Growth failure in cholestatic rats: the effect of malnutrition on insulin-like growth factor I.


:Low IGF-I levels are found in patients with chronic liver disease, but it is not known whether these reductions in IGF-I are secondary to hepatic dysfunction or to malnutrition. To determine whether malnutrition associated with hepatic dysfunction causes the decrease in these levels, serum and liver IGF-I concentrations and liver IGF-I mRNA content were compared in three groups of Sprague-Dawley rats: 15 rats underwent bile duct obstruction; 10 rats were sham-operated and pair-fed with operated rats to control for nutritional status; and 12 rats were sham-operated controls fed ad libitum. In addition, IGF-I peptide and mRNA were compared with food intake, crude nitrogen balance, total wt gain, tail length increase and leg muscle wt. All the parameters were lower in cholestatic and nutritionally deprived animals than in control animals (p less than 0.001). There was no difference in serum and hepatic IGF-I and liver IGF-I mRNA values between the 10 cholestatic and pair-fed animals, despite lower crude nitrogen balance, tail length gains, and leg muscle wt in the bile duct-obstructed animals. These studies suggest that in chronic bile duct obstruction, the low serum and hepatic IGF-I levels are primarily due to decreased food intake and appear unrelated to cholestatic liver disease itself. However, factors in addition to suboptimal nutrition and decreased IGF-I levels must also contribute to cholestasis-induced growth failure.


Pediatr Res


Pediatric research


Descos BP,Berry SA,Sharp HL,Gross CR,Weisdorf SA,Pescovitz OH




Has Abstract


1989-11-01 00:00:00












  • Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization.

    abstract::Matrix metalloproteinases (MMP) are likely effectors of normal lung development, especially branching morphogenesis, angiogenesis, and extracellular matrix degradation. Because hyperoxia exposure (>95% O(2)) from d 4 to 14 in newborn rat pups leads to arrest of alveolarization and mimics newborn chronic lung disease, ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hosford GE,Fang X,Olson DM

    更新日期:2004-07-01 00:00:00

  • Investigating the effects of cerebrospinal fluid removal on cerebral blood flow and oxidative metabolism in infants with post-hemorrhagic ventricular dilatation.

    abstract::BackgroundPost-hemorrhagic ventricular dilatation (PHVD) is predictive of mortality and morbidity among very-low-birth-weight preterm infants. Impaired cerebral blood flow (CBF) due to elevated intracranial pressure (ICP) is believed to be a contributing factor.MethodsA hyperspectral near-infrared spectroscopy (NIRS) ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: McLachlan PJ,Kishimoto J,Diop M,Milej D,Lee DSC,de Ribaupierre S,St Lawrence K

    更新日期:2017-10-01 00:00:00

  • Effects of upper airway obstruction or hypoxia on gastroesophageal reflux in newborn lambs.

    abstract:BACKGROUND:Although it is commonly accepted that upper airway obstruction (UAO) increases gastroesophageal reflux (GER), the link is poorly understood and insufficiently documented. In addition, while hypoxia is often encountered in infants with UAO, its consequences on GER are virtually unknown. The two aims of the pr...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Michaud A,Jia WL,Djeddi D,Samson N,Nadeau C,Geha S,Praud JP

    更新日期:2020-05-01 00:00:00

  • Immunologic studies of prothrombin in newborns.

    abstract::Prothrombin of newborns was investigated by means of the quantitative immunoelectrophoresis and the two-dimensional immunoelectrophoresis. The plasma of 10 of 24 healthy term newborns and of 5 preterm infants taken immediately after birth showed one prothrombin precipitate in the alpha-2-beta-globulin position when a ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Muntean W,Petek W,Rosanelli K,Mutz ID

    更新日期:1979-11-01 00:00:00

  • Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model.

    abstract::BackgroundThe mechanisms underlying aberrant activation of intestinal Toll-like receptor 4 (TLR4) signaling in necrotizing enterocolitis (NEC) remain unclear. In this study, we examined the role of single-immunoglobulin interleukin-1 receptor-related molecule (SIGIRR), an inhibitor of TLR signaling, in modulating expe...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Fawley J,Cuna A,Menden HL,McElroy S,Umar S,Welak SR,Gourlay DM,Li X,Sampath V

    更新日期:2018-01-01 00:00:00

  • Total body electrical conductivity measurements: an evaluation of current instrumentation for infants.

