Vitamin A deficiency and pulmonary oxygen toxicity: morphometric studies in the murine lung.


:Vitamin A and its precursor beta-carotene are naturally occurring antioxidants. The effects of diets deficient in beta-carotene and vitamin A on the alveolar-capillary membrane were studied in young adult BALB/C mice before and after exposure to 65% oxygen. One of three diets (standard complete, beta-carotene deficient, or beta-carotene and vitamin A deficient) was fed for a 6-wk period. Mice were then exposed to 65% oxygen for 0, 3, or 6 days, sacrificed, and their lungs examined by electron microscopy using the morphometric techniques of Weibel. The arithmetic and the harmonic mean thicknesses of the alveolar-capillary membrane and its components (epithelium, interstitium, and endothelium) were measured to assess the influences of diet and of duration of exposure to 65% oxygen. Analysis of variance and multiple comparisons of means (Student-Neuman-Keuls statistics) were applied. Diet alone did not significantly affect membrane thickness. However, duration of oxygen exposure increased the thicknesses of both the epithelium and interstitium in the group fed a diet deficient in both beta-carotene and vitamin A as compared to the other two groups although this was only significant for the epithelium. beta-Carotene deficiency alone did not affect the respiratory membrane either before or after oxygen exposure. These results suggest that vitamin A may be an important nutrient in the protection against pulmonary oxygen toxicity.


Pediatr Res


Pediatric research


Cohen-Addad N,Bollinger R,Chou J,Poland R




Has Abstract


1988-01-01 00:00:00












  • Scalp blood flow, measured by laser Doppler flowmetry, and transcutaneous PO2 and PCO2 in the lamb.

    abstract::To describe the relation between scalp blood flow and transcutaneous PO2 and PCO2, these three signals were recorded simultaneously in eight experiments on four healthy lambs in the first weeks after birth. Scalp blood flow was recorded by a laser Doppler flow sensor that was incorporated in the transcutaneous PO2 ele...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Smits TM,Aarnoudse JG,Zijlstra WG

    更新日期:1990-05-01 00:00:00

  • Utility of cytokines to predict neonatal sepsis.

    abstract:BACKGROUND:Sepsis is an important cause of neonatal morbidity and mortality worldwide. Diagnosis and treatment of neonatal sepsis relies on clinical judgment and interpretation of nonspecific laboratory tests. In a prospective cohort, we measured inflammatory cytokines as a potential biomarker for neonatal sepsis. MET...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ye Q,Du LZ,Shao WX,Shang SQ

    更新日期:2017-04-01 00:00:00

  • New and old immunodeficiencies.

    abstract::Yesterday's immunodeficiencies emphasized the clinical and familial associations of the syndromes and date from the 1920s (ataxia-telangiectasia, chronic mucocutaneous candidiasis), the 1930s (Wiskott-Aldrich syndrome), skipping the 1940s, but blossoming in the 15-y period from 1950 to 1965. In this period, primary im...

    journal_title:Pediatric research

    pub_type: 历史文章,杂志文章,评审


    authors: Stiehm ER

    更新日期:1993-01-01 00:00:00

  • Aceruloplasminemia.

    abstract::Aceruloplasminemia is an autosomal recessive disorder of iron metabolism characterized by diabetes, retinal degeneration, and neurologic symptoms. Affected patients evidence marked parenchymal iron accumulation in conjunction with an absence of circulating serum ceruloplasmin and molecular genetic analysis reveals inh...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Gitlin JD

    更新日期:1998-09-01 00:00:00

  • Nitric oxide in retinal and choroidal blood flow autoregulation in newborn pigs: interactions with prostaglandins.

    abstract::The role of nitric oxide (NO) as well as its interaction with prostaglandins (PG) in setting the limits of autoregulation of retinal blood flow (RBF) and choroidal blood flow (ChBF) were studied in newborn pigs (1-5 d old). Blood flows were measured by the microsphere technique. Low and high ocular perfusion pressures...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hardy P,Nuyt AM,Abran D,St-Louis J,Varma DR,Chemtob S

    更新日期:1996-03-01 00:00:00

  • Cancer stem cells.

