Growth failure in cholestatic rats: the effect of malnutrition on insulin-like growth factor I.


:Low IGF-I levels are found in patients with chronic liver disease, but it is not known whether these reductions in IGF-I are secondary to hepatic dysfunction or to malnutrition. To determine whether malnutrition associated with hepatic dysfunction causes the decrease in these levels, serum and liver IGF-I concentrations and liver IGF-I mRNA content were compared in three groups of Sprague-Dawley rats: 15 rats underwent bile duct obstruction; 10 rats were sham-operated and pair-fed with operated rats to control for nutritional status; and 12 rats were sham-operated controls fed ad libitum. In addition, IGF-I peptide and mRNA were compared with food intake, crude nitrogen balance, total wt gain, tail length increase and leg muscle wt. All the parameters were lower in cholestatic and nutritionally deprived animals than in control animals (p less than 0.001). There was no difference in serum and hepatic IGF-I and liver IGF-I mRNA values between the 10 cholestatic and pair-fed animals, despite lower crude nitrogen balance, tail length gains, and leg muscle wt in the bile duct-obstructed animals. These studies suggest that in chronic bile duct obstruction, the low serum and hepatic IGF-I levels are primarily due to decreased food intake and appear unrelated to cholestatic liver disease itself. However, factors in addition to suboptimal nutrition and decreased IGF-I levels must also contribute to cholestasis-induced growth failure.


Pediatr Res


Pediatric research


Descos BP,Berry SA,Sharp HL,Gross CR,Weisdorf SA,Pescovitz OH




Has Abstract


1989-11-01 00:00:00












  • Cardiac contraction affects respiratory airflow in the term newborn infant.

    abstract::In studies in the newborn infant, it is often assumed that there are similarities in airflow in successive breaths, and, therefore, it is only necessary to measure parameters in a small number of breaths. However, other studies have shown considerable variability in breathing patterns in successive breaths. It was, th...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hathorn MK

    更新日期:2000-07-01 00:00:00

  • Changes in sucking performance from nonnutritive sucking to nutritive sucking during breast- and bottle-feeding.

    abstract::Our aim was to obtain a better understanding of the differences between breast-feeding and bottle-feeding, particularly with regard to how sucking performance changes from nonnutritive sucking (NNS) to nutritive sucking (NS). Twenty-two normal term infants were studied while breast-feeding at 4 and 5 d postpartum. Fiv...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Mizuno K,Ueda A

    更新日期:2006-05-01 00:00:00

  • Mucosal immune response in a case of sudden infant death syndrome.

    abstract::A prospective study to define the normal patterns of development of mucosal immunity in 263 children provided a unique opportunity to study the mucosal immune response in an infant who unexpectedly died from sudden infant death syndrome. The subject initially had a normal pattern of mucosal immune function, which was ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Gleeson M,Clancy RL,Cripps AW

    更新日期:1993-06-01 00:00:00

  • Metabolomics of prematurity: analysis of patterns of amino acids, enzymes, and endocrine markers by categories of gestational age.

    abstract:BACKGROUND:Prematurity may influence the levels of amino acids, enzymes, and endocrine markers obtained through newborn screening. Identifying which analytes are the most affected by degree of prematurity could provide insight into how prematurity impacts metabolism. METHODS:Analytes from blood spots assayed by Newbor...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Wilson K,Hawken S,Ducharme R,Potter BK,Little J,Thébaud B,Chakraborty P

    更新日期:2014-02-01 00:00:00

  • Urinary metabolomic markers of aminoglycoside nephrotoxicity in newborn rats.

    abstract:BACKGROUND:Aminoglycoside exposure is a common cause of acute kidney injury (AKI). Delay in the diagnosis of AKI using conventional biomarkers has been one of the important obstacles in applying early effective interventions. We tested the hypothesis that urinary metabolomics could identify novel early biomarkers for t...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hanna MH,Segar JL,Teesch LM,Kasper DC,Schaefer FS,Brophy PD

    更新日期:2013-05-01 00:00:00

  • Relationship between T-cell HLA-DR expression and intravenous immunoglobulin treatment response in Kawasaki disease.

    abstract:BACKGROUND:Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of imm...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Wakiguchi H,Hasegawa S,Suzuki Y,Kudo K,Ichiyama T

    更新日期:2015-04-01 00:00:00

  • Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos.