    abstract::Quantitation of the body's fat and learn masses is an important component of nutritional assessment. Such measurements, however, are difficult to conduct routinely in infants due to the numerous limitations of traditional methods. The application of total body electrical conductivity measurements for quantitating fat-...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Fiorotto ML,de Bruin NC,Brans YW,Degenhart HJ,Visser HK

    更新日期:1995-01-01 00:00:00

  • Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway.

    abstract::Tracheal aspirate IL-8 concentration and airway epithelial cell IL-8 expression are each increased in premature infants undergoing mechanical ventilation. We sought to determine the cytokines responsible for IL-8 expression in this context. Tracheal aspirates were collected from 18 mechanically ventilated premature in...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Shimotake TK,Izhar FM,Rumilla K,Li J,Tan A,Page K,Brasier AR,Schreiber MD,Hershenson MB

    更新日期:2004-12-01 00:00:00

  • Adverse neuropsychiatric development following perinatal brain injury: from a preclinical perspective.

    abstract::Perinatal brain injury is a leading cause of death and disability in young children. Recent advances in obstetrics, reproductive medicine and neonatal intensive care have resulted in significantly higher survival rates of preterm or sick born neonates, at the price of increased prevalence of neurological, behavioural ...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Bendix I,Hadamitzky M,Herz J,Felderhoff-Müser U

    更新日期:2019-01-01 00:00:00

  • The effects of the estrogen receptor blocker, Faslodex (ICI 182,780), on estrogen-accelerated bone maturation in mice.

    abstract::Sex steroids accelerate bone maturation, but it is believed that estrogen action is needed for terminal epiphyseal fusion. In this study, we investigated the effects of a new estrogen-blocking agent, Faslodex (ICI 182,780), on estrogen-accelerated skeletal maturation in immature mice. On day-of-life 2 through 8, mice ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Gunther DF,Calikoglu AS,Underwood LE

    更新日期:1999-09-01 00:00:00

  • Epithelial-mesenchymal transformation and apoptosis in rat urethra development.

    abstract::BackgroundTo examine the mechanism of urethral seam formation during embryonal development of rat urethra.MethodsTime-mated Sprague-Dawley rats were killed and the genital tubercles of male pups harvested on embryonic day (ED) 15, 16, 18, and 19. External morphology was observed under scanning electron microscope. Ser...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Zhou Y,Liu X,Huang F,Liu Y,Cao X,Shen L,Long C,He D,Lin T,Wei G

    更新日期:2017-12-01 00:00:00

  • Caffeine administration modulates TGF-β signaling but does not attenuate blunted alveolarization in a hyperoxia-based mouse model of bronchopulmonary dysplasia.

    abstract:BACKGROUND:Caffeine is widely used to manage apnea of prematurity, and reduces the incidence of bronchopulmonary dysplasia (BPD). Deregulated transforming growth factor (TGF)-β signaling underlies arrested postnatal lung maturation in BPD. It is unclear whether caffeine impacts TGF-β signaling or postnatal lung develop...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Rath P,Nardiello C,Surate Solaligue DE,Agius R,Mižíková I,Hühn S,Mayer K,Vadász I,Herold S,Runkel F,Seeger W,Morty RE

    更新日期:2017-05-01 00:00:00

  • Effects of hyperoxia on the arousal response to upper airway obstruction in lambs.

    abstract::Experiments were done to investigate the effects of increased inspired oxygen on the arousal response from sleep to upper airway obstruction in 10 newborn lambs. Each lamb was anesthetized and instrumented for recordings of electrocorticograms, electrooculogram, nuchal and diaphragm electromyograms, and measurements o...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Baker SB,Fewell JE

    更新日期:1987-02-01 00:00:00

  • Growth hormone-releasing hexapeptide is a potent stimulator of growth hormone gene expression and release in the growth hormone-releasing hormone-deprived infant rat.

    abstract::The growth hormone-releasing hexapeptide (GHRP-6) specifically stimulates growth hormone (GH) secretion in several animal species and humans. The mechanism of action of GHRP-6 is largely unknown, although experimental evidence indicates that it may modulate growth hormone-releasing hormone (GHRH) and somatostatin acti...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Locatelli V,Grilli R,Torsello A,Cella SG,Wehrenberg WB,Müller EE

    更新日期:1994-08-01 00:00:00

  • Tissue engineering in cleft palate and other congenital malformations.

    abstract::Contributions from multidisciplinary investigations have focused attention on the potential of tissue engineering to yield novel therapeutics. Congenital malformations, including cleft palate, craniosynostosis, and craniofacial skeletal hypoplasias represent excellent targets for the implementation of tissue engineeri...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Panetta NJ,Gupta DM,Slater BJ,Kwan MD,Liu KJ,Longaker MT

