当前位置： SCI文献检索 > PEDIATRIC RESEARCH期刊下所有文献 > Interaction between inhaled nitric oxide and intravenous sildenafil in a porcine model of meconium aspiration syndrome.

Interaction between inhaled nitric oxide and intravenous sildenafil in a porcine model of meconium aspiration syndrome.

Abstract：

:There has been recent interest in the use of the phosphodiesterase-5 inhibitor sildenafil for treating pulmonary hypertension. We examined the interaction between inhaled nitric oxide (iNO) and i.v. sildenafil in 12 piglets with acute pulmonary hypertension and lung injury secondary to meconium aspiration. Six animals (controls) received no intervention after meconium instillation, and six received iNO (20 ppm) from 120 min, with the addition at 240 min of an i.v. sildenafil infusion (2 mg/kg over 2 h). Meconium instillation increased mean pulmonary artery (PA) pressure from 16.0 +/- 3.1 to 24.8 +/- 4.6 mm Hg (p < 0.01) and pulmonary vascular resistance (PVR) from 0.047 +/- 0.008 to 0.089 +/- 0.027 mm Hg. ml(-1). min(-1). kg(-1) (p < 0.01). Oxygenation index increased from 3 +/- 0.8 to 8.3 +/- 3.0 (p < 0.01). There were no further changes beyond 120 min in controls. iNO reduced PA pressure and PVR to baseline values, without influencing oxygenation. The addition of sildenafil further reduced PA pressure, tended to increase the cardiac output, and reduced PVR from 0.049 +/- 0.02 to 0.028 +/- 0.01 mm Hg. ml(-1). min(-1). kg(-1) (p < 0.05). Sildenafil lowered the systemic blood pressure and systemic vascular resistance and produced profound arterial hypoxemia, reducing arterial Po(2) from 69 +/- 23 mm Hg to 49 +/- 15 mm Hg, despite substantial increases first in inspired oxygen fraction and subsequently in mean airway pressures. Consequently, the oxygenation index increased by 13.9 +/- 4.8 (p = 0.01). When given in addition to iNO, sildenafil at a dose of >0.5 mg/kg produced profound pulmonary vasodilation, but this was coupled with an unacceptable deterioration in oxygenation and systemic vasodilation in this model of pulmonary hypertension with acute parenchymal lung disease.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Shekerdemian LS,Ravn HB,Penny DJ

doi

10.1203/01.PDR.0000112033.81970.C2

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

413-8

issue

3

eissn

0031-3998

issn

1530-0447

pii

01.PDR.0000112033.81970.C2

journal_volume

55

pub_type

杂志文章

相关文献

PEDIATRIC RESEARCH文献大全
  • A new look at the pathogenesis of the meconium aspiration syndrome: a role for fetal pancreatic proteolytic enzymes in epithelial cell detachment.

    abstract：:We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The exposure of the cells to 0.5 to 5% meconium resulted in significant disruption of connections between A549 cells and caused ...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/PDR.0b013e3181ebd4c3

    authors： Ivanov VA,Gewolb IH,Uhal BD

    更新日期：2010-09-01 00:00:00

  • The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death.

    abstract：:Hypoxia and other adverse conditions are commonly encountered by rapidly growing cells. The RNA-binding protein RBM3 (RNA-binding motif protein 3), which is transcriptionally induced by low temperature and hypoxia, has recently been implicated in survival of colon cancer cells by mechanisms involving cyclooxygenase-2 ...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/PDR.0b013e3181c13326

    authors： Wellmann S,Truss M,Bruder E,Tornillo L,Zelmer A,Seeger K,Bührer C

    更新日期：2010-01-01 00:00:00

  • Proliferative response of different human osteoblast-like cell models to proinflammatory cytokines.