    abstract::Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. Advances have been made in identifying and enriching CSC in leukemia and several solid tumors, including breast, brain and lung cancers. These studies suggest that, like no...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Guo W,Lasky JL 3rd,Wu H

    更新日期:2006-04-01 00:00:00

  • Deficient collagen-induced activation in the newborn platelet.

    abstract::We have investigated the impaired secretion response of neonatal platelets. We compared the response of washed neonatal and adult platelets to thrombin and collagen, and to specific activators of calcium flux (inositol trisphosphate) and protein kinase C activation (oleoyl-acetyl glycerol). Neonatal platelets show no ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Israels SJ,Daniels M,McMillan EM

    更新日期:1990-04-01 00:00:00

  • Comparative proteomic profiles of the normal and aganglionic hindgut in human Hirschsprung disease.

    abstract:BACKGROUND:Hirschsprung disease (HSCR) is the third most common congenital disorder of the gastrointestinal tract. This study aims to elucidate changes in protein expression between the normal and aganglionic hindgut in human HSCR. METHODS:The biopsies were obtained from the normal and aganglionic hindgut in human HSC...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Zhang SC,Chen F,Jiang KL,Yuan ZW,Wang WL

    更新日期:2014-06-01 00:00:00

  • Regulation of the renal response to atrial natriuretic peptide by sodium intake in preweaned rats.

    abstract::The neonate conserves sodium avidly, and sodium intake is normally limited to that present in maternal milk. To evaluate the role of atrial natriuretic peptide (ANP) in this adaptation, preweaned rat pups were artificially reared and fed a formula with either normal sodium (25 mEq/L) or high sodium (145 mEq/L) for 7-8...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Chevalier RL,Muchant DG,Thornhill BA,Belmonte DC,Pence RA,Baertschi AJ

    更新日期:1996-08-01 00:00:00

  • ERP evidence of preserved early memory function in term infants with neonatal encephalopathy following therapeutic hypothermia.

    abstract:BACKGROUND:Neonatal encephalopathy (NE) carries high risk for neurodevelopmental impairments. Therapeutic hypothermia (TH) reduces this risk, particularly for moderate encephalopathy (ME). Nevertheless, these infants often have subtle functional deficits, including abnormal memory function. Detection of deficits at the...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Pfister KM,Zhang L,Miller NC,Hultgren S,Boys CJ,Georgieff MK

    更新日期:2016-12-01 00:00:00

  • Endotoxin-induced hypoxic-ischemic tolerance is mediated by up-regulation of corticosterone in neonatal rat.

    abstract::Previous studies suggest that the endotoxin lipopolysaccharide (LPS) may have dual effects on brain damage induced by hypoxia-ischemia (HI) in 7-d-old rats, depending on the exposure paradigm. Although a 4-h interval between LPS administration and HI results in sensitization to HI brain injury, tolerance is observed w...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ikeda T,Yang L,Ikenoue T,Mallard C,Hagberg H

    更新日期:2006-01-01 00:00:00

  • Preserved fetal plasma amino acid concentrations in the presence of maternal hypoaminoacidemia.

    abstract::The effects on the conceptus of persistently decreased maternal plasma amino acid concentrations were studied in pregnant rats by the infusion of glucagon (0.21 mg/day) to the mother from day 14 to 20 of gestation with a subcutaneous, osmotically driven minipump. Controls received diluent. The experimental animals eit...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Domenech M,Gruppuso PA,Nishino VT,Susa JB,Schwartz R

    更新日期:1986-11-01 00:00:00

  • Effects of hypothermia on hypoxia-induced apoptosis in cultured neurons from developing rat forebrain: comparison with preconditioning.

    abstract::In neuronal cultures from the forebrain of 14-d-old rat embryos, transient hypoxia (95% N2/5% CO2, 37 degrees C) for 6 h has been shown to trigger delayed apoptotic death through sequential changes in protein synthesis, whereas preconditioning by a brief episode of hypoxia can rescue neurons. Because hypothermia has b...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Bossenmeyer-Pourié C,Koziel V,Daval JL

    更新日期:2000-03-01 00:00:00

  • Detection of a transcript abnormality in mRNA of the SLC12A3 gene extracted from urinary sediment cells of a patient with Gitelman's syndrome.

