Abstract:
INTRODUCTION:Current advances in neonatology have improved survival among preterm and low-birth-weight infants. However, the risk of neonatal death in preterm infants is much greater than in full-term neonates and is frequently associated with infections. METHODS:Little is known about the immune status of preterm neonates; therefore, we analyzed the frequency and absolute counts of different immune populations in 211 cord blood samples taken from very-preterm to full-term neonates. RESULTS:We found that absolute counts of all the immune subsets analyzed (i.e., monocytes, granulocytes, B cells, natural killer (NK) cells, CD4(+), and CD8(+) T cells) were markedly lower in preterm infants than in full-term infants. Surprisingly, we observed that regulatory T cells (Tregs) were the only cell subset that did not decrease in preterm infants, and their frequency was even higher than in full-term infants. DISCUSSION:Tregs are crucial to maternal-fetal tolerance, but their suppressive role could be also implicated in the leukopenia observed in preterm infants. We did not observe differences in thymic function, but we found that plasma levels of interleukin (IL)-7 and the frequency of its receptor were significantly decreased in preterm infants. Our results could help to identify leukopenia and to implement immune therapies that significantly diminish mortality in preterm neonates.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Correa-Rocha R,Pérez A,Lorente R,Ferrando-Martínez S,Leal M,Gurbindo D,Muñoz-Fernández MÁdoi
10.1038/pr.2012.6subject
Has Abstractpub_date
2012-05-01 00:00:00pages
590-7issue
5eissn
0031-3998issn
1530-0447pii
pr20126journal_volume
71pub_type
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