Abstract：
:Increased expression of CD38 on CD8(+) T cells is associated with activation of the immune system, progression of HIV disease, and death in adults. The prognostic significance of these cells in HIV-infected children, where the picture is complicated by age-related differences in CD38 expression, remains controversial. Measuring the unimodal expression of CD38 on CD8(+) T cells in adults and children by flow cytometry is best accomplished by quantitating the antigen on the cell surface. To our knowledge, this technique has not previously been reported in a pediatric population. Vertically HIV-infected children were age matched for mild (n = 26) and severe (n = 23) clinical disease. Eleven age-matched HIV-negative controls were included for comparison. Quantitation of CD38 on CD8(+) T cells was performed at baseline and 1 y later. The ages of the children in the three clinical groups did not differ significantly (p = 0.6004). HIV-infected children had significantly increased CD38 measurements in comparison with the HIV-negative controls (p = 0.0131), and the severe disease group tended to have higher measurements than the mild disease group. Increased CD38(+)CD8(+) T cells were significant predictors of death within the first year (p = 0.043). These findings support the view that increased CD38 expression on CD8(+) T cells has the same prognostic significance in pediatric as in adult HIV disease.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Sherman GG,Scott LE,Galpin JS,Kuhn L,Tiemessen CT,Simmank K,Meddows-Taylor S,Meyers TMdoi
10.1203/00006450-200206000-00013subject
Has Abstractpub_date
2002-06-01 00:00:00pages
740-5issue
6eissn
0031-3998issn
1530-0447journal_volume
51pub_type
杂志文章abstract：:Insulin-like growth factor-I (IGF-I) plays an important role in the stimulation of postnatal brain growth. In transgenic (Tg) mice, IGF-I overexpression stimulates postnatal brain growth, whereas decreased IGF-I availability caused by ectopic brain expression of IGF binding protein-1 [(IGFBP-1), an inhibitor of IGF-I ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199903000-00007
更新日期：1999-03-01 00:00:00
abstract：:Preterm infants are more prone to bone mineral deficiency the lower their birth weight. To achieve the intrauterine bone mineral accretion rate postnatally, 74 low-birth-weight infants (median birth weight, 980 g; range 430-1.580 g) were each supplemented enterally and/or parenterally with calcium and/or phosphorus in...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-199401000-00027
更新日期：1994-01-01 00:00:00
abstract：:Synchronized atrial contraction may be much more important in the newborn, who has a faster heart rate and a less compliant ventricle, than in the adult. We therefore investigated the extent by which synchronized atrioventricular contraction contributes to cardiac output and cardiac work in a neonatal circulation, and...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199803000-00004
更新日期：1998-03-01 00:00:00
abstract：:Lung development progresses through a process reliant on mechanical cell stretch. However, this process is not well defined at the molecular level. Our goal was to globally analyze the transcriptome of fetal mouse lungs following short periods of tracheal occlusion (TO) to identify cellular processes that are rapidly ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e31815eba47
更新日期：2008-02-01 00:00:00
abstract：:The developmental stages of each foregut organ are intimately linked to the development of the other foregut organs such that the ultimate function of any one foregut organ, such as the metabolic function of the liver, depends on organizational changes associated with the maturation of multiple foregut organs. These c...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/pr.2013.201
更新日期：2014-01-01 00:00:00
abstract：:We banded the trachea of 4-wk-old male rats and studied lung growth, lung morphometry, and static pulmonary mechanics 4 wk later. We compared the experimental animals to sham-operated male littermates of the same age, 8-wk-old normal male littermates, and weight-matched rats of a younger age. Tracheal banded animals w...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198103000-00014
