The effect of hyperoxic exposure on antioxidant enzyme activities of alveolar type II cells in neonatal and adult rats.

abstract：:DGCR6 is the most centromeric gene in the human DiGeorge critical region and is the only gene in the region with a second functional copy on a repeat localized more distally on chromosome 22. We isolated the chicken ortholog of DGCR6 and showed an embryonic expression pattern that is initially broad but becomes gradua...

journal_title：Pediatric research

authors： Hierck BP,Molin DG,Boot MJ,Poelmann RE,Gittenberger-de Groot AC

更新日期：2004-09-01 00:00:00

abstract：:Establishment of Helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. The association was soon also demonstrated in children as well. Applicatio...

journal_title：Pediatric research

authors： Blanchard TG,Czinn SJ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. METHODS:Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein co...

journal_title：Pediatric research

authors： Collell R,Closa-Monasterolo R,Ferré N,Luque V,Koletzko B,Grote V,Janas R,Verduci E,Escribano J

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Kawasaki disease was well known for coronary artery abnormalities with few reports of incidence of acute kidney injury (AKI). Our aim was to identify the rate of AKI in patients with Kawasaki disease and its associated factors. METHODS:All patients with Kawasaki disease admitted to a medical center from Feb...

journal_title：Pediatric research

authors： Chuang GT,Tsai IJ,Lin MT,Chang LY

更新日期：2016-08-01 00:00:00

abstract：:In its normal circulatory environment, the fetal left ventricle can maximally increase output less than 2-fold, in contrast to the nearly 3-fold increase that occurs at birth. Several studies have attributed this finding to fetal myocardial "immaturity," and speculated that there is a rapid maturation of the myocardiu...

journal_title：Pediatric research

authors： Teitel DF,Dalinghaus M,Cassidy SC,Payne BD,Rudolph AM

更新日期：1991-05-01 00:00:00

abstract：:Children with inborn errors of urea synthesis who survive neonatal hyperammonemic coma commonly exhibit cognitive deficits and neurologic abnormalities. Yet, there is evidence that ammonia is not the only neurotoxin. Hyperammonemia appears to induce a number of neurochemical alterations. In rodent models of hyperammon...

journal_title：Pediatric research

authors： Robinson MB,Heyes MP,Anegawa NJ,Gorry E,Djali S,Mellits ED,Batshaw ML

更新日期：1992-10-01 00:00:00

abstract：:Naloxone, a specific opiate antagonist with no agonist properties, in doses of 0.4 and 4.0 mg/kg was found to markedly reduce the duration of primary apnea in asphyxiated newborn rabbits. There was no effect on the duration of the hyperpneic phase (time to primary apnea) or on survival time (time to last gasp). It is ...

journal_title：Pediatric research

authors： Chernick V,Madansky DL,Lawson EE

更新日期：1980-04-01 00:00:00

abstract：:Factors, such as insulin, found in human and pig colostrum and mature milk likely influence small intestinal growth and development. Although pharmacologic doses of insulin injected parenterally may accelerate small intestinal development in altricial animals such as the rodent, the effects of oral insulin on intestin...

journal_title：Pediatric research

authors： Shulman RJ

更新日期：1990-08-01 00:00:00

abstract：:There is in vitro evidence that the ductus venosus of the fetal and newborn lamb relaxes to administration of E-series prostaglandins. We performed this study to determine whether the ductus venosus of the newborn lamb could be reopened by an infusion of prostaglandin E1. Fifteen lambs between 4 and 28 h of life and s...

journal_title：Pediatric research

authors： Morin FC 3rd

更新日期：1987-03-01 00:00:00

abstract：:Preterm infants are exposed to frequent painful procedures and agitating stimuli over the many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse neurobiological impact of pain and stress in the preterm infant has been well documented, including neuroimaging and neurobehavioral outc...

journal_title：Pediatric research

authors： McPherson C,Miller SP,El-Dib M,Massaro AN,Inder TE

更新日期：2020-08-01 00:00:00

abstract：:Alveolar hypoxia increases pulmonary artery pressure in lambs and sheep but increases lung lymph flow only in lambs; the reasons for this are unknown. To test the hypothesis that hypoxia-induced pulmonary venous constriction could in part explain the fluid filtration response in young lambs, eight young lambs (13 +/- ...

