The adaptation of neonatal blood to metabolic acidosis and its effect on cisternal oxygen tension.

abstract：:We have evaluated the effect of galanin (Gal), a newly identified hypothalamic peptide, on growth hormone (GH) secretion in 10 children with normal stature (NS), nine with constitutional growth delay (CGD), and five with isolated GH deficiency (IGHD). Gal was infused intravenously at a rate of 8 or 15 micrograms/kg/h....

journal_title：Pediatric research

authors： Loche S,Cella SG,Puggioni R,Stabilini L,Pintor C,Müller EE

更新日期：1989-10-01 00:00:00

abstract：:High speed cinemicrographs reveal that the ciliary configuration and beat pattern of rabbit tracheal cilia differ significantly from classid descriptions, although the basic forward and return pattern is still observed. The tracheal cilia are short and stout (about 6 mum in length) and are of a slightly bent original ...

journal_title：Pediatric research

authors： Cheung AT,Jahn TL

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:Early recognition of patients at risk for sepsis is paramount to improve clinical outcomes. We hypothesized that subtle signatures of illness are present in physiological and biochemical time series of pediatric-intensive care unit (PICU) patients in the early stages of sepsis. METHODS:We developed multivar...

journal_title：Pediatric research

authors： Spaeder MC,Moorman JR,Tran CA,Keim-Malpass J,Zschaebitz JV,Lake DE,Clark MT

更新日期：2019-11-01 00:00:00

abstract：:Amplitude-integrated EEG (aEEG) is used to select patients for neuroprotective therapy after perinatal asphyxia because of its prognostic accuracy within several hours after birth. We aimed to determine the natural course of aEEG patterns during the first 72 h of life, in relation to neurologic outcome, in a group of ...

journal_title：Pediatric research

authors： ter Horst HJ,Sommer C,Bergman KA,Fock JM,van Weerden TW,Bos AF

更新日期：2004-06-01 00:00:00

abstract：:Premature rabbits delivered by cesarean section at 28 d of gestation were each given intratracheally 75 mg/kg of radiolabeled preparation of either natural rabbit surfactant, natural calf surfactant, or surfactant-TA. Each newborn rabbit was ventilated for up to 6 h in a ventilator-plethysmograph with individual adjus...

journal_title：Pediatric research

authors： Seidner SR,Jobe AH,Ruffini L,Ikegami M,Pettenazzo A

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that infantile hypertrophic pyloric stenosis (IHPS) and congenital heart defects (CHDs) may share some genetic risk factors, but little is known about the co-occurrence of the two conditions in patients. METHODS:Our study cohort included 2,212,756 persons born in Denmark 1977-2013. We...

journal_title：Pediatric research

authors： Feenstra B,Gørtz S,Lund M,Ranthe MF,Geller F,Melbye M

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Preterm infants have a greater risk of necrotizing enterocolitis following transfusion. It is hypothesized that high glucose concentrations in red blood cell (RBC) preservatives lead to increased methylglyoxal (MG) metabolism, causing glycation-driven damage to transfused RBCs. Such changes to the RBCs could...

journal_title：Pediatric research

authors： Kiefer AS,Fleming T,Eckert GJ,Poindexter BB,Nawroth PP,Yoder MC

更新日期：2014-03-01 00:00:00

abstract：:Cerebral blood flow (CBF) measurement by near infrared spectroscopy (NIRS) using oxyhemoglobin (HbO2) as a tracer (CBF-HbO2) needs rapid changes in arterial oxygen saturation (SaO2) which often cannot be achieved in many sick infants. An alternative method based on the same adaptation of the Fick principle using i.v. ...

journal_title：Pediatric research

authors： Patel J,Marks K,Roberts I,Azzopardi D,Edwards AD

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Severe traumatic brain injury (TBI) is a leading cause of mortality in children, but the accurate prediction of outcomes at the point of admission remains very challenging. Admission laboratory results are a promising potential source of prognostic data, but have not been widely explored in paediatric cohort...

journal_title：Pediatric research

authors： Kayhanian S,Young AMH,Mangla C,Jalloh I,Fernandes HM,Garnett MR,Hutchinson PJ,Agrawal S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Histomorphometry of endomyocardial biopsies is one component of arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis, although there is a need for stricter diagnostic criteria for this disease in pediatrics. The clinical utility of biopsy analysis as a component of ARVC diagnosis was evaluated in...

