Heart rate dynamics in low risk human fetuses.


:Evaluation of nonlinear heart rate (HR) dynamics has received considerable attention in the pediatric literature because such analyses not only provide insight into underlying control mechanisms, but may also help to differentiate between normal and abnormal infants. The purpose of this study was to determine, in eight low risk human fetuses, if nonlinear HR dynamics could be identified by analyzing the dispersion of interbeat intervals at slow (Ds) and fast (Df) HRs. The fetal cardiac electrical signal was captured transabdominally at a resolution of +/- 1 ms. To test the null hypothesis, that the time series is the result of a linear stochastic process, Ds and Df for the original time series were compared with the values calculated for three linear models. The linear models were constructed to preserve the major statistical properties of the original time series, including the mean, SD, and the Fourier power spectrum. For each fetus, there was no evidence of nonlinear cardiac dynamics based on analyses of Ds and Df. In contrast, the distribution of adjacent R-R intervals and the pattern of change across three successive interbeat intervals both revealed significant nonlinearities in HR control in each fetus. If the difference between normal and abnormal infants is the result of aberrant control of nonlinear processes, then our findings indicate that parameters which describe the nonlinearity may be more useful then Ds and Df in assigning a risk status.


Pediatr Res


Pediatric research


Mooney DM,Groome LJ,Holland SB,Smith YD




Has Abstract


1998-07-01 00:00:00












  • Early childhood television viewing and kindergarten entry readiness.

    abstract:BACKGROUND:Using a large population-based sample, this study aims to verify whether televiewing at 29 mo, a common early childhood pastime, is prospectively associated with school readiness at 65 mo. METHODS:Participants are a prospective longitudinal cohort of 991 girls and 1,006 boys from the Quebec Longitudinal Stu...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Pagani LS,Fitzpatrick C,Barnett TA

    更新日期:2013-09-01 00:00:00

  • Newly identified forms of electron transfer flavoprotein deficiency in two patients with glutaric aciduria type II.

    abstract::Newly identified forms of electron transfer flavoprotein (ETF) deficiency in two patients with glutaric aciduria type II (GA II) were described. GA II has been attributed to a defect of either ETF or ETF dehydrogenase, resulting in multiple acyl-CoA dehydrogenation deficiency. ETF is a mitochondrial flavoprotein consi...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Yamaguchi S,Orii T,Suzuki Y,Maeda K,Oshima M,Hashimoto T

    更新日期:1991-01-01 00:00:00

  • A novel WT1 gene mutation associated with wilms' tumor and congenital male genitourinary malformation.

    abstract::WT1 is located on the short arm of human chromosome 11 and consists of 10 coding exons. Mutations of this gene have been reported to be the cause of Wilms' tumor, congenital male genitourinary malformations, and/or renal disorders. We describe here a novel WT1 gene mutation, i.e. a point mutation at intron 7 (+2) in b...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Sakamoto J,Takata A,Fukuzawa R,Kikuchi H,Sugiyama M,Kanamori Y,Hashizume K,Hata JI

    更新日期:2001-09-01 00:00:00

  • Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy.

    abstract:BACKGROUND:Therapeutic hypothermia (HT) is the only intervention that improves outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). However, the multifactorial mechanisms by which HT impacts HIE are incompletely understood. The complement system plays a major role in the pathogenesis of ischemia-reperfusion inju...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Shah TA,Nejad JE,Pallera HK,Lattanzio FA,Farhat R,Kumar PS,Hair PS,Bass WT,Krishna NK

    更新日期:2017-04-01 00:00:00

  • Low gestational age associated with abnormal retinal vascularization and increased blood pressure in adult women.

    abstract::The objective was to investigate any possible relationship between functional and structural vascular changes in women with low gestational age and/or low birth weight by analyzing the retinal vascular pattern in women with thoroughly documented blood pressure. Retinal vessel morphology was evaluated by digital image ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kistner A,Jacobson L,Jacobson SH,Svensson E,Hellstrom A

    更新日期:2002-06-01 00:00:00

  • Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age.

