Abstract：
BACKGROUND:Adolescents born preterm have altered hypothalamic-pituitary-adrenal axis function with a blunted cortisol stress response, however, the influences of intrauterine growth restriction and race are unclear. METHODS:We measured salivary cortisol before and 20 min after a maximal-exercise stress test and calculated the cortisol stress response. We used linear regression to compare cortisol stress responses between preterm and term groups, adjusting for birth weight z-score and maternal hypertension, and examined effect modification by race and sex. RESULTS:We evaluated 171 adolescents born preterm with very low birth weight and 50 born term. Adolescents born preterm had reduced cortisol stress response compared to term (0.03 vs. 0.08 μg/dL, p = 0.04). This difference was race dependent: non-Black adolescents born preterm had significantly reduced cortisol stress response compared to those born at term (adjusted β: -0.74; 95% CI -1.34, -0.15), while there was no difference in Black adolescents (0.53; -0.16, 1.22). Sex did not modify the relationship. CONCLUSIONS:Adolescents born preterm exhibit a reduced salivary cortisol response to exercise stress, suggesting long-term alterations in the hypothalamic-pituitary-adrenal axis. This relationship was evident in non-Black but not in Black adolescents, suggesting that race may modify the influence of preterm birth on stress alterations of the hypothalamic-pituitary-adrenal axis.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Brown CL,Myers K,South AM,Shaltout HA,Jensen ET,Nixon PA,Washburn LKdoi
10.1038/s41390-019-0682-3subject
Has Abstractpub_date
2020-05-01 00:00:00pages
1100-1105issue
6eissn
0031-3998issn
1530-0447pii
10.1038/s41390-019-0682-3journal_volume
87pub_type
杂志文章abstract：:The development of metabolic acidosis during neonatal sepsis with group B streptococci (GBS) has been attributed to progressive tissue ischemia resulting from reduced oxygen delivery (QO2). Using an animal model of GBS disease, we attempted to test this hypothesis by comparing the development of metabolic acidosis in ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198711000-00006
更新日期：1987-11-01 00:00:00
abstract：BACKGROUND:The prevalence of vitamin D (vitD) deficiency presenting as rickets is increasing worldwide. Insufficient sun exposure, vitD administration, and/or calcium intake are the main causes. However, vitD system-related genes may also have a role. METHODS:Prospective study: 109 rachitic children completed a 6-mo s...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2016.222
更新日期：2017-02-01 00:00:00
abstract：:Cell-mediated immunity is not well characterized in very low birth weight infants, and abnormalities may represent a significant vulnerability to infection. This report describes 165 serial studies in 58 infants between 700 and 1300 g birth weight during the first 8 wk of life. Two ml of blood were drawn at 2-wk inter...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198805000-00003
更新日期：1988-05-01 00:00:00
abstract：:The renal effects of endothelin-1 were investigated in 16 anesthetized and mechanically ventilated newborn rabbits. Renal blood flow and glomerular filtration rate were determined by the clearance of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In eight newborn rabbits, a bol...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199308000-00002
更新日期：1993-08-01 00:00:00
abstract：:We studied healthy and saline lavaged rabbits during high frequency oscillatory ventilation to determine what combination of frequency (f), tidal volume (Vt), and mean airway pressure (Paw) produced the lowest peak-to-peak alveolar pressure amplitude (Palv) and physiologic blood gas tensions. Sinusoidal volume changes...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199001000-00018
更新日期：1990-01-01 00:00:00
abstract：:There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the germinal zones of the immature brain. Studies using animal models of pediatric brain injuries have provided a clearer understanding of the responses of these progenitors to injury. In this review, we have c...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2017.261
更新日期：2018-01-01 00:00:00
abstract：:Ethylmalonic aciduria is a common biochemical finding in patients with inborn errors of short chain fatty acid beta-oxidation. The urinary excretion of ethylmalonic acid (EMA) may stem from decreased oxidation by short chain acyl-CoA dehydrogenase (SCAD) of butyryl-CoA, which is alternatively metabolized by propionyl-...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199606000-00021
更新日期：1996-06-01 00:00:00
abstract：:Serum insulin, growth hormone (GH), insulin-like growth factors (IGFs) I and II, cortisol, and albumin concentrations were measured in 15 children with kwashiorkor, 15 with marasmic-kwashiorkor, and 21 with marasmus, before and in the survivors, after nutritional rehabilitation, as well as in 10 underweight and eight ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198611000-00012
更新日期：1986-11-01 00:00:00
abstract：:Acute postasphyxial encephalopathy around the time of birth remains a major cause of death and disability. The possibility that hypothermia may be able to prevent or lessen asphyxial brain injury is a "dream revisited". In this review, a historical perspective is provided from the first reported use of therapeutic hyp...
