Blood metabolomics in infants enrolled in a dose escalation pilot trial of budesonide in surfactant.

abstract：BACKGROUND:Early identification of infants at risk for complications from patent ductus arteriosus (PDA) may improve treatment outcomes. The aim of this study was to identify biochemical markers associated with persistence of PDA, and with failure of pharmacological treatment for PDA, in extremely preterm infants. MET...

journal_title：Pediatric research

authors： Olsson KW,Larsson A,Jonzon A,Sindelar R

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. NeoDoppler is a novel ultrasound system, which can be gently fixed to the anterior fontanel and measure...

journal_title：Pediatric research

authors： Vik SD,Torp H,Follestad T,Støen R,Nyrnes SA

更新日期：2020-01-01 00:00:00

abstract：:New information is emerging concerning the influence of environmental factors (e.g., viruses, pollutants, nutrients) on fetal lung development and the prenatal modulation of cellular and molecular effectors essential to the control of airway function, which may shed new light into the pathogenesis of chronic obstructi...

journal_title：Pediatric research

authors： Piedimonte G,Harford TJ

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:A growing body of evidence defines inflammation as a hallmark feature of disease pathogenesis of Duchenne muscular dystrophy. To tailor potential immune modulatory interventions, a better understanding of immune dysregulation in Duchenne muscular dystrophy is needed. We now asked whether dystrophin deficienc...

journal_title：Pediatric research

authors： Kranig SA,Tschada R,Braun M,Patry C,Pöschl J,Frommhold D,Hudalla H

更新日期：2019-08-01 00:00:00

abstract：:WT1 is located on the short arm of human chromosome 11 and consists of 10 coding exons. Mutations of this gene have been reported to be the cause of Wilms' tumor, congenital male genitourinary malformations, and/or renal disorders. We describe here a novel WT1 gene mutation, i.e. a point mutation at intron 7 (+2) in b...

journal_title：Pediatric research

authors： Sakamoto J,Takata A,Fukuzawa R,Kikuchi H,Sugiyama M,Kanamori Y,Hashizume K,Hata JI

更新日期：2001-09-01 00:00:00

abstract：:Mutations of genes involved in the innate immune system have been reported to be associated with an increased sepsis rate in adults. We determined the -159T mutation of the CD14 gene, the 896G mutation of the toll-like receptor 4 gene, the 3020insC mutation of the NOD2 gene (NOD2-3020insC), the IL-6 174G/C promoter po...

journal_title：Pediatric research

authors： Ahrens P,Kattner E,Köhler B,Härtel C,Seidenberg J,Segerer H,Möller J,Göpel W,Genetic Factors in Neonatology Study Group.

更新日期：2004-04-01 00:00:00

abstract：:The ontogenetic renal responsiveness to exogenous cortisol was examined in the chronically cannulated ovine fetus. The contribution of effects at proximal and distal tubule of the kidney were studied also. Cortisol (81.5 micrograms/h) was infused into immature ovine fetuses (mean gestational age -113.9 days) on five o...

journal_title：Pediatric research

authors： Towstoless MK,McDougall JG,Wintour EM

更新日期：1989-07-01 00:00:00

abstract：:Gaucher disease, the most common of the sphingolipidoses, results from the inherited deficiency of the enzyme glucocerebrosidase (EC 3.2.1.45). Although type 2 (acute neuronopathic) Gaucher disease is associated with rapidly progressive and fatal neurologic deterioration, the pathophysiologic mechanisms leading to the...

journal_title：Pediatric research

authors： Orvisky E,Sidransky E,McKinney CE,Lamarca ME,Samimi R,Krasnewich D,Martin BM,Ginns EI

更新日期：2000-08-01 00:00:00

abstract：:In Chinese children with steroid-resistant nephrotic syndrome (SRNS), it was reported that NPHS2 mutation was detected in 4.3%, which was lower than that in Caucasians (10-30%). However, there were no data on WT1 mutation in nephrotic syndrome (NS), especially in early-onset NS of Chinese children. Thus, a study, whic...

journal_title：Pediatric research

authors： Li J,Ding J,Zhao D,Yu Z,Fan Q,Chen Y,Zhang H,Zhong X,Huang J,Yao Y,Xiao H

更新日期：2010-08-01 00:00:00

abstract：:The major variation in effect between undiluted cystic fibrosis and heterozygote sera on rabbit tracheal epithelium was in terms of the time after exposure at which changes occurred. Exposure to both types of sera for 3 min caused release of goblet cell mucus and ciliary resorption possibly by apical swelling of colum...

journal_title：Pediatric research

authors： Kennedy JR,Allen PL

更新日期：1980-11-01 00:00:00

abstract：:The aim of this study was to evaluate the changes in Doppler transmitral flow patterns during the 1st d of life. Doppler echocardiography of the ascending aorta and mitral valve was performed serially in 20 normal neonates at 2, 12, and 24 h of age. A computer-interfaced digitizer pad was used to measure the following...

