Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine.

abstract：:The role of plasma glucose concentration in the regulation of endogenous glucose production in the human newborn was examined by infusing glucose at 2.6-4.6 mg/kg . min as a continuous infusion to eight normal term appropriate for gestational age infants, five preterm, and six small for gestational age infants. All in...

journal_title：Pediatric research

authors： Kalhan SC,Oliven A,King KC,Lucero C

更新日期：1986-01-01 00:00:00

abstract：:An animal study to evaluate dual-energy x-ray absorptiometry (DXA) and magnetic resonance (MR) imaging and spectroscopy for measurement of neonatal body composition was performed. Twenty-three piglets with body weights ranging from 848 to 7550 g were used. After measuring total body water, animals were killed and body...

journal_title：Pediatric research

authors： Fusch C,Slotboom J,Fuehrer U,Schumacher R,Keisker A,Zimmermann W,Moessinger A,Boesch C,Blum J

更新日期：1999-10-01 00:00:00

abstract：:To determine the pathophysiologic significance of pertussis toxin (PT) on the human beta-adrenergic system, beta-adrenoceptor (beta-R)-density and cyclic AMP response of peripheral mononuclear blood cells (MN leukocytes) were studied in children during the paroxysmal stage of natural pertussis infection, after vaccina...

journal_title：Pediatric research

authors： Griese M,Sideropoulou O,Reinhardt D

更新日期：1989-02-01 00:00:00

abstract：:High-frequency oscillatory ventilation (HFOV) may improve pulmonary outcome in very preterm infants, but the effects on the brain are largely unknown. We hypothesized that early prolonged HFOV compared with low volume positive pressure ventilation (LV-PPV) would not increase the risk of delayed brain growth or injury ...

journal_title：Pediatric research

authors： Loeliger M,Inder TE,Shields A,Dalitz P,Cain S,Yoder B,Rees SM

更新日期：2009-11-01 00:00:00

abstract：:Prenatal maternal stress has been shown to impair functioning in nonhuman primate offspring. Little is known about the effects of prenatal stress on intellectual and language development in humans because it is difficult to identify sufficiently large samples of pregnant women who have been exposed to an independent s...

journal_title：Pediatric research

authors： Laplante DP,Barr RG,Brunet A,Galbaud du Fort G,Meaney ML,Saucier JF,Zelazo PR,King S

更新日期：2004-09-01 00:00:00

abstract：:Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although systemic and cerebrovascular physiologic factors play an important role in the initial phases of hypoxic-ischemic injuries, the intrinsic vulnerability of specific cell types and systems in the developing brain may be more important...

journal_title：Pediatric research

authors： Johnston MV,Trescher WH,Ishida A,Nakajima W

更新日期：2001-06-01 00:00:00

abstract：:It seems quite likely that the normal process of fetal lung biochemical maturation is delayed by maternal diabetes and that abnormalities in the pulmonary surfactant system are involved. The appearance of PG in amniotic fluid and possibly in fetal lung is impaired or at least delayed. The same is possibly true for DSP...

journal_title：Pediatric research

authors： Bourbon JR,Farrell PM

更新日期：1985-03-01 00:00:00

abstract：:Children with nephropathic cystinosis store 50 to 100 times normal amounts of free cystine in many cells and display negligible lysosomal cystine transport in their leucocytes and cultured fibroblasts. A patient with intermediate (adolescent) cystinosis exhibited a similar deficiency of egress out of fibroblast lysoso...

journal_title：Pediatric research

authors： Gahl WA,Tietze F

更新日期：1987-02-01 00:00:00

abstract：:Superoxide anion generation during severe asphyxia and reventilation was assessed in newborn pigs. Using closed cranial windows over the parietal cortices, superoxide dismutase (SOD)-inhibitable nitroblue tetrazolium (NBT) reduction was determined during asphyxia/reventilation. Asphyxia was induced by turning off the ...

journal_title：Pediatric research

authors： Pourcyrous M,Leffler CW,Mirro R,Busija DW

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Pediatric myocarditis is a rare disease with substantial mortality. Little is known regarding its prognostic factors. We hypothesize that certain comorbidities and procedural needs may increase risks of poor outcomes. This study aims to identify prognostic factors for pediatric myocarditis. METHODS:The nati...

