当前位置： SCI文献检索 > PEDIATRIC RESEARCH期刊下所有文献 > Effect of temperature on thromboelastography and implications for clinical use in newborns undergoing therapeutic hypothermia.

Effect of temperature on thromboelastography and implications for clinical use in newborns undergoing therapeutic hypothermia.

Abstract：

BACKGROUND:Encephalopathic neonates undergoing therapeutic hypothermia have increased risk for coagulopathy secondary to perinatal asphyxia and effects of cooling on the coagulation enzyme cascade. Thromboelastography (TEG) allows for a comprehensive assessment of coagulation that can be regulated for temperature. TEG has not been previously evaluated in newborns undergoing hypothermia treatment. METHODS:Encephalopathic neonates treated with systemic hypothermia were enrolled in this prospective observational study. Daily blood specimens were collected for standard coagulation tests and platelet counts during hypothermia and after rewarming. Concurrent TEG assays were performed at 33.5 and 37.0 °C for comparison. RESULTS:A total of 48 paired TEGs from 24 subjects were performed. Forty percent of the subjects were males, the mean (± SD) birth weight was 3.2 ± 0.7 kg, and the mean gestational age was 38.4 ± 1.4 wk. TEG results differed significantly between assays performed at 37.0 vs. 33.5 °C, indicating more impaired coagulation at 33.5 °C. TEG parameters clot kinetics, angle, maximum amplitude (MA), and coagulation index were significantly associated with clinical bleeding (P < 0.05). These remained significant (except for MA) after controlling for transfusion therapy. CONCLUSION:TEG results are affected by temperature, consistent with the known association of hypothermia with coagulopathy. Several TEG parameters are predictive of clinical bleeding in newborns undergoing hypothermia. Selected cutpoints to predict bleeding risk are temperature dependent.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Forman KR,Wong E,Gallagher M,McCarter R,Luban NL,Massaro AN

doi

10.1038/pr.2014.19

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

663-9

issue

5

eissn

0031-3998

issn

1530-0447

pii

pr201419

journal_volume

75

pub_type

杂志文章

相关文献

PEDIATRIC RESEARCH文献大全
  • Abnormal cell surface antigen expression in individuals with variant CD45 splicing and histiocytosis.

    abstract：:Hemophagocytic lymphohistiocytosis (HLH) and Langerhans cell histiocytosis (LCH) are members of a group of rare heterogenous disorders, the histiocytoses, characterized by uncontrolled accumulation of pleomorphic infiltrates of leukocytes. The etiology of these diseases is mainly unknown. CD45 is a hemopoietic cell sp...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.PDR.0000106803.15344.72

    authors： Boxall S,McCormick J,Beverley P,Strobel S,De Filippi P,Dawes R,Klersy C,Clementi R,De Juli E,Ferster A,Wallace D,Aricò M,Danesino C,Tchilian E

    更新日期：2004-03-01 00:00:00

  • The effect of maternal starvation on plasma insulin-like growth factor I concentrations in the late gestation ovine fetus.

    abstract：:In view of the suggested relationship between substrate availability, fetal growth and circulating fetal IGF-I concentrations, we investigated the effect of maternal starvation on plasma IGF-I levels in the late gestation ovine fetus. Ten fetuses aged 125-130 d gestation were sampled daily from indwelling arterial cat...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199004000-00015

    authors： Bassett NS,Oliver MH,Breier BH,Gluckman PD

    更新日期：1990-04-01 00:00:00

  • Experimental neonatal syphilis. II. Immunological responses of neonatal rabbits to intradermal inoculation with Treponema pallidum (Nichols strain).

    abstract：:The immunological competence of neonatal rabbits inoculated intradermally with Treponema pallidum was examined. Both cellular responses and the production of humoral antibody to specific T. pallidum antigens and to nonspecific antigens or mitogens were investigated. In blast transformation assays, splenic and poplitea...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-198410000-00013

    authors： Gamboa D,Miller JN,Lukehart SA,Baker-Zander SA,Sell S

    更新日期：1984-10-01 00:00:00

  • Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole-to-venous shunts.