    更新日期:2008-05-01 00:00:00

  • Insulin as a growth factor.

    abstract::Insulin is a potent mitogen for many cell types in vitro. During tissue culture, supraphysiological concentrations of insulin are necessary to promote cell replication in connective or musculoskeletal tissues. Insulin promotes the growth of these cells by binding, with low affinity, to the type I insulin-like growth f...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审


    authors: Hill DJ,Milner RD

    更新日期:1985-09-01 00:00:00

  • Surface and cytoplasmic immunoglobulin expression in circulating B-lymphocytes in acute Kawasaki disease.

    abstract::Kawasaki disease (KD) is an acute vasculitis of young childhood predominantly affecting the coronary arteries. IgA plasma cells have been found to infiltrate vascular and nonvascular tissues in fatal acute KD. To determine whether IgA B-lymphocytes were increased in the peripheral blood of patients with KD, we perform...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Shingadia D,O'Gorman M,Rowley AH,Shulman ST

    更新日期:2001-10-01 00:00:00

  • Comprehensive genetic variant discovery in the surfactant protein B gene.

    abstract::Completely penetrant mutations in the surfactant protein B gene (SFTPB) and >75% reduction of SFTPB expression disrupt pulmonary surfactant function and cause neonatal respiratory distress syndrome. To inform studies of genetic regulation of SFTPB expression, we created a catalogue of SFTPB variants by comprehensive r...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Hamvas A,Wegner DJ,Carlson CS,Bergmann KR,Trusgnich MA,Fulton L,Kasai Y,An P,Mardis ER,Wilson RK,Cole FS

    更新日期:2007-08-01 00:00:00

  • Immunomodulating actions of nucleotides: enhancement of immunoglobulin production by human cord blood lymphocytes.

    abstract::We have shown previously that polynucleotides enhance in vitro antibody and Ig production in response to T-dependent antigens in mice and augment Ig production by adult human peripheral blood mononuclear cells. Herein, we report their effects on umbilical cord blood mononuclear cells (CBMNC) obtained from full-term ba...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Jyonouchi H,Zhang-Shanbhag L,Georgieff M,Tomita Y

    更新日期:1993-11-01 00:00:00

  • Cysteine and glutathione levels in developing rat kidney and liver.

    abstract::Intracellular levels of cysteine (CSH) and reduced glutathione (GSH) in the kidney and liver of rats from the newborn to the adult period have been determined using a sensitive high performance liquid chromatography method. In the kidney, the intracellular level of free CSH increased 4-fold from 1 to 4 nmol/mg protein...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: States B,Foreman JW,Segal S

    更新日期:1987-11-01 00:00:00

  • Contribution of sarcoplasmic reticulum Ca²+ release and Ca²+ transporters on sarcolemmal channels to Ca²+ transient in fetal mouse heart.

    abstract::Sarcoplasmic reticulum (SR) Ca release has been shown not to be the predominant mechanism responsible for excitation-contraction (E-C) coupling in fetal myocytes. However, most of the studies have been conducted either on primary cultures or acutely isolated cells, in which an apparent reduction of ryanodine receptor ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Takizawa M,Ishiwata T,Kawamura Y,Kanai T,Kurokawa T,Nishiyama M,Ishida H,Asano Y,Nonoyama S

    更新日期:2011-04-01 00:00:00

  • Antenatal betamethasone alters vascular reactivity in adult female ovine cerebral arteries.

    abstract::Although the use of antenatal glucocorticoids has resulted in decreased neonatal morbidity/mortality, recent animal studies have raised concerns regarding adverse effects of these medications on postnatal cardiovascular function. We hypothesized that antenatal betamethasone (Beta) exposure alters cerebral vascular rea...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Eckman DM,Kerr BA,Fuloria M,Simandle SA,Watt SE,Rose JC,Figueroa JP

    更新日期:2010-10-01 00:00:00

  • Diffusion tensor imaging in preterm infants with punctate white matter lesions.

    abstract::Our aim was to compare white matter (WM) microstructure in preterm infants with and without punctate WM lesions on MRI using tract-based spatial statistics (TBSS) and probabilistic tractography. We studied 23 preterm infants with punctate lesions, median GA at birth 30 (25-35) wk, and 23 GA- and sex-matched preterm co...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Bassi L,Chew A,Merchant N,Ball G,Ramenghi L,Boardman J,Allsop JM,Doria V,Arichi T,Mosca F,Edwards AD,Cowan FM,Rutherford MA,Counsell SJ

