Abstract：
:Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although systemic and cerebrovascular physiologic factors play an important role in the initial phases of hypoxic-ischemic injuries, the intrinsic vulnerability of specific cell types and systems in the developing brain may be more important in determining the final pattern of damage and functional disability. Excitotoxicity, a term applied to the death of neurons and certain other cells caused by overstimulation of excitatory, mainly glutamate, neurotransmitter receptors, plays a critical role in these processes. Selected neuronal circuits as well as certain populations of glia such as immature periventricular oligodendroglia may die from excitotoxicity triggered by hypoxic ischemia. These patterns of neuropathologic vulnerability are associated with clinical syndromes of neurologic disability such as the extrapyramidal and spastic diplegia forms of cerebral palsy. The cascade of biochemical and histopathologic events triggered by hypoxic ischemia can extend for days to weeks after the insult is triggered, creating the potential for therapeutic interventions.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Johnston MV,Trescher WH,Ishida A,Nakajima Wdoi
10.1203/00006450-200106000-00003subject
Has Abstractpub_date
2001-06-01 00:00:00pages
735-41issue
6eissn
0031-3998issn
1530-0447journal_volume
49pub_type
杂志文章,评审abstract：:We investigated whether obese children and adolescents have early echocardiographic signs of subclinical cardiac dysfunction and evaluated the respective influence of obesity per se versus parameters of carbohydrate and lipid metabolism that are frequently abnormal in obese subjects. The role of tissue Doppler imaging...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e318176182b
更新日期：2008-08-01 00:00:00
abstract：:To determine the influence of an altered carotid body function on the laryngeal chemoreflex (LCR) response, reflex apnea was induced by laryngeal water stimulation during normoxia or acute hypoxia in unanesthetized awake lambs in which the ventilatory response to acute hypoxia was attenuated by prolonged postnatal hyp...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199312000-00024
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Staphylococcus epidermidis (SE) is an important cause of late-onset sepsis in neonates. SE frequently produces a polysaccharide intercellular adhesin (PIA) biofilm, important in the pathogenesis of these infections. Little is known about how the neonatal innate immune system reacts to SE biofilm-associated i...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2012.193
更新日期：2013-03-01 00:00:00
abstract：:Small bowel resection decreases brush border membrane (BBM) glucose uptake kinetics. Oral epidermal growth factor (EGF) returns net glucose transport across intact tissue to control levels despite persistence of a defect in BBM glucose uptake. The purpose of this study was to examine the effects of resection and EGF t...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000098500.94041.9B
更新日期：2004-01-01 00:00:00
abstract：:Although cisapride is widely used to treat gastrointestinal motility disorders, it has been associated with QT prolongation, torsades de pointes, and cardiac arrest. Only in children, however, has atrioventricular (AV) block after cisapride been reported. This study used Langendorff perfusion to determine the direct e...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000050122.67091.1D
更新日期：2003-03-01 00:00:00
abstract：:The investigation was designed to explore the use of tests tapping reversible aspects of behavior and performance and to find out whether these data can be correlated with concurrent metabolic changes in different dietary phases. The four subjects had classic phenylketonuria, diagnosed on the basis of a high level of ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197601000-00003
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Food allergy is common in children with prevalence up to 10%. We assessed the clinico-laboratory characteristics and frequency of food sensitization to the commonly consumed food among upper Egyptian preschool children with recurrent wheezy chest. METHODS:This cross-sectional descriptive study was conducted...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0960-0
更新日期：2020-10-01 00:00:00
abstract：:Although the pathogenesis of necrotizing enterocolitis remains uncertain, ischemia appears to be an important contributing factor to the development of this disorder. Reperfusion plays a major role in ischemia-related injury, and oxygen free radicals produced during reperfusion most likely contribute to the injury. Th...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199708000-00009
更新日期：1997-08-01 00:00:00
abstract：:The primary manifestations of Pompe disease are muscle weakness and cardiomyopathy. Although accumulation of glycogen has also been seen in the nervous system in patients, the significance of brain involvement in infantile-onset Pompe disease is not clear. In this study, brain development in five cases of infantile-on...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000233014.84318.4e
更新日期：2006-09-01 00:00:00
abstract：:Brain injury remains one of the major unsolved problems in neonatal care, with survivors at high risk of lifelong neurodisability. It is unlikely that a single intervention can ameliorate neonatal brain injury, given the complex interaction between pathological processes, developmental trajectory, genetic susceptibili...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/s41390-019-0729-5
更新日期：2019-12-18 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198908000-00012
更新日期：1989-08-01 00:00:00
abstract：:Blue and white phototherapy was given to infant (and weanling) homozygous Gunn rats treated with different doses of riboflavin-5-phosphate (ribofl.5'p.) During the first hours after a flavin-injection, the effect of phototherapy with both types of fluorescent lamps was enhanced. With equal radiant power applied, the s...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197912000-00001
更新日期：1979-12-01 00:00:00
abstract：:Changes in high-density lipoprotein (HDL) subclass distribution were evaluated in a group of premature infants during the early postnatal period to ascertain whether enteral feeding brought about a rapid shift from neonatal to adult-like distributions. All infants were fed a combination of breast milk and formula. Cor...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198806000-00001
更新日期：1988-06-01 00:00:00
abstract：INTRODUCTION:The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) serves 50% of infants and 25% of preschool-aged children in the United States and collects height and weight measurements from eligible children every 6 mo, making WIC data a valuable resource for studying childhood growth an...
