Prolonged survival in hereditary surfactant protein B (SP-B) deficiency associated with a novel splicing mutation.

abstract：:Cerebral concentrations of phenylalanine (PHE) were measured by means of quantitative in vivo 1H MR spectroscopy in 8 adult patients treated early for phenylketonuria type I. A 1.5-Tesla routine magnetic resonance scanner, localization sequence with short echo time (20 ms), and a fully automated data processing scheme...

journal_title：Pediatric research

authors： Pietz J,Kreis R,Boesch C,Penzien J,Rating D,Herschkowitz N

更新日期：1995-11-01 00:00:00

abstract：:Platelet-activating factor (PAF) has been implicated in the pathogenesis of gastrointestinal diseases such as necrotizing enterocolitis, Crohn's disease, and ulcerative colitis. However, neither the physiologic role of PAF in the intestine, nor the mechanisms by which PAF participates in the pathogenesis of disease ar...

journal_title：Pediatric research

authors： Claud EC,Li D,Xiao Y,Caplan MS,Jilling T

更新日期：2002-08-01 00:00:00

abstract：:We investigated the role of circulating bone marrow cells (BMC) in cardiomyocyte regeneration. BMC, isolated from transgenic mice expressing enhanced green fluorescent protein (GFP), were transplanted into lethally irradiated C57BL6 mice. Five weeks after bone marrow transplantation (BMT), flow cytometric analysis for...

journal_title：Pediatric research

authors： Kuramochi Y,Fukazawa R,Migita M,Hayakawa J,Hayashida M,Uchikoba Y,Fukumi D,Shimada T,Ogawa S

更新日期：2003-09-01 00:00:00

abstract：:Deficient quantity of amniotic fluid causes fetal guinea pig lung hypoplasia. Oligohydramnios that lasts only 5 days in early gestation is sufficient to reduce fetal lung growth significantly. We quantitated lung structural alterations at 50 days gestation (term is 67 days) of fetal guinea pigs whose amniotic fluid wa...

journal_title：Pediatric research

authors： Collins MH,Moessinger AC,Kleinerman J,James LS,Blanc WA

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Near-infrared spectroscopy is used in the assessment of regional splanchnic oxygen saturation (rsSO2), but solid reference values are scarce. We aimed to establish reference values of rsSO2 for preterm infants during the first week after birth, both crude and modeled based on predictors. METHODS:We included...

journal_title：Pediatric research

authors： van der Heide M,Dotinga BM,Stewart RE,Kalteren WS,Hulscher JBF,Reijneveld SA,Bos AF,Kooi EMW

更新日期：2021-01-27 00:00:00

abstract：:This work examines the dynamic surface pressure-area behavior of films of unconjugated bilirubin spread from chloroform solution at 22 degrees C on 0.15 M NaCl and buffered phosphate subphases. Film behavior is examined at pH 5.5, 7.4 and 8.0. The interactions of bilirubin in mixed films with dipalmitoyl phosphatidylc...

journal_title：Pediatric research

authors： Notter RH,Shapiro DL,Taubold R,Chen J

更新日期：1982-02-01 00:00:00

abstract：:Hirschsprung's disease, affecting one in 5000 live newborns, is the most common cause of neonatal intestinal obstruction. The obstruction or, later in life, constipation arises from the lack of enteric ganglia in the hindgut, thus resulting in poor coordination of peristalsis. Mutations in Hirschsprung patients have s...

journal_title：Pediatric research

authors： Svensson PJ,Von Tell D,Molander ML,Anvret M,Nordenskjöld A

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Phytosterols in soybean oil (SO) lipids likely contribute to parenteral nutrition-associated liver disease (PNALD) in infants. No characterization of phytosterol metabolism has been done in infants receiving SO lipids. METHODS:In a prospective cohort study, 45 neonates (36 SO lipid vs. 9 control) underwent ...

journal_title：Pediatric research

authors： Nghiem-Rao TH,Tunc I,Mavis AM,Cao Y,Polzin EM,Firary MF,Wang X,Simpson PM,Patel SB

更新日期：2015-08-01 00:00:00

abstract：:Simultaneous measurements of serum immunoreactive thyrocalcitonin (iTCT), immunoreactive parathyroid hormone (iPTH), calcium, inorganic phosphate, magnesium, and alkaline phosphatase were made in 37 normal children whose ages ranged from 6-12 years. Between the ages of 6 and 12 there is a statistically significant ris...

journal_title：Pediatric research

authors： Shainkin-Kerstenbaum R,Funkenstein B,Conforti A,Shani S,Berlyne GM

更新日期：1977-02-01 00:00:00

abstract：:The objective was to investigate any possible relationship between functional and structural vascular changes in women with low gestational age and/or low birth weight by analyzing the retinal vascular pattern in women with thoroughly documented blood pressure. Retinal vessel morphology was evaluated by digital image ...

