Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors.

Abstract:

:The objective was to determine in infants with perinatal depression whether the relative concentrations of N-acetylaspartate and lactate in the neonatal period are associated with (1) neurodevelopmental outcome at 30 mo of age or (2) deterioration in outcome from age 12 to 30 mo; and to determine whether socioeconomic factors are associated with deterioration in outcome. Thirty-seven term neonates were prospectively studied with single-voxel proton magnetic resonance spectroscopy of the basal nuclei and intervascular boundary zones. Thirty-month outcomes were classified as normal [if Mental Development Index of the Bayley Scales of Infant Development (MDI) >85 and neuromotor scores (NMS) <3; n = 15], abnormal [if MDI or=3 at 12 and 30 mo; n = 11], or deteriorated [if normal at 12 mo and abnormal at 30 mo (MDI or=3); n = 11]. Thirty percent (11/37) of our cohort deteriorated between 12 and 30 mo. N-acetylaspartate/choline decreased across the groups ordered as normal, deteriorated, and abnormal [in basal nuclei (p

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Miller SP,Newton N,Ferriero DM,Partridge JC,Glidden DV,Barnwell A,Chuang NA,Vigneron DB,Barkovich AJ

doi

10.1203/00006450-200207000-00014

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

71-7

issue

1

eissn

0031-3998

issn

1530-0447

journal_volume

52

pub_type

杂志文章
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    abstract::Tolazoline is used in neonatal intensive care to treat hypoxia secondary to persistent pulmonary hypertension of the newborn. Its use is often complicated by systemic hypotension. We compared the effect of tolazoline-induced hypotension on organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199008000-00007

    authors: Balsan MJ,Cronin CM,Shaw MD,Milley JR

    更新日期:1990-08-01 00:00:00

  • Controversies in the identification and management of acute pulmonary hypertension in preterm neonates.

    abstract::It is increasingly recognized that the abnormal physiologic consequences of pulmonary hypertension (PH) may contribute to poor cardiopulmonary health in premature babies. Conflicting literature has led to clinical uncertainty, pathological misinterpretation, and variability in treatment approaches among practitioners....

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/pr.2017.200

    authors: Giesinger RE,More K,Odame J,Jain A,Jankov RP,McNamara PJ

    更新日期:2017-12-01 00:00:00

  • In vitro studies of effects of light and riboflavin on DNA and HeLa cells.

    abstract::The widespread use of phototherapy for neonatal hyperbilirubinemia has caused some concern since substances other than bilirubin may be photoactivated. The toxic properties of these photoactivated substances might prove to be more harmful to the neonatal infant than bilirubin. The purpose of the present study was to i...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197503000-00009

    authors: Speck WT,Chen CC,Rosenkranz HS

    更新日期:1975-03-01 00:00:00

  • Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut.

    abstract:BACKGROUND:Hurricane Maria struck Puerto Rico on 20 September 2017 causing catastrophic devastation. Prolonged shortage of food had been a substantial challenge to the residents after Maria. Experiencing food insecurity in utero has been associated with negative health outcomes later in life. We aim to examine whether ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-0839-0

    authors: Wang L,de Ángel Solá D,Acevedo Flores M,Schriefer A,Wang L,Gerónimo López K,Chang A,Warner B,Shan L,Holtz LR,Rosario Matos N

    更新日期:2020-12-01 00:00:00

  • Pediatric brain repair from endogenous neural stem cells of the subventricular zone.

    abstract::There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the germinal zones of the immature brain. Studies using animal models of pediatric brain injuries have provided a clearer understanding of the responses of these progenitors to injury. In this review, we have c...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/pr.2017.261

    authors: Niimi Y,Levison SW

    更新日期:2018-01-01 00:00:00

  • Irisin serum levels are positively correlated with bone mineral status in a population of healthy children.

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    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0278-y

    authors: Colaianni G,Faienza MF,Sanesi L,Brunetti G,Pignataro P,Lippo L,Bortolotti S,Storlino G,Piacente L,D'Amato G,Colucci S,Grano M

    更新日期:2019-03-01 00:00:00

  • Perioperative levels of total IgE correlate with outcomes of prolonged mechanical ventilation after cardiopulmonary bypass in pediatric patients.

