Effectiveness of Bifidobacterium bifidum in mediating the clinical course of murine rotavirus diarrhea.

Abstract:

:Human Bifidobacterium sp strain bifidum (B. bifidum) was administered to BALB/c lactating mice (n = 58) and their litters (n = 327 pups) to evaluate the ingested strain's adherent properties and ability to inhibit murine rotavirus (MRV) infection. ELISA and anaerobic bacteriologic techniques were used to measure MRV shedding and colonization of Bifidobacterium in the small intestine. At 13-16 d gestation, pregnant dams (and their expected litters) were randomly assigned to one of four experimental groups: 1) normal controls; 2) B. bifidum-treated only; 3) MRV-infected only; and 4) B. bifidum-treated + MRV-infected dams and litters. During the acute phase of diarrhea, 80% of small-intestine cultures in B. bifidum-treated litters were positive for the ingested B. bifidum strain compared with 24% of fecal cultures. Examination of tissue cross sections under electron microscopy revealed the ingested B. bifidum strain survived passage through the upper gastrointestinal tract and adhered to the small-intestine epithelium. After the administration of the high dose of virus, diarrhea developed in all pups, but onset was significantly delayed in B. bifidum-treated + MRV-infected litters compared with litters infected with MRV only (p < 0.02). B. bifidum-treated+MRV-infected pups demonstrated a significant reduction in MRV shedding compared with litters challenged with MRV only at d 2 to 10 after inoculation (p < 0.009). More direct studies are needed to assess mechanisms by which this anaerobe can alter the course of MRV infection at the level of gut epithelium.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Duffy LC,Zielezny MA,Riepenhoff-Talty M,Dryja D,Sayahtaheri-Altaie S,Griffiths E,Ruffin D,Barrett H,Rossman J,Ogra PL

doi

10.1203/00006450-199406000-00014

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

690-5

issue

6

eissn

0031-3998

issn

1530-0447

journal_volume

35

pub_type

杂志文章
  • Opposing regulation of human alveolar type II cell differentiation by nitric oxide and hyperoxia.

    abstract::Clinical trials demonstrated decreasing rates of bronchopulmonary dysplasia in preterm infants with hypoxic respiratory failure treated with inhaled nitric oxide (iNO). However, the molecular and biochemical effects of iNO on developing human fetal lungs remain vastly unknown. By using a well-characterized model of hu...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3181d4f20f

    authors: Johnston LC,Gonzales LW,Lightfoot RT,Guttentag SH,Ischiropoulos H

    更新日期:2010-05-01 00:00:00

  • Synergistic effect of influenza a virus on endotoxin-induced mortality in rat pups: a potential model for sudden infant death syndrome.

    abstract::Sudden infant death syndrome is the most common cause of postneonatal infant mortality in the developed world. It is a diagnosis of exclusion with peak age of incidence between 2 and 6 mo. Fifty to 63% of these infants have a preexisting upper respiratory tract infection before death. We hypothesized that the immature...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200210000-00005

    authors: Blood-Siegfried J,Nyska A,Lieder H,Joe M,Vega L,Patterson R,Germolec D

    更新日期:2002-10-01 00:00:00

  • Murine hybridoma antibodies enhance bactericidal activity of human cord blood against K1 Escherichia coli strains.

    abstract::Murine hybridoma antibodies directed against the capsule and O-side chain determinants of the Escherichia coli strain Bort (018ac:K1:H7) were evaluated for their ability to enhance bactericidal activity of cord blood against K1 E. coli strains possessing O antigens common in neonatal E. coli infection, i.e. 018, 07, a...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199012000-00025

    authors: Kim KS,Cross AS,Kaufmann B,Zollinger W,Sadoff J

    更新日期:1990-12-01 00:00:00

  • Ultrastructural localization of concanavalin a surface receptors on brush-border enterocytes in normal children and during coeliac disease.

    abstract::Concanavalin A surface receptors were detected on brush border enterocytes from child intestinal biopsies by the concanavalin A-peroxidase method. On electron microscopy, these receptors appeared as electron-dense deposits, located on a band running along the innermost part of the brush border membrane glycocalyx. In ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198206000-00008

    authors: Vasmant D,Feldmann G,Fontaine JL

    更新日期:1982-06-01 00:00:00

  • Utility of volatile organic compounds as a diagnostic tool in preterm infants.

    abstract:BACKGROUND:Volatile organic compounds (VOCs) are hydrocarbons that originate within different healthy and diseased tissues. VOCs can be secreted into the circulation and then excreted in the urine and faeces. In the lungs, VOCs are locally produced and can be detected in exhaled breath. VOCs can be identified using non...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/s41390-020-0828-3

    authors: Wright H,Bannaga AS,Iriarte R,Mahmoud M,Arasaradnam RP

    更新日期:2020-03-02 00:00:00

  • Identification of increased expression of activating Fc receptors and novel findings regarding distinct IgE and IgM receptors in Kawasaki disease.

