Bilirubin binding in jaundiced newborns: from bench to bedside?

abstract：:Lung deposition of inhaled drugs in ventilated neonates has been studied in models of questionable relevance. With conventional nebulizers, pulmonary deposition has been limited to 1% of the total dose. The objective of this study was to assess lung delivery of aerosols in a model of neonatal ventilation using a conve...

journal_title：Pediatric research

authors： Dubus JC,Vecellio L,De Monte M,Fink JB,Grimbert D,Montharu J,Valat C,Behan N,Diot P

更新日期：2005-07-01 00:00:00

abstract：:Disorders affecting fetal growth are commonly associated with premature birth. IGFs and their binding proteins (IGFBPs) are potent regulators of fetal growth. In vitro evidence suggests that they regulate collagen turnover. Collagen turnover can be monitored by serum markers of type I collagen synthesis (PINP) and deg...

journal_title：Pediatric research

authors： Kajantie E,Hytinantti T,Koistinen R,Risteli J,Rutanen EM,Seppälä M,Andersson S

更新日期：2001-04-01 00:00:00

abstract：:Sugar alcohols have been found to play an important osmoregulatory role both in unicellular organisms and, more recently, in multicellular organisms, including mammals. This study shows that myo-inositol accumulates in the brains of chronically hypernatremic mice, as had been earlier found in rats, and demonstrates fo...

journal_title：Pediatric research

authors： Thurston JH,Sherman WR,Hauhart RE,Kloepper RF

更新日期：1989-11-01 00:00:00

abstract：:Surfactant-associated proteins (SP-A, SP-B, and SP-C) are critical for the endogenous function of surfactant. Keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF) are key regulators of lung development. The objective of this study was to evaluate the effects of early mechanical ventilation on...

journal_title：Pediatric research

authors： Digeronimo RJ,Mustafa SB,Ryan RM,Sternberg ZZ,Ashton DJ,Seidner SR

更新日期：2007-09-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency encountered in the neonatal intensive care unit. Despite advances in neonatal care, NEC remains a leading cause of morbidity and mortality among premature infants. Epidemiologic studies have identified multiple factors that ...

journal_title：Pediatric research

authors： Hunter CJ,Upperman JS,Ford HR,Camerini V

更新日期：2008-02-01 00:00:00

abstract：:Medium chain acyl-CoA dehydrogenase deficiency (MCAD) is a defect in the mitochondrial oxidation of fatty acids. The disorder typically presents with episodes of vomiting and hypoglycemia, sometimes with changes in mental status and hepatic failure. These Reye's-like features may culminate in coma and death. Stress, i...

journal_title：Pediatric research

authors： Ziadeh R,Hoffman EP,Finegold DN,Hoop RC,Brackett JC,Strauss AW,Naylor EW

更新日期：1995-05-01 00:00:00

abstract：:Evaluation of nonlinear heart rate (HR) dynamics has received considerable attention in the pediatric literature because such analyses not only provide insight into underlying control mechanisms, but may also help to differentiate between normal and abnormal infants. The purpose of this study was to determine, in eigh...

journal_title：Pediatric research

authors： Mooney DM,Groome LJ,Holland SB,Smith YD

更新日期：1998-07-01 00:00:00

abstract：:The objective was to investigate any possible relationship between functional and structural vascular changes in women with low gestational age and/or low birth weight by analyzing the retinal vascular pattern in women with thoroughly documented blood pressure. Retinal vessel morphology was evaluated by digital image ...

journal_title：Pediatric research

authors： Kistner A,Jacobson L,Jacobson SH,Svensson E,Hellstrom A

更新日期：2002-06-01 00:00:00

abstract：:Plasma aldosterone (A), corticosterone (B), deoxycorticosterone (DOC), progesterone (P), 17-hydroxyprogesterone (17-OHP), cortisol (F), and cortisone (E) were measured simultaneously by specific radioimmunoassays in small plasma samples obtained from 174 normal infants and children between 2 hr and 15 yr of age. The s...

journal_title：Pediatric research

authors： Sippell WG,Dörr HG,Bidlingmaier F,Knorr D

更新日期：1980-01-01 00:00:00

abstract：:Groups of newborn rats were transthoracically inoculated with 1 X 10(6) type III group B streptococci/g body wt, either alone or in combination with 1.5 microgram/g body wt of type-specific antibody derived from hybridoma cell lines. Ninety-four percent of the animals who received bacteria alone died. In contrast, non...