更新日期：1981-03-01 00:00:00
abstract：:The ability of erythrocytes from newborn babies and adults to maintain reduced glutathione levels during oxidative stress was studied. In vitro incubation of erythrocytes with H2O2, with or without inactivation of catalase, caused a rapid depletion of reduced glutathione (GSH) and concomitant accumulation of oxidized ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199210000-00006
更新日期：1992-10-01 00:00:00
abstract：:There is evidence that an elevated erythropoietin (EPO) concentration is associated with signs of iron deficient erythropoiesis. The aim of this study was to evaluate the iron status by means of novel cellular indices and serum iron markers and to determine whether these are associated with EPO and pH in the venous co...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e318179957d
更新日期：2008-08-01 00:00:00
abstract：:Evaluation of nonlinear heart rate (HR) dynamics has received considerable attention in the pediatric literature because such analyses not only provide insight into underlying control mechanisms, but may also help to differentiate between normal and abnormal infants. The purpose of this study was to determine, in eigh...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199807000-00018
更新日期：1998-07-01 00:00:00
abstract：:In artificial tubes as well as in blood vessels with diameters less than 500 microns, blood viscosity decreases with decreasing diameter (Fahraeus-Lindqvist effect). Our study measured viscosity of red blood cells (RBC) from 10 preterm infants, 10 term neonates, and 10 adults by means of a capillary viscometer. RBC we...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198906000-00009
更新日期：1989-06-01 00:00:00
abstract：:To study the effects of cytomegalovirus infection on T-lymphocyte subpopulations, we determined helper (Lyt 1.2) and suppressor (Lyt 2.2) T-lymphocyte subset numbers using monoclonal antibodies and measured lymphocyte responsiveness to mitogen during sublethal murine cytomegalovirus (MCMV) infection of 3-wk-old Balb/c...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198506000-00016
更新日期：1985-06-01 00:00:00
abstract：:Taurine is an essential amino acid during fetal life and appears to be vital for the growth of the fetus and for the development of the CNS. In intrauterine growth restriction (IUGR), fetal plasma concentrations of taurine are reduced, and we tested the hypothesis that this is caused by altered placental transport of ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199808000-00016
更新日期：1998-08-01 00:00:00
abstract：:A specific, enzyme-linked immunoabsorbent assay was used to determine the concentration of the 35,000 mol wt surfactant apoprotein (SP-A) in samples of amniotic fluid obtained from nondiabetic (n = 358) and diabetic (n = 29) women. The enzyme-linked immunoabsorbent assay was performed with rabbit antibodies directed a...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198812000-00016
更新日期：1988-12-01 00:00:00
abstract：:We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The exposure of the cells to 0.5 to 5% meconium resulted in significant disruption of connections between A549 cells and caused ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181ebd4c3
更新日期：2010-09-01 00:00:00
abstract：:The growth hormone-releasing hexapeptide (GHRP-6) specifically stimulates growth hormone (GH) secretion in several animal species and humans. The mechanism of action of GHRP-6 is largely unknown, although experimental evidence indicates that it may modulate growth hormone-releasing hormone (GHRH) and somatostatin acti...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199408000-00006
更新日期：1994-08-01 00:00:00
abstract：:Wu and colleagues analyzed the placental pathology from a subset of the neonates in the NEATO trial who had reports available and correlated the placental pathology findings with outcomes. This study highlights the importance of placental pathology, and its potential to bring precision medicine to critically-ill neona...