journal_title：Pediatric research

authors： Kistner A,Jacobson L,Jacobson SH,Svensson E,Hellstrom A

更新日期：2002-06-01 00:00:00

abstract：:Children treated for acute lymphoblastic leukemia may develop reduced bone mineral density during treatment, but there is little information on the mechanisms involved. In a prospective, longitudinal study on 15 children with ALL, we undertook serial measurements of markers of bone and collagen turnover, insulin-like ...

journal_title：Pediatric research

authors： Crofton PM,Ahmed SF,Wade JC,Elmlinger MW,Ranke MB,Kelnar CJ,Wallace WH

更新日期：2000-10-01 00:00:00

abstract：:We have previously shown that generation of superoxide anion occurs in cerebral cortex during asphyxia/reventilation in newborn pigs and that a high dose of indomethacin (5 mg/kg i.v.) abolishes superoxide anion production. The purposes of this study were 1) to determine whether the generation of superoxide anion occu...

journal_title：Pediatric research

authors： Pourcyrous M,Leffler CW,Bada HS,Korones SB,Busija DW

更新日期：1993-09-01 00:00:00

abstract：:BackgroundHyperoxic lung injury is characterized by cellular damage from high oxygen concentrations that lead to an inflammatory response and it disrupts normal alveolarization in the developing newborn lung. Adenosine is a signaling molecule that is generated extracellularly by ecto-5'-nucleotidase (CD73) in response...

journal_title：Pediatric research

authors： Li H,Karmouty-Quintana H,Chen NY,Mills T,Molina J,Blackburn MR,Davies J

更新日期：2017-08-23 00:00:00

abstract：:The objective of the present study is to compare the emergence of a circadian respiratory pattern in subsequent siblings of SIDS and controls infants to see whether the unique time and age of SIDS is correlated with altered circadian manifestations. During the first three months of life, a pattern in respiratory rates...

journal_title：Pediatric research

authors： Hoppenbrouwers T,Jensen DK,Hodgman JE,Harper RM,Sterman MB

更新日期：1980-04-01 00:00:00

abstract：:A study using fractional clearances during orally induced water diuresis was designed to delineate the mechanism underlying defective tubular reabsorption of sodium in very low-birth-weight neonates. The use of clearance methodology during maximal water diuresis may give an indirect estimate of distal sodium delivery ...

journal_title：Pediatric research

authors： Rodríguez-Soriano J,Vallo A,Oliveros R,Castillo G

更新日期：1983-12-01 00:00:00

abstract：:Defective arousal mechanisms are viewed as contributory to sleep hypopnea disorders and sudden infant death syndrome. Sighs (i.e. augmented breaths) as well as startles have not traditionally been viewed as arousal-related phenomena in infants. We hypothesized that, if sighs and startles are the initial event in a seq...

journal_title：Pediatric research

authors： Wulbrand H,McNamara F,Thach BT

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Childhood body mass index (BMI) trajectory classes are rarely linked to early puberty risk, particularly among Chinese children. We estimated early puberty risk across BMI trajectory classes, investigated factors contributing to pubertal development, and examined differences in final adult height between chi...

journal_title：Pediatric research

authors： Fan HY,Lee YL,Hsieh RH,Yang C,Chen YC

更新日期：2020-07-01 00:00:00

abstract：:Injuries continue to be the leading cause of morbidity and mortality for children, adolescents, and young adults aged 1-24 years in industrialized countries in the twenty-first century. In this age group, injuries cause more fatalities than all other causes combined in the United States (U.S.). Importantly, many of th...

journal_title：Pediatric research

authors： Dorney K,Dodington JM,Rees CA,Farrell CA,Hanson HR,Lyons TW,Lee LK,and the Injury Free Coalition for Kids®.

更新日期：2020-01-01 00:00:00

abstract：:We established an experimental animal model of the gastrointestinal colonization and systemic disease following oral challenge of type III group B streptococcal strain in 3-day-old newborn rats. Two type III group B streptococcal strains isolated from the cerebrospinal fluid of septic newborn infants produced coloniza...

journal_title：Pediatric research

authors： Kim KS,Dunn K,McGeary SA,Stiehm ER

更新日期：1984-12-01 00:00:00

abstract：:Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions ar...

journal_title：Pediatric research

authors： Berning RA,Klautz RJ,Teitel DF

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of neonatal group B Streptococcus (GBS) lung infection may be associated with surfactant dysfunction or deficiency. This study aimed to investigate the efficacy of surfactants on early postnatal GBS infection in ventilated newborn rabbit lungs. METHODS:A near-term newborn rabbit model was e...