journal_title：Pediatric research

authors： Harada K,Shiota T,Takahashi Y,Tamura M,Toyono M,Takada G

更新日期：1994-04-01 00:00:00

abstract：:Naloxone has been shown to reverse the hemodynamic sequelae of experimental septic shock in adult animal models. Its effectiveness in the newborn has not been studied. To further investigate the efficacy of naloxone, we instrumented 18 piglets for continuous measurement of mean arterial pressure, mean pulmonary arteri...

journal_title：Pediatric research

authors： Miller RR,Menke JA,Hansen NB,Zwick DL,Bickers RG,Nowicki PT

更新日期：1986-08-01 00:00:00

abstract：:D-myo-Inositol 1,4,5-triphosphate (IP3) is a key second messenger in many cells, including macrophages, T and B cells, and neutrophils, in which it regulates free intracellular calcium ion levels. In human polymorphonuclear leukocytes the rise of intracellular [Ca2+] is the signal that activates a number of functions ...

journal_title：Pediatric research

authors： Santoro P,Agosti V,Viggiano D,Palumbo A,Sarno T,Ciccimarra F

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Prematurity may influence the levels of amino acids, enzymes, and endocrine markers obtained through newborn screening. Identifying which analytes are the most affected by degree of prematurity could provide insight into how prematurity impacts metabolism. METHODS:Analytes from blood spots assayed by Newbor...

journal_title：Pediatric research

authors： Wilson K,Hawken S,Ducharme R,Potter BK,Little J,Thébaud B,Chakraborty P

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:General movements (GMs) in infants occur as fidgety movements (FMs) between postterm 9 and 20 weeks. We aimed to evaluate FMs and motor repertoire in infants with cystic fibrosis (CF) and their relation with clinical findings. METHODS:Demographic and clinical characteristics were recorded. FMs and motor rep...

journal_title：Pediatric research

authors： Tekerlek H,Mutlu A,Inal-Ince D,Livanelioglu A,Kahraman A,Eryilmaz-Polat S,Karakaya J,Ozcelik U

更新日期：2020-07-27 00:00:00

abstract：:High speed cinemicrographs reveal that the ciliary configuration and beat pattern of rabbit tracheal cilia differ significantly from classid descriptions, although the basic forward and return pattern is still observed. The tracheal cilia are short and stout (about 6 mum in length) and are of a slightly bent original ...

journal_title：Pediatric research

authors： Cheung AT,Jahn TL

更新日期：1976-02-01 00:00:00

abstract：:We examined the long-term effects of dietary protein restriction during rat pregnancy on serum IGF-I, serum IGF binding proteins, and liver IGF-I gene expression during postnatal development. Pregnant Wistar rats were fed ad libitum throughout gestation a normal (20% casein diet; P20 controls) or a low (5% casein; P5)...

journal_title：Pediatric research

authors： Muaku SM,Beauloye V,Thissen JP,Underwood LE,Fossion C,Gérard G,Ketelslegers JM,Maiter D

更新日期：1996-04-01 00:00:00

abstract：:Newborn rats exposed to 60% O(2) for 14 d demonstrated a bronchopulmonary dysplasia-like lung morphology and pulmonary hypertension. A 21-aminosteroid antioxidant, U74389G, attenuated both pulmonary hypertension and macrophage accumulation in the O(2)-exposed lungs. To determine whether macrophage accumulation played ...

journal_title：Pediatric research

authors： Jankov RP,Luo X,Belcastro R,Copland I,Frndova H,Lye SJ,Hoidal JR,Post M,Tanswell AK

更新日期：2001-08-01 00:00:00

abstract：:A number of neuromuscular diseases are associated with molecular defects in the mitochondrial DNA (mtDNA). These include: 1) a missense mutation at nucleotide 11778 in the mtDNA of Leber's hereditary optic neuropathy patients; 2) a heterogeneous array of deletions in the mtDNA of ocular myopathy patients; and 3) small...

journal_title：Pediatric research

authors： Wallace DC,Lott MT,Lezza AM,Seibel P,Voljavec AS,Shoffner JM

更新日期：1990-11-01 00:00:00

abstract：:Blood volume (BV), red cell mass (RCM; Cr-51) and plasma volume (125I-labeled albumin) were measured in 205 piglets from 28 litters shortly after birth. Spontaneous cord rupture in healthy piglets occurred during delivery (n = 25) or within 190 sec of birth (n = 82). Spontaneous and induced delay of cord rupture resul...

