Blood flow distribution and brain metabolism during tolazoline-induced hypotension in newborn dogs.


:Tolazoline is used in neonatal intensive care to treat hypoxia secondary to persistent pulmonary hypertension of the newborn. Its use is often complicated by systemic hypotension. We compared the effect of tolazoline-induced hypotension on organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic newborn dogs whose mean arterial pressure fell by more than 20% with a second group whose blood pressure fell by less than 20%. Blood flows were measured by the radioactive microsphere technique. We found no changes in organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic animals whose mean arterial blood pressure decreased less than 20% during tolazoline administration. However, in those animals whose mean arterial blood pressure decreased more than 20%, we found a decrease in cerebral blood flow. As a consequence of decreased cerebral blood flow, cerebral oxygen delivery decreased. However, oxygen extraction increased so that cerebral metabolic rate was preserved.


Pediatr Res


Pediatric research


Balsan MJ,Cronin CM,Shaw MD,Milley JR




Has Abstract


1990-08-01 00:00:00












  • Home documented monitoring of cardiorespiratory pattern and oxygen saturation in healthy infants.

    abstract::The objective of this study was to establish longitudinal normative limits for home memory monitors during early infancy. Eighty-eight healthy infants were monitored overnight at 0.25-19 wk of age using the Healthdyne Smart Monitor. Apnea settings were 14 s for recording and 40 s for alarm; the bradycardia setting was...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hunt CE,Hufford DR,Bourguignon C,Oess MA

    更新日期:1996-02-01 00:00:00

  • Effects of vitamin D supplementation on circulating concentrations of growth factors and immune-mediators in healthy women during pregnancy.

    abstract:BACKGROUND:For the second aim of the Kellogg Foundation grant, this double-blind RCT investigated the impact of plasma vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy. We hypothesized that higher 25(OH)D concentrations would associate with reduced pro-inflammatory and incr...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Khatiwada A,Wolf BJ,Mulligan JK,Shary JR,Hewison M,Baatz JE,Newton DA,Hawrylowicz C,Hollis BW,Wagner CL

    更新日期:2020-04-20 00:00:00

  • Nutritional rickets: vitamin D, calcium, and the genetic make-up.

    abstract:BACKGROUND:The prevalence of vitamin D (vitD) deficiency presenting as rickets is increasing worldwide. Insufficient sun exposure, vitD administration, and/or calcium intake are the main causes. However, vitD system-related genes may also have a role. METHODS:Prospective study: 109 rachitic children completed a 6-mo s...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: El Kholy M,Elsedfy H,Fernández-Cancio M,Hamza RT,Amr NH,Ahmed AY,Toaima NN,Audí L

    更新日期:2017-02-01 00:00:00

  • Plasma levels of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, cortisol, and cortisone during infancy and childhood.

    abstract::Plasma aldosterone (A), corticosterone (B), deoxycorticosterone (DOC), progesterone (P), 17-hydroxyprogesterone (17-OHP), cortisol (F), and cortisone (E) were measured simultaneously by specific radioimmunoassays in small plasma samples obtained from 174 normal infants and children between 2 hr and 15 yr of age. The s...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Sippell WG,Dörr HG,Bidlingmaier F,Knorr D

    更新日期:1980-01-01 00:00:00

  • Neutrophil chemotaxis to leukotriene B4 in vitro is decreased for the human neonate.

    abstract::Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism and a potent chemoattractant for adult polymorphonuclear leukocytes (PMN). LTB4 may be an important inflammatory mediator in neonatal lung disorders such as bronchopulmonary dysplasia, but neonatal PMN chemotaxis to LTB4 has not been studied. We compare...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Dos Santos C,Davidson D

    更新日期:1993-03-01 00:00:00

  • Effect of oxypurinol, a xanthine oxidase inhibitor, on hepatic injury in the bile duct-ligated rat.

    abstract::Oxidant stress has been implicated as playing a role in the pathogenesis of cholestatic liver injury. The objective of this study was to determine whether the xanthine oxidase/xanthine dehydrogenase enzyme system was involved in this oxidant stress. Adult Sprague-Dawley rats were treated with the xanthine oxidase inhi...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Sokol RJ,Devereaux MW,Khandwala R

