Vitamin A deficiency and pulmonary oxygen toxicity: morphometric studies in the murine lung.


:Vitamin A and its precursor beta-carotene are naturally occurring antioxidants. The effects of diets deficient in beta-carotene and vitamin A on the alveolar-capillary membrane were studied in young adult BALB/C mice before and after exposure to 65% oxygen. One of three diets (standard complete, beta-carotene deficient, or beta-carotene and vitamin A deficient) was fed for a 6-wk period. Mice were then exposed to 65% oxygen for 0, 3, or 6 days, sacrificed, and their lungs examined by electron microscopy using the morphometric techniques of Weibel. The arithmetic and the harmonic mean thicknesses of the alveolar-capillary membrane and its components (epithelium, interstitium, and endothelium) were measured to assess the influences of diet and of duration of exposure to 65% oxygen. Analysis of variance and multiple comparisons of means (Student-Neuman-Keuls statistics) were applied. Diet alone did not significantly affect membrane thickness. However, duration of oxygen exposure increased the thicknesses of both the epithelium and interstitium in the group fed a diet deficient in both beta-carotene and vitamin A as compared to the other two groups although this was only significant for the epithelium. beta-Carotene deficiency alone did not affect the respiratory membrane either before or after oxygen exposure. These results suggest that vitamin A may be an important nutrient in the protection against pulmonary oxygen toxicity.


Pediatr Res


Pediatric research


Cohen-Addad N,Bollinger R,Chou J,Poland R




Has Abstract


1988-01-01 00:00:00












  • Inherited copper toxicity in Long-Evans cinnamon rats exhibiting spontaneous hepatitis: a model of Wilson's disease.

    abstract::The copper concentrations in organs of developing Long-Evans Cinnamon (LEC) rats (2 d to 13 mo) were measured to elucidate the pathogenesis of their hereditary hepatitis. Hepatic copper contents of LEC rats were significantly higher than those of control rats (26 to 92 times higher). The subcellular distribution of he...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Okayasu T,Tochimaru H,Hyuga T,Takahashi T,Takekoshi Y,Li Y,Togashi Y,Takeichi N,Kasai N,Arashima S

    更新日期:1992-03-01 00:00:00

  • Respiratory effects of lactic acid injected into the jugular vein of newborn rabbits.

    abstract::To define respiratory effects of peripheral acidemia during early development, we injected lactic acid (LA) into the jugular vein of 32 1- to 7-d-old rabbit pups and four adult rabbits. The body weight of newborns varied between 67 +/- 17 g in 1-d-old and 119.8 +/- 33.7 g in 7-d-old animals versus 4 +/- 0.1 kg in adul...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ducros G,Trippenbach T

    更新日期:1991-06-01 00:00:00

  • Naloxone decreases the duration of primary apnea with neonatal asphyxia.

    abstract::Naloxone, a specific opiate antagonist with no agonist properties, in doses of 0.4 and 4.0 mg/kg was found to markedly reduce the duration of primary apnea in asphyxiated newborn rabbits. There was no effect on the duration of the hyperpneic phase (time to primary apnea) or on survival time (time to last gasp). It is ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Chernick V,Madansky DL,Lawson EE

    更新日期:1980-04-01 00:00:00

  • T cell receptor repertoire diversity and clonal expansion in human neonates.

    abstract::Newborn human infants, particularly those born prematurely, are susceptible to infection with a variety of microorganisms. We questioned whether limitations in the T cell repertoire contribute to the neonatal immunocompromised state. To describe developmental changes of the T cell repertoire, cDNA segments correspondi...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Schelonka RL,Raaphorst FM,Infante D,Kraig E,Teale JM,Infante AJ

    更新日期:1998-03-01 00:00:00

  • Tissue engineering in cleft palate and other congenital malformations.

    abstract::Contributions from multidisciplinary investigations have focused attention on the potential of tissue engineering to yield novel therapeutics. Congenital malformations, including cleft palate, craniosynostosis, and craniofacial skeletal hypoplasias represent excellent targets for the implementation of tissue engineeri...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Panetta NJ,Gupta DM,Slater BJ,Kwan MD,Liu KJ,Longaker MT

    更新日期:2008-05-01 00:00:00

  • Sex differences in the ovine fetal cortisol response to stress.

    abstract::This study tested the hypothesis that the sexually dimorphic adrenocortical response to stress is already established before birth. Chronically instrumented late gestation pregnant sheep carrying 16 male and 15 female age-matched singleton fetuses were subjected to an acute episode of hypoxic stress. Maternal and feta...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Giussani DA,Fletcher AJ,Gardner DS