    abstract：:Children with inflammatory bowel disease are known to be at risk of osteopenia. The cause of this osteopenia is likely to be multifactorial, but the inflammatory process with its characteristic overproduction of cytokines has been implicated. To investigate this possible contribution of the disease activity to the dev...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-200008000-00008

    authors： Harbour ME,Gregory JW,Jenkins HR,Evans BA

    更新日期：2000-08-01 00:00:00

  • Lung fluid balance in hypoxic lambs.

    abstract：:In spontaneously breathing newborn lambs, alveolar hypoxia increases lung microvascular pressure, which causes lung lymph flow to increase and the concentration of protein in lymph to decrease. To see if this response derives from hypoxia itself rather than from the change in breathing pattern that occurs during hypox...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-198405000-00009

    authors： Hansen TN,Haberkern CM,Hazinski TA,Bland RD

    更新日期：1984-05-01 00:00:00

  • Effect of oxypurinol, a xanthine oxidase inhibitor, on hepatic injury in the bile duct-ligated rat.

    abstract：:Oxidant stress has been implicated as playing a role in the pathogenesis of cholestatic liver injury. The objective of this study was to determine whether the xanthine oxidase/xanthine dehydrogenase enzyme system was involved in this oxidant stress. Adult Sprague-Dawley rats were treated with the xanthine oxidase inhi...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199809000-00022

    authors： Sokol RJ,Devereaux MW,Khandwala R

    更新日期：1998-09-01 00:00:00

  • Frequency, tidal volume, and mean airway pressure combinations that provide adequate gas exchange and low alveolar pressure during high frequency oscillatory ventilation in rabbits.

    abstract：:We studied healthy and saline lavaged rabbits during high frequency oscillatory ventilation to determine what combination of frequency (f), tidal volume (Vt), and mean airway pressure (Paw) produced the lowest peak-to-peak alveolar pressure amplitude (Palv) and physiologic blood gas tensions. Sinusoidal volume changes...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199001000-00018

    authors： Kamitsuka MD,Boynton BR,Villanueva D,Vreeland PN,Frantz ID 3rd

    更新日期：1990-01-01 00:00:00

  • Early cardiac abnormalities in obese children: importance of obesity per se versus associated cardiovascular risk factors.

    abstract：:We investigated whether obese children and adolescents have early echocardiographic signs of subclinical cardiac dysfunction and evaluated the respective influence of obesity per se versus parameters of carbohydrate and lipid metabolism that are frequently abnormal in obese subjects. The role of tissue Doppler imaging...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/PDR.0b013e318176182b

    authors： Van Putte-Katier N,Rooman RP,Haas L,Verhulst SL,Desager KN,Ramet J,Suys BE

    更新日期：2008-08-01 00:00:00

  • Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.

    abstract：BACKGROUND:Toll-like receptor (TLR)-mediated inflammation may contribute to neonatal sepsis, for which pentoxifylline (PTX), a phosphodiesterase inhibitor that raises intracellular cAMP, is a candidate adjunctive therapy. We characterized the anti-inflammatory effects of PTX toward TLR-mediated production of inflammato...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/pr.2017.6

    authors： Speer EM,Dowling DJ,Ozog LS,Xu J,Yang J,Kennady G,Levy O

    更新日期：2017-05-01 00:00:00

  • Low incidence of childhood celiac disease in The Netherlands.

    abstract：:The incidence and prevalence of celiac disease vary internationally. We studied the incidence of identified cases of childhood celiac disease in six Dutch provinces that cover 47.9% of the surface area and 67.6% of the total population of The Netherlands. Children with celiac disease aged 0-14 y, diagnosed from Januar...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199502000-00015

    authors： George EK,Mearin ML,van der Velde EA,Houwen RH,Bouquet J,Gijsbers CF,Vandenbroucke JP

    更新日期：1995-02-01 00:00:00

  • Lecithin/sphingomyelin ratios in tracheal aspirates from newborn infants.

