Abstract:
BACKGROUND:Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of immunological responses in IVIG-resistant KD patients. We assessed the possibility that T-cell activation is a contributing mechanism underlying this phenomenon. METHODS:We analyzed human leukocyte antigen-DR (HLA-DR) expression on peripheral blood CD4+ and CD8+ T cells in 82 children with KD who were admitted to the hospital between October 2007 and February 2012. We compared the percentages of HLA-DR+ T cells among the CD4+ T-cell and CD8+ T-cell populations for the IVIG-effective and IVIG-resistant groups. RESULTS:Among the 82 subjects, 51 had IVIG-effective KD and 31 children had IVIG-resistant KD. The percentages of HLA-DR+ T cells among the CD4+ T-cell and CD8+ T-cell populations in the IVIG-effective group were significantly lower than those in the IVIG-resistant group. CONCLUSION:Our results suggest that increased T-cell HLA-DR expression is associated with IVIG resistance in KD patients, indicating that HLA-DR expression would be a useful tool for predicting IVIG responsiveness during KD pathogenesis.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Wakiguchi H,Hasegawa S,Suzuki Y,Kudo K,Ichiyama Tdoi
10.1038/pr.2015.12subject
Has Abstractpub_date
2015-04-01 00:00:00pages
536-40issue
4eissn
0031-3998issn
1530-0447pii
pr201512journal_volume
77pub_type
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abstract::Sudden infant death syndrome (SIDS) remains one of the primary causes of infant mortality in developed countries. Although the causes of SIDS remain largely inconclusive, some of the most informative associations implicate molecular, genetic, anatomical, physiological, and environmental (i.e., infant sleep) factors. T...
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abstract::The fetal brain develops rapidly during the last trimester of pregnancy. Therefore, the brain of infants who are born preterm is vulnerable to changes in oxygen and nutrient supply in the neonatal period. The objective was to determine the effect of gestational age (GA) on the cerebral O2 supply threshold level for pr...
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abstract::Lung development progresses through a process reliant on mechanical cell stretch. However, this process is not well defined at the molecular level. Our goal was to globally analyze the transcriptome of fetal mouse lungs following short periods of tracheal occlusion (TO) to identify cellular processes that are rapidly ...
journal_title:Pediatric research
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doi:10.1203/PDR.0b013e31815eba47
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journal_title:Pediatric research
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doi:
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pub_type: 杂志文章
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-198106000-00005
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pub_type: 杂志文章
doi:10.1203/00006450-197907000-00012
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abstract::Spleens from 1-20-wk-old guinea pigs infected in utero with Treponema pallidum and age-matched controls, born to normal and heat-killed (56 degrees C, 2 h.) T. pallidum-injected mothers, were examined for their in vitro lymphoproliferative response to phytohemagglutinin, concanavalin A, and lipopolysaccharide. Additio...
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-197708000-00008
更新日期:1977-08-01 00:00:00
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journal_title:Pediatric research
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doi:10.1203/PDR.0b013e31822a36db
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journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/01.PDR.0000139928.60530.7D
更新日期:2004-10-01 00:00:00
abstract::The effects of passive respiratory syncytial virus (RSV) immune serum given as preinoculation prophylaxis, postinoculation prophylaxis, and as therapy on d 5 after inoculation were evaluated in an illness model of RSV infection in BALB/c mice. Pre- and postinoculation prophylaxis reduced RSV replication in lung after ...
journal_title:Pediatric research
pub_type: 杂志文章
doi:10.1203/00006450-199308000-00013
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doi:10.1203/00006450-199311000-00003
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1985-03-01 00:00:00
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doi:10.1203/00006450-197908000-00007
更新日期:1979-08-01 00:00:00
abstract::Bone disease is an important complication among very low birth weight (VLBW, <1500 g) infants. In adults, osteoporosis is associated with polymorphisms of vitamin D receptor (VDR), estrogen receptor (ER), and collagen Ialpha1 (COLIA1) genes. However, limited information is available regarding the role of these polymor...
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abstract::Lung infections are a common cause of morbidity and mortality in neonates. To evaluate neonatal lung defenses against pneumococci, we challenged rats with aerosols of encapsulated pneumococci in an airborne infection apparatus. Whereas adult rats cleared greater than 95% of inhaled type 1 or type 25 pneumococci within...
journal_title:Pediatric research
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doi:10.1203/00006450-198712000-00025
更新日期:1987-12-01 00:00:00
abstract::Establishment of Helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. The association was soon also demonstrated in children as well. Applicatio...
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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更新日期:2006-04-01 00:00:00
abstract::Sex steroids accelerate bone maturation, but it is believed that estrogen action is needed for terminal epiphyseal fusion. In this study, we investigated the effects of a new estrogen-blocking agent, Faslodex (ICI 182,780), on estrogen-accelerated skeletal maturation in immature mice. On day-of-life 2 through 8, mice ...
journal_title:Pediatric research
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更新日期:1999-09-01 00:00:00
abstract::Small bowel resection decreases brush border membrane (BBM) glucose uptake kinetics. Oral epidermal growth factor (EGF) returns net glucose transport across intact tissue to control levels despite persistence of a defect in BBM glucose uptake. The purpose of this study was to examine the effects of resection and EGF t...
journal_title:Pediatric research
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doi:10.1203/01.PDR.0000098500.94041.9B
更新日期:2004-01-01 00:00:00