Urine and kidney epidermal growth factor: ontogeny and sex difference in the mouse.

Abstract:

:We have explored the physiology of urinary epidermal growth factor (EGF) in the mouse by studying its ontogeny, and the effects of testosterone therapy on immunoreactive EGF (IR-EGF) concentrations in urine, kidney, serum and submandibular gland (SMG). Urine IR-EGF (U-EGF) increased about 100-fold relative to urea concentration and about 1000-fold relative to urine volume from the 1st day of life to adulthood. Most of this increase occurred between days 6 and 18, which is the known period of steep rise in plasma thyroid hormone concentration in the mouse. A small F greater than M sex difference was present in the adult. This difference was opposite in direction to the large M greater than F sex difference in adult SMG-EGF concentration. On day 26 (age of appearance of morphological sex difference in SMG) the sex difference was not yet present in urine, although in SMG it was even larger than in the adult. Kidney EGF concentration was low relative to U-EGF: 1 ml of adult urine contained approximately as much IR-EGF as 100 pairs of adult kidneys. In the adult, but not on day 26, there was a sex difference in kidney EGF concentration parallel to the sex difference in urine: female levels were about 30% higher than male levels. Ten days of testosterone treatment of adult female mice evoked an increase in IR-EGF concentration which was 1.7-fold for serum and 5-fold for SMG. In contrast, this treatment did not increase kidney or urine IR-EGF concentrations although kidney weight increased 1.3-fold.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Perheentupa J,Lakshmanan J,Fisher DA

doi

10.1203/00006450-198505000-00004

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

428-32

issue

5

eissn

0031-3998

issn

1530-0447

journal_volume

19

pub_type

杂志文章
  • Perioperative levels of total IgE correlate with outcomes of prolonged mechanical ventilation after cardiopulmonary bypass in pediatric patients.

    abstract:BACKGROUND:Although cardiopulmonary bypass (CPB) has been previously studied as risking infection and inflammatory responses, few studies evaluate the relationship of preoperative high total immunoglobulin E (tIgE) to outcomes in pediatric patients predisposed to atopy undergoing cardiac surgery with CPB. METHODS:Seru...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-018-0048-2

    authors: Li Y,Zhu L,Chen J,Singson MTG,Rui X,Li N,Zhou L,Liu J

    更新日期:2018-11-01 00:00:00

  • Genetic variations in hypoxia response genes influence hypertrophic cardiomyopathy phenotype.

    abstract:BACKGROUND:Risk factors for diastolic dysfunction in hypertrophic cardiomyopathy (HCM) are poorly understood. We investigated the association of variants in hypoxia-response genes with phenotype severity in pediatric HCM. METHODS:A total of 80 unrelated patients <21 y and 14 related members from eight families with HC...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2012.126

    authors: Alkon J,Friedberg MK,Manlhiot C,Manickaraj AK,Kinnear C,McCrindle BW,Benson LN,Addonizio LJ,Colan SD,Mital S

    更新日期:2012-12-01 00:00:00

  • Where to make a difference: research and the social determinants in pediatrics and child health in the COVID-19 era.

    abstract:IMPACT:Raises the importance of Social Determinants of Health in pediatrics. Considers the impact of Social Determinants of Health on COVID-19. Offers opportunities for research in the future. ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-01253-0

    authors: Lachman P

    更新日期:2020-11-10 00:00:00

  • Mesenteric blood flow velocity and its relation to transitional circulatory adaptation in appropriate for gestational age preterm infants.

    abstract::We investigated the early postnatal changes of the mesenteric circulation and its relation to the systemic circulation in 15 preterm infants. The infants were studied before the first feeding on d 1 and pre- and postprandially on d 3, 4, 5, and 7. Blood flow velocity was measured by ultrasound Doppler in the superior ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199602000-00015

    authors: Martinussen M,Brubakk AM,Vik T,Yao AC

    更新日期:1996-02-01 00:00:00

  • Home documented monitoring of cardiorespiratory pattern and oxygen saturation in healthy infants.

    abstract::The objective of this study was to establish longitudinal normative limits for home memory monitors during early infancy. Eighty-eight healthy infants were monitored overnight at 0.25-19 wk of age using the Healthdyne Smart Monitor. Apnea settings were 14 s for recording and 40 s for alarm; the bradycardia setting was...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199602000-00005

    authors: Hunt CE,Hufford DR,Bourguignon C,Oess MA

    更新日期:1996-02-01 00:00:00

  • Role of pili in Haemophilus influenzae adherence to, and internalization by, respiratory cells.