    更新日期:1998-09-01 00:00:00

  • Purine dysfunction in cells from patients with adenosine deaminase deficiency.

    abstract::Conversion of adenosine to inosine is decreased in adenosine deaminase (ADA)-deficient fibroblasts at all concentrations of adenosine tested. Adenosine is not differentially toxic to ADA-deficient fibroblasts except at very high (5 X 10(-4) -1 X 10(-3) M) adenosine levels. Conversion of [14C] adenosine to GTP is not d...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Benke PJ,Dittmar D

    更新日期:1976-07-01 00:00:00

  • Cardiovascular responses to feeding in newborn piglets.

    abstract::Cardiovascular responses to feeding have been observed in several species during various periods of development and have been implicated in the development of cardiovascular regulation. In the rat, these responses are characterized by short-lasting, large increases in blood pressure (BP) and moderate increases in hear...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Scalzo FM

    更新日期:1992-07-01 00:00:00

  • Spontaneous premature birth as a target of genomic research.

    abstract::Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Si...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Hallman M,Haapalainen A,Huusko JM,Karjalainen MK,Zhang G,Muglia LJ,Rämet M

    更新日期:2019-03-01 00:00:00

  • Mesenteric blood flow velocity and its relation to circulatory adaptation during the first week of life in healthy term infants.

    abstract::We investigated early postnatal changes of the mesenteric circulation and its relationship to the systemic circulation in two groups of newborn infants. Group I (n = 10) was studied before the first feeding at 1 h and preprandially at 6 and 24 h. Group II (n = 10) was studied before the first feeding at 2 h of age and...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Martinussen M,Brubakk AM,Linker DT,Vik T,Yao AC

    更新日期:1994-09-01 00:00:00

  • Phototherapy for neonatal jaundice: in vivo clearance of bilirubin photoproducts.

    abstract::Phototherapy results in the conversion of native bilirubin to more water-soluble configurational and structural isomers. The serum half-life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of photothe...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ennever JF,Knox I,Denne SC,Speck WT

    更新日期:1985-02-01 00:00:00

  • Developmental regulation of the sarcoplasmic reticulum calcium pump in the rabbit heart.

    abstract::Previous studies have demonstrated that myocardial function changes during mammalian perinatal development. The purpose of this study was to evaluate the subcellular basis underlying the slower relaxation in the developing heart by examining perinatal changes in sarcoplasmic reticulum (SR) function, and in SR Ca2+ pum...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Fisher DJ,Tate CA,Phillips S

    更新日期:1992-05-01 00:00:00

  • Effects of Bifidobacterium lactis Bb12 supplementation on body weight, fecal pH, acetate, lactate, calprotectin, and IgA in preterm infants.

    abstract::Preterm infants are prone to abnormal bacterial colonization of the intestine with ensuing adverse health effects. To examine whether the oral application of Bifidobacterium lactis Bb12 (probiotic) may improve selected indicators of health status in preterm infants, a double blind, placebo controlled randomized clinic...

    journal_title:Pediatric research

    pub_type: 杂志文章,随机对照试验


    authors: Mohan R,Koebnick C,Schildt J,Mueller M,Radke M,Blaut M

    更新日期:2008-10-01 00:00:00

  • The immediate ventilatory response to added inspiratory elastic and resistive loads in preterm infants.

    abstract::We measured the changes in tidal volume, duration of the various phases of the respiratory cycle, and peak nasal pressure during elastic and resistive loading in preterm infants. Values were calculated during the first loaded breath, when chemical drive was unchanged. Tidal volume decreased by equivalent percentages w...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Boychuk RB,Seshia MM,Rigatto H

    更新日期:1977-04-01 00:00:00

  • Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project.