    abstract：:A sensitive and rapid high-performance liquid chromatography method for determining lecithin/sphingomyelin (L/S) ratios in small volume tracheal aspirates has been evaluated in 115 infants sampled within 3 h of delivery. Respiratory distress syndrome was present in 41 infants and all had L/S ratios of less than or equ...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-198708000-00010

    authors： D'Costa M,Dassin R,Bryan H

    更新日期：1987-08-01 00:00:00

  • Hyperoxia downregulates angiotensin-converting enzyme-2 in human fetal lung fibroblasts.

    abstract：BACKGROUND:Angiotensin (ANG) II is involved in experimental hyperoxia-induced lung fibrosis. Angiotensin-converting enzyme-2 (ACE-2) degrades ANG II and is thus protective, but is downregulated in adult human and experimental lung fibrosis. Hyperoxia is a known cause of chronic fibrotic lung disease in neonates, but th...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/pr.2015.27

    authors： Oarhe CI,Dang V,Dang M,Nguyen H,Gopallawa I,Gewolb IH,Uhal BD

    更新日期：2015-05-01 00:00:00

  • Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease.

    abstract：:Despite the availability of successful prevention strategies to prevent excessive hyperbilirubinemia, the neurological sequelae of bilirubin neurotoxicity (BNTx) still occur throughout the world. Kernicterus, encephalopathy due to BNTx, is now understood to be a spectrum of severity and phenotypes known as kernicterus...

    journal_title：Pediatric research

    pub_type： 杂志文章,评审

    doi：10.1038/s41390-019-0608-0

    authors： Riordan SM,Shapiro SM

    更新日期：2020-01-01 00:00:00

  • Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B.

    abstract：:Deficiency of the lipoprotein complex, surfactant, can lead to respiratory distress syndrome (RDS) in the prematurely born infant. The surfactant proteins (SP) play important roles in the function of surfactant. Previously, we have characterized four allelic variants of the SP-A1 gene (6A, 6A2, 6A3, and 6A4) and five ...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199802000-00003

    authors： Kala P,Ten Have T,Nielsen H,Dunn M,Floros J

    更新日期：1998-02-01 00:00:00

  • The somatostatin analogue octreotide inhibits neuroblastoma growth in vivo.

    abstract：:Neuroblastoma, a neural crest-derived childhood tumor of the sympathetic nervous system, may in some cases differentiate to a benign ganglioneuroma or regress due to apoptosis. However, the majority of neuroblastomas are diagnosed as metastatic tumors with a poor prognosis despite intensive multimodal therapy. The neu...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199909000-00014

    authors： Borgström P,Hassan M,Wassberg E,Refai E,Jonsson C,Larsson SA,Jacobsson H,Kogner P

    更新日期：1999-09-01 00:00:00

  • Body mass index growth trajectories, early pubertal maturation, and short stature.

    abstract：BACKGROUND:Childhood body mass index (BMI) trajectory classes are rarely linked to early puberty risk, particularly among Chinese children. We estimated early puberty risk across BMI trajectory classes, investigated factors contributing to pubertal development, and examined differences in final adult height between chi...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/s41390-019-0690-3

    authors： Fan HY,Lee YL,Hsieh RH,Yang C,Chen YC

    更新日期：2020-07-01 00:00:00

  • Prevalence of iron deficiency in Swedish adolescents.

    abstract：:The prevalence of iron deficiency was determined in Göteborg, Sweden, in a sample of 15- to 16-y-old girls (n = 220) and boys (n = 207) using serum ferritin (SF). In a recent study in women on the relationship between SF and stainable bone marrow iron, it was established that at a cutoff value for SF of < 16 microgram...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199311000-00023

    authors： Hallberg L,Hultén L,Lindstedt G,Lundberg PA,Mark A,Purens J,Svanberg B,Swolin B

    更新日期：1993-11-01 00:00:00

  • Home documented monitoring of cardiorespiratory pattern and oxygen saturation in healthy infants.

