Insulin-like growth factor I in substrate-deprived, growth-retarded fetal rats.

abstract：:Human milk was fractionated to obtain a partially purified growth factor preparation. The growth factor in this fraction, designated as human milk growth factor III, exhibits chromatographic and biological characteristics similar to epidermal growth factor-urogastrone. Pretreatment of mice with human milk growth facto...

journal_title：Pediatric research

authors： Dai S,Klagsbrun M,Shing YW

更新日期：1985-09-01 00:00:00

abstract：:We describe a method based on a Fabry-Perot interferometer at the tip of an optic fiber with a diameter of 0.25 mm for direct measurement of tracheal pressure in pediatric respiratory monitoring. The response time of the pressure transducer and its influence on the resistance of pediatric endotracheal tubes (internal ...

journal_title：Pediatric research

authors： Sondergaard S,Karason S,Hanson A,Nilsson K,Hojer S,Lundin S,Stenqvist O

更新日期：2002-03-01 00:00:00

abstract：:Prematurity is associated with delayed postnatal activation of mitochondrial oxidative phosphorylation and impaired switch from glycolytic to oxidative metabolism. Fatty acids (FA), which represent a major energy substrate in mature muscle cells, are engaged in the postnatal activation of genes of energy metabolism an...

journal_title：Pediatric research

authors： Brauner P,Kopecký P,Flachs P,Ruffer J,Sebron V,Plavka R,Vítková I,Vorlícek J,Kopecký J

更新日期：2003-04-01 00:00:00

abstract：:To determine whether human milk contained soluble receptors and cytokine antagonists that might contribute to its anti-inflammatory properties, ELISA and enzyme-amplified sensitivity immunoassay methods were used to quantitate soluble intercellular and vascular cell adhesion molecules, soluble E-selectin, soluble IL-6...

journal_title：Pediatric research

authors： Buescher ES,Malinowska I

更新日期：1996-12-01 00:00:00

abstract：:Pathomechanisms involved in obstructive apneas remain obscure. Apnea arousal failure has been proposed as a cause for sudden death during sleep. The present study hypothesizes an interdependency between upper airway dilating submental muscle electromyogram (EMG) activity (EMGsub), diaphragmatic muscle activity (EMGdia...

journal_title：Pediatric research

authors： Wulbrand H,Von Zezschwitz G,Bentele KH

更新日期：1995-09-01 00:00:00

abstract：:Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia, hypoxic ischemic encephalopathy, and intraventricular hemorrhage. Absent engraftment an...

journal_title：Pediatric research

authors： Park WS,Ahn SY,Sung SI,Ahn JY,Chang YS

更新日期：2018-01-01 00:00:00

abstract：:The head sizes of 38 patients, growth hormone (GH) deficient following craniospinal (n = 26) or cranial irradiation (n = 12), have been assessed before (n = 38) and on completion of GH therapy (n = 15) or at the end of a similar period of observation without GH (n = 7). These results were compared to the change in hea...

journal_title：Pediatric research

authors： Clayton PE,Shalet SM,Price DA,Surtees RA,Pearson D

更新日期：1987-10-01 00:00:00

abstract：:Increased fetal lung expansion profoundly inhibits surfactant protein gene expression and stimulates cellular proliferation in the fetal lung. Our aim was to determine whether increased expansion of the lung after birth, by the application of a continuous positive airway pressure (CPAP) for 12 h, inhibits surfactant p...

journal_title：Pediatric research

authors： Lines AL,Davey MG,Harding R,Hooper SB

更新日期：2001-12-01 00:00:00

abstract：:This study aimed to characterize early neonatal microvascular function after preeclamptic pregnancy with respect to infant sex and in utero growth. Peripheral microvascular blood flow was examined prospectively from 6 to 72 h of age using laser Doppler flowmetry in a cohort of term infants of normotensive women and wo...

journal_title：Pediatric research

authors： Stark MJ,Clifton VL,Wright IM

更新日期：2009-03-01 00:00:00

abstract：:Developmental differences in myocardial performance are known to exist. It is likely that the profile of protein isoforms present on the developing thin filament contributes to these observed differences. We have prepared thin filaments from developing and mature rat hearts by using an immunoprecipitation procedure de...