    abstract::Altered transfer of nutrients from mother to conceptus may be involved in the pathogenesis of the developmental disturbances in offspring of diabetic mothers. In our study, the embryonic uptake of a saturated (palmitic acid) and a nonsaturated (arachidonic acid) fatty acid was evaluated in a normal and a diabetes-like...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Engström E,Haglund A,Eriksson UJ

    更新日期:1991-08-01 00:00:00

  • RT-PCR detection of respiratory pathogens in newborn children admitted to a neonatal medium care unit.

    abstract:BACKGROUND:This study aimed to determine the prevalence of respiratory pathogens among newborns admitted to a neonatal medium care unit (NMCU) and to identify clinical predictors. METHODS:A 1-y observational study was performed of neonates admitted to an NMCU in Amsterdam, The Netherlands. Nasopharyngeal samples were ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Smit PM,Pronk SM,Kaandorp JC,Weijer O,Lauw FN,Smits PH,Claas EC,Mulder JW,Beijnen JH,Brandjes DP

    更新日期:2013-03-01 00:00:00

  • Role of adenosine 3', 5'-monophosphate in maturation of fetal lungs.

    abstract::Fetal lung cyclic AMP phosphodiesterase, cyclic AMP, phosphatidyl choline, and incorporation of precursors into phosphatidyl choline were measured in rabbits after maternal administration of hydrocortisone phosphate and aminophylline. Both agents inhibited lung phosphodiesterase activity and augmented cyclic AMP conce...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Barrett CT,Sevanian A,Lavin N,Kaplan SA

    更新日期:1976-06-01 00:00:00

  • Sonic hedgehog is essential for first pharyngeal arch development.

    abstract::The secreted protein sonic hedgehog (Shh) is essential for normal development of many organs. Targeted disruption of Shh in mouse leads to near complete absence of craniofacial skeletal elements at birth, and mutation of SHH in human causes holoprosencephaly (HPE), frequently associated with defects of derivatives of ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Yamagishi C,Yamagishi H,Maeda J,Tsuchihashi T,Ivey K,Hu T,Srivastava D

    更新日期:2006-03-01 00:00:00

  • Medium chain acyl-CoA dehydrogenase deficiency in Pennsylvania: neonatal screening shows high incidence and unexpected mutation frequencies.

    abstract::Medium chain acyl-CoA dehydrogenase deficiency (MCAD) is a defect in the mitochondrial oxidation of fatty acids. The disorder typically presents with episodes of vomiting and hypoglycemia, sometimes with changes in mental status and hepatic failure. These Reye's-like features may culminate in coma and death. Stress, i...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ziadeh R,Hoffman EP,Finegold DN,Hoop RC,Brackett JC,Strauss AW,Naylor EW

    更新日期:1995-05-01 00:00:00

  • Antenatal cocaine exposure produces accelerated surfactant maturation without stimulation of antioxidant enzyme development in the late gestation rat.

    abstract::Antenatal cocaine administration is associated with increases in catecholamines and glucocorticoids and results in fetal hypoxemia, with the speculated potential for increased free radical formation in the fetus. Because of this, we hypothesized that antenatal cocaine exposure would produce not only accelerated pulmon...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Sosenko IR

    更新日期:1993-04-01 00:00:00

  • Brain superoxide anion generation during asphyxia and reventilation in newborn pigs.

    abstract::Superoxide anion generation during severe asphyxia and reventilation was assessed in newborn pigs. Using closed cranial windows over the parietal cortices, superoxide dismutase (SOD)-inhibitable nitroblue tetrazolium (NBT) reduction was determined during asphyxia/reventilation. Asphyxia was induced by turning off the ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Pourcyrous M,Leffler CW,Mirro R,Busija DW

    更新日期:1990-12-01 00:00:00

  • Magnetic resonance in preterm and term newborns: 1H-spectroscopy in developing human brain.

    abstract::Localized proton magnetic resonance spectra were recorded from human cerebellum in vivo with a 1.5-T magnet. The spectra from healthy adults and preterm and term babies showed resonances from N-acetylaspartate, creatine and phosphocreatine, choline-containing compounds such as phosphocholine and glycerophosphocholine,...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hüppi PS,Posse S,Lazeyras F,Burri R,Bossi E,Herschkowitz N