    abstract:BACKGROUND:Although cardiopulmonary bypass (CPB) has been previously studied as risking infection and inflammatory responses, few studies evaluate the relationship of preoperative high total immunoglobulin E (tIgE) to outcomes in pediatric patients predisposed to atopy undergoing cardiac surgery with CPB. METHODS:Seru...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-018-0048-2

    authors: Li Y,Zhu L,Chen J,Singson MTG,Rui X,Li N,Zhou L,Liu J

    更新日期:2018-11-01 00:00:00

  • Effectiveness of Bifidobacterium bifidum in mediating the clinical course of murine rotavirus diarrhea.

    abstract::Human Bifidobacterium sp strain bifidum (B. bifidum) was administered to BALB/c lactating mice (n = 58) and their litters (n = 327 pups) to evaluate the ingested strain's adherent properties and ability to inhibit murine rotavirus (MRV) infection. ELISA and anaerobic bacteriologic techniques were used to measure MRV s...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199406000-00014

    authors: Duffy LC,Zielezny MA,Riepenhoff-Talty M,Dryja D,Sayahtaheri-Altaie S,Griffiths E,Ruffin D,Barrett H,Rossman J,Ogra PL

    更新日期:1994-06-01 00:00:00

  • Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy.

    abstract::Dietary n-3 polyunsaturated fatty acids (PUFA) may represent a mode of allergy prevention. Cord blood (CB) CD34+ hemopoietic progenitors are altered in infants at risk of atopy. We therefore studied the effects of dietary n-3 PUFA supplementation during pregnancy on numbers and function of progenitors in neonates at h...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1203/01.PDR.0000148279.72611.1D

    authors: Denburg JA,Hatfield HM,Cyr MM,Hayes L,Holt PG,Sehmi R,Dunstan JA,Prescott SL

    更新日期:2005-02-01 00:00:00

  • Morphometry of hypoplastic fetal guinea pig lungs following amniotic fluid leak.

    abstract::Deficient quantity of amniotic fluid causes fetal guinea pig lung hypoplasia. Oligohydramnios that lasts only 5 days in early gestation is sufficient to reduce fetal lung growth significantly. We quantitated lung structural alterations at 50 days gestation (term is 67 days) of fetal guinea pigs whose amniotic fluid wa...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198610000-00013

    authors: Collins MH,Moessinger AC,Kleinerman J,James LS,Blanc WA

    更新日期:1986-10-01 00:00:00

  • Choline incorporation into lecithin in response to insulin or dexamethasone in homogeneous cell cultures of rat lung epithelial cells and fibroblasts.

    abstract::Labeled choline incorporation into adult rat lung alveolar epithelial cells and adult rat lung fibroblasts in monolayer culture was determined after incubation with insulin (Ins) 10 micrograms/ml, Dexamethasone (Dex) 10(-6)M, or no drug (ND). Incubation periods were 1, 3, 4, and 5 hours. The lecithin (phosphatidyl cho...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198007000-00014

    authors: Sharp MJ,Borer RC Jr,Vadnay L,Douglas WH

    更新日期:1980-07-01 00:00:00

  • Effect of polymyxin B sulfate on endotoxin activity in a gram-negative septicemia model.

    abstract::The antiendotoxin effect of polymyxin B was investigated in experimentally induced septicemia in rabbits. The Pasteurella multocida organisms were sensitive to the antibacterial action of penicillin but not to polymyxin B. Animals pre-treated with polymyxin showed positive blood cultures and significantly reduced plas...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197901000-00011

    authors: Corrigan JJ Jr,Kiernat JF

    更新日期:1979-01-01 00:00:00

  • System A amino acid transporter activity in human placental microvillous membrane vesicles in relation to various anthropometric measurements in appropriate and small for gestational age babies.

    abstract::Fetal growth and development is dependent on the transfer of amino acids from maternal to fetal blood across the microvillous plasma membrane (MVM) and basal plasma membrane of placental syncytiotrophoblast. The aim of this study was to determine the relationship of system A amino acid transporter (SysA) activity in M...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199906000-00005

    authors: Harrington B,Glazier J,D'Souza S,Sibley C

    更新日期:1999-06-01 00:00:00

  • New and old immunodeficiencies.

    abstract::Yesterday's immunodeficiencies emphasized the clinical and familial associations of the syndromes and date from the 1920s (ataxia-telangiectasia, chronic mucocutaneous candidiasis), the 1930s (Wiskott-Aldrich syndrome), skipping the 1940s, but blossoming in the 15-y period from 1950 to 1965. In this period, primary im...

    journal_title:Pediatric research

    pub_type: 历史文章,杂志文章,评审

    doi:10.1203/00006450-199305001-00007

    authors: Stiehm ER

    更新日期:1993-01-01 00:00:00

  • Direct measurement of intratracheal pressure in pediatric respiratory monitoring.