journal_title：Pediatric research

authors： Sreetharan S,MacIntyre CJ,Fatah M,Warren AE,Wilson GJ,Hamilton RM

更新日期：2018-10-01 00:00:00

abstract：:We determined the concentrations of copper, the activities of ceruloplasmin and peptidylglycine alpha-amidating monooxygenase (PAM), and the stimulation index of PAM by the in vitro addition of copper in plasma samples obtained from three male patients with occipital horns and a milder Menkes disease phenotype, having...

journal_title：Pediatric research

authors： Prohaska JR,Tamura T,Percy AK,Turnlund JR

更新日期：1997-12-01 00:00:00

abstract：:We assessed the patterns of Helicobacter pylori (H. pylori) specific maternal antibodies in maternal serum, cord blood, and milk, which might play a role in prevention of H. pylori infection because transferred to the infant. Between November 2000 and November 2001, mothers were recruited after delivery of their offsp...

journal_title：Pediatric research

authors： Weyermann M,Borowski C,Bode G,Gürbüz B,Adler G,Brenner H,Rothenbacher D

更新日期：2005-11-01 00:00:00

abstract：:The first days of postnatal life are energetically demanding as metabolic functions change dramatically to accommodate drastic environmental and physiologic transitions after birth. It is increasingly appreciated that metabolic pathways are not only crucial for nutrition but also play important roles in regulating inf...

journal_title：Pediatric research

authors： Conti MG,Angelidou A,Diray-Arce J,Smolen KK,Lasky-Su J,De Curtis M,Levy O

更新日期：2020-01-01 00:00:00

abstract：:We have shown previously that polynucleotides enhance in vitro antibody and Ig production in response to T-dependent antigens in mice and augment Ig production by adult human peripheral blood mononuclear cells. Herein, we report their effects on umbilical cord blood mononuclear cells (CBMNC) obtained from full-term ba...

journal_title：Pediatric research

authors： Jyonouchi H,Zhang-Shanbhag L,Georgieff M,Tomita Y

更新日期：1993-11-01 00:00:00

abstract：:We examined the effect of inspiratory resistive loaded breathing (IRL) on the electromyographic (EMG) activity of the costal and crural diaphragm in nine anesthetized spontaneously breathing piglets (age 10-23 days, weight 2.8-4.4 kg). Bipolar wire electrodes were inserted into the anterior paratendinous costal diaphr...

journal_title：Pediatric research

authors： Watchko JF,Mayock DE,Standaert TA,Woodrum DE

更新日期：1987-01-01 00:00:00

abstract：:The global burden of kidney disease is increasing, and several etiologies first begin in childhood. Risk factors for pediatric kidney disease are common in Africa, but data regarding its prevalence are lacking. We completed a systematic review of community-based studies describing the prevalence of proteinuria, hematu...

journal_title：Pediatric research

authors： Kayange NM,Smart LR,Tallman JE,Chu EY,Fitzgerald DW,Pain KJ,Peck RN

更新日期：2015-02-01 00:00:00

abstract：:There has been recent interest in the use of the phosphodiesterase-5 inhibitor sildenafil for treating pulmonary hypertension. We examined the interaction between inhaled nitric oxide (iNO) and i.v. sildenafil in 12 piglets with acute pulmonary hypertension and lung injury secondary to meconium aspiration. Six animals...

journal_title：Pediatric research

authors： Shekerdemian LS,Ravn HB,Penny DJ

更新日期：2004-03-01 00:00:00

abstract：:Acute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped kidneys, baseline biomarker values may differ. We describe baseline values of urinary neutrophil gelatinase-associated lipocali...

journal_title：Pediatric research

authors： Askenazi DJ,Koralkar R,Levitan EB,Goldstein SL,Devarajan P,Khandrika S,Mehta RL,Ambalavanan N

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Risk factors for diastolic dysfunction in hypertrophic cardiomyopathy (HCM) are poorly understood. We investigated the association of variants in hypoxia-response genes with phenotype severity in pediatric HCM. METHODS:A total of 80 unrelated patients <21 y and 14 related members from eight families with HC...

journal_title：Pediatric research

authors： Alkon J,Friedberg MK,Manlhiot C,Manickaraj AK,Kinnear C,McCrindle BW,Benson LN,Addonizio LJ,Colan SD,Mital S

更新日期：2012-12-01 00:00:00

abstract：:We measured the changes in tidal volume, duration of the various phases of the respiratory cycle, and peak nasal pressure during elastic and resistive loading in preterm infants. Values were calculated during the first loaded breath, when chemical drive was unchanged. Tidal volume decreased by equivalent percentages w...

journal_title：Pediatric research

authors： Boychuk RB,Seshia MM,Rigatto H

更新日期：1977-04-01 00:00:00

abstract：:Early childhood overweight and obesity have alarmingly increased over the years. Adulthood obesity is a well demonstrated significant independent predictor of cardiovascular risk (CVR) and/or mortality, which predisposes to the major components of metabolic syndrome (MS). Evidence of MS in obese children has been also...