    abstract：:The objective of this study was to establish longitudinal normative limits for home memory monitors during early infancy. Eighty-eight healthy infants were monitored overnight at 0.25-19 wk of age using the Healthdyne Smart Monitor. Apnea settings were 14 s for recording and 40 s for alarm; the bradycardia setting was...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199602000-00005

    authors： Hunt CE,Hufford DR,Bourguignon C,Oess MA

    更新日期：1996-02-01 00:00:00

  • Sex differences in the relationships among weight gain, subcutaneous skinfold tissue and saltatory length growth spurts in infancy.

    abstract：:As the mechanisms controlling the amount and timing of growth saltations are not well understood, the identification of physiologic coupling in weight and length growth are important for further understanding normal growth biology. Thirty-four healthy infants (13 males, 21 females) participated in a longitudinal growt...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.pdr.0000184327.65102.a6

    authors： Lampl M,Thompson AL,Frongillo EA

    更新日期：2005-12-01 00:00:00

  • Measurement of cerebral blood flow in newborn infants using near infrared spectroscopy with indocyanine green.

    abstract：:Cerebral blood flow (CBF) measurement by near infrared spectroscopy (NIRS) using oxyhemoglobin (HbO2) as a tracer (CBF-HbO2) needs rapid changes in arterial oxygen saturation (SaO2) which often cannot be achieved in many sick infants. An alternative method based on the same adaptation of the Fick principle using i.v. ...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199801000-00006

    authors： Patel J,Marks K,Roberts I,Azzopardi D,Edwards AD

    更新日期：1998-01-01 00:00:00

  • The activity of galactose-1-phosphate uridyltransferase and galactokinase in human fetal organs.

    abstract：:The activity of galactose-1-phosphate uridyltransferase (transferase) and galactokinase in several organs from human fetuses 7-28 weeks old was measured by using radioactive substrates and column chromatography for product identification. The specific activity of transferase and galactokinase increased with gestationa...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-197710000-00004

    authors： Shin-Buehring YS,Beier T,Tan A,Osang M,Schaub J

    更新日期：1977-10-01 00:00:00

  • Glucocorticoid receptor expression on circulating leukocytes in healthy and asthmatic adolescents in response to exercise.

    abstract：:BackgroundPoor aerobic fitness is associated with worsening of asthma symptoms, and fitness training may improve asthma control. The mechanism linking fitness with asthma is not known. We hypothesized that repeated bouts of exercise would lead to a downregulation of glucocorticoid receptor (GR) expression on circulati...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/pr.2017.66

    authors： Lu KD,Cooper D,Haddad F,Zaldivar F,Kraft M,Radom-Aizik S

    更新日期：2017-08-01 00:00:00

  • Effects of oxygen-induced lung damage on megakaryocytopoiesis and platelet homeostasis in a rat model.

    abstract：:The association between lung injury and thrombocytopenia was investigated by comparing the megakaryocyte and platelet counts, and platelet activation using P-selectin as a marker, between the prepulmonary (right atrial) and postpulmonary (left atrial) blood in adult and neonatal (preterm and term) rats with and withou...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.PDR.0000079186.86219.29

    authors： Yang J,Yang M,Xu F,Li K,Lee SK,Ng PC,Tam JS,Yuen PM,Fok TF

    更新日期：2003-09-01 00:00:00

  • Influence of antenatal glucocorticoid on preterm lamb diaphragm.

    abstract：:BackgroundPregnant women at a high risk of preterm delivery receive glucocorticoids to accelerate fetal lung maturation and surfactant synthesis. However, the effect of antenatal steroids on the developing diaphragm remains unclear. We hypothesized that maternal betamethasone impairs the fetal diaphragm, and the magni...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1038/pr.2017.99

    authors： Mahzabin T,Pillow JJ,Pinniger GJ,Bakker AJ,Noble PB,White RB,Karisnan K,Song Y