journal_title：Pediatric research

authors： L'Ecuyer TJ,Schulte D,Lin JJ

更新日期：1991-09-01 00:00:00

abstract：:The objective of this study was to obtain insight into bone formation and resorption in children with newly diagnosed untreated acute lymphoblastic leukemia (ALL). In 23 consecutive children with ALL, a bone biopsy was taken from the crista iliaca posterior under ketamine anesthesia, together with the diagnostic marro...

journal_title：Pediatric research

authors： Leeuw JA,Koudstaal J,Wiersema-Buist J,Kamps WA,Timens W

更新日期：2003-12-01 00:00:00

abstract：:The lipid profile, total cholesterol, triglycerides, and lipoproteins (beta-, pre-beta-, and alpha-) of cord blood, is presented for 419 black and white infants (94% of the eligible population) born during an 18-month period in Bogalusa, Louisiana. At birth, white neonates of both sexes had higher average levels than ...

journal_title：Pediatric research

authors： Frerichs RR,Srinivasan SR,Webber LS,Rieth MC,Berenson GS

更新日期：1978-08-01 00:00:00

abstract：:Tracheal epithelial cells obtained from adult and infant ferrets were grown in primary culture in vitro. Cells from adult animals grew readily, and many ciliated cells were observed in the cultures. Successful cultures were derived from infant animals, but cell number in infant and adult cultures began to decrease aft...

journal_title：Pediatric research

authors： Kercsmar CM,Chung Y,Davis PB

更新日期：1991-07-01 00:00:00

abstract：:Infants dying with bronchopulmonary dysplasia (BPD) demonstrate increased numbers of pulmonary neuroendocrine cells (PNEC). These infants also possess altered airway epithelial and smooth muscle dimensions reminiscent of oxygen-exposed animals. Because the pathogenesis of BPD involves oxygen toxicity, we hypothesized ...

journal_title：Pediatric research

authors： Shenberger JS,Shew RL,Johnson DE

更新日期：1997-10-01 00:00:00

abstract：:Synchronized atrial contraction may be much more important in the newborn, who has a faster heart rate and a less compliant ventricle, than in the adult. We therefore investigated the extent by which synchronized atrioventricular contraction contributes to cardiac output and cardiac work in a neonatal circulation, and...

journal_title：Pediatric research

authors： Klautz RJ,Baan J,Teitel DF

更新日期：1998-03-01 00:00:00

abstract：:In dissociated whole brain cell cultures from newborn mice, we have previously shown that during glucose deprivation under normoxia, D-beta-hydroxybutyrate and oleic acid are increasingly used for energy production. We now asked whether this glucose dependency of the utilization of D-beta-hydroxybutyrate and oleic aci...

journal_title：Pediatric research

authors： Bossi E,Kohler E,Herschkowitz N

更新日期：1989-11-01 00:00:00

abstract：:We studied the effect of maternal concentration and mode of administration on transfer rate of TSH-releasing hormone (TRH) in an in vitro model of dually perfused isolated lobule of human term placenta. Varying concentrations (4-40 microg dL(-1)) of TRH were added either to the open maternal circulation to mimic an in...

journal_title：Pediatric research

authors： Bajoria R,Fisk NM

更新日期：1997-05-01 00:00:00

abstract：:Four protein dietary groups of rats were used in this study, namely: 27% casein diet fed throughout gestation and lactation (group C-C); 27% gestation, 10% lactation (group C-D); 10% gestation, 27% lactation (group D-C); 10% throughout gestation and lactation (group D-D). Mean body weight of group D-D at warning was 1...

journal_title：Pediatric research

authors： Kissane JQ,Hawrylewicz EJ

更新日期：1975-03-01 00:00:00

abstract：:Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions ar...

journal_title：Pediatric research

authors： Berning RA,Klautz RJ,Teitel DF

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:For the second aim of the Kellogg Foundation grant, this double-blind RCT investigated the impact of plasma vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy. We hypothesized that higher 25(OH)D concentrations would associate with reduced pro-inflammatory and incr...

journal_title：Pediatric research

authors： Khatiwada A,Wolf BJ,Mulligan JK,Shary JR,Hewison M,Baatz JE,Newton DA,Hawrylowicz C,Hollis BW,Wagner CL

更新日期：2020-04-20 00:00:00

abstract：:The metabolic demands of the newborn heart are met primarily by glucose and lactate. Mitochondria are impermeable to the NADH produced by these cytosolic reactions. The malate/aspartate and alpha-glycerophosphate (alpha-GP) shuttles provide two pathways to transport reducing equivalents into mitochondria. The goals of...