journal_title：Pediatric research

authors： Hazinski TA,Kennedy KA

更新日期：1987-12-01 00:00:00

abstract：:The metabolism of proteoglycans in normal growth plate and the changes in growth plate morphology induced by diabetes and malnutrition were studied in rats. The proteoglycans had a significantly faster turnover (half-life measured with [35S]sulfate labeling: 25-30 h) than the cells in the growth plate. Morphometric st...

journal_title：Pediatric research

authors： Axelsson I,Pita JC,Howell DS,Lorentzon R,Berman I,Boquist L

更新日期：1990-01-01 00:00:00

abstract：:We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease. Therefore, we examined whether recombinant human (rh) IGF-I is a safer alternative for the treatment of growth failure in...

journal_title：Pediatric research

authors： Trachtman H,Maesaka J,Futterweit S,Ma C,Valderrama E,Chan JC,Chan W

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this study was to begin to examine the influence of inhaled NO on O2 toxicity. The survival of Sprague-Dawley rats exposed to >95% O2, >95% O2 + 10 ppm NO, >95% O2 + 100 ppm NO, and >95% O2 + 3 ppm NO2 was determined. Survival at 120 h was 2/24 in >95% O2, 2/12 in >95% O2 + 10 ppm NO, and 1/12 in >95% O...

journal_title：Pediatric research

authors： Nelin LD,Welty SE,Morrisey JF,Gotuaco C,Dawson CA

更新日期：1998-06-01 00:00:00

abstract：:Previously, we have reported marked pulmonary inflammation in infants who develop chronic lung disease of prematurity. We revisited these infants who did not have clinical or laboratory evidence of infection and searched for Ureaplasma urealyticum, group B streptococci, and other microbes by reverse transcription-PCR ...

journal_title：Pediatric research

authors： Kotecha S,Hodge R,Schaber JA,Miralles R,Silverman M,Grant WD

更新日期：2004-01-01 00:00:00

abstract：:Altered transfer of nutrients from mother to conceptus may be involved in the pathogenesis of the developmental disturbances in offspring of diabetic mothers. In our study, the embryonic uptake of a saturated (palmitic acid) and a nonsaturated (arachidonic acid) fatty acid was evaluated in a normal and a diabetes-like...

journal_title：Pediatric research

authors： Engström E,Haglund A,Eriksson UJ

更新日期：1991-08-01 00:00:00

abstract：:Adenylate cyclase activity was measured in membrane preparations of cultured fibroblasts from controls and patients with cystic fibrosis. Enzyme activity increased as the transition from exponential growth to confluence occurred; sodium fluoride-stimulated activity more markedly displayed this relationship than basal ...

journal_title：Pediatric research

authors： Wright RK,Buehler BA,Schott SN,Rennert OM

更新日期：1978-08-01 00:00:00

abstract：:The precise mechanism by which the most common cause of bacterial enterocolitis in humans, Campylobacter jejuni, perturbs the intestinal mucosa remains elusive. To define effects of C. jejuni infection on mucosal permeability, Madin-Darby canine kidney (MDCK)-I and T84 cell monolayers were infected with C. jejuni for ...

journal_title：Pediatric research

authors： Wine E,Chan VL,Sherman PM

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Therapeutic hypothermia (TH) has become standard treatment for severe and moderate hypoxic-ischemic neonatal encephalopathy (HIE). Our group has developed an optically based, noninvasive concept of assessing the capacity for oxygen delivery from the microcirculation to the cells of a tissue under investigati...

journal_title：Pediatric research

authors： Fredly S,Fugelseth D,Nygaard CS,Salerud EG,Stiris T,Kvernebo K

更新日期：2016-06-01 00:00:00

abstract：:In human infants and newborn rats, white light at the intensity used to treat hyperbilirubinemia lowers serum calcium concentration. Occipital shielding or (in newborn rats) exogenous melatonin prevents this effect. Propranolol, by inhibiting melatonin synthesis, also causes hypocalcemia, which is preventable by melat...

journal_title：Pediatric research

authors： Hakanson DO,Bergstrom WH

更新日期：1990-06-01 00:00:00

abstract：:The activity of lysozyme in saliva and serum was determined in 51 patients with cystic fibrosis. Measurements were made on two occasions at least 1 month apart and compared to those of 25 normal healthy individuals of the same ages, sex, and race. The mean serum lysozyme activity of normal individuals was 5.8 microgra...