    更新日期：2017-09-01 00:00:00

  • In vitro studies of effects of light and riboflavin on DNA and HeLa cells.

    abstract：:The widespread use of phototherapy for neonatal hyperbilirubinemia has caused some concern since substances other than bilirubin may be photoactivated. The toxic properties of these photoactivated substances might prove to be more harmful to the neonatal infant than bilirubin. The purpose of the present study was to i...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-197503000-00009

    authors： Speck WT,Chen CC,Rosenkranz HS

    更新日期：1975-03-01 00:00:00

  • Comparison of maximal oxygen consumption between black and white prepubertal and pubertal children.

    abstract：:The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children and whether a difference existed to determine whether it was related to hematologic profiles, body composition, and/or physical activity/inactivity level. Fort...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.PDR.0000141521.77229.8D

    authors： Andreacci JL,Robertson RJ,Dubé JJ,Aaron DJ,Balasekaran G,Arslanian SA

    更新日期：2004-11-01 00:00:00

  • Reduced Na+, K(+)-ATPase activity in patients with pseudohypoaldosteronism.

    abstract：:Pseudohypoaldosteronism is a hereditary salt-wasting syndrome usually seen in infancy with weight loss, dehydration, and failure to thrive. The pathophysiologic origin of pseudohypoaldosteronism is unknown. The defect could be related to the unresponsiveness of target organs to mineralocorticoids resulting in hyponatr...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199403000-00021

    authors： Bistritzer T,Evans S,Cotariu D,Goldberg M,Aladjem M

    更新日期：1994-03-01 00:00:00

  • The effect of recombinant human insulin-like growth factor-I on chronic puromycin aminonucleoside nephropathy in rats.

    abstract：:We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside (PAN) nephropathy, an experimental model of glomerular disease. Therefore, we examined whether recombinant human (rh) IGF-I is a safer alternative for the treatment of growth failure in...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/00006450-199601000-00002

    authors： Trachtman H,Maesaka J,Futterweit S,Ma C,Valderrama E,Chan JC,Chan W

    更新日期：1996-01-01 00:00:00

  • Retraction Note: Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats.

    abstract：:This paper has been retracted at the request of the authors. ...

    journal_title：Pediatric research

    pub_type： 杂志文章,撤回出版物

    doi：10.1038/s41390-019-0529-y

    authors： Choi CW,Kim BI,Mason SN,Potts-Kant EN,Brahmajothi MV,Auten RL

    更新日期：2019-11-01 00:00:00

  • Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS.

    abstract：:Genetic variants of surfactant protein B (SP-B) have been associated with respiratory distress syndrome (RDS) in the prematurely born infant. We wished to determine linkage between RDS and SP-B single nucleotide polymorphisms (SNPs) [-18 (A/C), 1013 (A/C), 1580 (C/T), and 9306 (A/G)] or SP-B-linked microsatellite [(D2...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.pdr.0000203145.48585.2c

    authors： Floros J,Thomas NJ,Liu W,Papagaroufalis C,Xanthou M,Pereira S,Fan R,Guo X,Diangelo S,Pavlovic J

    更新日期：2006-04-01 00:00:00

  • Autonomic nervous system dysregulation: breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome.

    abstract：:This study characterizes cardiorespiratory dysregulation in young girls with MECP2 mutation-confirmed Rett syndrome (RS). Respiratory inductance plethysmography of chest/abdomen and ECG was obtained during daytime wakefulness in 47 girls with MECP2 mutation-confirmed RS and 47 age-, gender-, and ethnicity-matched cont...

    journal_title：Pediatric research

    pub_type： 杂志文章

    doi：10.1203/01.pdr.0000238302.84552.d0

    authors： Weese-Mayer DE,Lieske SP,Boothby CM,Kenny AS,Bennett HL,Silvestri JM,Ramirez JM

    更新日期：2006-10-01 00:00:00