    更新日期:2011-06-01 00:00:00

  • Lactic acidosis in a newborn with adrenal calcifications.

    abstract::A patient is reported who presented in the newborn period with an unusual combination of congenital lactic acidosis and bilateral calcifications in the adrenal medulla, visible on standard abdominal x-ray and ultrasound examination. At birth, the proband was hypotonic and dystrophic. She developed respiratory insuffic...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Zecic A,Smet JE,De Praeter CM,Vanhaesebrouck P,Viscomi C,Van Den Broecke C,De Paepe B,Lohse P,Martin JJ,Jackson JG,Campbell CR,De Meirleir LJ,Zeviani M,Seneca SH,Lissens W,Van Coster RN

    更新日期:2009-09-01 00:00:00

  • Effect of racemic epinephrine on ventilatory function in the neonate postextubation.

    abstract::The use of nebulized racemic epinephrine to improve ventilatory function in the newborn postextubation was studied. Forty-five infants intubated for more than 3 days were randomized to receive racemic epinephrine by nebulization immediately postextubation or to receive only warmed, humidified gas. Measurements of air ...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Courtney SE,Wachtl JP,Hopson JF,Siervogel RM

    更新日期:1987-04-01 00:00:00

  • Dexamethasone inhibits maturation and alters function of monocyte-derived dendritic cells from cord blood.

    abstract::Critically ill infants are treated with dexamethasone (Dx) and other glucocorticoids to reduce inflammation and to promote lung and cardiac function. The neonatal immune system is immature, so neonatal dendritic cells (DCs) might be especially sensitive to glucocorticoid-mediated immunosuppression. To test this, we co...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Mainali ES,Kikuchi T,Tew JG

    更新日期:2005-07-01 00:00:00

  • 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo.

    abstract::To determine the importance of peroxisomes and mitochondria in hydroxyeicosatetraenoic acid (HETE) oxidation in vivo, urinary excretion of 12- and 15-HETE was measured in eight patients with a peroxisome deficiency disorder (Zellweger syndrome) showing normal mitochondrial beta-oxidation capacity, in three patients wi...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Mayatepek E,Lehmann WD

    更新日期:1996-01-01 00:00:00

  • Cerebellar injury in the premature infant is associated with impaired growth of specific cerebral regions.

    abstract::We have shown that cerebellar injury in the premature infant is followed by significant growth impairment of the contralateral cerebral hemisphere evident as early as term adjusted age. In this study, we hypothesize that this remote growth restriction is region specific in the cerebrum. In a prospectively enrolled coh...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Limperopoulos C,Chilingaryan G,Guizard N,Robertson RL,Du Plessis AJ

    更新日期:2010-08-01 00:00:00

  • Reduced Na+, K(+)-ATPase activity in patients with pseudohypoaldosteronism.

    abstract::Pseudohypoaldosteronism is a hereditary salt-wasting syndrome usually seen in infancy with weight loss, dehydration, and failure to thrive. The pathophysiologic origin of pseudohypoaldosteronism is unknown. The defect could be related to the unresponsiveness of target organs to mineralocorticoids resulting in hyponatr...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Bistritzer T,Evans S,Cotariu D,Goldberg M,Aladjem M

    更新日期:1994-03-01 00:00:00

  • The developing gut-lung axis: postnatal growth restriction, intestinal dysbiosis, and pulmonary hypertension in a rodent model.

    abstract:BACKGROUND:Postnatal growth restriction (PNGR) in premature infants increases risk of pulmonary hypertension (PH). In a rodent model, PNGR causes PH, while combining PNGR and hyperoxia increases PH severity. We hypothesized that PNGR causes intestinal dysbiosis and that treatment with a probiotic attenuates PNGR-associ...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Wedgwood S,Warford C,Agvatisiri SR,Thai PN,Chiamvimonvat N,Kalanetra KM,Lakshminrusimha S,Steinhorn RH,Mills DA,Underwood MA

    更新日期:2020-02-01 00:00:00

  • Impaired pulmonary clearance of pneumococci in neonatal rats.

    abstract::Lung infections are a common cause of morbidity and mortality in neonates. To evaluate neonatal lung defenses against pneumococci, we challenged rats with aerosols of encapsulated pneumococci in an airborne infection apparatus. Whereas adult rats cleared greater than 95% of inhaled type 1 or type 25 pneumococci within...

    journal_title:Pediatric research

    pub_type: 杂志文章


    authors: Coonrod JD,Jarrells MC,Bridges RB

    更新日期:1987-12-01 00:00:00