journal_title：Pediatric research

authors： Xu Y,Dong Y,Guo X,Sun B

更新日期：2019-08-01 00:00:00

abstract：:Plasma, amniotic fluid, and tissue concentrations of IGF-I were examined in nutritionally deprived, growth-retarded fetal rats to determine whether IGF-I concentration serves as a marker for nutritional status. Growth retardation was induced by 72 h of maternal fasting. Twenty-three control and 17 growth-retarded fetu...

journal_title：Pediatric research

authors： Bernstein IM,DeSouza MM,Copeland KC

更新日期：1991-08-01 00:00:00

abstract：:Infants with sudden infant death syndrome have higher hypoxanthine (Hx) concentrations in their vitreous humor than infants with respiratory distress syndrome and other infant control populations. However, previous research on piglets and pigs applying continuous hypoxemia has not been able to reproduce the concentrat...

journal_title：Pediatric research

authors： Stoltenberg L,Rootwelt T,Oyasaeter S,Rognum TO,Saugstad OD

更新日期：1993-12-01 00:00:00

abstract：:Genetic variants of surfactant protein B (SP-B) have been associated with respiratory distress syndrome (RDS) in the prematurely born infant. We wished to determine linkage between RDS and SP-B single nucleotide polymorphisms (SNPs) [-18 (A/C), 1013 (A/C), 1580 (C/T), and 9306 (A/G)] or SP-B-linked microsatellite [(D2...

journal_title：Pediatric research

authors： Floros J,Thomas NJ,Liu W,Papagaroufalis C,Xanthou M,Pereira S,Fan R,Guo X,Diangelo S,Pavlovic J

更新日期：2006-04-01 00:00:00

abstract：:Intrahepatic and intracerebral metabolic responses to neonatal fasting or enteric carbohydrate alimentation were investigated among newborn dogs. Pups were either fasted or given an intravenous glucose infusion (alimented) before an enteric feeding of physiologic quantities of either glucose or galactose. These pups w...

journal_title：Pediatric research

authors： Kliegman RM,Miettinen EL,Morton SK

更新日期：1983-04-01 00:00:00

abstract：:Zidovudine (azidothymidine, AZT) is used in pregnancy to reduce mother to infant transmission of HIV. Understanding the disposition of AZT in the fetus is necessary to optimize therapeutic regimens directed toward the fetus. Recent studies in primates found similar steady-state levels of the glucuronide metabolite of ...

journal_title：Pediatric research

authors： Garland M,Szeto HH,Daniel SS,Tropper PJ,Myers MM,Stark RI

更新日期：1998-07-01 00:00:00

abstract：:Uteroplacental insufficiency alters the anabolic metabolism of the fetus, resulting in intrauterine growth retardation (IUGR). The metabolic and physiologic factors that cause IUGR have long standing consequences after birth. Postnatal growth and glucose metabolism are altered in the IUGR infant. Skeletal muscle is an...

journal_title：Pediatric research

authors： Lane RH,Chandorkar AK,Flozak AS,Simmons RA

更新日期：1998-05-01 00:00:00

abstract：:The effect of resuscitation with varying levels of O2 on pulmonary hemodynamics at birth is not well known. We hypothesized that the decrease in pulmonary vascular resistance (PVR) and subsequent response to pulmonary vasoconstrictors and vasodilators will differ following resuscitation with 21%, 50%, or 100% O2 for 3...

journal_title：Pediatric research

authors： Lakshminrusimha S,Russell JA,Steinhorn RH,Swartz DD,Ryan RM,Gugino SF,Wynn KA,Kumar VH,Mathew B,Kirmani K,Morin FC 3rd

更新日期：2007-09-01 00:00:00

abstract：:Glutaryl-CoA dehydrogenase (GCDH) deficiency is a rare inborn disorder of L-lysine, L-hydroxylysine, and L-tryptophan metabolism complicated by striatal damage during acute encephalopathic crises. Three decades after its description, the natural history and how to treat this disorder are still incompletely understood....

journal_title：Pediatric research

authors： Kölker S,Garbade SF,Greenberg CR,Leonard JV,Saudubray JM,Ribes A,Kalkanoglu HS,Lund AM,Merinero B,Wajner M,Troncoso M,Williams M,Walter JH,Campistol J,Martí-Herrero M,Caswill M,Burlina AB,Lagler F,Maier EM,Schwahn B

更新日期：2006-06-01 00:00:00

abstract：:The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between clinically obese black and white children and if a difference existed to determine whether it was related to hematological profiles and/or physical activity/inactivity levels. Twenty-three black and 21 white...

journal_title：Pediatric research

authors： Andreacci JL,Robertson RJ,Dubé JJ,Aaron DJ,Dixon CB,Arslanian SA

更新日期：2005-09-01 00:00:00