    abstract::To date, many mutations, including intronic nucleotide changes, in the SLC12A3 gene encoding the thiazide-sensitive sodium-chloride cotransporter (NCCT) have been reported in Gitelman's syndrome (GS) patients. However, it has not been clarified whether intronic nucleotide changes affect mRNA content. Since mRNA analys...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kaito H,Nozu K,Fu XJ,Kamioka I,Fujita T,Kanda K,Krol RP,Suminaga R,Ishida A,Iijima K,Matsuo M

    更新日期:2007-04-01 00:00:00

  • Atrial myocardial blood flow during acute right ventricular pressure load and adenosine infusion in late gestation fetal sheep.

    abstract::The purpose of this study was to investigate atrial myocardial blood flow in the fetus under conditions of acute right ventricular pressure load and adenosine infusion. Late gestation fetal sheep were instrumented for acute right ventricular pressure loading or adenosine infusion, and regional myocardial blood flow wa...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Lohr JL,Reller MD,Morton MJ,Wu DE,Thornburg KL

    更新日期:1994-03-01 00:00:00

  • Growth failure in cholestatic rats: the effect of malnutrition on insulin-like growth factor I.

    abstract::Low IGF-I levels are found in patients with chronic liver disease, but it is not known whether these reductions in IGF-I are secondary to hepatic dysfunction or to malnutrition. To determine whether malnutrition associated with hepatic dysfunction causes the decrease in these levels, serum and liver IGF-I concentratio...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Descos BP,Berry SA,Sharp HL,Gross CR,Weisdorf SA,Pescovitz OH

    更新日期:1989-11-01 00:00:00

  • Serum diamine oxidase activity in acute gastroenteritis in children.

    abstract::Serum diamine oxidase (DAO) activities were measured in 20 control patients and in 24 patients with gastroenteritis. Results (mean +/- SE) were as follows: 1) control patients (n = 20), 36.2 +/- 5.7 pmol h-1 ml-1; 2) gastroenteritis (acute phase) (n = 11), 31 +/- 4.9 pmol h-1 ml-1; 3) gastroenteritis (healing phase) (...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Forget P,Saye Z,Van Cutsem JL,Dandrifosse G

    更新日期:1985-01-01 00:00:00

  • Heart rate variability: impact of differences in outlier identification and management strategies on common measures in three clinical populations.

    abstract::Heart rate variability (HRV) is reported increasingly in pediatric research, but different strategies used to identify and manage potential outlier beats impact HRV parameter values in adults and animals. Do they in pediatrics? To compare the impact of different strategies to identifying and managing outliers, we used...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kemper KJ,Hamilton C,Atkinson M

    更新日期:2007-09-01 00:00:00

  • Sonic hedgehog is essential for first pharyngeal arch development.

    abstract::The secreted protein sonic hedgehog (Shh) is essential for normal development of many organs. Targeted disruption of Shh in mouse leads to near complete absence of craniofacial skeletal elements at birth, and mutation of SHH in human causes holoprosencephaly (HPE), frequently associated with defects of derivatives of ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Yamagishi C,Yamagishi H,Maeda J,Tsuchihashi T,Ivey K,Hu T,Srivastava D

    更新日期:2006-03-01 00:00:00

  • Achondrogenesis type II, abnormalities of extracellular matrix.

    abstract::Immune and lectin histochemical and microchemical methods were employed to study growth cartilage from seven cases of achondrogenesis type II (Langer-Saldino). The normal architecture of the epiphyseal and growth plate cartilage was replaced by a morphologically heterogeneous tissue. Some areas were comprised of vascu...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Horton WA,Machado MA,Chou JW,Campbell D

    更新日期:1987-09-01 00:00:00

  • Fåhraeus and Fåhreaus-Lindqvist effects for neonatal and adult red blood cell suspensions.

    abstract::In blood vessels with diameters less than 500 microns, both the hematocrit and viscosity decrease with decreasing tube diameter [Fåhraeus effect (FE) and Fåhraeus-Lindqvist effect (FLE)]. Because both effects may be influenced by red blood cell (RBC) volume and osmolality, the effects of RBC type and suspending medium...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: McKay CB,Linderkamp O,Meiselman HJ

    更新日期:1993-10-01 00:00:00

  • Determination and characterization of ciliary ATPase in the presence of serum from cystic fibrosis patients.