    abstract：:Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) commonly affects premature neonates. The gravity of the consequences associated with GMH-IVH makes it a major concern in their care. GMH-IVH begins in the germinal matrix tissue and is, most commonly, the result of venous rupture. Arteriole-to-venous pre...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-200210000-00015

    authors： Anstrom JA,Brown WR,Moody DM,Thore CR,Challa VR,Block SM

    更新日期：2002-10-01 00:00:00

  • The relationship between hyperbilirubinemia and the promoter region and first exon of UGT1A1 gene polymorphisms in Vietnamese newborns.

    abstract：BACKGROUND:To investigate the relationship between unexplained indirect hyperbilirubinemia of Vietnamese newborns and the polymorphism of the promoter TATA box and exon 1 of bilirubin uridine diphosphate glucuronosyltransferase (UGT1A1) gene. METHODS:A total of 149 neonates were divided into the hyperbilirubinemia gro...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/s41390-020-0825-6

    authors： Nguyen TT,Zhao W,Yang X,Zhong DN

    更新日期：2020-12-01 00:00:00

  • How a patent ductus arteriosus effects the premature lamb's ability to handle additional volume loads.

    abstract：:A model of patent ductus arteriosus in premature lambs was created to examine the lamb's ability to handle the volume load imposed by a patent ductus arteriosus and to determine the lamb's ability to handle any additional volume load. Fifteen preterm lambs [133 +/- 2 (+/- SD) days gestation, term 145 days], whose duct...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-198711000-00012

    authors： Clyman RI,Roman C,Heymann MA,Mauray F

    更新日期：1987-11-01 00:00:00

  • A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants.

    abstract：:In preterm infants, low levels of insulin like growth factor 1 (IGF-I) have been associated with impaired growth and retinopathy of prematurity. Our objective was to study safety and pharmacokinetics of i.v. administered rhIGF-I with its binding protein 3 (rhIGFBP-3) to preterm infants. At 3 d chronological age, an i....

    journal_title：Pediatric research

    pub_type： 临床试验,杂志文章

    doi：10.1203/PDR.0b013e31819d9e8c

    authors： Löfqvist C,Niklasson A,Engström E,Friberg LE,Camacho-Hübner C,Ley D,Borg J,Smith LE,Hellström A

    更新日期：2009-05-01 00:00:00

  • Fåhraeus and Fåhreaus-Lindqvist effects for neonatal and adult red blood cell suspensions.

    abstract：:In blood vessels with diameters less than 500 microns, both the hematocrit and viscosity decrease with decreasing tube diameter [Fåhraeus effect (FE) and Fåhraeus-Lindqvist effect (FLE)]. Because both effects may be influenced by red blood cell (RBC) volume and osmolality, the effects of RBC type and suspending medium...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199310000-00031

    authors： McKay CB,Linderkamp O,Meiselman HJ

    更新日期：1993-10-01 00:00:00

  • Growth hormone-releasing hexapeptide is a potent stimulator of growth hormone gene expression and release in the growth hormone-releasing hormone-deprived infant rat.

    abstract：:The growth hormone-releasing hexapeptide (GHRP-6) specifically stimulates growth hormone (GH) secretion in several animal species and humans. The mechanism of action of GHRP-6 is largely unknown, although experimental evidence indicates that it may modulate growth hormone-releasing hormone (GHRH) and somatostatin acti...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199408000-00006

    authors： Locatelli V,Grilli R,Torsello A,Cella SG,Wehrenberg WB,Müller EE

    更新日期：1994-08-01 00:00:00

  • Cyclic AMP-sensitive chloride efflux in rabbit pancreatic acini.

