Abstract：
:The role of plasma glucose concentration in the regulation of endogenous glucose production in the human newborn was examined by infusing glucose at 2.6-4.6 mg/kg . min as a continuous infusion to eight normal term appropriate for gestational age infants, five preterm, and six small for gestational age infants. All infants were healthy, had no overt clinical problems and were studied 6 h after their last feed. Glucose production rates were measured during the basal state and during glucose infusion by tracer dilution using [6,6(2)H2]glucose. The rate of glucose production during the basal state was similar in preterm and term appropriate for gestational age infants (appropriate for gestational age 3.53 +/- 0.32, preterm 3.49 +/- 0.38 mg/kg . min, mean +/- SD), while it was higher in the small for gestational age infants (4.25 +/- 0.98, p less than 0.03) as compared with appropriate for gestational age. During glucose infusion, the peak glucose concentration was related to the rate of glucose infusion. The endogenous glucose production rates during glucose infusion were variable in the three groups. However, a negative correlation between peak glucose concentration and endogenous glucose production rate was observed (r = 0.59, p = 0.006). The insulin response to glucose infusion was comparable in all infants. In addition, three small gestational age and one preterm infants, who had become hypoglycemic in the immediate newborn period, were studied while they were receiving parenteral glucose and their plasma glucose had stabilized at 55.5 +/- 10.25 mg/dl. Tracer kinetic studies showed persistence of endogenous glucose production in these infants even though they were receiving high rates of exogenous glucose infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Kalhan SC,Oliven A,King KC,Lucero Cdoi
10.1203/00006450-198601000-00013subject
Has Abstractpub_date
1986-01-01 00:00:00pages
49-52issue
1eissn
0031-3998issn
1530-0447journal_volume
20pub_type
杂志文章abstract：:Myocardial oxygen demand may be increased in chronically hypoxemic lambs because of their increased heart rate. Therefore, we determined whether left ventricular (LV) oxygen supply, oxygen uptake and oxygen demand were proportionally increased in 6-wk-old lambs, after 4 wk of hypoxemia (n = 15), as compared with contr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199310000-00017
更新日期：1993-10-01 00:00:00
abstract：:Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism and a potent chemoattractant for adult polymorphonuclear leukocytes (PMN). LTB4 may be an important inflammatory mediator in neonatal lung disorders such as bronchopulmonary dysplasia, but neonatal PMN chemotaxis to LTB4 has not been studied. We compare...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199303000-00006
更新日期：1993-03-01 00:00:00
abstract：:The mechanisms of how glutamine benefits critically ill patients have not been established. The purpose of this study was to determine the effects of dietary and endogenously produced glutamine on small intestinal morphology using light and transmission electron microscopy in artificially reared rat pups. It was hypot...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200209000-00021
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:Real-time detection and classification of apneic episodes remain significant challenges. This study explores the applicability of a novel method of monitoring the respiratory effort and dynamics for rapid detection and classification of apneic episodes. METHODS:Obstructive apnea (OA) and hypopnea/central ap...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2015.69
更新日期：2015-07-01 00:00:00
abstract：:Neutrophils contribute to ischemic brain injury in adult animals. The role of neutrophils in perinatal hypoxic-ischemic (HI) brain injury is unknown. Allopurinol reduces neutrophil accumulation after tissue ischemia and is protective against HI brain injury. This study was designed to investigate how neutrophils contr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199705000-00002
更新日期：1997-05-01 00:00:00
abstract：:Serial plasma concentrations of immunoreactive 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), the stable hydration product of prostacyclin (PGI2), were measured with radioimmunoassay during the first month of life in 25 preterm infants with idiopathic respiratory distress syndrome (IRDS) and 38 preterm controls wi...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198210000-00005
更新日期：1982-10-01 00:00:00
abstract：:Wu and colleagues analyzed the placental pathology from a subset of the neonates in the NEATO trial who had reports available and correlated the placental pathology findings with outcomes. This study highlights the importance of placental pathology, and its potential to bring precision medicine to critically-ill neona...
