Erythropoietin production by macrophages from preterm infants: implications regarding the cause of the anemia of prematurity.

Abstract:

:In the human fetus, liver macrophages appear to be the primary source of erythropoietin (Epo). Epo production shifts from the liver to peritubular cells in the kidney sometime during the 3rd trimester. Some preterm infants experience a hyporegenerative anemia that appears to be caused by inadequate Epo production. It is not clear whether this anemia is due to deficient Epo production by liver macrophages or renal peritubular cells. To assess this situation, we measured Epo mRNA and protein in macrophages obtained from cord blood of preterm and term infants and from peripheral blood of adults. Macrophages from preterm infants generated Epo mRNA and protein as effectively as those from term infants and adults. It appears that the anemia of prematurity is not due to defective Epo production by macrophages.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Ohls RK,Li Y,Trautman MS,Christensen RD

doi

10.1203/00006450-199402000-00008

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

169-70

issue

2

eissn

0031-3998

issn

1530-0447

journal_volume

35

pub_type

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