    abstract：:We studied chloride efflux from isolated rabbit pancreatic acini in suspension, by loading with 36Cl to steady state and rapidly washing acini by filtration to determine 36Cl cpm/micrograms DNA remaining. Linear loss of acinar chloride occurred over 5 min (k = 0.038 +/- 0.008 min-1, n = 5). Forskolin (5 x 10(-5) M) in...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199106010-00002

    authors： Kopelman H,Gauthier C

    更新日期：1991-06-01 00:00:00

  • Peripheral blood immune response elicited by beta-lactoglobulin in childhood cow's milk allergy.

    abstract：:Several studies analyzing the immune responses in patients with cow's milk allergy (CMA) have used T-cell lines or T-cell clones that require prolonged in vitro cell culturing and may result in a switched cell phenotype and function. We investigated immune responses to beta-lactoglobulin (b-LG) in peripheral blood mon...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/PDR.0b013e318232739c

    authors： Vocca I,Canani RB,Camarca A,Ruotolo S,Nocerino R,Radano G,Del Mastro A,Troncone R,Gianfrani C

    更新日期：2011-12-01 00:00:00

  • Determination and characterization of ciliary ATPase in the presence of serum from cystic fibrosis patients.

    abstract：:The purpose of this investigation was twofold: (1) to identify and characterize the enzymatic ATP hydrolysis system of epithelial cilia, and (2) to develop a quantitative, biochemical test for the ciliotoxic cystic fibrosis (CF) factor based on inhibition of ATP utilization by ciliary preparations. Our rationale for s...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-197602000-00012

    authors： Farrell PM,Fox GN,Spicer SS

    更新日期：1976-02-01 00:00:00

  • Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model.

    abstract：BACKGROUND:We examined the extent of fetal lung hypoplasia and lung maturation using the amniotic lamellar body count (LBC) in congenital diaphragmatic hernia (CDH). METHODS:We obtained 30 amniotic fluid samples from human CDH cases during cesarean section. We assessed LBC, magnetic resonance imaging (MRI), and ultras...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/pr.2012.187

    authors： Watanabe Y,Tsuda H,Kotani T,Sumigama S,Mano Y,Hayakawa M,Sato Y,Kikkawa F

    更新日期：2013-03-01 00:00:00

  • Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease.

    abstract：:The aim of the present study was to determine the proportion of gamma/delta T-lymphocytes and CD16/CD56 (CD3- and CD3+) cells in the peripheral blood of children and adolescents with Graves' disease (GD; n = 27; mean age, 15.5 +/- 5.1 y) and nontoxic nodular goiter (NTNG; n = 25; mean age, 15.2 +/- 5.7 y), in comparis...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.PDR.0000076663.94850.44

    authors： Bossowski A,Urban M,Stasiak-Barmuta A

    更新日期：2003-09-01 00:00:00

  • Opposing regulation of human alveolar type II cell differentiation by nitric oxide and hyperoxia.

    abstract：:Clinical trials demonstrated decreasing rates of bronchopulmonary dysplasia in preterm infants with hypoxic respiratory failure treated with inhaled nitric oxide (iNO). However, the molecular and biochemical effects of iNO on developing human fetal lungs remain vastly unknown. By using a well-characterized model of hu...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/PDR.0b013e3181d4f20f

    authors： Johnston LC,Gonzales LW,Lightfoot RT,Guttentag SH,Ischiropoulos H

    更新日期：2010-05-01 00:00:00

  • Perioperative levels of total IgE correlate with outcomes of prolonged mechanical ventilation after cardiopulmonary bypass in pediatric patients.

    abstract：BACKGROUND:Although cardiopulmonary bypass (CPB) has been previously studied as risking infection and inflammatory responses, few studies evaluate the relationship of preoperative high total immunoglobulin E (tIgE) to outcomes in pediatric patients predisposed to atopy undergoing cardiac surgery with CPB. METHODS:Seru...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/s41390-018-0048-2

    authors： Li Y,Zhu L,Chen J,Singson MTG,Rui X,Li N,Zhou L,Liu J

    更新日期：2018-11-01 00:00:00

  • Phagocytosis of neonatal pathogens by peripheral blood neutrophils and monocytes from newborn preterm and term infants.