    abstract::To determine the role of pili in mediating adherence of type b and nontypeable Haemophilus influenzae to several respiratory cell types, piliated bacteria, nonpiliated phase variants, and nonpiliated mutants possessing insertionally inactivated pilin genes were tested. Both piliated and nonpiliated strains adhered to ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199602000-00025

    authors: Gilsdorf JR,Tucci M,Marrs CF

    更新日期:1996-02-01 00:00:00

  • Effect of lipids and other substances on the adsorption of dipalmitoyl phosphatidylcholine.

    abstract::The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198107000-00010

    authors: Meban C

    更新日期:1981-07-01 00:00:00

  • Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome.

    abstract::Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cereb...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1203/PDR.0b013e3181eee738

    authors: Idro R,Marsh K,John CC,Newton CR

    更新日期:2010-10-01 00:00:00

  • Effectiveness of Bifidobacterium bifidum in mediating the clinical course of murine rotavirus diarrhea.

    abstract::Human Bifidobacterium sp strain bifidum (B. bifidum) was administered to BALB/c lactating mice (n = 58) and their litters (n = 327 pups) to evaluate the ingested strain's adherent properties and ability to inhibit murine rotavirus (MRV) infection. ELISA and anaerobic bacteriologic techniques were used to measure MRV s...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199406000-00014

    authors: Duffy LC,Zielezny MA,Riepenhoff-Talty M,Dryja D,Sayahtaheri-Altaie S,Griffiths E,Ruffin D,Barrett H,Rossman J,Ogra PL

    更新日期:1994-06-01 00:00:00

  • 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo.

    abstract::To determine the importance of peroxisomes and mitochondria in hydroxyeicosatetraenoic acid (HETE) oxidation in vivo, urinary excretion of 12- and 15-HETE was measured in eight patients with a peroxisome deficiency disorder (Zellweger syndrome) showing normal mitochondrial beta-oxidation capacity, in three patients wi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199601000-00022

    authors: Mayatepek E,Lehmann WD

    更新日期:1996-01-01 00:00:00

  • Utility of volatile organic compounds as a diagnostic tool in preterm infants.

    abstract:BACKGROUND:Volatile organic compounds (VOCs) are hydrocarbons that originate within different healthy and diseased tissues. VOCs can be secreted into the circulation and then excreted in the urine and faeces. In the lungs, VOCs are locally produced and can be detected in exhaled breath. VOCs can be identified using non...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1038/s41390-020-0828-3

    authors: Wright H,Bannaga AS,Iriarte R,Mahmoud M,Arasaradnam RP

    更新日期:2020-03-02 00:00:00

  • Preserved fetal plasma amino acid concentrations in the presence of maternal hypoaminoacidemia.

    abstract::The effects on the conceptus of persistently decreased maternal plasma amino acid concentrations were studied in pregnant rats by the infusion of glucagon (0.21 mg/day) to the mother from day 14 to 20 of gestation with a subcutaneous, osmotically driven minipump. Controls received diluent. The experimental animals eit...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198611000-00002

    authors: Domenech M,Gruppuso PA,Nishino VT,Susa JB,Schwartz R

    更新日期:1986-11-01 00:00:00

  • The auditory brainstem response (ABR) evaluates risk factors for hearing loss in the newborn.

    abstract::Fourteen of 100 unselected patients in an intensive care nursery were found by the auditory brainstem evoked response (ABR) method to suffer significant hearing loss; of these 8 were ultimately discharged home. Analysis of the 100 clinical records identified 9 risk factors of which most, like low Apgar scores, are alr...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198002000-00019

    authors: Galambos R,Despland PA

    更新日期:1980-02-01 00:00:00

  • Multiple mechanisms of lung surfactant inhibition.

    abstract::We studied the mechanisms by which C16:0 lysophosphatidylcholine (LPC) and albumin inhibit the surface activity of calf lung surfactant extract (CLSE) by using a pulsating bubble apparatus with a specialized hypophase exchange system, plus adsorption and Wilhelmy balance measurements. In the absence of inhibitors, CLS...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199907000-00015

    authors: Holm BA,Wang Z,Notter RH

    更新日期:1999-07-01 00:00:00

  • Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia.