journal_title：Pediatric research

authors： Chou FS,Ghimire LV

更新日期：2020-11-18 00:00:00

abstract：:Our objective was to determine the quantitative changes of individual triacylglycerol (TG) species in liver and carcass during early postnatal growth. Pregnant rats were killed at d 21 of pregnancy, and neonatal rats were killed at d 3 or 9 after birth. Quantitative changes in fatty acids and TG species of fetal/neona...

journal_title：Pediatric research

authors： Chen ZY,Cunnane SC

更新日期：1992-01-01 00:00:00

abstract：:The worldwide burden of disease due to Epstein-Barr virus (EBV) infection is enormous. Diseases include endemic Burkitt lymphoma, infectious mononucleosis, cancers after transplantation, Hodgkin lymphoma, and nasopharyngeal carcinoma. A prophylactic EBV vaccine has the potential to significantly reduce the incidence a...

journal_title：Pediatric research

authors： Balfour HH Jr,Schmeling DO,Grimm-Geris JM

更新日期：2020-01-01 00:00:00

abstract：:Tolazoline is used in neonatal intensive care to treat hypoxia secondary to persistent pulmonary hypertension of the newborn. Its use is often complicated by systemic hypotension. We compared the effect of tolazoline-induced hypotension on organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic...

journal_title：Pediatric research

authors： Balsan MJ,Cronin CM,Shaw MD,Milley JR

更新日期：1990-08-01 00:00:00

abstract：:Acute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped kidneys, baseline biomarker values may differ. We describe baseline values of urinary neutrophil gelatinase-associated lipocali...

journal_title：Pediatric research

authors： Askenazi DJ,Koralkar R,Levitan EB,Goldstein SL,Devarajan P,Khandrika S,Mehta RL,Ambalavanan N

更新日期：2011-09-01 00:00:00

abstract：:Progress has been made in the reduction of morbidity and mortality from neonatal sepsis. However, diagnosis continues to rely primarily on conventional microbiologic techniques, which can be inaccurate. The objective of this review is to provide the clinician with an overview of the current information available on di...

journal_title：Pediatric research

authors： Iroh Tam PY,Bendel CM

更新日期：2017-10-01 00:00:00

abstract：:Premature newborn rabbits, delivered by hysterotomy on day 27 of gestation, were tracheotomized at birth, kept in body plethysmographs, and subjected to pressure-generated ventilation at a working pressure of 25 cm H2O, 100% O2, and frequency 40/min. Thirty-seven animals received 50 microliters of heterologous surfact...

journal_title：Pediatric research

authors： Lachmann B,Berggren P,Curstedt T,Grossmann G,Robertson B

更新日期：1982-11-01 00:00:00

abstract：:The perinatal ontogeny of preprotachykinin-A gene expression was assessed in central respiration-related structures. On the day of birth, there was an enhanced expression of preprotachykinin-A mRNA in the region of the nucleus tractus solitarii, the primary relay station for respiratory and cardiovascular reflexes. Th...

journal_title：Pediatric research

authors： Srinivasan M,Yamamoto Y,Persson H,Lagercrantz H

更新日期：1991-04-01 00:00:00

abstract：:Epidemiologic studies have linked intrauterine growth restriction (IUGR) with an increased incidence of cardiovascular disease later in life; reduced cardiomyocyte number in IUGR hearts may underlie such prenatal programming. Our aim was to examine the effect of IUGR, as a result of maternal protein restriction, on th...

journal_title：Pediatric research

authors： Corstius HB,Zimanyi MA,Maka N,Herath T,Thomas W,van der Laarse A,Wreford NG,Black MJ

更新日期：2005-06-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) is a recognized risk factor for neurologic deficits later in life. Abnormal fetal blood flow in the presence of fetal growth retardation helps to distinguish true fetal growth impairment from small but normally grown infants. The present study aimed to investigate the influence o...

journal_title：Pediatric research

authors： Ley D,Marsal K,Dahlgren J,Hellstrom A

更新日期：2004-07-01 00:00:00

abstract：:The fibroblast of the fetal and neonatal lung is intimately involved with lung development and function. Additionally, the perinatal rat lung fibroblast is a significant source of prostaglandins (PG) I2 and E2, which in turn affect lung development and function. Their effects may be mediated by cAMP. We, therefore, te...

journal_title：Pediatric research

authors： Teixeira FJ,Bevan ML,Olson DM

更新日期：1992-04-01 00:00:00

abstract：:Pulmonary surfactant is inactivated in meconium aspiration syndrome and neonatal pneumonia. Development of an exogenous surfactant less sensitive to inactivation might be useful for treating these diseases. We investigated in vitro whether addition of the cationic cyclic membrane cross-linking peptide polymyxin B (PxB...