    abstract:BACKGROUND:Kawasaki disease (KD) is associated with expression and methylation of Fc gamma receptor genes. We characterized immunoglobulin A (IgA), IgE, IgG, and IgM receptor expression levels in KD. METHODS:Fc receptor expression levels were characterized using GeneChip Human Transcriptome Array 2.0 (HTA 2.0) with 18...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-019-0707-y

    authors: Chang LS,Ming-Huey Guo M,Lo MH,Kuo HC

    更新日期:2019-12-09 00:00:00

  • Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs.

    abstract::Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by amplitude-integrated EEG (aEEG) had only recovered to 42 ± 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3182276b11

    authors: Lafuente H,Alvarez FJ,Pazos MR,Alvarez A,Rey-Santano MC,Mielgo V,Murgia-Esteve X,Hilario E,Martinez-Orgado J

    更新日期:2011-09-01 00:00:00

  • Developmental aspects of renal beta-amino acid transport I. Ontogeny of taurine reabsorption and accumulation in rat renal cortex.

    abstract::Newborn Sprague-Dawley rat pups were found to have reduced net tubular reclamation of the beta-amino acid taurine in vivo. The reabsorption of this compound increased between the 2nd and 4th week of life and the excreted taurine fell despite a rise in glomerular filtration rate indicative of increased transport with m...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197907000-00012

    authors: Chesney RW,Jax DK

    更新日期:1979-07-01 00:00:00

  • Genetic variations in hypoxia response genes influence hypertrophic cardiomyopathy phenotype.

    abstract:BACKGROUND:Risk factors for diastolic dysfunction in hypertrophic cardiomyopathy (HCM) are poorly understood. We investigated the association of variants in hypoxia-response genes with phenotype severity in pediatric HCM. METHODS:A total of 80 unrelated patients <21 y and 14 related members from eight families with HC...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2012.126

    authors: Alkon J,Friedberg MK,Manlhiot C,Manickaraj AK,Kinnear C,McCrindle BW,Benson LN,Addonizio LJ,Colan SD,Mital S

    更新日期:2012-12-01 00:00:00

  • Caries resistance in children with chronic renal failure: plaque pH, salivary pH, and salivary composition.

    abstract::We studied properties of saliva and of dental plaque which affect the caries process in an effort to understand the low prevalence of caries in patients with chronic renal failure. Plaque pH, before and following carbohydrate exposure, saliva pH, and saliva composition were evaluated in children and adolescents with c...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198508000-00003

    authors: Peterson S,Woodhead J,Crall J

    更新日期:1985-08-01 00:00:00

  • Hexapeptides from human milk prevent the induction of oxidative stress from parenteral nutrition in the newborn guinea pig.

    abstract:INTRODUCTION:In preterm neonates, peroxides contaminating total parenteral nutrition (TPN) contribute to oxidative stress, which is suspected to be a strong inducer of hepatic complications related to prematurity. Recently, others reported that hexapeptides derived from human milk (HM) exerted free radical-scavenging a...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2012.29

    authors: Miloudi K,Tsopmo A,Friel JK,Rouleau T,Comte B,Lavoie JC

    更新日期:2012-06-01 00:00:00

  • Cultured skin fibroblasts derived from patients with mucolipidosis 4 are auto-fluorescent.

    abstract::Mucolipidosis 4 (ML4) is an autosomal recessive disorder with both lipid and mucopolysaccharide storage. The disease is characterized by severe visual impairment and psychomotor retardation. In our effort to find a phenotypic marker for ML4 fibroblasts, living cells were stained with fluorescent compounds. The stainin...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199506000-00003

    authors: Goldin E,Blanchette-Mackie EJ,Dwyer NK,Pentchev PG,Brady RO

    更新日期:1995-06-01 00:00:00

  • Effect of early nutritional deprivation and diet on translocation of bacteria from the gastrointestinal tract in the newborn rat.

    abstract::The gastrointestinal (GI) barrier function is immature in the preterm neonate and might thus facilitate translocation of enteric bacteria and gut-derived septicemia. Circumstantial evidence suggests that bacterial uptake from the intestine may be further enhanced by an alteration of the host nutritional status. To tes...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199603000-00007

    authors: Steinwender G,Schimpl G,Sixl B,Kerbler S,Ratschek M,Kilzer S,Hollwarth ME,Wenzl HH

    更新日期:1996-03-01 00:00:00

  • Early feeding, antenatal glucocorticoids, and human milk decrease intestinal permeability in preterm infants.