journal_title：Pediatric research

authors： Christensen RD,Rothstein G,Hill HR,Pincus SH

更新日期：1983-10-01 00:00:00

abstract：:Acute postasphyxial encephalopathy around the time of birth remains a major cause of death and disability. The possibility that hypothermia may be able to prevent or lessen asphyxial brain injury is a "dream revisited". In this review, a historical perspective is provided from the first reported use of therapeutic hyp...

journal_title：Pediatric research

authors： Gunn AJ,Laptook AR,Robertson NJ,Barks JD,Thoresen M,Wassink G,Bennet L

更新日期：2017-01-01 00:00:00

abstract：:Responses of pial arterioles to topically applied arachidonic acid, conversion of exogenous arachidonic acid to prostanoids, and pial arteriolar dilation to hypercapnia were examined before and at progressive times after treatment with indomethacin (5 mg/kg i.v.) in chloralose-anesthetized newborn pigs with closed cra...

journal_title：Pediatric research

authors： Leffler CW,Mirro R,Shibata M,Parfenova H,Armstead WM,Zuckerman S

更新日期：1993-06-01 00:00:00

abstract：:The field of regenerative medicine continues to make substantial advancements in therapeutic strategies addressing urologic diseases. Tissue engineering borrows principles from the fields of cell biology, materials science, transplantation and engineering in an effort to repair or replace damaged tissues. This review ...

journal_title：Pediatric research

authors： Yamzon JL,Kokorowski P,Koh CJ

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:The aim of the study was to describe and contrast the brain development and outcome among very preterm infants that were and were not exposed to surgery requiring general anesthesia prior to term equivalent age (TEA). METHODS:Preterm infants born ≤30 weeks' gestation who did (n = 25) and did not (n = 59) ha...

journal_title：Pediatric research

authors： Walsh BH,Paul RA,Inder TE,Shimony JS,Smyser CD,Rogers CE

更新日期：2020-06-23 00:00:00

abstract：:To determine the effects of age, feeding regimen, and antenatal glucocorticoids on intestinal permeability, preterm infants (n = 132) were stratified by gestational age and by diet (mothers' own milk versus preterm formula), and assigned randomly to one of four feeding regimens: early-continuous, early-bolus, standard...

journal_title：Pediatric research

authors： Shulman RJ,Schanler RJ,Lau C,Heitkemper M,Ou CN,Smith EO

更新日期：1998-10-01 00:00:00

abstract：:In Krabbe's disease (globoid cell leukodystrophy), galactosylsphingosine (psychosine) is considered to be a causative agent of the pathology found in the nervous system of the patients. In our study, we examined the cytotoxic effect of psychosine in neural cell cultures derived from the rat nervous system. The concent...

journal_title：Pediatric research

authors： Sugama S,Kim SU,Ida H,Eto Y

更新日期：1990-11-01 00:00:00

abstract：:The sheep has served as an informative animal model for investigation of human fetal and newborn erythropoiesis and red blood cell (RBC) kinetics. We previously validated the permanent label (14C)cyanate for measuring red cell volume (RCV) in sheep. Here, we validate biotin labeling of RBCs as a nonradioactive method ...

journal_title：Pediatric research

authors： Mock DM,Mock NI,Lankford GL,Burmeister LF,Strauss RG,Widness JA

更新日期：2008-11-01 00:00:00

abstract：:Human GH is encoded by the GH-1 gene which belongs to the GH gene cluster encompassing a distance of about 65 kb on the long arm of chromosome 17. Familial isolated growth hormone deficiency (IGHD) is associated with at least four Mendelian disorders. These include two forms that have autosomal recessive inheritance (...

journal_title：Pediatric research

authors： Wagner JK,Eblé A,Hindmarsh PC,Mullis PE

更新日期：1998-01-01 00:00:00

abstract：:A 2-month-old white girl had severe liver disease (but without signs of hepatic necrosis, infection or cirrhosis), urinary cytomegalovirus, transient reduction of alpha 1-antitrypsin concentration and transient abnormal alpha 1-antitrypsin phenotype that were not present in her parents. Five serum specimens that were ...

journal_title：Pediatric research

authors： Hug G,Chuck G,Bowles B

更新日期：1982-03-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) have traditionally been defined according to their immunologic phenotype. Far from being concluded, the search for human genes that, when mutated, cause PID is actively being pursued. During the last year, four novel genetic defects that cause severe combined immunodeficiency and seve...

journal_title：Pediatric research

authors： Pessach I,Walter J,Notarangelo LD

更新日期：2009-05-01 00:00:00

abstract：:Quantitative determinations of cryoglobulins (IgG, IgA, IgM, and C3) were performed by a laser nephelometry microtechnique on 250 serum samples from a group of pediatric patients suspected of having immune complex-mediated disorders. Approximately 50% of these samples were cryoglobulin positive. Patients with cryoglob...