    abstract::The etiology of biliary atresia (BA) is not yet understood, but recent studies have shown inflammation with an up-regulated interferon (IFN) activity in the intra- and extrahepatic bile ducts of patients with BA. These findings support an inflammatory/infectious cause of BA as mimicked in our infective murine model. T...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000219860.96732.09

    authors: Kuebler JF,Czech-Schmidt G,Leonhardt J,Ure BM,Petersen C

    更新日期:2006-06-01 00:00:00

  • Cytokines in human colostrum and neonatal jaundice.

    abstract::Breast-fed infants have higher bilirubin levels than formula-fed infants, possibly because of variations in the composition of the breast milk. The aim of this study was to investigate whether there is a relationship between cytokine levels in the colostrum of nursing mothers and neonatal jaundice (NJ). Breast milk sa...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e31809871c9

    authors: Zanardo V,Golin R,Amato M,Trevisanuto D,Favaro F,Faggian D,Plebani M

    更新日期:2007-08-01 00:00:00

  • Protein profiles in breast milk from mothers delivering term and preterm babies.

    abstract::During the last few years, advances in the care of low-birth-weight and preterm neonates has stimulated research on the best dietetic program to improve survival and to reduce handicap incidence. At present, fortification of human milk with artificial formulas is the most usual dietetic solution. As yet, however, litt...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199905010-00008

    authors: Velonà T,Abbiati L,Beretta B,Gaiaschi A,Flaùto U,Tagliabue P,Galli CL,Restani P

    更新日期:1999-05-01 00:00:00

  • Changes in the auditory brainstem response associated with intravenous infusion of unconjugated bilirubin into infant rhesus monkeys.

    abstract::The auditory brainstem response (ABR) was monitored in nine infant rhesus monkeys during the intravenous infusion of 50-168 mg/kg of unconjugated bilirubin. Sulfisoxazole (200 mg/kg) was sometimes given near the end of or just before the bilirubin infusion if no obvious ABR change had yet occurred. Five of the animals...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198606000-00005

    authors: Ahlfors CE,Bennett SH,Shoemaker CT,Ellis WG,Davis SL,Wennberg RP,Goetzman BW

    更新日期:1986-06-01 00:00:00

  • Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?

    abstract::Prenatal exposure to infection and subsequent inflammatory responses have been implicated in the etiology of schizophrenia and autism. In this review, we summarize current evidence from human and animal studies supporting the hypothesis that the pathogenesis of these two disorders is linked via exposure to inflammatio...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1203/PDR.0b013e318212c196

    authors: Meyer U,Feldon J,Dammann O

    更新日期:2011-05-01 00:00:00

  • Autism spectrum disorders in extremely preterm infants and placental pathology findings: a matched case-control study.

    abstract:BACKGROUND:The prevalence of autism spectrum disorders (ASD) is 5-fold higher in preterm (PT) infants born ≤28 weeks gestational age (GA) as compared to the general population. The relationship between placental pathologic lesions and ASD in PT infants has not been studied. OBJECTIVES:The objective of this study was t...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-01160-4

    authors: Mir IN,White SP,Steven Brown L,Heyne R,Rosenfeld CR,Chalak LF

    更新日期:2020-09-19 00:00:00

  • CD38 expression on CD8(+) T cells as a prognostic marker in vertically HIV-infected pediatric patients.

    abstract::Increased expression of CD38 on CD8(+) T cells is associated with activation of the immune system, progression of HIV disease, and death in adults. The prognostic significance of these cells in HIV-infected children, where the picture is complicated by age-related differences in CD38 expression, remains controversial....

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200206000-00013

    authors: Sherman GG,Scott LE,Galpin JS,Kuhn L,Tiemessen CT,Simmank K,Meddows-Taylor S,Meyers TM

    更新日期:2002-06-01 00:00:00

  • Influence of intravenous sildenafil on cerebral oxygenation measured by near-infrared spectroscopy in infants after cardiac surgery.

    abstract::Sildenafil (Viagra) has been shown to be an effective pulmonary vasodilator and is increasingly used in patients with pulmonary hypertension. Its effects on the cerebral circulation are unclear and have not yet been described. We investigated the effect of i.v. sildenafil treatment on cerebral oxygenation in 13 childr...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章

    doi:10.1203/01.pdr.0000198772.26417.66

    authors: Nagdyman N,Fleck T,Bitterling B,Ewert P,Abdul-Khaliq H,Stiller B,Hübler M,Lange PE,Berger F,Schulze-Neick I

    更新日期:2006-03-01 00:00:00

  • Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut.