    更新日期:2011-02-01 00:00:00

  • Myocardial excitation-contraction coupling in the fetus of alloxan-diabetic rabbit.

    abstract::This study was conducted to investigate myocardial excitation-contraction coupling in the fetus of the diabetic rabbit (FDM). On day 14 of gestation, diabetes was induced in pregnant rabbits by alloxan injection. On day 28 of gestation, mechanical function of the fetal myocardium was determined in the isolated arteria...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Nakanishi T,Matsuoka S,Uemura S,Shimizu T,Nishioka K,Neufeld ND,Jarmakani JM

    更新日期:1984-12-01 00:00:00

  • Short-term efficacy of umbilical cord milking in preterm infants: systematic review and meta-analysis.

    abstract:BACKGROUND:To systematically evaluate short-term efficacy of UCM versus other interventions in preterm infants. METHODS:Six engines were searched until February 2020 for randomized controlled trials (RCTs) assessing UCM versus immediate cord clamping (ICC), delayed cord clamping (DCC), or no intervention. Primary outc...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Barboza JJ,Albitres-Flores L,Rivera-Meza M,Rodriguez-Huapaya J,Caballero-Alvarado J,Pasupuleti V,Hernandez AV

    更新日期:2020-04-21 00:00:00

  • Oxygen desaturations in the early neonatal period predict development of bronchopulmonary dysplasia.

    abstract:BACKGROUND:Bradycardia and oxygen desaturation episodes are common among preterm very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU), and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. METHODS:For 502 VLBW infants we quantified bradycardias (HR ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Fairchild KD,Nagraj VP,Sullivan BA,Moorman JR,Lake DE

    更新日期:2019-06-01 00:00:00

  • Perinatal changes of 2,3-diphosphoglycerate and oxygen affinity in mammals not having fetal type hemoglobins.

    abstract::The interrelationship of 2,3-diphosphoglycerate (2,3-DPG) and P50 levels during the fetal and postnatal life were determined in two mammalian species which do not have a switchover of hemoglobin type at the end of their fetal development. In the guinea pig and rabbit, the 2,3-DPG levels remain low during fetal life an...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Bard H,Shapiro M

    更新日期:1979-03-01 00:00:00

  • Opposing regulation of human alveolar type II cell differentiation by nitric oxide and hyperoxia.

    abstract::Clinical trials demonstrated decreasing rates of bronchopulmonary dysplasia in preterm infants with hypoxic respiratory failure treated with inhaled nitric oxide (iNO). However, the molecular and biochemical effects of iNO on developing human fetal lungs remain vastly unknown. By using a well-characterized model of hu...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Johnston LC,Gonzales LW,Lightfoot RT,Guttentag SH,Ischiropoulos H

    更新日期:2010-05-01 00:00:00

  • Real-time spectral analysis of the fetal EEG: a new approach to monitoring sleep states and fetal condition during labor.

    abstract::Adverse perinatal events affecting cerebral functions are a major cause of neonatal mortality, morbidity, and long-term neurologic deficit. Intrapartum fetal EEG, which records fetal brain electrical activity, provides a monitoring modality for evaluating the fetal CNS during labor. In this study, we describe a new ap...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Thaler I,Boldes R,Timor-Tritsch I

    更新日期:2000-09-01 00:00:00

  • Functional development of fat absorption in term and preterm neonates strongly correlates with ability to absorb long-chain Fatty acids from intestinal lumen.

    abstract::Our goal for this study was to determine whether the maturation of fat absorption in neonatal life is functionally related to an increased ability to hydrolyze dietary fat, to absorb long-chain fatty acids, or to do both. In 16 preterm and in eight term neonates, the intestinal ability to hydrolyze triacylglycerols an...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Rings EH,Minich DM,Vonk RJ,Stellaard F,Fetter WP,Verkade HJ

    更新日期:2002-01-01 00:00:00

  • Comprehensive genetic variant discovery in the surfactant protein B gene.

    abstract::Completely penetrant mutations in the surfactant protein B gene (SFTPB) and >75% reduction of SFTPB expression disrupt pulmonary surfactant function and cause neonatal respiratory distress syndrome. To inform studies of genetic regulation of SFTPB expression, we created a catalogue of SFTPB variants by comprehensive r...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hamvas A,Wegner DJ,Carlson CS,Bergmann KR,Trusgnich MA,Fulton L,Kasai Y,An P,Mardis ER,Wilson RK,Cole FS