    abstract:BACKGROUND:Later life metabolic dysfunction is a well-recognized consequence of being born small for gestational age (SGA). This study has applied metabolomics to identify whether there are changes in these pathways in prepubertal short SGA children and aimed to compare the intracellular and extracellular metabolome in...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Murray PG,Butcher I,Dunn WB,Stevens A,Perchard R,Hanson D,Whatmore A,Westwood M,Clayton PE

    更新日期:2016-08-01 00:00:00

  • Association between pesticide usage during pregnancy and neonatal hyperbilirubinemia requiring treatment: the Japan Environment and Children's Study.

    abstract:BACKGROUND:Maternal exposure to pesticides during pregnancy may cause oxidative hemolysis leading to neonatal hyperbilirubinemia. This investigation examined for associations between maternal use of pesticides or repellents during pregnancy and neonatal hyperbilirubinemia requiring phototherapy. METHODS:We used the da...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Shibazaki T,Motoki N,Misawa Y,Ohira S,Inaba Y,Kanai M,Kurita H,Nakazawa Y,Tsukahara T,Nomiyama T,Japan Environment & Children’s Study (JECS) Group.

    更新日期:2020-08-05 00:00:00

  • Resistance of the male gonad to a high galactose diet.

    abstract::Rats were fed a 50% galactose diet during pregnancy and nursing, and the testes were later examined and hormone levels determined in male offspring. Exposure to galactose for various periods during pregnancy, throughout the entire gestation, or postnatally to nursing mother until pups were 5 wk of age produced no sign...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Chen YT,Mattison DR,Bercu BB,Schulman JD

    更新日期:1984-04-01 00:00:00

  • Comparison of maximal oxygen consumption between obese black and white adolescents.

    abstract::The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between clinically obese black and white children and if a difference existed to determine whether it was related to hematological profiles and/or physical activity/inactivity levels. Twenty-three black and 21 white...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Andreacci JL,Robertson RJ,Dubé JJ,Aaron DJ,Dixon CB,Arslanian SA

    更新日期:2005-09-01 00:00:00

  • Uteroplacental insufficiency alters cerebral mitochondrial gene expression and DNA in fetal and juvenile rats.

    abstract::Uteroplacental insufficiency increases the risk of perinatal and long-term neurologic morbidity by depriving the fetus of oxidative substrate and causing intrauterine growth retardation. Skeletal muscle and liver from growth retarded fetal and juvenile rats respond to this deprivation by altering mitochondrial gene ex...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Lane RH,Tsirka AE,Gruetzmacher EM

    更新日期:2000-06-01 00:00:00

  • Quality of growth in exclusively breast-fed infants in the first six months of life: an Italian study.

    abstract::Nutrition in early life, growth, and subsequent health over a lifetime are significantly interrelated. The aim of this study was to assess body composition changes in exclusively breast-fed infants from birth up to 6 mo of age. An observational, prospective, cohort study was conducted. Fifty-nine full-term, healthy, e...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Roggero P,Giannì ML,Orsi A,Piemontese P,Amato O,Liotto N,Morlacchi L,Taroni F,Fields DA,Catalano PM,Mosca F

    更新日期:2010-12-01 00:00:00

  • Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease.

    abstract::Establishment of Helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. The association was soon also demonstrated in children as well. Applicatio...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Blanchard TG,Czinn SJ

    更新日期:2017-01-01 00:00:00

  • Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.

    abstract:BACKGROUND:Toll-like receptor (TLR)-mediated inflammation may contribute to neonatal sepsis, for which pentoxifylline (PTX), a phosphodiesterase inhibitor that raises intracellular cAMP, is a candidate adjunctive therapy. We characterized the anti-inflammatory effects of PTX toward TLR-mediated production of inflammato...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Speer EM,Dowling DJ,Ozog LS,Xu J,Yang J,Kennady G,Levy O

    更新日期:2017-05-01 00:00:00

  • Perioperative levels of total IgE correlate with outcomes of prolonged mechanical ventilation after cardiopulmonary bypass in pediatric patients.

    abstract:BACKGROUND:Although cardiopulmonary bypass (CPB) has been previously studied as risking infection and inflammatory responses, few studies evaluate the relationship of preoperative high total immunoglobulin E (tIgE) to outcomes in pediatric patients predisposed to atopy undergoing cardiac surgery with CPB. METHODS:Seru...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Li Y,Zhu L,Chen J,Singson MTG,Rui X,Li N,Zhou L,Liu J

