Abstract:
:Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cerebral malaria a leading cause of childhood neurodisability in the region. The pathogenesis of neurocognitive sequelae is poorly understood: coma develops through multiple mechanisms and there may be several mechanisms of brain injury. It is unclear how an intravascular parasite causes such brain injury. Understanding these mechanisms is important to develop appropriate neuroprotective interventions. This article examines possible mechanisms of brain injury in cerebral malaria, relating this to the pathogenesis of the disease, and explores prospects for improved neurocognitive outcome.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Idro R,Marsh K,John CC,Newton CRdoi
10.1203/PDR.0b013e3181eee738subject
Has Abstractpub_date
2010-10-01 00:00:00pages
267-74issue
4eissn
0031-3998issn
1530-0447journal_volume
68pub_type
杂志文章,评审abstract::We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The exposure of the cells to 0.5 to 5% meconium resulted in significant disruption of connections between A549 cells and caused ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181ebd4c3
更新日期:2010-09-01 00:00:00
abstract::This study was aimed at describing abdominal and laryngeal muscle responses to upper airway occlusion (UAO) in early life and the effect of sleep states on these responses. Twelve nonsedated, 9-26-d-old lambs were studied. We simultaneously recorded 1) airflow (pneumotachograph + face mask); 2) sleep states (electroco...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199706000-00011
更新日期:1997-06-01 00:00:00
abstract::Completely penetrant mutations in the surfactant protein B gene (SFTPB) and >75% reduction of SFTPB expression disrupt pulmonary surfactant function and cause neonatal respiratory distress syndrome. To inform studies of genetic regulation of SFTPB expression, we created a catalogue of SFTPB variants by comprehensive r...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3180a03232
更新日期:2007-08-01 00:00:00
abstract::To determine whether human milk contained soluble receptors and cytokine antagonists that might contribute to its anti-inflammatory properties, ELISA and enzyme-amplified sensitivity immunoassay methods were used to quantitate soluble intercellular and vascular cell adhesion molecules, soluble E-selectin, soluble IL-6...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199612000-00011
更新日期:1996-12-01 00:00:00
abstract::The proposed actions of atrial natriuretic factor (ANF) are mediated through specific plasma membrane (R1) receptors coupled to guanylate cyclase. A second receptor, R2, has been characterized by its ability to bind to an acyclic, truncated ANF analog (C-ANF4-23). The ANF-R2 receptor has not been identified in the fet...
journal_title:Pediatric research
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Cardiovascular (CV) complications are the most significant cause of mortality in adults with Cushing disease (CD); little is known about CV risk factors in children with CD. Measurement of lipoprotein particles by nuclear magnetic resonance (NMR) spectroscopy is a novel technology to assess CV risk. The obje...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-019-0438-0
更新日期:2019-09-01 00:00:00
abstract::The presence of high concentrations of sodium in the sweat of patients with cystic fibrosis is widely accepted by all investigators as one of the most important manifestations of the genetic defect. However, the simple means of sweat collection utilized for diagnostic purposes has been extended to the biochemical and ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198508000-00020
更新日期:1985-08-01 00:00:00
abstract::In blood vessels with diameters less than 500 microns, both the hematocrit and viscosity decrease with decreasing tube diameter [Fåhraeus effect (FE) and Fåhraeus-Lindqvist effect (FLE)]. Because both effects may be influenced by red blood cell (RBC) volume and osmolality, the effects of RBC type and suspending medium...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199310000-00031
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:To understand the increased susceptibility of preterm neonates to infection. METHODS:A murine listeriosis model using immunohistochemistry, microarray technology, and real-time polymerase chain reaction (PCR). RESULTS:We report that recombinant serum amyloid A (SAA) administered prophylactically 18 h befor...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2013.164
更新日期:2013-12-01 00:00:00
abstract::Serial plasma concentrations of immunoreactive 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), the stable hydration product of prostacyclin (PGI2), were measured with radioimmunoassay during the first month of life in 25 preterm infants with idiopathic respiratory distress syndrome (IRDS) and 38 preterm controls wi...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198210000-00005
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:To investigate whether the YAP/TAZ (Yes-associated protein/transcriptional coactivator with PDZ binding motif) pathway contributes to the pathogenesis of lymphatic malformations (LMs). METHODS:YAP, TAZ, CTGF (connective tissue growth factor), and Ki-67 were detected in LMs by immunohistochemistry. The coloc...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-020-0863-0
更新日期:2020-04-12 00:00:00
abstract::Previous studies have demonstrated metabolic dysfunction in the mononuclear cells of some children with abnormal cell-mediated immunity. Interpretation of these observations has been complicated by the extreme heterogeneity of cell types examined. The glycolytic metabolism of relatively enriched T-cells, non-T mononuc...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198002000-00005
更新日期:1980-02-01 00:00:00
abstract:INTRODUCTION:Data regarding neonatal arterial ischemic stroke (NAIS) topography are still sparse and inaccurate. Despite the importance of locating NAIS to predict the long-term outcome of neonates, a map of arterial territories is not yet available. Our aim was therefore to generate the first three-dimensional map of ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-019-0724-x
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Earlier attempts to deliver effective lung doses of surfactant by aerosolization were unsuccessful, mostly because of technical shortcomings. We aimed at quantifying the lung deposition of poractant alfa with a new supraglottic delivery system for surfactant atomization in an experimental neonatal model. ME...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/s41390-019-0696-x
更新日期:2020-05-01 00:00:00
abstract::Concanavalin A surface receptors were detected on brush border enterocytes from child intestinal biopsies by the concanavalin A-peroxidase method. On electron microscopy, these receptors appeared as electron-dense deposits, located on a band running along the innermost part of the brush border membrane glycocalyx. In ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198206000-00008
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:No study has examined the association between prenatal phthalate exposure and intrauterine growth retardation (IUGR). This study aimed to investigate whether prenatal exposure to phthalates was associated with increased risk of IUGR. METHODS:A total of 126 mother-newborn pairs, including 42 IUGR cases and 8...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2014.103
更新日期:2014-10-01 00:00:00
abstract::The aim of this study was to evaluate the changes in Doppler transmitral flow patterns during the 1st d of life. Doppler echocardiography of the ascending aorta and mitral valve was performed serially in 20 normal neonates at 2, 12, and 24 h of age. A computer-interfaced digitizer pad was used to measure the following...