    abstract::To determine the effects of age, feeding regimen, and antenatal glucocorticoids on intestinal permeability, preterm infants (n = 132) were stratified by gestational age and by diet (mothers' own milk versus preterm formula), and assigned randomly to one of four feeding regimens: early-continuous, early-bolus, standard...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1203/00006450-199810000-00009

    authors: Shulman RJ,Schanler RJ,Lau C,Heitkemper M,Ou CN,Smith EO

    更新日期:1998-10-01 00:00:00

  • Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate.

    abstract:BACKGROUND:Near-infrared spectroscopy (NIRS) is an upcoming clinical method for monitoring regional cerebral oxygen saturation (rScO2) in neonates. There is a growing market offering different devices and sensors. Even though this technique is increasingly clinically applied, little is known about the similarities and/...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2013.133

    authors: Dix LM,van Bel F,Baerts W,Lemmers PM

    更新日期:2013-11-01 00:00:00

  • Adenosine deaminase deficiency without immunodeficiency: clinical and metabolic studies.

    abstract::A child diagnosed at birth as deficient in red blood cell adenosine deaminase (ADA) but with substantial residual lymphocyte ADA has been evaluated for two and one-half years. The only immunologic abnormality observed was hypogammaglobulinemia during the fifth month of life. This was unexpected because children with t...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198007000-00009

    authors: Borkowsky W,Gershon AA,Shenkman L,Hirschhorn R

    更新日期:1980-07-01 00:00:00

  • Detection of cardiac hypertrophy in the fetus by approximation of the current dipole using magnetocardiography.

    abstract::To determine the developmental changes in the myocardial current during fetal life, and to evaluate the clinical usefulness of magnetocardiography for prenatal diagnosis of cardiac hypertrophy or enlargement, we approximated the magnitude of the one-current dipole of the fetal heart using fetal magnetocardiography (fM...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200108000-00013

    authors: Horigome H,Shiono J,Shigemitsu S,Asaka M,Matsui A,Kandori A,Miyashita T,Tsukada K

    更新日期:2001-08-01 00:00:00

  • Beta-glucuronidase deficiency in a dog: a model of human mucopolysaccharidosis VII.

    abstract::This report describes a third mucopolysaccharidosis in animals: canine mucopolysaccharidosis VII. The affected dog was the offspring of a father-daughter mating. Weakness in the rear legs was evident at 8 weeks of age and became progressively worse. He had a large head, a shortened maxilla, and corneal granularities. ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198410000-00014

    authors: Haskins ME,Desnick RJ,DiFerrante N,Jezyk PF,Patterson DF

    更新日期:1984-10-01 00:00:00

  • Mesenteric blood flow velocity and its relation to circulatory adaptation during the first week of life in healthy term infants.

    abstract::We investigated early postnatal changes of the mesenteric circulation and its relationship to the systemic circulation in two groups of newborn infants. Group I (n = 10) was studied before the first feeding at 1 h and preprandially at 6 and 24 h. Group II (n = 10) was studied before the first feeding at 2 h of age and...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199409000-00011

    authors: Martinussen M,Brubakk AM,Linker DT,Vik T,Yao AC

    更新日期:1994-09-01 00:00:00

  • Diffusion tensor imaging in preterm infants with punctate white matter lesions.

    abstract::Our aim was to compare white matter (WM) microstructure in preterm infants with and without punctate WM lesions on MRI using tract-based spatial statistics (TBSS) and probabilistic tractography. We studied 23 preterm infants with punctate lesions, median GA at birth 30 (25-35) wk, and 23 GA- and sex-matched preterm co...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3182182836

    authors: Bassi L,Chew A,Merchant N,Ball G,Ramenghi L,Boardman J,Allsop JM,Doria V,Arichi T,Mosca F,Edwards AD,Cowan FM,Rutherford MA,Counsell SJ

    更新日期:2011-06-01 00:00:00

  • The relation of severe malnutrition in infancy to the intelligence of school children with differing life histories.

    abstract::The IQ's of Jamaican boys aged 6-10 were associated significantly with the presence or absence of severe malnutrition in infancy, with height at time of IQ testing, and with a measure of the boys' social background. A multiple correlation coefficient of 0.674 was obtained between IQ and the three factors. Social backg...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197601000-00011

    authors: Richardson SA

    更新日期:1976-01-01 00:00:00

  • Quality of reaching and postural control in young preterm infants is related to neuromotor outcome at 6 years.