    更新日期:1991-12-01 00:00:00

  • Development of natural killer cytotoxicity during childhood: marked increases in number of natural killer cells with adequate cytotoxic abilities during infancy to early childhood.

    abstract::The cytotoxicity of natural killer (NK) cells against K562 cells and their responsiveness to interferon-alpha and interleukin 2 (IL-2) were studied throughout childhood using 51Cr-release and single-cell assays. Although NK activity was extremely low in the neonatal period, it almost reached the adult level during 1 t...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Yabuhara A,Kawai H,Komiyama A

    更新日期:1990-10-01 00:00:00

  • Viscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding.

    abstract:BACKGROUND:Continuous and intermittent bolus orogastric feedings are strategies used in infants unable to tolerate normal feeds. METHODS:To determine the effects of feeding modality on protein synthesis in different tissues, neonatal pigs received a balanced formula by orogastric tube as an intermittent bolus feed eve...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: El-Kadi SW,Gazzaneo MC,Suryawan A,Orellana RA,Torrazza RM,Srivastava N,Kimball SR,Nguyen HV,Fiorotto ML,Davis TA

    更新日期:2013-08-01 00:00:00

  • Regional activity of galactose-1-phosphate uridyltransferase in rat brain.

    abstract::The sp act of galactose-1-phosphate uridyltransferase has been measured in individual regions of adult rat brain to see if site-specific differences in enzyme activity can aid in the understanding of brain abnormalities observed in well-treated galactosemic patients. The sp act in the cerebellum, brain stem, and midbr...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Rogers S,Heidenreich R,Mallee J,Segal S

    更新日期:1992-05-01 00:00:00

  • Selective impairment of taurine transport by cyclosporin A in a human placental cell line.

    abstract::We investigated, using a human placental choriocarcinoma cell line as a model, the effects of the immunosuppressive drug cyclosporin A on several placental transport systems mediating the transfer of glucose and amino acids from mother to fetus. The results of the investigation show that the transport system responsib...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ramamoorthy S,Leibach FH,Mahesh VB,Ganapathy V

    更新日期:1992-07-01 00:00:00

  • Gitelman disease associated with growth hormone deficiency, disturbances in vasopressin secretion and empty sella: a new hereditary renal tubular-pituitary syndrome?

    abstract::Gitelman disease was diagnosed in two unrelated children with hypokalemic metabolic alkalosis and growth failure (a boy and a girl aged 7 mo and 9.5 y, respectively, at clinical presentation) on the basis of mutations detected in the gene encoding the thiazide-sensitive NaCl cotransporter of the distal convoluted tubu...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Bettinelli A,Rusconi R,Ciarmatori S,Righini V,Zammarchi E,Donati MA,Isimbaldi C,Bevilacqua M,Cesareo L,Tedeschi S,Garavaglia R,Casari G

    更新日期:1999-08-01 00:00:00

  • Hepatic and cerebral energy metabolism after neonatal canine alimentation.

    abstract::Intrahepatic and intracerebral metabolic responses to neonatal fasting or enteric carbohydrate alimentation were investigated among newborn dogs. Pups were either fasted or given an intravenous glucose infusion (alimented) before an enteric feeding of physiologic quantities of either glucose or galactose. These pups w...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kliegman RM,Miettinen EL,Morton SK

    更新日期:1983-04-01 00:00:00

  • Evolution of surfactant therapy for respiratory distress syndrome: past, present, and future.

    abstract::Respiratory distress syndrome (RDS) due to surfactant deficiency is the most common cause of respiratory failure in preterm infants. Tremendous progress has been made since the original description that surfactant deficiency is the major cause of RDS. Surfactant therapy has been extensively studied in preterm infants ...

    journal_title:Pediatric research

    pub_type: 历史文章,杂志文章,评审


    authors: Sardesai S,Biniwale M,Wertheimer F,Garingo A,Ramanathan R

    更新日期:2017-01-01 00:00:00

  • Effect of racemic epinephrine on ventilatory function in the neonate postextubation.

    abstract::The use of nebulized racemic epinephrine to improve ventilatory function in the newborn postextubation was studied. Forty-five infants intubated for more than 3 days were randomized to receive racemic epinephrine by nebulization immediately postextubation or to receive only warmed, humidified gas. Measurements of air ...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Courtney SE,Wachtl JP,Hopson JF,Siervogel RM

