Functional activity of class-specific antibodies to type III, group B streptococcus.

Abstract:

:The functional activity of naturally acquired IgG and IgM with specificity for the capsular polysaccharide of type III, group B Streptococcus (III-GBS) was compared. Sera collected during convalescence from 14 infants who had developed specific antibodies following III-GBS infection were employed for separation of IgG from IgM by ion-exchange chromatography. Bactericidal killing of III-GBS was similar for IgG- and IgM-rich samples (37 and 42%, respectively) in reactions containing a mean of 1.0 or 1.9 micrograms/ml of III-GBS specific IgG or IgM antibody. Purified IgA lacked opsonophagocytic activity for III-GBS. These results indicate that III-GBS-specific IgG and IgM antibodies in infant sera promote opsonophagocytosis at low concentrations, and that their functional capacity is comparable.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Campbell JR,Baker CJ,Metzger TG,Edwards MS

doi

10.1203/00006450-198801000-00007

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

31-4

issue

1

eissn

0031-3998

issn

1530-0447

journal_volume

23

pub_type

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