Abstract:
:Epidermal growth factor (EGF), a potent mitogen present in milk, is postulated to play an important physiologic role in the ontogeny of the intestine. An artificial rat milk, free of EGF, was developed and fed to newborn rats in an effort to evaluate the physiologic role of EGF on intestinal glucose transport. Comparisons were made between mother-fed (group 1) and artificially fed pups (group 2). Group 1 was divided into two subgroups to received either the EGF vehicle (group 1-A) or twice daily subcutaneous injections (0.1 micrograms/g body weight/day) of EGF (group 1-B). Group 2 was divided into four subgroups: formula without EGF (group 2-A), formula with 62 ng/ml of EGF (group 2-B), formula with 200 ng/ml EGF (group 2-C), and formula without EGF but added anti-EGF IgG (40 ng/ml) plus subcutaneous injections of 1 micrograms anti-EGF twice daily (group 2-D). Treatment regimens were initiated on day 3 and assays performed on day 11 of life. Glucose transport was measured using gut "sheet" preparations in all but group 2-C, which utilized brush border membrane preparations. Group 1-B showed a significant (p less than 0.03) increase in gut length (47.5 +/- 1.2 versus 42 +/- 0.9 cm) and an increase (p less than 0.03) in both Vmax (10.2 +/- 0.5 versus 7.2 +/- 0.3 nM/mg tissue) and Km (2.74 +/- 0.49 versus 1.20 +/- 0.19 mM) compared to group 1-A.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Greene HL,Moore MC,Said HM,Ghishan FK,Orth DNdoi
10.1203/00006450-198704000-00017subject
Has Abstractpub_date
1987-04-01 00:00:00pages
404-8issue
4eissn
0031-3998issn
1530-0447journal_volume
21pub_type
杂志文章abstract:BACKGROUND:A growing body of evidence defines inflammation as a hallmark feature of disease pathogenesis of Duchenne muscular dystrophy. To tailor potential immune modulatory interventions, a better understanding of immune dysregulation in Duchenne muscular dystrophy is needed. We now asked whether dystrophin deficienc...
journal_title:Pediatric research
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abstract::The treatment of multiple acyl-CoA-dehydrogenase deficiency (MADD) includes a low-fat, low-protein, high-carbohydrate diet, avoiding long fasting periods. However, there is no useful biochemical marker to determine the response to different diets or fasting periods. The aims of this study are to report a patient with ...
journal_title:Pediatric research
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更新日期:1984-07-01 00:00:00
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更新日期:2014-03-01 00:00:00
abstract::The development of the intestinal mucosal immune barrier is an important protective adaptation for postnatal life. The distribution and phenotype of T and B lymphocytes in human fetal intestine and lymphoid tissues have been characterized and compared to the distribution and phenotype of lymphocytes in postnatal intes...
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更新日期:1986-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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更新日期:1978-05-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198912000-00002
更新日期:1989-12-01 00:00:00
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199011000-00007
更新日期:1990-11-01 00:00:00
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journal_title:Pediatric research
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doi:10.1038/pr.2017.301
更新日期:2018-03-01 00:00:00
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doi:10.1203/01.PDR.0000114481.58902.FB
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41390-020-0961-z
更新日期:2020-05-21 00:00:00
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doi:10.1203/PDR.0b013e3181659774
更新日期:2008-04-01 00:00:00
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doi:10.1203/01.PDR.0000072783.22373.FF
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更新日期:2011-10-01 00:00:00
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更新日期:2013-09-01 00:00:00
abstract::The effect of somatomedin and cortisol on embryonic chick cartilage in vitro indicates that somatomedin stimulates 35SO4 uptake while cortisol decreases it with no effect on glycosaminoglycan turnover. Xylosyltransferase activity is increased in crude fractions of somatomedin-treated cartilage but decreased in cortiso...
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更新日期:1979-02-01 00:00:00
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更新日期:1991-01-01 00:00:00
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更新日期:2003-08-01 00:00:00
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更新日期:1991-09-01 00:00:00