth factor (VEGF) and its receptors (VEGF-Rs) play an important role. Until now...

journal_title：Pediatric research

authors： Weber SC,Rheinlaender C,Sarioglu N,Peiser C,Rüdiger M,Obladen M,Koehne PS

更新日期：2008-10-01 00:00:00

abstract：:Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cereb...

journal_title：Pediatric research

authors： Idro R,Marsh K,John CC,Newton CR

更新日期：2010-10-01 00:00:00

abstract：:Ambient oxygen concentration and vascular endothelial growth factor (VEGF)-A are vital in lung development. Since hypoxia stimulates VEGF-A production and hyperoxia reduces it, we hypothesized that VEGF-A down-regulation by exposure of airways to hyperoxia may result in abnormal lung development. An established model ...

journal_title：Pediatric research

authors： Esquibies AE,Bazzy-Asaad A,Ghassemi F,Nishio H,Karihaloo A,Cantley LG

更新日期：2008-01-01 00:00:00