journal_title：Pediatric research

authors： Aggoun Y

更新日期：2007-06-01 00:00:00

abstract：:Many attempts have been made to obtain safe and effective analgesia in newborns. Oral glucose-water has been found to have analgesic properties in neonates. We investigated whether other sensory stimulation added to oral glucose provided more effective analgesia than oral glucose alone. In a randomized prospective dou...

journal_title：Pediatric research

authors： Bellieni CV,Bagnoli F,Perrone S,Nenci A,Cordelli DM,Fusi M,Ceccarelli S,Buonocore G

更新日期：2002-04-01 00:00:00

abstract：:Nasopharyngeal radium irradiation (NRI) was widely used from 1940 through 1970 to treat otitis serosa in children and barotrauma in airmen and submariners. We assessed whether NRI-exposed individuals were at higher risk for benign tumors, nonmelanoma skin cancer, thyroid disorders, and conditions related to regulatory...

journal_title：Pediatric research

authors： Ronckers CM,Land CE,Hayes RB,Verduijn PG,Stovall M,van Leeuwen FE

更新日期：2002-12-01 00:00:00

abstract：:We analyzed by means of immunoblot technique the patterns of antibodies binding to polypeptides of Borrelia burgdorferi B31 in the sera of 21 children with different stages of Lyme disease. All sera but one recognized the flagellar protein 41 kD and all but two the 83-kD protein. The number of proteins recognized rose...

journal_title：Pediatric research

authors： Nadal D,Taverna C,Hitzig WH

更新日期：1989-10-01 00:00:00

abstract：:The metabolism of proteoglycans in normal growth plate and the changes in growth plate morphology induced by diabetes and malnutrition were studied in rats. The proteoglycans had a significantly faster turnover (half-life measured with [35S]sulfate labeling: 25-30 h) than the cells in the growth plate. Morphometric st...

journal_title：Pediatric research

authors： Axelsson I,Pita JC,Howell DS,Lorentzon R,Berman I,Boquist L

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:To systematically evaluate short-term efficacy of UCM versus other interventions in preterm infants. METHODS:Six engines were searched until February 2020 for randomized controlled trials (RCTs) assessing UCM versus immediate cord clamping (ICC), delayed cord clamping (DCC), or no intervention. Primary outc...

journal_title：Pediatric research

authors： Barboza JJ,Albitres-Flores L,Rivera-Meza M,Rodriguez-Huapaya J,Caballero-Alvarado J,Pasupuleti V,Hernandez AV

更新日期：2020-04-21 00:00:00

abstract：:Oxygen is critical for multicellular existence. Its reduction to water by the mitochondrial electron transport chain helps supply the metabolic demands of human life. The incompletely reduced, reactive oxygen byproducts of this reaction, however, can be quite toxic. In this review, we explore the mechanisms responsibl...

journal_title：Pediatric research

authors： Maltepe E,Saugstad OD

更新日期：2009-03-01 00:00:00

abstract：:In this study we examined the body composition at onset of puberty in intrauterine growth retarded (IUGR), postnatal food restricted (FR), and control male and female rats. IUGR was induced by ligation of the uterine artery on d 17 of gestation and FR by litter enlargement to 20 pups per mother from d 2 after birth un...

journal_title：Pediatric research

authors： Engelbregt MJ,van Weissenbruch MM,Popp-Snijders C,Lips P,Delemarre-van de Waal HA

更新日期：2001-10-01 00:00:00

abstract：:In a patient with extrapyramidal movement disorder and extremely low creatinine concentrations in serum and urine, in vivo proton magnetic resonance spectroscopy disclosed a generalized depletion of creatinine in the brain. Oral substitution of arginine, a substrate for creatine synthesis, resulted in an increase of b...

journal_title：Pediatric research

authors： Stöckler S,Holzbach U,Hanefeld F,Marquardt I,Helms G,Requart M,Hänicke W,Frahm J

更新日期：1994-09-01 00:00:00

abstract：:Neonatal group B streptococcal (GBS) sepsis produces pulmonary arterial hypertension and hypoxemia that are preventable by pretreatment with the selective thromboxane A2 synthase inhibitor, dazmegrel. In the present experiment we administered dazmegrel (8 mg/kg) 2 h after the initiation of a 2 1/2 h infusion of 5 X 10...

journal_title：Pediatric research

authors： Truog WE,Gibson RL,Juul SE,Henderson WR,Redding GJ

更新日期：1988-04-01 00:00:00