    更新日期:1987-04-01 00:00:00

  • General immune dampening is associated with disturbed metabolism at diagnosis of type 1 diabetes.

    abstract:BACKGROUND:Type 1 diabetes (T1D) is a serious diagnosis with the prospect of grave short- and long-term complications and even death if poorly managed. An attempt has been made to describe how clinical and immunological deviations might influence each other close to the diagnosis of T1D. METHODS:Sixty-nine newly diagn...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Rydén A,Ludvigsson J,Fredrikson M,Faresjö M

    更新日期:2014-01-01 00:00:00

  • Selected nutrient intakes of free-living white children ages 6-19 years. The Lipid Research Clinics Program Prevalence Study.

    abstract::We report energy intake and selected nutrient intakes-protein, fat (total, saturated, and polyunsaturated), carbohydrate (total, starch, and sucrose), and cholesterol-for 1251 white children ages 6-19 years. The data were obtained, by means of a 24-h dietary recall, from children who were randomly selected from the No...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Salz KM,Tamir I,Ernst N,Kwiterovich P,Glueck C,Christensen B,Larsen R,Pirhonen D,Prewitt TE,Scott LW

    更新日期:1983-02-01 00:00:00

  • Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants.

    abstract:BACKGROUND:Extremely preterm birth is associated with subsequent behavioral problems. We hypothesized that perinatal systemic inflammation, a risk factor for cerebral white matter injury and cognitive impairment, is associated with behavior problems observed at 2 y. METHODS:In a cohort of 600 children born before 28 w...

    journal_title:Pediatric research

    pub_type: 杂志文章,多中心研究


    authors: O'Shea TM,Joseph RM,Kuban KC,Allred EN,Ware J,Coster T,Fichorova RN,Dammann O,Leviton A,ELGAN Study Investigators.

    更新日期:2014-06-01 00:00:00

  • Of the bugs that shape us: maternal obesity, the gut microbiome, and long-term disease risk.

    abstract::Chronic disease risk is inextricably linked to our early-life environment, where maternal, fetal, and childhood factors predict disease risk later in life. Currently, maternal obesity is a key predictor of childhood obesity and metabolic complications in adulthood. Although the mechanisms are unclear, new and emerging...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Gohir W,Ratcliffe EM,Sloboda DM

    更新日期:2015-01-01 00:00:00

  • High performance liquid chromatography for the detection of homozygotes and heterozygotes of Niemann-Pick disease.

    abstract::A method is developed for the detection of homozygotes and heterozygote carriers of Niemann-Pick disease type A by employing a high performance liquid chromatography (HPLC) technique for the measurement of sphingomyelin (SP) as well as for the assay of the enzyme sphingomyelinase (SPase) in skin fibroblasts and amniot...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Jungalwala FB,Milunsky A

    更新日期:1978-05-01 00:00:00

  • Fructose-induced hyperuricemia: observations in normal children and in patients with hereditary fructose intolerance and galactosemia.

    abstract::After the infusion of fructose, 0.25 g/kg body wt, the mean peak plasma uric acid level was 5.4 +/- 0.7 (SEM) mg/100 ml in six normal children and was not significantly increased compared with that of the mean basal value of 4.1 +/- 0.5 mg/100 ml. The mean blood inorganic phosphate (Pi) levels were significantly less ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Kogut MD,Roe TF,Ng W,Nonnel GN

    更新日期:1975-10-01 00:00:00

  • Experimental study of coil embolization using a new atelocollagen spring coil.

    abstract::Spring steel coils have been used to occlude abnormal vessels in patients with a congenital heart malformation. However, long-term adverse effects of steel spring coils remain uncertain, although some long-term results appear to be good. The purpose of this study was to evaluate the angiographic and histologic results...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Ino T,Kishiro M,Yamashiro Y,Tanaka A,Ito H

    更新日期:1998-04-01 00:00:00

  • Quality of reaching and postural control in young preterm infants is related to neuromotor outcome at 6 years.

    abstract::A substantial proportion of the "apparently normal" preterm infants exhibit minor and moderate dysfunctions in neuromotor outcome as they grow older. Birth characteristics, minor abnormalities on the neonatal ultrasound scan of the brain, and motor milestones have only limited value in the early detection of these chi...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Fallang B,Øien I,Hellem E,Saugstad OD,Hadders-Algra M

    更新日期:2005-08-01 00:00:00