Effects of iron supplementation on auditory brainstem response in marginally LBW infants.

Abstract:

:LBW infants are at risk of iron deficiency (ID), which is associated with impaired nervous system development and may lead to prolonged auditory brainstem response (ABR) latencies. We hypothesized that iron supplementation shortens ABR latencies in marginally LBW (MLBW, 2000-2500 g) infants. In a randomized, controlled trial, 285 healthy MLBW infants received 0, 1, or 2 mg iron/kg/d of iron supplements from 6 wk to 6 mo of age. ABR absolute wave V latencies and central conduction time (CCT) were measured at the endpoint. There were no significant differences between groups in ABR wave V latencies (n = 218). Furthermore, there were no significantly prolonged ABR latencies in infants with ID (n = 32). CCT was significantly higher in the 2 mg group than in the placebo group (n = 126). However, there were no significant correlations between CCT and iron intake or any iron status variable, suggesting that differences in CCT were not caused by iron. We conclude that iron supplements did not improve ABR latencies, and iron-deficient MLBW infants did not have impaired ABR latencies at 6 mo, suggesting that ABR is not a sensitive measure of impaired neurological development or that mild/moderate ID causes no such impairment in MLBW infants.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Berglund SK,Westrup B,Haraldsson E,Engström B,Domellöf M

doi

10.1203/PDR.0b013e3182320cd0

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

601-6

issue

6

eissn

0031-3998

issn

1530-0447

journal_volume

70

pub_type

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