journal_title：Pediatric research
pub_type： 杂志文章,多中心研究
doi：10.1038/pr.2011.37
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:The pathogenesis of neonatal group B Streptococcus (GBS) lung infection may be associated with surfactant dysfunction or deficiency. This study aimed to investigate the efficacy of surfactants on early postnatal GBS infection in ventilated newborn rabbit lungs. METHODS:A near-term newborn rabbit model was e...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0421-9
更新日期：2019-08-01 00:00:00
abstract：:Twenty-two reported cases of neuroblastoma missed by the mass screening programs were reviewed (six cases in Sapporo City where a quantitative measurement for both vanillylmandelic acid (VMA) and homovanillic acid (HVA) is used and 16 cases in the districts of qualitative judgment only for VMA), and some potential fac...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198912000-00018
更新日期：1989-12-01 00:00:00
abstract：:BackgroundThe mechanisms underlying aberrant activation of intestinal Toll-like receptor 4 (TLR4) signaling in necrotizing enterocolitis (NEC) remain unclear. In this study, we examined the role of single-immunoglobulin interleukin-1 receptor-related molecule (SIGIRR), an inhibitor of TLR signaling, in modulating expe...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.211
更新日期：2018-01-01 00:00:00
abstract：:The intranasal live attenuated influenza vaccine (LAIV), FluMist, has been widely appreciated by pediatricians, parents, and children alike for its ease of administration. However, concerns regarding lack of effectiveness in recent influenza seasons led to the CDC Advisory Committee on Immunization Practices (ACIP) re...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2017.239
更新日期：2018-01-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/PDR.0b013e3181b0cbd8
更新日期：2009-10-01 00:00:00
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journal_title：Pediatric research
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更新日期：2019-02-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2012.6
更新日期：2012-05-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197708000-00008
更新日期：1977-08-01 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0999-y
更新日期：2020-06-05 00:00:00
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journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000047653.73271.C4
更新日期：2003-02-01 00:00:00
abstract：:Hereditary surfactant protein B (SP-B) deficiency has been lethal in the first year of life without lung transplantation. We tested the hypothesis that SP-B gene mutations may result in milder phenotypes by investigating the mechanisms for lung disease in two children with less severe symptoms than have been previousl...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200009000-00003
更新日期：2000-09-01 00:00:00
abstract：:To understand scoliosis, related comorbidities, and phenotype-genotype correlations in individuals with Rett syndrome (RTT), the Rare Disease Clinical Research Network database for RTT was probed. Clinical evaluations included a detailed history and physical examination, comprehensive anthropometric measurements, and ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181d0187f
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Physical activity (PA) is essential for children throughout their growth and maturation. It improves physiological and psychological health and limits the risk of developing metabolic disorders. However, some chronic physiological and metabolic diseases may lead to decreased PA. The diversity of outcomes in ...
journal_title：Pediatric research
pub_type： 杂志文章,meta分析
doi：10.1038/s41390-019-0409-5
更新日期：2019-08-01 00:00:00
abstract：:Tolazoline is used in neonatal intensive care to treat hypoxia secondary to persistent pulmonary hypertension of the newborn. Its use is often complicated by systemic hypotension. We compared the effect of tolazoline-induced hypotension on organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199008000-00007
更新日期：1990-08-01 00:00:00
abstract：:We investigated the relative contribution of the two pathways of phosphatidylcholine (PC) synthesis in lungs from chick embryos of 12 to 20 days of incubation as well as from hatched chicks and adult chickens. Lung "blocks" were incubated for 60 min in vitro in the presence of [3H]methionine and [14C]choline. PC was s...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198105000-00008
更新日期：1981-05-01 00:00:00
abstract：:The objective was to investigate any possible relationship between functional and structural vascular changes in women with low gestational age and/or low birth weight by analyzing the retinal vascular pattern in women with thoroughly documented blood pressure. Retinal vessel morphology was evaluated by digital image ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200206000-00003
更新日期：2002-06-01 00:00:00