    更新日期:2018-11-01 00:00:00

  • Transferrin C subtypes in extremely premature newborn infants.

    abstract::Genetic typing of serum transferrin was performed in a group of 88 extremely premature infants (gestation age less than 32 wk) and in a control group of 351 full-term infants, using isoelectric focusing technique on ultrathin layer of polyacrilamide gel. A major incidence of C2 type was found among the preterm infants...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Auconi P,Biagini R,Colarizi P,Pascali V

    更新日期:1982-12-01 00:00:00

  • Carbohydrate and energy metabolism in the brain of rats with thromboxane A2-induced fetal growth restriction.

    abstract::Fetal growth restriction (FGR) remains a cause of perinatal brain injury, sometimes leading to neurological and intellectual impairment. Although the mechanisms and pathophysiology of CNS injuries have not been elucidated completely, it is possible carbohydrate and energy metabolism may have an important role in the F...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hayakawa M,Sato Y,Hattori T,Ichinohashi Y,Nakayama A,Yamamoto H,Hemmi H,Ito M,Ieda K,Kojima S

    更新日期:2011-07-01 00:00:00

  • Real-time detection, classification, and quantification of apneic episodes using miniature surface motion sensors in rats.

    abstract:BACKGROUND:Real-time detection and classification of apneic episodes remain significant challenges. This study explores the applicability of a novel method of monitoring the respiratory effort and dynamics for rapid detection and classification of apneic episodes. METHODS:Obstructive apnea (OA) and hypopnea/central ap...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Waisman D,Lev-Tov L,Levy C,Faingersh A,Colman Klotzman I,Bibi H,Rotschild A,Landesberg A

    更新日期:2015-07-01 00:00:00

  • Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.

    abstract:BACKGROUND:To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity. METHODS:Immun...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Irabu H,Shimizu M,Kaneko S,Inoue N,Mizuta M,Tasaki Y,Ohta K,Yachie A,Wada T

    更新日期:2020-05-14 00:00:00

  • Poly-lactic-glycolic acid microspheres: a biodegradable marker for the diagnosis of aspiration in hamsters.

    abstract::Aspiration is a major cause of lung disease in infants and young children. As the symptoms and signs of aspiration are not specific, the diagnosis is delayed due to a low index of suspicion and low sensitivity and specificity of the available diagnostic tests. In the present study, we evaluated the utility of microsph...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Springer C,Benita S,Sherman Y,Gursoy N,Gilhar D,Avital A

    更新日期:2005-09-01 00:00:00

  • Early human brain development: insights into macroscale connectome wiring.

    abstract:BACKGROUND:Early brain development is closely dictated by distinct neurobiological principles. Here, we aimed to map early trajectories of structural brain wiring in the neonatal brain. METHODS:We investigated structural connectome development in 44 newborns, including 23 preterm infants and 21 full-term neonates scan...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Keunen K,van der Burgh HK,de Reus MA,Moeskops P,Schmidt R,Stolwijk LJ,de Lange SC,Išgum I,de Vries LS,Benders MJ,van den Heuvel MP

    更新日期:2018-12-01 00:00:00

  • Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis.

    abstract::We have previously demonstrated that enterally administered heparin-binding EGF-like growth factor (HB-EGF) produced in Escherichia coli decreases the incidence and severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis (NEC). In preparation for upcoming human clinical trials, large-scale p...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Radulescu A,Zorko NA,Yu X,Besner GE

    更新日期:2009-04-01 00:00:00

  • Bilirubin binding in jaundiced newborns: from bench to bedside?

    abstract:BACKGROUND:Bilirubin-induced neurologic dysfunction (BIND) is a spectrum of preventable neurological sequelae in jaundiced newborns. Current total plasma bilirubin (BT) concentration thresholds for phototherapy and/or exchange transfusion poorly predict BIND. METHODS:The unbound (free) bilirubin (Bf) measured at these...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Ahlfors CE,Bhutani VK,Wong RJ,Stevenson DK