journal_title：Pediatric research
pub_type： 评论,杂志文章
doi：10.1038/s41390-020-0807-8
更新日期：2020-04-01 00:00:00
abstract：:Response characteristics of a transcutaneous PO2 electrode to step changes in PaO2 were determined. In vitro lag time and 95% response time of a transcutaneous PO2 monitor were compared to in vivo response. Release of arterial occlusion was used to produce rapid local PaO2 changes in human infants and adults. In vitro...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198102000-00012
更新日期：1981-02-01 00:00:00
abstract：:Vascular dopamine (DA1) receptors may modulate circulatory hemodynamics in lambs. We evaluated resting dopaminergic tone in lambs by pharmacologically manipulating peripheral DA1 receptors with i.v. SCH 23390, (a highly selective, competitive DA1 receptor antagonist) and i.v. fenoldopam, (a highly selective DA1 recept...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199302000-00018
更新日期：1993-02-01 00:00:00
abstract：:Very young children with organic brain damage, intractable seizures, and developmental retardation are at particular risk of developing fatal hepatic dysfunction coincident with valproate therapy, especially if the children are also receiving other anticonvulsant drugs. The mechanism of valproate-associated hepatic fa...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199204000-00023
更新日期：1992-04-01 00:00:00
abstract：:Pyritinol-HCl was tested for its impact on the cognitive functions of children with learning disabilities. This study is a contribution to scientific discussion on the complicated methodologic problems in evaluating the clinical efficacy of psychopharmacologic agents. Sixty-seven pupils of slow learner classes between...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-197509000-00006
更新日期：1975-09-01 00:00:00
abstract：:Catecholamines (CA) are released from and resynthesized in the adrenal medulla in response to stress. In the mature animal, stimulus-secretion-synthesis coupling occurs through transsynaptic (neuronal) activity. In contrast, in the immature animal, before functional adrenal innervation, certain stressors (hypoglycemia...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199412000-00006
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:Maternal exposure to pesticides during pregnancy may cause oxidative hemolysis leading to neonatal hyperbilirubinemia. This investigation examined for associations between maternal use of pesticides or repellents during pregnancy and neonatal hyperbilirubinemia requiring phototherapy. METHODS:We used the da...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-1100-6
更新日期：2020-08-05 00:00:00
abstract：:Twenty-four samples of breast milk from nine mothers of infants suffering from breast milk jaundice were studied. Eight samples of milk from mothers of nonjaundiced infants, along with five formula milks enriched with polyunsaturated fatty acids, served as controls. Milks from mothers with jaundiced infants had no inh...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197606000-00007
更新日期：1976-06-01 00:00:00
abstract：:Low IGF-I levels are found in patients with chronic liver disease, but it is not known whether these reductions in IGF-I are secondary to hepatic dysfunction or to malnutrition. To determine whether malnutrition associated with hepatic dysfunction causes the decrease in these levels, serum and liver IGF-I concentratio...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198911000-00009
更新日期：1989-11-01 00:00:00
abstract：:Evaluation of nonlinear heart rate (HR) dynamics has received considerable attention in the pediatric literature because such analyses not only provide insight into underlying control mechanisms, but may also help to differentiate between normal and abnormal infants. The purpose of this study was to determine, in eigh...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199807000-00018
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Necrotising enterocolitis (NEC) and late-onset sepsis (LOS) are the leading causes of death among preterm infants in the developed world. This study aimed to explore the serum proteome and metabolome longitudinally in preterm infants with NEC or LOS, matched to controls. METHODS:Nineteen patients (10 cases,...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2015.235
更新日期：2016-03-01 00:00:00
abstract：:Obese children have a great risk of hypertension and cardiovascular morbidity in adults. The insulin-like growth factor type II (IGF-II) regulates glucose homeostasis, cardiovascular functions, and lipid metabolism. IGF2 gene variants have shown a strong association with weight, body mass index (BMI), and metabolic pr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e3181d22757
更新日期：2010-04-01 00:00:00
abstract：:Inhibition of IGF-I action by circulating IGF-I receptor autoantibodies is a potential mechanism of IGF-I resistance in growing children. To define the prevalence of IGF-I receptor antibodies in short-statured children, we have examined serum and plasma samples from a well-characterized group of 34 short, prepubertal,...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199210000-00016
更新日期：1992-10-01 00:00:00
abstract：:Glutaryl-CoA dehydrogenase (GCDH) deficiency is a rare inborn disorder of L-lysine, L-hydroxylysine, and L-tryptophan metabolism complicated by striatal damage during acute encephalopathic crises. Three decades after its description, the natural history and how to treat this disorder are still incompletely understood....
