Vitamin A deficiency and pulmonary oxygen toxicity: morphometric studies in the murine lung.

Abstract:

:Vitamin A and its precursor beta-carotene are naturally occurring antioxidants. The effects of diets deficient in beta-carotene and vitamin A on the alveolar-capillary membrane were studied in young adult BALB/C mice before and after exposure to 65% oxygen. One of three diets (standard complete, beta-carotene deficient, or beta-carotene and vitamin A deficient) was fed for a 6-wk period. Mice were then exposed to 65% oxygen for 0, 3, or 6 days, sacrificed, and their lungs examined by electron microscopy using the morphometric techniques of Weibel. The arithmetic and the harmonic mean thicknesses of the alveolar-capillary membrane and its components (epithelium, interstitium, and endothelium) were measured to assess the influences of diet and of duration of exposure to 65% oxygen. Analysis of variance and multiple comparisons of means (Student-Neuman-Keuls statistics) were applied. Diet alone did not significantly affect membrane thickness. However, duration of oxygen exposure increased the thicknesses of both the epithelium and interstitium in the group fed a diet deficient in both beta-carotene and vitamin A as compared to the other two groups although this was only significant for the epithelium. beta-Carotene deficiency alone did not affect the respiratory membrane either before or after oxygen exposure. These results suggest that vitamin A may be an important nutrient in the protection against pulmonary oxygen toxicity.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Cohen-Addad N,Bollinger R,Chou J,Poland R

doi

10.1203/00006450-198801000-00017

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

76-80

issue

1

eissn

0031-3998

issn

1530-0447

journal_volume

23

pub_type

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