    更新日期:2018-10-01 00:00:00

  • Intrauterine inflammation alters cardiopulmonary but not cerebral hemodynamics during open endotracheal tube suction in preterm lambs.

    abstract:BACKGROUND:Intrauterine inflammation adversely affects cardiopulmonary, systemic, and cerebral hemodynamics in preterm neonates, but its impact on responses to endotracheal tube (ETT) suction, known to affect hemodynamics, is unknown. We hypothesized that intrauterine inflammation would alter the cardiopulmonary and ce...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Galinsky R,Moss TJ,Polglase GR,Hooper SB

    更新日期:2013-07-01 00:00:00

  • Identification of prognostic factors for pediatric myocarditis with a random forests algorithm-assisted approach.

    abstract:BACKGROUND:Pediatric myocarditis is a rare disease with substantial mortality. Little is known regarding its prognostic factors. We hypothesize that certain comorbidities and procedural needs may increase risks of poor outcomes. This study aims to identify prognostic factors for pediatric myocarditis. METHODS:The nati...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Chou FS,Ghimire LV

    更新日期:2020-11-18 00:00:00

  • Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal rat.

    abstract::Neurogenesis persists throughout life in the rodent subventricular zone (SVZ) and increases in the adult after brain injury. In this study, postnatal day 7 (P7) rats underwent right carotid artery ligation followed by 8% O2 exposure for 90 min, a lesioning protocol that resulted in ipsilateral forebrain hypoxic-ischem...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ong J,Plane JM,Parent JM,Silverstein FS

    更新日期:2005-09-01 00:00:00

  • Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy.

    abstract::In persistent hyperinsulinemic hypoglycemia of infancy, ketone body concentrations are abnormally low at times of hypoglycemia, depriving the brain of its most important alternative fuel. The neuroprotective effect of endogenous ketone bodies is evidenced by animal and human studies, but knowledge about exogenous supp...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章


    authors: Plecko B,Stoeckler-Ipsiroglu S,Schober E,Harrer G,Mlynarik V,Gruber S,Moser E,Moeslinger D,Silgoner H,Ipsiroglu O

    更新日期:2002-08-01 00:00:00

  • Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants.

    abstract::Astrocyte end-feet ensheathe blood vessels in the brain and are believed to provide structural integrity to the cerebral vasculature. We sought to determine in developing infants whether the coverage of blood vessels by astrocyte end-feet is decreased in germinal matrix (GM) compared with cerebral cortex and white mat...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: El-Khoury N,Braun A,Hu F,Pandey M,Nedergaard M,Lagamma EF,Ballabh P

    更新日期:2006-05-01 00:00:00

  • Leukotriene antagonists attenuate thromboxane-inducible pulmonary hypertension.

    abstract::Leukotrienes C4 and D4 and thromboxane A2 are potent vasoconstrictors that may mediate pulmonary vasoconstriction in many clinical situations. There is a complex interaction among leukotrienes and thromboxane A2, because inhibition of thromboxane synthesis prevents some of the hemodynamic effects of exogenous leukotri...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Soifer SJ,Schreiber MD,Heymann MA

    更新日期:1989-08-01 00:00:00

  • Effect of reconstituted pulmonary surfactant containing the 6000-dalton hydrophobic protein on lung compliance of prematurely delivered rabbit fetuses.

    abstract::Chloroform:methanol extracts of bovine pulmonary surfactant contain small hydrophobic proteins, designated surfactant-associated apoproteins 6,000 (SAP-6), but do not contain the major surfactant-associated 35,000-dalton glycoprotein, designated SAP-35. Examination of lipid extract surfactant on sodium dodecylsulfate-...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Yu SH,Wallace D,Bhavnani B,Enhorning G,Harding PG,Possmayer F

    更新日期:1988-01-01 00:00:00

  • 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo.

    abstract::To determine the importance of peroxisomes and mitochondria in hydroxyeicosatetraenoic acid (HETE) oxidation in vivo, urinary excretion of 12- and 15-HETE was measured in eight patients with a peroxisome deficiency disorder (Zellweger syndrome) showing normal mitochondrial beta-oxidation capacity, in three patients wi...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Mayatepek E,Lehmann WD

    更新日期:1996-01-01 00:00:00