    abstract::A substantial proportion of the "apparently normal" preterm infants exhibit minor and moderate dysfunctions in neuromotor outcome as they grow older. Birth characteristics, minor abnormalities on the neonatal ultrasound scan of the brain, and motor milestones have only limited value in the early detection of these chi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000170898.60160.09

    authors: Fallang B,Øien I,Hellem E,Saugstad OD,Hadders-Algra M

    更新日期:2005-08-01 00:00:00

  • ERP evidence of preserved early memory function in term infants with neonatal encephalopathy following therapeutic hypothermia.

    abstract:BACKGROUND:Neonatal encephalopathy (NE) carries high risk for neurodevelopmental impairments. Therapeutic hypothermia (TH) reduces this risk, particularly for moderate encephalopathy (ME). Nevertheless, these infants often have subtle functional deficits, including abnormal memory function. Detection of deficits at the...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2016.169

    authors: Pfister KM,Zhang L,Miller NC,Hultgren S,Boys CJ,Georgieff MK

    更新日期:2016-12-01 00:00:00

  • Serum diamine oxidase activity in acute gastroenteritis in children.

    abstract::Serum diamine oxidase (DAO) activities were measured in 20 control patients and in 24 patients with gastroenteritis. Results (mean +/- SE) were as follows: 1) control patients (n = 20), 36.2 +/- 5.7 pmol h-1 ml-1; 2) gastroenteritis (acute phase) (n = 11), 31 +/- 4.9 pmol h-1 ml-1; 3) gastroenteritis (healing phase) (...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198501000-00008

    authors: Forget P,Saye Z,Van Cutsem JL,Dandrifosse G

    更新日期:1985-01-01 00:00:00

  • Role of caregiver-reported outcomes in identification of children with prenatal alcohol exposure during the first year of life.

    abstract:BACKGROUND:Earlier identification of children with prenatal alcohol exposure (PAE) remains a challenge. The objective of this study was to identify neurobehavioral (NB) outcomes associated with PAE in infants. METHODS:This manuscript evaluates NB outcomes at 6.33±1.12 months of age in 93 infants (39 PAE and 54 No-PAE)...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2018.26

    authors: Bakhireva LN,Lowe J,Garrison LM,Cano S,Leyva Y,Qeadan F,Stephen JM

    更新日期:2018-09-01 00:00:00

  • Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup.

    abstract::Hypoxic-ischemic (HI) injury in the preterm neonate incurs numerous functional deficits, however little is known about the neurochemically-defined brain nuclei that may underpin them. Key candidates are the brainstem catecholamine neurons. Using an immature animal model, the postnatal day (P)-3 (P3) rat pup, we invest...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3181659774

    authors: Buller KM,Wixey JA,Pathipati P,Carty M,Colditz PB,Williams CE,Scheepens A

    更新日期:2008-04-01 00:00:00

  • Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by cotreatment with pantothenate and carnitine in developing mice: possible clinical significance.

    abstract::Very young children with organic brain damage, intractable seizures, and developmental retardation are at particular risk of developing fatal hepatic dysfunction coincident with valproate therapy, especially if the children are also receiving other anticonvulsant drugs. The mechanism of valproate-associated hepatic fa...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199204000-00023

    authors: Thurston JH,Hauhart RE

    更新日期:1992-04-01 00:00:00

  • Suppression of sigma spindle electroencephalographic activity as a measure of transient arousal after spontaneous and occlusion-evoked sighs and startles.

    abstract::Defective arousal mechanisms are viewed as contributory to sleep hypopnea disorders and sudden infant death syndrome. Sighs (i.e. augmented breaths) as well as startles have not traditionally been viewed as arousal-related phenomena in infants. We hypothesized that, if sighs and startles are the initial event in a seq...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199811000-00021

    authors: Wulbrand H,McNamara F,Thach BT

    更新日期:1998-11-01 00:00:00

  • Genetic variants of haemophilia B detected by immunoradiometric assay: implications for prenatal diagnosis.

    abstract::Fifty patients with haemophilia B, belonging to 29 kindreds, were investigated with a highly sensitive immunoradiometric assay based on a homologous antibody to factor IX. The assay measures factor IX antigen (f.IX:Ag) in plasma down to 0.025 U/dl. Seventeen of 18 investigated patients with severe haemophilia B had ve...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198203000-00019

    authors: Ljung R,Holmberg L

    更新日期:1982-03-01 00:00:00

  • Sex differences in the ovine fetal cortisol response to stress.

    abstract::This study tested the hypothesis that the sexually dimorphic adrenocortical response to stress is already established before birth. Chronically instrumented late gestation pregnant sheep carrying 16 male and 15 female age-matched singleton fetuses were subjected to an acute episode of hypoxic stress. Maternal and feta...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3182042a20

    authors: Giussani DA,Fletcher AJ,Gardner DS

    更新日期:2011-02-01 00:00:00