    更新日期:2007-08-01 00:00:00

  • Effects of active compression-decompression cardiopulmonary resuscitation with the inspiratory threshold valve in a young porcine model of cardiac arrest.

    abstract::Active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) with the inspiratory threshold valve (ITV) has been recently recommended by the American Heart Association for treatment of adults in cardiac arrest (class IIb: alternative, useful intervention), but this new technique has never been used in a ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Voelckel WG,Lurie KG,Sweeney M,McKnite S,Zielinski T,Lindstrom P,Peterson C,Wenzel V,Lindner KH

    更新日期:2002-04-01 00:00:00

  • Increased beta-lactoglobulin absorption during rotavirus enteritis in infants: relationship to sugar permeability.

    abstract::We studied absorption of the potentially allergenic protein beta-lactoglobulin during acute rotavirus diarrhea in infants and assessed the relationship of this macromolecular absorption with intestinal sugar permeability. After oral rehydration, 38 patients with acute gastroenteritis were given orally a 100-ml solutio...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Jalonen T,Isolauri E,Heyman M,Crain-Denoyelle AM,Sillanaukee P,Koivula T

    更新日期:1991-09-01 00:00:00

  • Fetomaternal potassium relations in the rat on the twentieth day of gestation. II. Effects of maternal hypokalemia.

    abstract::Time-corrected measurements of transplacental and transamniotic electrical potentials were made in potassium-deficient rats on the 20th day of gestation. These averaged 6.4 mV and 2.0 mV, respectively, in the deficient group as compared with 14.3 and 18.4, respectively, in the controls. The measured maternal potassium...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Fantel AG

    更新日期:1978-10-01 00:00:00

  • Spontaneous premature birth as a target of genomic research.

    abstract::Spontaneous preterm birth is a serious and common pregnancy complication associated with hormonal dysregulation, infection, inflammation, immunity, rupture of fetal membranes, stress, bleeding, and uterine distention. Heredity is 25-40% and mostly involves the maternal genome, with contribution of the fetal genome. Si...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Hallman M,Haapalainen A,Huusko JM,Karjalainen MK,Zhang G,Muglia LJ,Rämet M

    更新日期:2019-03-01 00:00:00

  • Effect of pH and CO2 on in vitro susceptibility of Pseudomonas cepacia to beta-lactams.

    abstract::Inhibition of Pseudomonas cepacia (but not Pseudomonas aeruginosa) by beta-lactams was decreased in 5% CO2 in air compared with air alone. The effect of CO2 and pH (range, 6.0 to 8.0) on beta-lactam susceptibility, beta-lactamase expression, and outer membrane proteins was studied in isolates recovered from the sputum...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Corkill JE,Deveney J,Pratt J,Shears P,Smyth A,Heaf D,Hart CA

    更新日期:1994-03-01 00:00:00

  • The effects of intraventricular/periventricular blood on cerebral 3',5'-cyclic adenosine monophosphate concentration and cerebrovascular reactivity in newborn pigs.

    abstract::This study investigated the effects of intraventricular/periventricular blood on cerebral cAMP production and cortical cerebrovascular reactivity. Under halothane and N2O anesthesia, 3 mL of either autologous blood or artificial cerebrospinal fluid (CSF) were injected into the left caudate nucleus; volume was adequate...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Pourcyrous M,Parfenova H,Shibata M,Bada HS,Korones SB,Leffler CW

    更新日期:1997-09-01 00:00:00

  • Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.

    abstract:BACKGROUND:Toll-like receptor (TLR)-mediated inflammation may contribute to neonatal sepsis, for which pentoxifylline (PTX), a phosphodiesterase inhibitor that raises intracellular cAMP, is a candidate adjunctive therapy. We characterized the anti-inflammatory effects of PTX toward TLR-mediated production of inflammato...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Speer EM,Dowling DJ,Ozog LS,Xu J,Yang J,Kennady G,Levy O

    更新日期:2017-05-01 00:00:00

  • Intellectual, neurologic, and neuropsychologic outcome in untreated subjects with nonphenylketonuria hyperphenylalaninemia. German Collaborative Study on Phenylketonuria.

    abstract::Based on the serum phenylalanine levels under free diet patients with hyperphenylalaninemia are classified as "classical" (>1200 micromol/L), "mild" (600-1200 micromol/L), or "non-phenylketonuria (PKU)-hyperphenylalaninemia" (<600 micromol/L). Recent studies revealed intellectual, neurologic, and neuropsychologic defi...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Weglage J,Ullrich K,Pietsch M,Fünders B,Güttler F,Harms E