    abstract:BACKGROUND:Hurricane Maria struck Puerto Rico on 20 September 2017 causing catastrophic devastation. Prolonged shortage of food had been a substantial challenge to the residents after Maria. Experiencing food insecurity in utero has been associated with negative health outcomes later in life. We aim to examine whether ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-0839-0

    authors: Wang L,de Ángel Solá D,Acevedo Flores M,Schriefer A,Wang L,Gerónimo López K,Chang A,Warner B,Shan L,Holtz LR,Rosario Matos N

    更新日期:2020-12-01 00:00:00

  • Gadolinium chloride inhibits pulmonary macrophage influx and prevents O(2)-induced pulmonary hypertension in the neonatal rat.

    abstract::Newborn rats exposed to 60% O(2) for 14 d demonstrated a bronchopulmonary dysplasia-like lung morphology and pulmonary hypertension. A 21-aminosteroid antioxidant, U74389G, attenuated both pulmonary hypertension and macrophage accumulation in the O(2)-exposed lungs. To determine whether macrophage accumulation played ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200108000-00003

    authors: Jankov RP,Luo X,Belcastro R,Copland I,Frndova H,Lye SJ,Hoidal JR,Post M,Tanswell AK

    更新日期:2001-08-01 00:00:00

  • Effects of dietary choline and N,N-dimethylaminoethanol on lung phospholipid and surfactant of newborn rats.

    abstract::Pups delivered by rats fed during pregnancy a choline-deficient (CD) diet containing 1% N,N-dimethylaminoethanol (DME) die within 36 hr of birth. The concentrations of sphingomyelins, phosphatidyl cholines, and disaturated phosphatidyl cholines in the lungs of these pups are lower than those in the lungs of pups deliv...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197809000-00014

    authors: Katyal SL,Lombardi B

    更新日期:1978-09-01 00:00:00

  • The effects of low protein during gestation on mouse pancreatic development and beta cell regeneration.

    abstract::Beta cells are partially replaced in neonatal rodents after deletion with streptozotocin (STZ). Exposure of pregnant rats to a low protein (LP) diet impairs endocrine pancreas development in the offspring, leading to glucose intolerance in adulthood. Our objective was to determine whether protein restriction has a sim...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/PDR.0b013e3181e17c90

    authors: Cox AR,Gottheil SK,Arany EJ,Hill DJ

    更新日期:2010-07-01 00:00:00

  • Newly identified forms of electron transfer flavoprotein deficiency in two patients with glutaric aciduria type II.

    abstract::Newly identified forms of electron transfer flavoprotein (ETF) deficiency in two patients with glutaric aciduria type II (GA II) were described. GA II has been attributed to a defect of either ETF or ETF dehydrogenase, resulting in multiple acyl-CoA dehydrogenation deficiency. ETF is a mitochondrial flavoprotein consi...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199101000-00012

    authors: Yamaguchi S,Orii T,Suzuki Y,Maeda K,Oshima M,Hashimoto T

    更新日期:1991-01-01 00:00:00

  • Lipoprotein changes in relation to body mass index in Native American adolescents.

    abstract::In view of their known high incidence of noninsulin dependent diabetes (NIDDM), we sought to determine whether Native American (Plains Indian) children and adolescents show evidence of risk factors for both NIDDM and cardiovascular disease. Children and adolescents between the ages of 4 and 19 y were recruited, and fi...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章

    doi:10.1203/00006450-199607000-00014

    authors: Blackett PR,Taylor T,Russell D,Lu M,Fesmire J,Lee ET

    更新日期:1996-07-01 00:00:00

  • Serial assessment of fat and fat-free mass accretion in very preterm infants: a randomized trial.

    abstract:BACKGROUND:Clinicians could modify dietary interventions during early infancy by monitoring fat and fat-free mass accretion in very preterm infants. METHODS:Preterm infants were randomly assigned to either having reports on infant body composition available to the clinicians caring for them (intervention group) or not...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-1052-x

    authors: Salas AA,Jerome ML,Chandler-Laney P,Ambalavanan N,Carlo WA

    更新日期:2020-11-01 00:00:00

  • The relation of severe malnutrition in infancy to the intelligence of school children with differing life histories.

    abstract::The IQ's of Jamaican boys aged 6-10 were associated significantly with the presence or absence of severe malnutrition in infancy, with height at time of IQ testing, and with a measure of the boys' social background. A multiple correlation coefficient of 0.674 was obtained between IQ and the three factors. Social backg...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197601000-00011

    authors: Richardson SA

    更新日期:1976-01-01 00:00:00