journal_title：Pediatric research

authors： Linderkamp O,Betke K,Güntner M,Jap GH,Riegel KP,Walser K

更新日期：1981-01-01 00:00:00

abstract：:Platelet volume was measured in 20 healthy children, 18 patients with acute idiopathic thrombocytopenic purpura (ITP), 24 patients with chronic ITP, 22 patients with aplastic anemia, and 17 patients with acute leukemia in childhood. The authors compared the platelet volume of these patients by use of peak platelet vol...

journal_title：Pediatric research

authors： Tomita E,Akatsuka JI,Kokubun Y

更新日期：1980-02-01 00:00:00

abstract：:Previous studies have demonstrated that myocardial function changes during mammalian perinatal development. The purpose of this study was to evaluate the subcellular basis underlying the slower relaxation in the developing heart by examining perinatal changes in sarcoplasmic reticulum (SR) function, and in SR Ca2+ pum...

journal_title：Pediatric research

authors： Fisher DJ,Tate CA,Phillips S

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is the most common systemic vasculitis syndrome primarily affecting medium-sized arteries, particularly the coronary arteries. Though KD may be associated with immunological problems, the involvement of microRNAs (miRs) has not been fully described. METHODS:We enrolled 23 KD patients a...

journal_title：Pediatric research

authors： Saito K,Nakaoka H,Takasaki I,Hirono K,Yamamoto S,Kinoshita K,Miyao N,Ibuki K,Ozawa S,Watanabe K,Bowles NE,Ichida F

更新日期：2016-09-01 00:00:00

abstract：:Astrocyte end-feet ensheathe blood vessels in the brain and are believed to provide structural integrity to the cerebral vasculature. We sought to determine in developing infants whether the coverage of blood vessels by astrocyte end-feet is decreased in germinal matrix (GM) compared with cerebral cortex and white mat...

journal_title：Pediatric research

authors： El-Khoury N,Braun A,Hu F,Pandey M,Nedergaard M,Lagamma EF,Ballabh P

更新日期：2006-05-01 00:00:00

abstract：:Groups of newborn rats were transthoracically inoculated with 1 X 10(6) type III group B streptococci/g body wt, either alone or in combination with 1.5 microgram/g body wt of type-specific antibody derived from hybridoma cell lines. Ninety-four percent of the animals who received bacteria alone died. In contrast, non...

journal_title：Pediatric research

authors： Christensen RD,Rothstein G,Hill HR,Pincus SH

更新日期：1983-10-01 00:00:00

abstract：:Deficient quantity of amniotic fluid causes fetal guinea pig lung hypoplasia. Oligohydramnios that lasts only 5 days in early gestation is sufficient to reduce fetal lung growth significantly. We quantitated lung structural alterations at 50 days gestation (term is 67 days) of fetal guinea pigs whose amniotic fluid wa...

journal_title：Pediatric research

authors： Collins MH,Moessinger AC,Kleinerman J,James LS,Blanc WA

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Adolescents born preterm have altered hypothalamic-pituitary-adrenal axis function with a blunted cortisol stress response, however, the influences of intrauterine growth restriction and race are unclear. METHODS:We measured salivary cortisol before and 20 min after a maximal-exercise stress test and calcul...

journal_title：Pediatric research

authors： Brown CL,Myers K,South AM,Shaltout HA,Jensen ET,Nixon PA,Washburn LK

更新日期：2020-05-01 00:00:00

abstract：:Human Bifidobacterium sp strain bifidum (B. bifidum) was administered to BALB/c lactating mice (n = 58) and their litters (n = 327 pups) to evaluate the ingested strain's adherent properties and ability to inhibit murine rotavirus (MRV) infection. ELISA and anaerobic bacteriologic techniques were used to measure MRV s...

journal_title：Pediatric research

authors： Duffy LC,Zielezny MA,Riepenhoff-Talty M,Dryja D,Sayahtaheri-Altaie S,Griffiths E,Ruffin D,Barrett H,Rossman J,Ogra PL

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVES:(1) Examine associations of a branched-chain amino acid (BCAA) metabolite pattern with metabolic risk across adolescence; (2) use Least Absolute Shrinkage and Selection Operator (LASSO) to identify novel metabolites of metabolic risk. METHODS:We used linear regression to examine associations of a BCAA score...

journal_title：Pediatric research

authors： Perng W,Tang L,Song PXK,Tellez-Rojo MM,Cantoral A,Peterson KE

更新日期：2019-02-01 00:00:00

abstract：:We evaluated the hypothesis that increased endogenous opioid activity mediates part or all of the left ventricular contractile and pump dysfunction previously demonstrated in HCl-induced metabolic acidemia. Eighteen Western newborn lambs were catheterized and instrumented; pacing wires were sutured to the right atrial...

journal_title：Pediatric research

authors： Fisher DJ,Dreyer WJ,Tate C,Michael L,Smith EO,Entman M

更新日期：1988-06-01 00:00:00