    abstract：BACKGROUND:Deficiencies in phagocytosis may contribute to the increased susceptibility of infants to early life infections. Data on phagocytosis of the major neonatal pathogens Staphylococcus epidermidis (SE), Staphylococcus aureus (SA), and Escherichia coli (EC) by preterm infant leukocytes are inconsistent. METHODS:...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/pr.2013.145

    authors： Prosser A,Hibbert J,Strunk T,Kok CH,Simmer K,Richmond P,Burgner D,Currie A

    更新日期：2013-11-01 00:00:00

  • Early-life growth of preterm infants and its impact on neurodevelopment.

    abstract：BACKGROUND:Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time. METHODS:We studied two cohorts of ...

    journal_title：Pediatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41390-018-0139-0

    authors： Ruys CA,Hollanders JJ,Bröring T,van Schie PEM,van der Pal SM,van de Lagemaat M,Lafeber HN,Rotteveel J,Finken MJJ

    更新日期：2019-02-01 00:00:00

  • The effects of omega-3 fatty acid supplementation in pregnancy on maternal eicosanoid, cytokine, and chemokine secretion.

    abstract：:The incidence of allergic diseases has increased, and a relation between allergy and dietary fatty acids has been proposed. Modulation of the maternal immune function during pregnancy may have an impact on future clinical outcomes in the child. The aim of this study was to determine the effects of omega (omega)-3 long...

    journal_title：Pediatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1203/PDR.0b013e3181aabd1c

    authors： Warstedt K,Furuhjelm C,Duchén K,Fälth-Magnusson K,Fagerås M

    更新日期：2009-08-01 00:00:00

  • Lung fluid balance in hypoxic lambs.

    abstract：:In spontaneously breathing newborn lambs, alveolar hypoxia increases lung microvascular pressure, which causes lung lymph flow to increase and the concentration of protein in lymph to decrease. To see if this response derives from hypoxia itself rather than from the change in breathing pattern that occurs during hypox...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-198405000-00009

    authors： Hansen TN,Haberkern CM,Hazinski TA,Bland RD

    更新日期：1984-05-01 00:00:00

  • Epstein-Barr virus-infected marmoset cells do not form lymphomas in mice with severe combined immunodeficiency.

    abstract：:EBV has been associated with several malignancies in humans. EBV can also infect marmoset B lymphocytes, which, as opposed to human B cells, are permissive for lytic Epstein-Barr viral replication. Mice with a severe combined immunodeficiency phenotype (SCID mice) are extremely susceptible to EBV-induced lymphomagenes...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199410000-00007

    authors： Katz BZ,Salimi B,Saini U,McNamara JG,Eisen R

    更新日期：1994-10-01 00:00:00

  • Angiopoietin 1 and angiopoietin 2 are associated with medial thickening of hepatic arterial branches in biliary atresia.

    abstract：BACKGROUND:Biliary atresia (BA) is an infantile disorder characterized by progressive sclerosing cholangiopathy leading to biliary obstruction. First-line treatment of BA is hepatoportoenterostomy, the prognosis of which is related to age at surgery and to histological variables such as extent of fibrosis and ductular ...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/pr.2013.177

    authors： de Souza AF,Meurer L,da Silveira TR,Gregório C,Reus N,Uribe C,Matte U,dos Santos JL

    更新日期：2014-01-01 00:00:00

  • Effect of insulin with concurrent amino acid infusion on protein metabolism in rapidly growing pubertal children with type 1 diabetes.

    abstract：:Insulin treatment of prepubertal children with insulin-dependent diabetes improves body protein balance by decreasing the rate of protein degradation without stimulating protein synthesis. However, insulin also causes hypoaminoacidemia, so the inability of insulin to stimulate protein synthesis may have been limited b...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.PDR.0000169976.20029.64

    authors： Godil MA,Wilson TA,Garlick PJ,McNurlan MA

    更新日期：2005-08-01 00:00:00

  • Influence of race on the effect of premature birth on salivary cortisol response to stress in adolescents.