    abstract:OBJECTIVES:(1) Examine associations of a branched-chain amino acid (BCAA) metabolite pattern with metabolic risk across adolescence; (2) use Least Absolute Shrinkage and Selection Operator (LASSO) to identify novel metabolites of metabolic risk. METHODS:We used linear regression to examine associations of a BCAA score...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Perng W,Tang L,Song PXK,Tellez-Rojo MM,Cantoral A,Peterson KE

    更新日期:2019-02-01 00:00:00

  • Glutaric aciduria type II: in vitro studies on substrate oxidation, acyl-CoA dehydrogenases, and electron-transferring flavoprotein in cultured skin fibroblasts.

    abstract::The previous biochemical evidence had suggested that glutaric aciduria type II (GA II) is due to deficient dehydrogenation of multiple short-chain acyl coenzyme A's (CoA's), bu the precise biochemical mechanism underlying this disease was unknown. We investigated substrate oxidation and in vitro activities of isovaler...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Rhead W,Mantagos S,Tanaka K

    更新日期:1980-12-01 00:00:00

  • Electronic health record-based predictive models for acute kidney injury screening in pediatric inpatients.

    abstract::BackgroundAcute kidney injury (AKI) is common in pediatric inpatients and is associated with increased morbidity, mortality, and length of stay. Its early identification can reduce severity.MethodsTo create and validate an electronic health record (EHR)-based AKI screening tool, we generated temporally distinct develo...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Wang L,McGregor TL,Jones DP,Bridges BC,Fleming GM,Shirey-Rice J,McLemore MF,Chen L,Weitkamp A,Byrne DW,Van Driest SL

    更新日期:2017-09-01 00:00:00

  • The expression of CD40 on monocytes of children with primary humoral immunodeficiencies.

    abstract::The interactions between CD40 and CD40L (CD154) are critical for effective humoral immune response. CD40 signaling facilitates T lymphocyte dependent B cell proliferation and immunoglobulin isotype switch. The objective of our study was to investigate the CD40 and CD40L expression on peripheral blood mononuclear cells...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kowalczyk D,Macura-Biegun A,Zembala M

    更新日期:2006-06-01 00:00:00

  • Hyperoxia-induced airway remodeling and pulmonary neuroendocrine cell hyperplasia in the weanling rat.

    abstract::Infants dying with bronchopulmonary dysplasia (BPD) demonstrate increased numbers of pulmonary neuroendocrine cells (PNEC). These infants also possess altered airway epithelial and smooth muscle dimensions reminiscent of oxygen-exposed animals. Because the pathogenesis of BPD involves oxygen toxicity, we hypothesized ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Shenberger JS,Shew RL,Johnson DE

    更新日期:1997-10-01 00:00:00

  • Oxygen desaturations in the early neonatal period predict development of bronchopulmonary dysplasia.

    abstract:BACKGROUND:Bradycardia and oxygen desaturation episodes are common among preterm very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU), and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. METHODS:For 502 VLBW infants we quantified bradycardias (HR ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Fairchild KD,Nagraj VP,Sullivan BA,Moorman JR,Lake DE

    更新日期:2019-06-01 00:00:00

  • Pharmacokinetics and local safety profile of propranolol eye drops in rabbits.

    abstract:BACKGROUND:Oral propranolol, a nonselective β-blocker, is able to reduce the progression of retinopathy of prematurity in newborns, but it appeared unsafe. This study aimed to find, in rabbits, a propranolol eye drop concentration able to induce lower plasma but higher retinal concentrations than those obtained after o...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Padrini L,Isacchi B,Bilia AR,Pini A,Lanzi C,Masini E,Della Bona ML,Calvani AM,Ceccantini R,la Marca G,Filippi L

    更新日期:2014-10-01 00:00:00

  • Yeast opsonisation and complement in children with liver disease. Analysis of 69 cases.

    abstract::Opsonisation of heat-killed bakers yeast and C3 and C4 concentrations were determined in sera from 69 children with liver disease and 39 controls as simple screening procedures for abnormalities in the complement system. Where significant defects in these moieties were encountered, the activity of the following was me...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Larcher VF,Wyke RJ,Vergani D,Mowat AP,Williams R

    更新日期:1983-04-01 00:00:00

  • Achondrogenesis type II, abnormalities of extracellular matrix.