journal_title:Pediatric research
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Oxygen is critical for multicellular existence. Its reduction to water by the mitochondrial electron transport chain helps supply the metabolic demands of human life. The incompletely reduced, reactive oxygen byproducts of this reaction, however, can be quite toxic. In this review, we explore the mechanisms responsibl...
journal_title:Pediatric research
pub_type: 杂志文章,评审
doi:10.1203/PDR.0b013e31818fc83f
更新日期:2009-03-01 00:00:00
abstract::Medium chain acyl-CoA dehydrogenase deficiency (MCAD) is a defect in the mitochondrial oxidation of fatty acids. The disorder typically presents with episodes of vomiting and hypoglycemia, sometimes with changes in mental status and hepatic failure. These Reye's-like features may culminate in coma and death. Stress, i...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199505000-00021
更新日期:1995-05-01 00:00:00
abstract::Children with cystic fibrosis excreted elevated urinary levels of all three polyamines--putrescine, spermidine, and spermine. Heterozygote parents excreted intermediate concentrations of the polyamines, but not levels significantly different from levels in normal controls. Patients with cystic fibrosis who were admini...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197910000-00011
更新日期:1979-10-01 00:00:00
abstract::Liposomes can be used for the delivery of drugs in cancer chemotherapy. After i.v. injection liposomes are to a large extent taken up by the mononuclear phagocytic system (MPS). When treating diseases in the MPS, such as the histiocytic syndromes, this property is of potential value for drug targeting and may lead to ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199507000-00002
更新日期:1995-07-01 00:00:00
abstract::The zeta subunit of the CD3 T-cell receptor complex and the major histocompatibility complex class 1 (MHC-I) are important not only for the immune response to antigens, they also function as signal molecules in the brain, where they play a role in the postnatal maturation process. The expression of these molecules can...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.pdr.0000238246.74817.a0
更新日期:2006-10-01 00:00:00
abstract::In seven patients with mucopolysaccharidoses (1 Hurler, 1 Hurler-Scheie, 4 Hunter, 1 Sly), cranial (1)H-magnetic resonance spectroscopy was performed to evaluate the accumulation of mucopolysaccharides and biochemical changes in the CNS in vivo before and after bone marrow transplantation (BMT). In two of seven patien...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-200103000-00008
更新日期:2001-03-01 00:00:00
abstract::This study was carried out to determine the influence and site of action of N omega-nitro-L-arginine methylester, an L-arginine analogue, on basal pulmonary vascular tone and hypoxic vasoconstriction in neonatal pig lungs. We studied isolated lungs from pigs, age 14.5 +/- 0.5 (SD) d and weight 3.6 +/- 0.7 kg, perfused...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199309000-00022
更新日期:1993-09-01 00:00:00
abstract::The response to the capsular polysaccharide of Haemophilus influenzae type b (Hib PS) has been used to determine the molecular basis of antibody gene diversity in humans. In contrast to the relatively restricted nature of anti-Hib PS heavy-chain variable region gene expression, a variety of light-chain variable region...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199303000-00022
更新日期:1993-03-01 00:00:00
abstract::Staphylococcus aureus has been isolated at an increasing rate from infants' stools during the last decades, but it is not known whether this species can colonize and persist in the intestinal microflora. To investigate this, 49 Swedish infants were followed prospectively from birth until 12 months of age. S. aureus wa...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-200012000-00007
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of imm...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1038/pr.2015.12
更新日期:2015-04-01 00:00:00
abstract::Malignant osteopetrosis is a fatal congenital bone disorder characterized by defective osteoclastic function. Death frequently occurs within the first decade of life. The precise molecular defect(s) that causes osteopetrosis is not known. The possibility that osteoclasts, like macrophages, are controlled by interactio...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199304000-00014
更新日期:1993-04-01 00:00:00
abstract::A patient is reported who presented in the newborn period with an unusual combination of congenital lactic acidosis and bilateral calcifications in the adrenal medulla, visible on standard abdominal x-ray and ultrasound examination. At birth, the proband was hypotonic and dystrophic. She developed respiratory insuffic...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e3181b40a80
更新日期:2009-09-01 00:00:00
abstract::Sarcoplasmic reticulum (SR) Ca release has been shown not to be the predominant mechanism responsible for excitation-contraction (E-C) coupling in fetal myocytes. However, most of the studies have been conducted either on primary cultures or acutely isolated cells, in which an apparent reduction of ryanodine receptor ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/PDR.0b013e31820bc69b
更新日期:2011-04-01 00:00:00