    abstract：BACKGROUND:Adolescents born preterm have altered hypothalamic-pituitary-adrenal axis function with a blunted cortisol stress response, however, the influences of intrauterine growth restriction and race are unclear. METHODS:We measured salivary cortisol before and 20 min after a maximal-exercise stress test and calcul...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/s41390-019-0682-3

    authors： Brown CL,Myers K,South AM,Shaltout HA,Jensen ET,Nixon PA,Washburn LK

    更新日期：2020-05-01 00:00:00

  • Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy.

    abstract：BACKGROUND:Abnormal PCO2 is common in infants with hypoxic ischemic encephalopathy (HIE). The objective was to determine whether hypocapnia was independently associated with unfavorable outcome (death or severe neurodevelopmental disability at 18 mo) in infants with moderate-to-severe HIE. METHODS:This was a post hoc ...

    journal_title：Pediatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/pr.2016.62

    authors： Lingappan K,Kaiser JR,Srinivasan C,Gunn AJ

    更新日期：2016-08-01 00:00:00

  • The relationship between dog ownership, dog play, family dog walking, and pre-schooler social-emotional development: findings from the PLAYCE observational study.

    abstract：BACKGROUND:Regular physical activity provides children with health and developmental benefits. This study investigated if active play and walking with the family dog was associated with better social-emotional development in young children. METHODS:We surveyed 1646 parents to ascertain if families with pre-schoolers o...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/s41390-020-1007-2

    authors： Wenden EJ,Lester L,Zubrick SR,Ng M,Christian HE

    更新日期：2020-07-06 00:00:00

  • Quality of growth in exclusively breast-fed infants in the first six months of life: an Italian study.

    abstract：:Nutrition in early life, growth, and subsequent health over a lifetime are significantly interrelated. The aim of this study was to assess body composition changes in exclusively breast-fed infants from birth up to 6 mo of age. An observational, prospective, cohort study was conducted. Fifty-nine full-term, healthy, e...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/PDR.0b013e3181f85a20

    authors： Roggero P,Giannì ML,Orsi A,Piemontese P,Amato O,Liotto N,Morlacchi L,Taroni F,Fields DA,Catalano PM,Mosca F

    更新日期：2010-12-01 00:00:00

  • Pulmonary toxicity of monocrotaline differs at critical periods of lung development.

    abstract：:We injected 3-day-old (neonatal), 8-day-old (infant), and 8-wk-old (adult) Sprague-Dawley rats with monocrotaline to examine the effect of a toxic agent at various stages of lung development. Two and four weeks after injection the rats were killed and the heart and lungs removed: the right and left ventricles were sep...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-198507000-00019

    authors： Todd L,Mullen M,Olley PM,Rabinovitch M

    更新日期：1985-07-01 00:00:00

  • Circulating interferon-gamma and white matter brain damage in preterm infants.

    abstract：:The fetal inflammatory response has been suggested as causal in neonatal morbidity. Serial levels of circulating cytokines were evaluated in 74 infants with a mean gestational age (GA) of 27.1 wk. Pro-inflammatory [tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), IL-1 beta, IL-2, IL-6, IL-8, IL-1...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.PDR.0000182592.76702.E8

    authors： Hansen-Pupp I,Harling S,Berg AC,Cilio C,Hellström-Westas L,Ley D

    更新日期：2005-11-01 00:00:00

  • Myocardial excitation-contraction coupling in the fetus of alloxan-diabetic rabbit.

    abstract：:This study was conducted to investigate myocardial excitation-contraction coupling in the fetus of the diabetic rabbit (FDM). On day 14 of gestation, diabetes was induced in pregnant rabbits by alloxan injection. On day 28 of gestation, mechanical function of the fetal myocardium was determined in the isolated arteria...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-198412000-00026

    authors： Nakanishi T,Matsuoka S,Uemura S,Shimizu T,Nishioka K,Neufeld ND,Jarmakani JM

    更新日期：1984-12-01 00:00:00