journal_title：Pediatric research

authors： Stichtenoth G,Jung P,Walter G,Johansson J,Robertson B,Curstedt T,Herting E

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Observational studies suggest that asthma control improves after adenotonsillectomy, but longitudinal studies that correlate the effect of the procedure on the levels of biomarkers associated with airway inflammation are limited. METHODS:We conducted a longitudinal, observational study on pediatric patients...

journal_title：Pediatric research

authors： Levin JC,Gagnon L,He X,Baum ED,Karas DE,Chupp GL

更新日期：2014-03-01 00:00:00

abstract：:Early childhood overweight and obesity have alarmingly increased over the years. Adulthood obesity is a well demonstrated significant independent predictor of cardiovascular risk (CVR) and/or mortality, which predisposes to the major components of metabolic syndrome (MS). Evidence of MS in obese children has been also...

journal_title：Pediatric research

authors： Aggoun Y

更新日期：2007-06-01 00:00:00

abstract：:To determine the developmental changes in the myocardial current during fetal life, and to evaluate the clinical usefulness of magnetocardiography for prenatal diagnosis of cardiac hypertrophy or enlargement, we approximated the magnitude of the one-current dipole of the fetal heart using fetal magnetocardiography (fM...

journal_title：Pediatric research

authors： Horigome H,Shiono J,Shigemitsu S,Asaka M,Matsui A,Kandori A,Miyashita T,Tsukada K

更新日期：2001-08-01 00:00:00

abstract：:To compare the hemodynamic effects of isoproterenol, dopamine, and dobutamine in the immature animal, each drug was infused into anesthetized open chest puppies and cardiac output was measured, as were systemic arterial blood pressure, heart rate, and renal artery blood flow. Cardiac output was increased by dopamine a...

journal_title：Pediatric research

authors： Driscoll DJ,Gillette PC,Lewis RM,Hartley CJ,Schwartz A

更新日期：1979-09-01 00:00:00

abstract：:The two pathways of de novo lecithin synthesis, choline incorporation (I) and phosphatidylethanolamine methylation (II), were examined in lung slices from rhesus monkey fetuses throughout the last half of gestation. Incorporation rates of pathway-specific radioactive precursors were used as a measure of lecithin produ...

journal_title：Pediatric research

authors： Epstein MF,Farrell PM

更新日期：1975-08-01 00:00:00

abstract：:The objective of the present study was to explore whether a free radical spin trap agent, alpha-phenyl-N-tert-butyl nitrone (PBN), influences bioenergetic failure induced in the 20-day-old fetal brain by 30 min of intrauterine ischemia in Wistar rats. Fetal brains were frozen in situ at the end of ischemia and after 1...

journal_title：Pediatric research

authors： Nakai A,Asakura H,Taniuchi Y,Koshino T,Araki T,Siesjö BK

更新日期：2000-04-01 00:00:00

abstract：:Early-life stress has been shown to destabilize the homeostatic synaptic plasticity and compromise the developing brain to the later encountered insults. This study would determine the long-term epileptogenic effect of neonatal isolation (NI) on early-life seizure. There were five groups: normal rearing (NR) rats; NI ...

journal_title：Pediatric research

authors： Lai MC,Lui CC,Yang SN,Wang JY,Huang LT

更新日期：2009-10-01 00:00:00

abstract：:Essential fatty acid deficiency (EFAD) occurs in infants fed fat-free mixtures of glucose and amino acids. Although infusion of lipid emulsion rapidly reverses clinical symptoms, little is known about effects on tissue fatty acids. To study this question, five groups (n = 4/group) of neonatal pigs were studied. Three ...

journal_title：Pediatric research

authors： Andersen DW,Filer LJ Jr,Stegink LD

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Bilirubin-induced neurologic dysfunction (BIND) is a spectrum of preventable neurological sequelae in jaundiced newborns. Current total plasma bilirubin (BT) concentration thresholds for phototherapy and/or exchange transfusion poorly predict BIND. METHODS:The unbound (free) bilirubin (Bf) measured at these...

journal_title：Pediatric research

authors： Ahlfors CE,Bhutani VK,Wong RJ,Stevenson DK

更新日期：2018-10-01 00:00:00