journal_title：Pediatric research
pub_type： 历史文章,杂志文章,评审
doi：10.1038/pr.2016.198
更新日期：2017-01-01 00:00:00
abstract：:BackroundMicrocephaly can either be isolated or it may coexist with other neurological entities and/or multiple congenital anomalies, known as syndromic microcephaly. Although many syndromic cases can be classified based on the characteristic phenotype, some others remain uncertain and require further investigation. T...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.65
更新日期：2017-08-01 00:00:00
abstract：:New information is emerging concerning the influence of environmental factors (e.g., viruses, pollutants, nutrients) on fetal lung development and the prenatal modulation of cellular and molecular effectors essential to the control of airway function, which may shed new light into the pathogenesis of chronic obstructi...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/s41390-019-0657-4
更新日期：2020-01-01 00:00:00
abstract：:Soft bedding has been shown in epidemiologic studies to increase the risk for sudden, unexpected death in prone-sleeping infants. We compared the physical properties of conventional bedding to bedding from two sources: 1) bedding that covered the airways of victims of sudden infant death syndrome (SIDS) lying prone an...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199407001-00002
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:After birth, breastfeeding is the exclusive source of hormonal signaling between mother and infant. Hospitalized infants often receive donor milk when their own mother's milk is unavailable. METHODS:The presence of insulin, leptin, cortisol, progesterone, and testosterone was examined in samples from milk b...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0789-6
更新日期：2020-10-01 00:00:00
abstract：:Studies were conducted in an attempt to determine the hemolytic potential of acetylsalicylic acid (ASA) on normal intact red blood cells (RBCs). ASA (25 mg/100 ml) did not impair RBC G-6-PD, glutathione peroxidase or catalase activity, glutathione stability, or hexose monophosphate shunt activity. Hemolysis was not ob...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197809000-00009
更新日期：1978-09-01 00:00:00
abstract：:The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198107000-00010
更新日期：1981-07-01 00:00:00
abstract：:The present study investigates the effects of polycythemia on renal hemodynamics and function in 15 anesthetized newborn dogs, 2-10 days of age. Microspheres were used to study renal blood flow. Experimental animals received an exchange transfusion with adult dog packed red blood cells resulting in an increase in hema...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198202000-00014
更新日期：1982-02-01 00:00:00
abstract：:The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout of a single imprinted gene, encoding IGF-2, results in one pattern of ...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/01.PDR.0000181381.82856.23
更新日期：2005-11-01 00:00:00
abstract：:The mononuclear cells of newborn infants compared to those of normal adults contain diminished activity of pyruvate kinase (PK) (14.9 +/- 1.2 vs. 22.3 +/- 1.3 mumol/10(10) cells/min) and phosphoglycerate kinase (PGK) (195 +/- 10 vs. 415 +/- 19). These deficiencies are accentuated in the cells of premature infants (4.9...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197710000-00008
更新日期：1977-10-01 00:00:00
abstract：:In order to study the neonatal microcirculation, the capillary hemodynamics in skin was investigated in 43 full-term infants 2-7 days after birth. The nailfold capillaries of the thumb were visualized by means of television microscopy and the capillary blood cell velocity (CBV) was videophotometrically quantified in 1...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198806000-00011
更新日期：1988-06-01 00:00:00
abstract：:In seven patients with mucopolysaccharidoses (1 Hurler, 1 Hurler-Scheie, 4 Hunter, 1 Sly), cranial (1)H-magnetic resonance spectroscopy was performed to evaluate the accumulation of mucopolysaccharides and biochemical changes in the CNS in vivo before and after bone marrow transplantation (BMT). In two of seven patien...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200103000-00008