journal_title：Pediatric research

authors： Scholz TD,Koppenhafer SL

更新日期：1995-08-01 00:00:00

abstract：:This prospective randomized pilot study aimed to test the hypotheses that partial liquid ventilation combined with a high positive end-expiratory pressure (PEEP) and a moderate tidal volume results in improved gas exchange and lung mechanics without negative hemodynamic influences compared with conventional mechanical...

journal_title：Pediatric research

authors： Rödl S,Urlesberger B,Knez I,Dacar D,Zobel G

更新日期：2002-08-01 00:00:00

abstract：:The fetal brain develops rapidly during the last trimester of pregnancy. Therefore, the brain of infants who are born preterm is vulnerable to changes in oxygen and nutrient supply in the neonatal period. The objective was to determine the effect of gestational age (GA) on the cerebral O2 supply threshold level for pr...

journal_title：Pediatric research

authors： van Os S,Liem D,Hopman J,Klaessens J,van de Bor M

更新日期：2005-03-01 00:00:00

abstract：:Taurine is an essential amino acid during fetal life and appears to be vital for the growth of the fetus and for the development of the CNS. In intrauterine growth restriction (IUGR), fetal plasma concentrations of taurine are reduced, and we tested the hypothesis that this is caused by altered placental transport of ...

journal_title：Pediatric research

authors： Norberg S,Powell TL,Jansson T

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Regular physical activity provides children with health and developmental benefits. This study investigated if active play and walking with the family dog was associated with better social-emotional development in young children. METHODS:We surveyed 1646 parents to ascertain if families with pre-schoolers o...

journal_title：Pediatric research

authors： Wenden EJ,Lester L,Zubrick SR,Ng M,Christian HE

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:A lack of consensus exists as to the timing of kidney biopsy in children with steroid-dependent nephrotic syndrome (SDNS) where minimal change disease (MCD) predominates. This study aimed at examining the applicability of a biomarker-assisted risk score model to select SDNS patients at high risk of focal seg...

journal_title：Pediatric research

authors： Chan CY,Resontoc LP,Qader MA,Chan YH,Liu ID,Lau PY,Than M,Yeo WS,Loh AH,Tan PH,Wei C,Reiser J,Biswas SK,Ng KH,Yap HK

更新日期：2019-03-01 00:00:00

abstract：:Previous studies suggest that the endotoxin lipopolysaccharide (LPS) may have dual effects on brain damage induced by hypoxia-ischemia (HI) in 7-d-old rats, depending on the exposure paradigm. Although a 4-h interval between LPS administration and HI results in sensitization to HI brain injury, tolerance is observed w...

journal_title：Pediatric research

authors： Ikeda T,Yang L,Ikenoue T,Mallard C,Hagberg H

更新日期：2006-01-01 00:00:00

abstract：:Previously, we have reported marked pulmonary inflammation in infants who develop chronic lung disease of prematurity. We revisited these infants who did not have clinical or laboratory evidence of infection and searched for Ureaplasma urealyticum, group B streptococci, and other microbes by reverse transcription-PCR ...

journal_title：Pediatric research

authors： Kotecha S,Hodge R,Schaber JA,Miralles R,Silverman M,Grant WD

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Maternal smoking impairs fetal growth; however, if postnatal growth differs between children born small for gestational age (SGA) with smoking and non-smoking mother is unknown. METHODS:Cohort-study of term born children born appropriate for gestational age with non-smoking mother (AGA-NS, n = 30,561), SGA ...

journal_title：Pediatric research

authors： Lindström L,Wikström AK,Bergman E,Mulic-Lutvica A,Högberg U,Ahlsson F,Lundgren M

更新日期：2019-06-01 00:00:00

abstract：:Three patients with Menkes' disease, an inherited disorder of copper transport, were studied to determine whether the copper deficiency was associated with a lipoprotein disorder. Hypocuprinemia was documented in all three cases. Two patients had severe copper and ceruloplasmin deficiencies, whereas the third patient ...

journal_title：Pediatric research

authors： Blackett PR,Lee DM,Donaldson DL,Fesmire JD,Chan WY,Holcombe JH,Rennert OM

更新日期：1984-09-01 00:00:00