    abstract::Immune and lectin histochemical and microchemical methods were employed to study growth cartilage from seven cases of achondrogenesis type II (Langer-Saldino). The normal architecture of the epiphyseal and growth plate cartilage was replaced by a morphologically heterogeneous tissue. Some areas were comprised of vascu...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Horton WA,Machado MA,Chou JW,Campbell D

    更新日期:1987-09-01 00:00:00

  • Excitation-contraction coupling in the day 15 embryonic chick heart with persistent truncus arteriosus.

    abstract::Ca2+ transients were examined in embryonic chick hearts with an experimentally induced cardiac neural crest-related outflow tract defect known as persistent truncus arteriosus (PTA). In all of the animal models of neural crest-related heart defects, prenatal mortality is too high to be attributed to structural defects...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Creazzo TL,Brotto MA,Burch J

    更新日期:1997-12-01 00:00:00

  • Vitamin K-dependent carboxylase activity in fetal rat lung: developmental effects of dexamethasone and triiodothyronine.

    abstract::Dexamethasone (Dex) and triiodothyronine (T3) were administered to pregnant rats during late gestation to evaluate potential developmental effects on fetal lung vitamin K-dependent carboxylation. Maternal rats were injected on the 2 d before study with Dex (0.2 mg/kg intraperitoneally), with T3 (0.7, 3.5, or 7 mg/kg i...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Gallaher KJ,Rannels DE,Rannels SR

    更新日期:1989-05-01 00:00:00

  • Respiratory effects of lactic acid injected into the jugular vein of newborn rabbits.

    abstract::To define respiratory effects of peripheral acidemia during early development, we injected lactic acid (LA) into the jugular vein of 32 1- to 7-d-old rabbit pups and four adult rabbits. The body weight of newborns varied between 67 +/- 17 g in 1-d-old and 119.8 +/- 33.7 g in 7-d-old animals versus 4 +/- 0.1 kg in adul...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ducros G,Trippenbach T

    更新日期:1991-06-01 00:00:00

  • Prostaglandin- and isoproterenol-stimulated cyclic AMP accumulation in rat perinatal lung fibroblasts: effects of developmental age.

    abstract::The fibroblast of the fetal and neonatal lung is intimately involved with lung development and function. Additionally, the perinatal rat lung fibroblast is a significant source of prostaglandins (PG) I2 and E2, which in turn affect lung development and function. Their effects may be mediated by cAMP. We, therefore, te...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Teixeira FJ,Bevan ML,Olson DM

    更新日期:1992-04-01 00:00:00

  • Leptin levels and body fatness in children: effects of gender, ethnicity, and sexual development.

    abstract::Leptin, a hormone secreted by adipocytes, is elevated in blood of obese adults. It is unknown whether the concentration is affected by gender, ethnicity, age, or stage of sexual maturation in children. We measured serum leptin levels in 183 children and 27 young adults using a double-antibody ELISA assay. Body fat mas...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ellis KJ,Nicolson M

    更新日期:1997-10-01 00:00:00

  • Sleep organization and energy expenditure of breast-fed and formula-fed infants.

    abstract::Sleep organization of infants may be influenced by differences in nutrient intakes from human milk and formula. Because sleep/awake and sleep stage patterns affect energy expenditure, we hypothesized that differences in sleep organization between breast-fed and formula-fed infants might account in part for differences...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Butte NF,Jensen CL,Moon JK,Glaze DG,Frost JD Jr

    更新日期:1992-11-01 00:00:00

  • Pyritinol hydrochloride and cognitive functions: influence on children in slow learner classes.

    abstract::Pyritinol-HCl was tested for its impact on the cognitive functions of children with learning disabilities. This study is a contribution to scientific discussion on the complicated methodologic problems in evaluating the clinical efficacy of psychopharmacologic agents. Sixty-seven pupils of slow learner classes between...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章


    authors: Wälti U,Kuenzler M,Schild J,Vassella F,Pavlincova E,Bircher J,Herschkowitz N

    更新日期:1975-09-01 00:00:00