journal_title：Pediatric research

authors： Hughes WT,Koblin BA,Rosenstein BJ

更新日期：1982-10-01 00:00:00

abstract：:Sudden infant death syndrome (SIDS) is multifactorial and may result from the interaction of a number of environmental, genetic, and developmental factors. We studied three major genes causing long QT syndrome in 42 Japanese SIDS victims and found five mutations, KCNQ1-K598R, KCNH2-T895M, SCN5A-F532C, SCN5A-G1084S, an...

journal_title：Pediatric research

authors： Otagiri T,Kijima K,Osawa M,Ishii K,Makita N,Matoba R,Umetsu K,Hayasaka K

更新日期：2008-11-01 00:00:00

abstract：:Cerebral blood flow (CBF) was measured by means of Celabeled microspheres in infant (20-day-old) and adult (3-month-old) rats, anesthetised with Na-5-ethyl-5-(1-methylpropyl)2-thiobarbituric acid. Cerebral arteriovenous differences of acetoacetate, D-beta-hydroxybutyrate, glucose, lactate, and oxygen and brain DNA con...

journal_title：Pediatric research

authors： Dahlquist G,Persson B

更新日期：1976-11-01 00:00:00

abstract：:A rabbit model of group B Streptococcal (GBS) shock was used to determine if myocardial dysfunction contributes to GBS shock and, if so, to ascertain if prostaglandins modulate this dysfunction. The infusion of heat-killed GBS (group I) produced a dramatic decrease in the first derivative of left ventricular pressure ...

journal_title：Pediatric research

authors： Peevy KJ,Chartrand SA,Wiseman HJ,Boerth RC,Olson RD

更新日期：1985-06-01 00:00:00

abstract：:We hypothesized that nitric oxide (NO) production by the fetal ductus arteriosus is limited because of low fetal PO2, but that at neonatal PO2, NO might be an important regulator of ductus arteriosus tone. We exposed isolated rings of fetal lamb ductus arteriosus to elevated PO2. L-NG-nitro-L-arginine methyl ester (L-...

journal_title：Pediatric research

authors： Clyman RI,Waleh N,Black SM,Riemer RK,Mauray F,Chen YQ

更新日期：1998-05-01 00:00:00

abstract：:Tonsillectomy and adenoidectomy (T&A) is a frequent surgical procedure in children with obstructive sleep apnea (OSA). Many symptomatic children who do not fulfill the currently recommended criteria for T&A may benefit from topical intranasal steroid therapy. However, the expression of glucocorticoid receptor (GCR) ex...

journal_title：Pediatric research

authors： Goldbart AD,Veling MC,Goldman JL,Li RC,Brittian KR,Gozal D

更新日期：2005-02-01 00:00:00

abstract：:The worldwide burden of disease due to Epstein-Barr virus (EBV) infection is enormous. Diseases include endemic Burkitt lymphoma, infectious mononucleosis, cancers after transplantation, Hodgkin lymphoma, and nasopharyngeal carcinoma. A prophylactic EBV vaccine has the potential to significantly reduce the incidence a...

journal_title：Pediatric research

authors： Balfour HH Jr,Schmeling DO,Grimm-Geris JM

更新日期：2020-01-01 00:00:00

abstract：:LBW infants are at risk of iron deficiency (ID), which is associated with impaired nervous system development and may lead to prolonged auditory brainstem response (ABR) latencies. We hypothesized that iron supplementation shortens ABR latencies in marginally LBW (MLBW, 2000-2500 g) infants. In a randomized, controlle...

journal_title：Pediatric research

authors： Berglund SK,Westrup B,Haraldsson E,Engström B,Domellöf M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The present study examined the association between 9/11-related adolescent behavioral problems on mental health outcomes in early adulthood. METHODS:Data from enrollees of the World Trade Center Health Registry, who completed at least one adolescent (2006-2007 or 2011-2012) and adult survey (2011-2012 or 20...

journal_title：Pediatric research

authors： Gargano LM,Locke S,Li J,Farfel MR

更新日期：2018-08-01 00:00:00

abstract：:A dietary-related deficiency of docosahexaenoic acid [C22:6(n-3)] in infant cerebral cortex has been identified. Absence or very low rates of hepatic synthesis from the essential fatty acid precursor, alpha-linolenic acid [C18:3(n-3)], in early life may have been a contributory factor. We have analyzed liver total lip...

journal_title：Pediatric research

authors： Farquharson J,Jamieson EC,Logan RW,Patrick WJ,Howatson AG,Cockburn F

更新日期：1995-09-01 00:00:00