更新日期：2001-03-01 00:00:00
abstract：:Chitosan is a natural, cationic polysaccharide derived from fully or partially deacetylated chitin. Chitosan is capable of inducing large phospholipid aggregates, closely resembling the function of nonionic polymers tested previously as additives to therapeutic lung surfactants. The effects of chitosan on improving th...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000227558.14024.57
更新日期：2006-08-01 00:00:00
abstract：INTRODUCTION:Current advances in neonatology have improved survival among preterm and low-birth-weight infants. However, the risk of neonatal death in preterm infants is much greater than in full-term neonates and is frequently associated with infections. METHODS:Little is known about the immune status of preterm neon...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2012.6
更新日期：2012-05-01 00:00:00
abstract：:The field of regenerative medicine continues to make substantial advancements in therapeutic strategies addressing urologic diseases. Tissue engineering borrows principles from the fields of cell biology, materials science, transplantation and engineering in an effort to repair or replace damaged tissues. This review ...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/PDR.0b013e31816a704a
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:To investigate whether the YAP/TAZ (Yes-associated protein/transcriptional coactivator with PDZ binding motif) pathway contributes to the pathogenesis of lymphatic malformations (LMs). METHODS:YAP, TAZ, CTGF (connective tissue growth factor), and Ki-67 were detected in LMs by immunohistochemistry. The coloc...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0863-0
更新日期：2020-04-12 00:00:00
abstract：:The role of microbial colonization is indispensable for keeping a balanced immune response in life. However, the events that regulate the establishment of the microbiota, their timing, and the way in which they interact with the host are not yet fully understood. Factors such as gestational age, mode of delivery, envi...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2015.54
更新日期：2015-06-01 00:00:00
abstract：:Unconjugated bilirubin promotes intestinal secretion without affecting nutrient digestion or absorption. In the current study, the effects of unconjugated bilirubin (UCB) on the barrier function of the intestinal epithelium were investigated. The apical side of human intestinal cell line Caco-2 monolayers was challeng...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000220344.09034.63
更新日期：2006-07-01 00:00:00
abstract：:Heart rate variability (HRV) is reported increasingly in pediatric research, but different strategies used to identify and manage potential outlier beats impact HRV parameter values in adults and animals. Do they in pediatrics? To compare the impact of different strategies to identifying and managing outliers, we used...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e318123fbcc
更新日期：2007-09-01 00:00:00
abstract：:To localize fetal rabbit lung beta-adrenoreceptors before and after glucocorticoid treatment, light microscopic autoradiography was performed with the reversible radiolabeled beta-adrenergic antagonist, [3H]dihydroalprenolol, on day 26 of gestation. Autoradiograms of adult lung and fetal myocardium were also prepared....
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198411000-00028
更新日期：1984-11-01 00:00:00
abstract：:The objective of this study was to establish longitudinal normative limits for home memory monitors during early infancy. Eighty-eight healthy infants were monitored overnight at 0.25-19 wk of age using the Healthdyne Smart Monitor. Apnea settings were 14 s for recording and 40 s for alarm; the bradycardia setting was...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199602000-00005
更新日期：1996-02-01 00:00:00
abstract：:The two pathways of de novo lecithin synthesis, choline incorporation (I) and phosphatidylethanolamine methylation (II), were examined in lung slices from rhesus monkey fetuses throughout the last half of gestation. Incorporation rates of pathway-specific radioactive precursors were used as a measure of lecithin produ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197508000-00009
更新日期：1975-08-01 00:00:00