    更新日期:1997-09-01 00:00:00

  • System A amino acid transporter activity in human placental microvillous membrane vesicles in relation to various anthropometric measurements in appropriate and small for gestational age babies.

    abstract::Fetal growth and development is dependent on the transfer of amino acids from maternal to fetal blood across the microvillous plasma membrane (MVM) and basal plasma membrane of placental syncytiotrophoblast. The aim of this study was to determine the relationship of system A amino acid transporter (SysA) activity in M...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Harrington B,Glazier J,D'Souza S,Sibley C

    更新日期:1999-06-01 00:00:00

  • Effectiveness of Bifidobacterium bifidum in mediating the clinical course of murine rotavirus diarrhea.

    abstract::Human Bifidobacterium sp strain bifidum (B. bifidum) was administered to BALB/c lactating mice (n = 58) and their litters (n = 327 pups) to evaluate the ingested strain's adherent properties and ability to inhibit murine rotavirus (MRV) infection. ELISA and anaerobic bacteriologic techniques were used to measure MRV s...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Duffy LC,Zielezny MA,Riepenhoff-Talty M,Dryja D,Sayahtaheri-Altaie S,Griffiths E,Ruffin D,Barrett H,Rossman J,Ogra PL

    更新日期:1994-06-01 00:00:00

  • Improvement in asthma control and inflammation in children undergoing adenotonsillectomy.

    abstract:BACKGROUND:Observational studies suggest that asthma control improves after adenotonsillectomy, but longitudinal studies that correlate the effect of the procedure on the levels of biomarkers associated with airway inflammation are limited. METHODS:We conducted a longitudinal, observational study on pediatric patients...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Levin JC,Gagnon L,He X,Baum ED,Karas DE,Chupp GL

    更新日期:2014-03-01 00:00:00

  • A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants.

    abstract::In preterm infants, low levels of insulin like growth factor 1 (IGF-I) have been associated with impaired growth and retinopathy of prematurity. Our objective was to study safety and pharmacokinetics of i.v. administered rhIGF-I with its binding protein 3 (rhIGFBP-3) to preterm infants. At 3 d chronological age, an i....

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章


    authors: Löfqvist C,Niklasson A,Engström E,Friberg LE,Camacho-Hübner C,Ley D,Borg J,Smith LE,Hellström A

    更新日期:2009-05-01 00:00:00

  • Impact of music on pediatric oncology outpatients.

    abstract::Music is widely used to enhance well-being. We wished to assess music's effect on pediatric oncology outpatients. Patients who had leukemia and were in maintenance or consolidation outpatient treatment served as their own control at two visits. At visit 1, children rested for 20 min; at visit 2, for 20 min they listen...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kemper KJ,Hamilton CA,McLean TW,Lovato J

    更新日期:2008-07-01 00:00:00

  • Developmental expression of calcitriol receptors, 9-kilodalton calcium-binding protein, and calcidiol 24-hydroxylase in human intestine.

    abstract::Human intestinal mucosa consists of highly active epithelial cells in continual renewal and differentiation processes located at different portions of the villi. The crypt contains abundant replicating cells which, upon reaching the villus tip, acquire their fully differentiated state. Besides its well recognized role...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Delvin EE,Lopez V,Levy E,Ménard D

    更新日期:1996-11-01 00:00:00

  • Glucose metabolism of human mononuclear cell subpopulations.

    abstract::Previous studies have demonstrated metabolic dysfunction in the mononuclear cells of some children with abnormal cell-mediated immunity. Interpretation of these observations has been complicated by the extreme heterogeneity of cell types examined. The glycolytic metabolism of relatively enriched T-cells, non-T mononuc...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Storch S,Klein W,Feig SA,Henderson T

    更新日期:1980-02-01 00:00:00

  • Sleep state organization in premature infants of less than 35 weeks' gestational age.

    abstract::To assess sleep organization in premature infants of < 35 wk gestational age (w GA), we performed polygraphic recordings in 24 neurologically normal neonates (eight per group): artificially ventilated 27-30 and 31-34 w GA infants and nonventilated 31-34 w GA infants. Sleep states were defined by concordance of EEG and...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Curzi-Dascalova L,Figueroa JM,Eiselt M,Christova E,Virassamy A,d'Allest AM,Guimarâes H,Gaultier C,Dehan M

    更新日期:1993-11-01 00:00:00