Abstract:
:Prematurity is associated with delayed postnatal activation of mitochondrial oxidative phosphorylation and impaired switch from glycolytic to oxidative metabolism. Fatty acids (FA), which represent a major energy substrate in mature muscle cells, are engaged in the postnatal activation of genes of energy metabolism and lipid oxidation. To understand the mechanism activating mitochondria in human newborns, expression of the genes for mitochondrial uncoupling proteins (UCP) was characterized in autopsy samples of skeletal (n = 28) and cardiac (n = 13) muscles of preterm neonates, who mostly died during the first postnatal month, and two aborted fetuses. Transcripts levels for UCP2, UCP3, and also for genes engaged in the transport of FA between cytoplasm and mitochondria were measured using real-time reverse transcriptase PCR. In accordance with studies in mice, our results document postnatal induction of UCP3 gene expression in skeletal muscle, involvement of nutritional FA in the induction, and a role of UCP3 in mitochondrial FA oxidation. They suggest impaired postnatal activation of UCP3 gene in neonates delivered before approximately 26 wk of gestation. Mean levels of the UCP3 transcript in skeletal muscle were by two orders of magnitude higher than in the heart. In contrast to UCP3, the UCP2 gene was active in fetuses, and its expression was not affected by nutrition. Our results support a role of UCP3 in postnatal activation of lipid oxidation in skeletal muscle and suggest the involvement of UCP3 in the delayed activation of mitochondrial energy conversion in very immature preterm neonates.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Brauner P,Kopecký P,Flachs P,Ruffer J,Sebron V,Plavka R,Vítková I,Vorlícek J,Kopecký Jdoi
10.1203/01.PDR.0000054687.07095.0Bsubject
Has Abstractpub_date
2003-04-01 00:00:00pages
691-7issue
4eissn
0031-3998issn
1530-0447pii
01.PDR.0000054687.07095.0Bjournal_volume
53pub_type
杂志文章abstract::Increased deposition of hyaluronan (HA) is part of the early response to fibrogenic stimulus in the lung exposed to bleomycin injury and has been associated with increased lung water in adult animals. Early respiratory distress syndrome (RDS) in premature infants is characterized by increased lung water, and late sequ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199402000-00024
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Aminoglycoside exposure is a common cause of acute kidney injury (AKI). Delay in the diagnosis of AKI using conventional biomarkers has been one of the important obstacles in applying early effective interventions. We tested the hypothesis that urinary metabolomics could identify novel early biomarkers for t...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2013.34
更新日期:2013-05-01 00:00:00
abstract::Cerebellar injury has been increasingly recognized as a complication of preterm birth, with decreased cerebellar volumes seen on follow-up neuroimaging. A cohort of 38 preterm newborns, including 14 with two scans, was studied with MRI, including single-shot fast spin-echo diffusion tensor imaging (DTI) sequence speci...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181a1fb3d
更新日期:2009-07-01 00:00:00
abstract::Several neuropathologic findings in infants and children with human immunodeficiency virus type-1 (HIV-1) infection are different from those observed in adults, probably related to the fact that the retroviral infection occurs in the setting of neuro-development. This report describes the interaction and biologic acti...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199511000-00025
更新日期:1995-11-01 00:00:00
abstract::Human intestinal mucosa consists of highly active epithelial cells in continual renewal and differentiation processes located at different portions of the villi. The crypt contains abundant replicating cells which, upon reaching the villus tip, acquire their fully differentiated state. Besides its well recognized role...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199611000-00004
更新日期:1996-11-01 00:00:00
abstract::LBW infants are at risk of iron deficiency (ID), which is associated with impaired nervous system development and may lead to prolonged auditory brainstem response (ABR) latencies. We hypothesized that iron supplementation shortens ABR latencies in marginally LBW (MLBW, 2000-2500 g) infants. In a randomized, controlle...