journal_title：Pediatric research

authors： Yang LC,Norman ME,Doughty RA

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:Diseases of adulthood, such as diabetes and hypertension, may be related to changes during pregnancy, particularly in kidney. We hypothesized that acute kidney injury progresses more rapidly in cases of fetal programming. METHODS:Diabetic dams' offspring were divided into: CC (controls, receiving vehicle); ...

journal_title：Pediatric research

authors： Corrêa RR,Pucci KR,Rocha LP,Pereira Júnior CD,Helmo FR,Machado JR,Rocha LB,Rodrigues AR,Glória MA,Guimarães CS,Câmara NO,Reis MA

更新日期：2015-03-01 00:00:00

abstract：:Allergies are increasing, and despite deeper insights into the immunologic basis of these diseases, preventive measures are not yet efficient. As the induction of allergic diseases is often triggered in early childhood, perinatal or prenatal preventive strategies would be beneficial. We investigated the transfer of in...

journal_title：Pediatric research

authors： Szépfalusi Z,Loibichler C,Pichler J,Reisenberger K,Ebner C,Urbanek R

更新日期：2000-09-01 00:00:00

abstract：:Most preterm infants breathe at birth, but need additional respiratory support due to immaturity of the lung and respiratory control mechanisms. To avoid lung injury, the focus of respiratory support has shifted from invasive towards non-invasive ventilation. However, applying effective non-invasive ventilation is dif...

journal_title：Pediatric research

authors： Dekker J,van Kaam AH,Roehr CC,Flemmer AW,Foglia EE,Hooper SB,Te Pas AB

更新日期：2019-06-19 00:00:00

abstract：:Four protein dietary groups of rats were used in this study, namely: 27% casein diet fed throughout gestation and lactation (group C-C); 27% gestation, 10% lactation (group C-D); 10% gestation, 27% lactation (group D-C); 10% throughout gestation and lactation (group D-D). Mean body weight of group D-D at warning was 1...

journal_title：Pediatric research

authors： Kissane JQ,Hawrylewicz EJ

更新日期：1975-03-01 00:00:00

abstract：:Human and ovine placental tissue homogenates were assayed for dipeptidase activity in vitro. Glycyl-L-leucine, L-leucyl glycine, glycyl-L-lysine, and L-lysyl glycine were hydrolyzed by placental homogenates. The pH optimum for the reaction was 8.0. The relationship between enzyme activity and concentration was linear ...

journal_title：Pediatric research

authors： Crandell SS,Adcock EW 3rd,Morriss FH Jr

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:Caffeine is a nonspecific adenosine receptor antagonist used in premature neonates to treat apnea of prematurity. While its use may reduce the incidence of bronchopulmonary dysplasia (BPD), the precise mechanisms remain unknown. Evidence of increased adenosine levels are noted in chronic lung diseases includ...

journal_title：Pediatric research

authors： Dayanim S,Lopez B,Maisonet TM,Grewal S,Londhe VA

更新日期：2014-03-01 00:00:00

abstract：:Tolazoline is used in neonatal intensive care to treat hypoxia secondary to persistent pulmonary hypertension of the newborn. Its use is often complicated by systemic hypotension. We compared the effect of tolazoline-induced hypotension on organ blood flow, regional brain blood flow, and cerebral metabolism in hypoxic...

journal_title：Pediatric research

authors： Balsan MJ,Cronin CM,Shaw MD,Milley JR

更新日期：1990-08-01 00:00:00

abstract：:We have identified two unrelated girls with chronic neutropenia [absolute neutrophil counts (ANC) 10-870 and 10-940/microL in patients 1 and 2, respectively] and severe defect in superoxide anion generation by granulocytes. Formyl-methionyl-leucyl-phenylalanine-induced superoxide release was 1.2 +/- 0.9 and 1.9 +/- 1....

journal_title：Pediatric research

authors： Káposzta R,Maródi L

更新日期：1995-01-01 00:00:00

abstract：:Genetic factors cannot explain the recent rapid increase in the incidence of atopic diseases. The phenomenon has been explained by environmental factors, and there are data for and against the hypothesis that a decline in the pressure of microbial stimulation early in life could be behind the allergy epidemic. Changes...

journal_title：Pediatric research

authors： Kero J,Gissler M,Grönlund MM,Kero P,Koskinen P,Hemminki E,Isolauri E

更新日期：2002-07-01 00:00:00