journal_title：Pediatric research
pub_type： 评论,杂志文章
doi：10.1038/s41390-020-0807-8
更新日期：2020-04-01 00:00:00
abstract：:Two infants with disorders of propionate metabolism were studied at 7 months of age to determine optimum levels of intake of protein and calories to meet the requirements for essential amino acid for growth in infancy, and at the same time minimize the accumulation of toxic intermediates. An effect of alanine was foun...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198501000-00023
更新日期：1985-01-01 00:00:00
abstract：:In the human fetus, liver macrophages appear to be the primary source of erythropoietin (Epo). Epo production shifts from the liver to peritubular cells in the kidney sometime during the 3rd trimester. Some preterm infants experience a hyporegenerative anemia that appears to be caused by inadequate Epo production. It ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199402000-00008
更新日期：1994-02-01 00:00:00
abstract：:The objective of this study was to obtain insight into bone formation and resorption in children with newly diagnosed untreated acute lymphoblastic leukemia (ALL). In 23 consecutive children with ALL, a bone biopsy was taken from the crista iliaca posterior under ketamine anesthesia, together with the diagnostic marro...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000090929.16450.DE
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Volatile organic compounds (VOCs) are hydrocarbons that originate within different healthy and diseased tissues. VOCs can be secreted into the circulation and then excreted in the urine and faeces. In the lungs, VOCs are locally produced and can be detected in exhaled breath. VOCs can be identified using non...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1038/s41390-020-0828-3
更新日期：2020-03-02 00:00:00
abstract：:BACKGROUNDLow birth weight is associated with childhood stunting, but equivalent associations for birth body composition (BC) remain unknown. The aim of this study was to assess associations between birth BC and height-for-age z-score (HAZ) at 2 years of age.METHODSIn a prospective cohort study, fat mass (FM) and fat-...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.59
更新日期：2017-08-01 00:00:00
abstract：:The effect of intrauterine growth retardation (IUGR) on cerebral and adrenal monoamine metabolism was studied in the fetuses of eight nulliparous rat dams after unilateral uterine artery ligation on d 18 of gestation. On d 22 (term = 23 d), four dams were subjected to normoxia and four to hypoxia (10% O2) for 58 min w...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199202000-00008
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND:Exposure to inflammation exacerbates injury in neonatal encephalopathy (NE). We hypothesized that brain biomarker mRNA, cytokine mRNA and microRNA differentiate inflammation (E. coli LPS), hypoxia (Hypoxia), and inflammation-sensitized hypoxia (LPS+Hypoxia) in an NE piglet model. METHODS:Sixteen piglets wer...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0986-3
更新日期：2020-06-10 00:00:00
abstract：:To elucidate the impact of nutrition in cystic fibrosis (CF), we compared the phenotypic traits of Cftr -/- mice fed either a lipid-enriched liquid diet (Peptamen) or a standard chow combined with polyethylenglycol osmotic laxative (PEG), two strategies commonly used to prevent intestinal obstruction in CF mice. Survi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e318155a61d
更新日期：2007-11-01 00:00:00
abstract：:The syndrome of hypoxemia-related myocardial dysfunction in the newborn is generally associated with severe intrapartum asphyxia. We investigated the changes in total and regional distribution of myocardial blood flow (MBF) that occur during asphyxia and the factors that regulate MBF, in the chronically prepared, near...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198408000-00019
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:This study aimed to assess cortical gray matter growth and maturation in neonates with congenital heart disease (CHD). METHODS:Thirty-one (near) term neonates with severe CHD (8 univentricular heart malformation (UVH), 21 d-transposition of great arteries (d-TGA) and 2 aortic coarctation) underwent cerebral...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2016.145
更新日期：2016-11-01 00:00:00
abstract：:BackgroundExtracellular adenine nucleotides contribute to ischemia-reperfusion injury following infant cardiopulmonary bypass (CPB), whereas conversion to adenosine may be protective. Alkaline phosphatase (AP), a key enzyme responsible for this conversion, decreases after infant CPB. Indirect evidence suggests that so...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.325
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Type 1 diabetes (T1D) is a serious diagnosis with the prospect of grave short- and long-term complications and even death if poorly managed. An attempt has been made to describe how clinical and immunological deviations might influence each other close to the diagnosis of T1D. METHODS:Sixty-nine newly diagn...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2013.167
更新日期：2014-01-01 00:00:00
abstract：:The cerebral metabolic effects of hypoglycemia due to intrauterine growth retardation were studied in newborn dogs. Intrauterine growth retardation was induced in newborn dogs after 3 days of maternal nutritional deprivation (birth weight 251 +/- 7 versus 227 +/- 7 g, p less than 0.01). After birth, growth retarded pu...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198811000-00022
更新日期：1988-11-01 00:00:00
abstract：:Spleens from 1-20-wk-old guinea pigs infected in utero with Treponema pallidum and age-matched controls, born to normal and heat-killed (56 degrees C, 2 h.) T. pallidum-injected mothers, were examined for their in vitro lymphoproliferative response to phytohemagglutinin, concanavalin A, and lipopolysaccharide. Additio...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199712000-00013
更新日期：1997-12-01 00:00:00