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000219387.79887.86
更新日期：2006-06-01 00:00:00
abstract：:The metabolism of proteoglycans in normal growth plate and the changes in growth plate morphology induced by diabetes and malnutrition were studied in rats. The proteoglycans had a significantly faster turnover (half-life measured with [35S]sulfate labeling: 25-30 h) than the cells in the growth plate. Morphometric st...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199001000-00014
更新日期：1990-01-01 00:00:00
abstract：:We hypothesized that cardiac and respiratory modulation of postganglionic peroneal activity appeared in an age-related manner. In anesthetized, paralyzed and artificially ventilated piglets, simultaneous recordings of efferent phrenic and peroneal discharges were obtained during hyperoxia (fraction of inspired oxygen,...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199601000-00012
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Intrauterine growth restriction (IUGR) has been linked to heart disease in adulthood. Hence the IUGR heart is likely to be vulnerable to diabetic heart disease. The aim of this study was to examine the effect of induction of type 1 diabetes on myocardial collagen deposition and cardiac function in adult rats...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2012.94
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Animal models have shown that insulin-like growth factor I (IGF-I) may mediate protein-induced kidney growth. Our aim was to analyze the effect of IGF-I on protein-induced kidney growth in healthy infants. METHODS:This is a secondary analysis of a randomized trial that compared growth of infants fed with a ...
journal_title：Pediatric research
pub_type： 杂志文章,随机对照试验
doi：10.1038/pr.2013.87
更新日期：2013-08-01 00:00:00
abstract：:The present study examined the extent to which abundance of the prolactin receptor (PRLR) and a range of primary mitochondrial proteins are influenced by either maternal nutrition and/or fetal number in adipose tissue. Pregnant sheep were control fed [consuming 100% of total metabolizable energy (ME) requirements (tak...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000047653.73271.C4
更新日期：2003-02-01 00:00:00
abstract：:The dipeptides carnosine and anserine, found exclusively in meats, are hydrolyzed in serum by the enzyme carnosinase. Several reports of serum carnosinase deficiency describe a variable phenotype, which ranges from normal to severe psychomotor retardation, hypotonia, and myoclonic seizures in the first year of life. W...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199702000-00009
更新日期：1997-02-01 00:00:00
abstract：:Premature newborns are highly susceptible to severe bacterial infections. This is partially due to their immature innate immune system, characterized by decreased neutrophil and monocyte activity as well as by reduced concentrations of complement factors. However, additional mechanisms might be important for innate im...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000163397.53466.0F
更新日期：2005-07-01 00:00:00
abstract：:Children with nephropathic cystinosis store 50 to 100 times normal amounts of free cystine in many cells and display negligible lysosomal cystine transport in their leucocytes and cultured fibroblasts. A patient with intermediate (adolescent) cystinosis exhibited a similar deficiency of egress out of fibroblast lysoso...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198702000-00016
更新日期：1987-02-01 00:00:00
abstract：IMPACT:Raises the importance of Social Determinants of Health in pediatrics. Considers the impact of Social Determinants of Health on COVID-19. Offers opportunities for research in the future. ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-01253-0
更新日期：2020-11-10 00:00:00
abstract：:The effects of early protein-deficiency on lung development were studied in the rat. Newborn male rats were nursed in groups of eight. Control dams and pups received a 15% protein diet during the whole experiment. Test mothers only received 12 and 8% proteins from the 7th and the 14th day of lactation. Test rats fed a...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198707000-00012
更新日期：1987-07-01 00:00:00