journal_title:Pediatric research
pub_type: 杂志文章,随机对照试验
doi:10.1203/PDR.0b013e3182320cd0
更新日期:2011-12-01 00:00:00
abstract::Milk gangliosides inhibit Vibrio cholerae enterotoxin and Escherichia coli heat-labile enterotoxin. Human milk gangliosides showed considerably higher enterotoxin-inhibitory activity compared to bovine and formula milk gangliosides as measured in vitro by enzyme-linked immunosorbent assay and in vivo in rabbit small b...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198605000-00008
更新日期:1986-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2012.126
更新日期:2012-12-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1038/pr.2016.65
更新日期:2016-08-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/01.pdr.0000252439.48564.37
更新日期:2007-03-01 00:00:00
abstract::The functional activity of naturally acquired IgG and IgM with specificity for the capsular polysaccharide of type III, group B Streptococcus (III-GBS) was compared. Sera collected during convalescence from 14 infants who had developed specific antibodies following III-GBS infection were employed for separation of IgG...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198801000-00007
更新日期:1988-01-01 00:00:00
abstract::Continuous EEG monitoring has not been used widely in neonatal intensive care, especially in the care of extremely premature infants, probably in part because of a lack of a reliable quantitative method. The purpose of this study was to quantify the EEG of the very premature infants just after birth by using spectral ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.PDR.0000153868.77623.43
更新日期:2005-03-01 00:00:00
abstract::The fetal and maternal concentration of various plasma proteins alters during pregnancy. Cells in the livers of fetal hamsters accumulate serum amyloid A (SAA) and C-reactive protein (CRP) mRNA, major acute phase reactants, when lipopolysaccharide is administered to the fetal circulation. No fetal SAA or CRP mRNA resp...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199111000-00010
更新日期:1991-11-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198408000-00018
更新日期:1984-08-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/00006450-200003000-00017
更新日期:2000-03-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197601000-00003
更新日期:1976-01-01 00:00:00
abstract::The IQ's of Jamaican boys aged 6-10 were associated significantly with the presence or absence of severe malnutrition in infancy, with height at time of IQ testing, and with a measure of the boys' social background. A multiple correlation coefficient of 0.674 was obtained between IQ and the three factors. Social backg...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197601000-00011
更新日期:1976-01-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199205000-00021
更新日期:1992-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199210000-00016
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198409000-00015
更新日期:1984-09-01 00:00:00
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doi:10.1203/PDR.0b013e31821b9d7c
更新日期:2011-07-01 00:00:00
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更新日期:2021-01-19 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198307000-00004
更新日期:1983-07-01 00:00:00
abstract::Little is known about factors determining height outcome during GH treatment in Turner syndrome (TS). We investigated 987 TS children within the Kabi International Growth Study (KIGS) who had reached near adult height (NAH) after >4 y GH treatment (including >1 y before puberty). Through multiple regression analysis w...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.pdr.0000250039.42000.c9
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that infantile hypertrophic pyloric stenosis (IHPS) and congenital heart defects (CHDs) may share some genetic risk factors, but little is known about the co-occurrence of the two conditions in patients. METHODS:Our study cohort included 2,212,756 persons born in Denmark 1977-2013. We...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-019-0369-9
更新日期:2019-06-01 00:00:00
abstract::Obese children have a great risk of hypertension and cardiovascular morbidity in adults. The insulin-like growth factor type II (IGF-II) regulates glucose homeostasis, cardiovascular functions, and lipid metabolism. IGF2 gene variants have shown a strong association with weight, body mass index (BMI), and metabolic pr...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181d22757
更新日期:2010-04-01 00:00:00
abstract::The proposed actions of atrial natriuretic factor (ANF) are mediated through specific plasma membrane (R1) receptors coupled to guanylate cyclase. A second receptor, R2, has been characterized by its ability to bind to an acyclic, truncated ANF analog (C-ANF4-23). The ANF-R2 receptor has not been identified in the fet...
journal_title:Pediatric research
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Oxygen is critical for multicellular existence. Its reduction to water by the mitochondrial electron transport chain helps supply the metabolic demands of human life. The incompletely reduced, reactive oxygen byproducts of this reaction, however, can be quite toxic. In this review, we explore the mechanisms responsibl...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1203/PDR.0b013e31818fc83f
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD) is an important cause of morbidity. The aim of this study was to evaluate the preventive effect of cytidine 5'-diphosphocholine (CDP-choline) treatment on hyperoxic lung injury in a neonatal rat model. METHODS:A total of 30 newborn pups were divided into control, hyperoxia, ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2013.68
更新日期:2013-07-01 00:00:00
abstract::The antiendotoxin effect of polymyxin B was investigated in experimentally induced septicemia in rabbits. The Pasteurella multocida organisms were sensitive to the antibacterial action of penicillin but not to polymyxin B. Animals pre-treated with polymyxin showed positive blood cultures and significantly reduced plas...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197901000-00011
更新日期:1979-01-01 00:00:00