    abstract::We describe a method based on a Fabry-Perot interferometer at the tip of an optic fiber with a diameter of 0.25 mm for direct measurement of tracheal pressure in pediatric respiratory monitoring. The response time of the pressure transducer and its influence on the resistance of pediatric endotracheal tubes (internal ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200203000-00013

    authors: Sondergaard S,Karason S,Hanson A,Nilsson K,Hojer S,Lundin S,Stenqvist O

    更新日期:2002-03-01 00:00:00

  • Lung and systemic inflammation in preterm lambs on continuous positive airway pressure or conventional ventilation.

    abstract::Intratracheal lipopolysaccharide (LPS) causes acute inflammation and injurious mechanical ventilation results in pulmonary and systemic inflammation. We aimed to determine in preterm lungs if continuous positive airway pressure (CPAP) protects against pulmonary and systemic inflammation, compared with conventional mec...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e318189487e

    authors: Polglase GR,Hillman NH,Ball MK,Kramer BW,Kallapur SG,Jobe AH,Pillow JJ

    更新日期:2009-01-01 00:00:00

  • Impairment of rat postnatal lung alveolar development by glucocorticoids: involvement of the p21CIP1 and p27KIP1 cyclin-dependent kinase inhibitors.

    abstract::It has been shown that glucocorticoids accelerate lung development by limiting alveolar formation resulting from a premature maturation of the alveolar septa. Based on these data, the aim of the present work was to analyze the influence of dexamethasone on cell cycle control mechanisms during postnatal lung developmen...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200202000-00008

    authors: Corroyer S,Schittny JC,Djonov V,Burri PH,Clement A

    更新日期:2002-02-01 00:00:00

  • Hyperoxia downregulates angiotensin-converting enzyme-2 in human fetal lung fibroblasts.

    abstract:BACKGROUND:Angiotensin (ANG) II is involved in experimental hyperoxia-induced lung fibrosis. Angiotensin-converting enzyme-2 (ACE-2) degrades ANG II and is thus protective, but is downregulated in adult human and experimental lung fibrosis. Hyperoxia is a known cause of chronic fibrotic lung disease in neonates, but th...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2015.27

    authors: Oarhe CI,Dang V,Dang M,Nguyen H,Gopallawa I,Gewolb IH,Uhal BD

    更新日期:2015-05-01 00:00:00

  • In vitro copper stimulation of plasma peptidylglycine alpha-amidating monooxygenase in Menkes disease variant with occipital horns.

    abstract::We determined the concentrations of copper, the activities of ceruloplasmin and peptidylglycine alpha-amidating monooxygenase (PAM), and the stimulation index of PAM by the in vitro addition of copper in plasma samples obtained from three male patients with occipital horns and a milder Menkes disease phenotype, having...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199712000-00023

    authors: Prohaska JR,Tamura T,Percy AK,Turnlund JR

    更新日期:1997-12-01 00:00:00

  • WT1 gene mutations in Chinese children with early onset nephrotic syndrome.

    abstract::In Chinese children with steroid-resistant nephrotic syndrome (SRNS), it was reported that NPHS2 mutation was detected in 4.3%, which was lower than that in Caucasians (10-30%). However, there were no data on WT1 mutation in nephrotic syndrome (NS), especially in early-onset NS of Chinese children. Thus, a study, whic...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3181e4c9e3

    authors: Li J,Ding J,Zhao D,Yu Z,Fan Q,Chen Y,Zhang H,Zhong X,Huang J,Yao Y,Xiao H

    更新日期:2010-08-01 00:00:00

  • Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism.

    abstract::Normal hemostasis depends in part on the balance achieved between proaggregatory and prothrombotic platelet thromboxane A2, measured as its stable end-product thromboxane B2 (TXB2), and vascular prostacyclin (PGI2), which inhibits platelet aggregation and is antithrombotic. Cystathionine-beta-synthase deficiency is ch...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198206000-00018

    authors: Graeber JE,Slott JH,Ulane RE,Schulman JD,Stuart MJ

    更新日期:1982-06-01 00:00:00

  • Vitamin A deficiency and pulmonary oxygen toxicity: morphometric studies in the murine lung.

    abstract::Vitamin A and its precursor beta-carotene are naturally occurring antioxidants. The effects of diets deficient in beta-carotene and vitamin A on the alveolar-capillary membrane were studied in young adult BALB/C mice before and after exposure to 65% oxygen. One of three diets (standard complete, beta-carotene deficien...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198801000-00017

    authors: Cohen-Addad N,Bollinger R,Chou J,Poland R

    更新日期:1988-01-01 00:00:00

  • Vagal responsiveness to gavage feeding as an index of preterm status.