    abstract::The purpose of this investigation was twofold: (1) to identify and characterize the enzymatic ATP hydrolysis system of epithelial cilia, and (2) to develop a quantitative, biochemical test for the ciliotoxic cystic fibrosis (CF) factor based on inhibition of ATP utilization by ciliary preparations. Our rationale for s...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Farrell PM,Fox GN,Spicer SS

    更新日期:1976-02-01 00:00:00

  • Direct measurement of intratracheal pressure in pediatric respiratory monitoring.

    abstract::We describe a method based on a Fabry-Perot interferometer at the tip of an optic fiber with a diameter of 0.25 mm for direct measurement of tracheal pressure in pediatric respiratory monitoring. The response time of the pressure transducer and its influence on the resistance of pediatric endotracheal tubes (internal ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Sondergaard S,Karason S,Hanson A,Nilsson K,Hojer S,Lundin S,Stenqvist O

    更新日期:2002-03-01 00:00:00

  • Epigenetics of long-range chromatin interactions.

    abstract::DNA segments that are separated from the promoter region of a gene by many thousands of bases may nonetheless regulate the transcriptional activity of that gene. This finding has led to the investigation of mechanisms underlying long-range chromatin interactions. In intermitotic cells, chromosomes decondense, filling ...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Ling JQ,Hoffman AR

    更新日期:2007-05-01 00:00:00

  • Effect of insulin with concurrent amino acid infusion on protein metabolism in rapidly growing pubertal children with type 1 diabetes.

    abstract::Insulin treatment of prepubertal children with insulin-dependent diabetes improves body protein balance by decreasing the rate of protein degradation without stimulating protein synthesis. However, insulin also causes hypoaminoacidemia, so the inability of insulin to stimulate protein synthesis may have been limited b...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Godil MA,Wilson TA,Garlick PJ,McNurlan MA

    更新日期:2005-08-01 00:00:00

  • Effect of lipids and other substances on the adsorption of dipalmitoyl phosphatidylcholine.

    abstract::The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Meban C

    更新日期:1981-07-01 00:00:00

  • Development of immune functions related to allergic mechanisms in young children.

    abstract::The newborn immune system differs quantitatively and functionally from that of adults. Development of the immune system has important implications for childhood diseases. The immaturity of the immune system in the first years of life may contribute to failure of tolerance induction and in the development of allergic d...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Koning H,Baert MR,Oranje AP,Savelkoul HF,Neijens HJ

    更新日期:1996-09-01 00:00:00

  • Role of per-rectal portal scintigraphy in long-term follow-up of congenital portosystemic shunt.

    abstract:BACKGROUND:Congenital portosystemic shunt (CPSS) has the potential to cause hepatic encephalopathy and thus needs long-term follow-up, but an effective follow-up method has not yet been established. We aimed to evaluate the importance of per-rectal portal scintigraphy (PRPS) for long-term follow-up of CPSS. METHODS:We...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Cho Y,Tokuhara D,Shimono T,Yamamoto A,Higashiyama S,Kotani K,Kawabe J,Okano Y,Shiomi S,Shintaku H

    更新日期:2014-05-01 00:00:00

  • Beyond screening: a review of pediatric primary care models to address maternal depression.

    abstract::Depression is one of the most debilitating chronic disorders in the United States, affecting 15 million children in homes with depressed mothers, many of whom endure household chaos, inconsistent nurturing, inadequate safety practices, and harsh discipline. Depressed mothers are under diagnosed and undertreated, yet t...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Weiss-Laxer NS,Platt R,Osborne LM,Kimmel M,Solomon BS,Mendelson T,Webb L,Riley AW

    更新日期:2016-01-01 00:00:00

  • Physical properties of bedding that may increase risk of sudden infant death syndrome in prone-sleeping infants.

    abstract::Soft bedding has been shown in epidemiologic studies to increase the risk for sudden, unexpected death in prone-sleeping infants. We compared the physical properties of conventional bedding to bedding from two sources: 1) bedding that covered the airways of victims of sudden infant death syndrome (SIDS) lying prone an...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kemp JS,Nelson VE,Thach BT

    更新日期:1994-07-01 00:00:00