    abstract::Vagal responsivity to orogastric stimulation is necessary for gastrointestinal function and may reflect autonomic regulation. Our study evaluated vagal responsivity during gavage feeding as an index of preterm clinical status. Vagal and behavioral responsivity of 26 preterm infants during gavage feeding was measured. ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199103000-00003

    authors: DiPietro JA,Porges SW

    更新日期:1991-03-01 00:00:00

  • Bone turnover and growth during and after continuing chemotherapy in children with acute lymphoblastic leukemia.

    abstract::Children treated for acute lymphoblastic leukemia may develop reduced bone mineral density during treatment, but there is little information on the mechanisms involved. In a prospective, longitudinal study on 15 children with ALL, we undertook serial measurements of markers of bone and collagen turnover, insulin-like ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200010000-00012

    authors: Crofton PM,Ahmed SF,Wade JC,Elmlinger MW,Ranke MB,Kelnar CJ,Wallace WH

    更新日期:2000-10-01 00:00:00

  • Association between pesticide usage during pregnancy and neonatal hyperbilirubinemia requiring treatment: the Japan Environment and Children's Study.

    abstract:BACKGROUND:Maternal exposure to pesticides during pregnancy may cause oxidative hemolysis leading to neonatal hyperbilirubinemia. This investigation examined for associations between maternal use of pesticides or repellents during pregnancy and neonatal hyperbilirubinemia requiring phototherapy. METHODS:We used the da...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-1100-6

    authors: Shibazaki T,Motoki N,Misawa Y,Ohira S,Inaba Y,Kanai M,Kurita H,Nakazawa Y,Tsukahara T,Nomiyama T,Japan Environment & Children’s Study (JECS) Group.

    更新日期:2020-08-05 00:00:00

  • Long chain non-esterified fatty acid pattern in plasma of cystic fibrosis patients and their parents.

    abstract::The absolute and the percentage plasma NEFA pattern of healthy children, Cystic Fibrosis (C.F.) patients and their parents have been determined (table I, III, V) and compared with those of age and sex matched control subjects (table II, Iv, V). There is a striking difference in the percentage plasma NEFA pattern of C....

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198009000-00015

    authors: Rogiers V,Dab I,Crokaert R,Vis HL

    更新日期:1980-09-01 00:00:00

  • NeoDoppler: New ultrasound technology for continous cerebral circulation monitoring in neonates.

    abstract:BACKGROUND:There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. NeoDoppler is a novel ultrasound system, which can be gently fixed to the anterior fontanel and measure...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0535-0

    authors: Vik SD,Torp H,Follestad T,Støen R,Nyrnes SA

    更新日期:2020-01-01 00:00:00

  • Co-occurrence of infantile hypertrophic pyloric stenosis and congenital heart defects: a nationwide cohort study.

    abstract:BACKGROUND:Recent studies suggest that infantile hypertrophic pyloric stenosis (IHPS) and congenital heart defects (CHDs) may share some genetic risk factors, but little is known about the co-occurrence of the two conditions in patients. METHODS:Our study cohort included 2,212,756 persons born in Denmark 1977-2013. We...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0369-9

    authors: Feenstra B,Gørtz S,Lund M,Ranthe MF,Geller F,Melbye M

    更新日期:2019-06-01 00:00:00

  • Multiple mechanisms of lung surfactant inhibition.

    abstract::We studied the mechanisms by which C16:0 lysophosphatidylcholine (LPC) and albumin inhibit the surface activity of calf lung surfactant extract (CLSE) by using a pulsating bubble apparatus with a specialized hypophase exchange system, plus adsorption and Wilhelmy balance measurements. In the absence of inhibitors, CLS...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199907000-00015

    authors: Holm BA,Wang Z,Notter RH

    更新日期:1999-07-01 00:00:00

  • Ontogeny of hepatic type I insulin-like growth factor receptors in the rat.

    abstract::We studied the pre- and postnatal developmental regulation of the hepatic type I IGF receptor in the rat. Fetal rat liver membranes bound IGF-I throughout the latter part of gestation (d 17 to 21). After birth, binding diminished rapidly, reaching barely detectable levels by the 13th postnatal d. However, the presence...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199103000-00002

    authors: Gruppuso PA,Walker TD,Carter PA

    更新日期:1991-03-01 00:00:00